SU(2) Low-Energy Constants from Mixed-Action Lattice QCD

An analysis of the pion mass and pion decay constant is performed using mixed-action Lattice QCD calculations with domain-wall valence quarks on ensembles of rooted, staggered n_f = 2+1 MILC configurations. Calculations were performed at two lattice spacings of b~0.125 fm and b~0.09 fm, at two strange quark masses, multiple light quark masses, and a number of lattice volumes. The ratios of light quark to strange quark masses are in the range 0.1 <= m_l / m_s <= 0.6, while pion masses are in the range 235 < m_\pi < 680 MeV. A two-flavor chiral perturbation theory analysis of the Lattice QCD calculations constrains the Gasser-Leutwyler coefficients bar{l}_3 and bar{l}_4 to be bar{l}_3 = 4.04(40)(+73-55) and bar{l}_4 = 4.30(51)(+84-60). All systematic effects in the calculations are explored, including those from the finite lattice space-time volume, the finite lattice spacing, and the finite fifth dimension in the domain-wall quark action. A consistency is demonstrated between a chiral perturbation theory analysis at fixed lattice spacing combined with a leading order continuum extrapolation, and the mixed-action chiral perturbation theory analysis which explicitly includes the leading order discretization effects. Chiral corrections to the pion decay constant are found to give f_\pi / f = 1.062(26)(+42-40) where f is the decay constant in the chiral limit. The most recent scale setting by the MILC Collaboration yields a postdiction of f_\pi = 128.2(3.6)(+4.4-6.0)(+1.2-3.3) MeV at the physical pion mass.Comment: 28 pages, 9 figures; version 2 accepted for publication in PR

High Statistics Analysis using Anisotropic Clover Lattices: (IV) Volume Dependence of Light Hadron Masses

The volume dependence of the octet baryon masses and relations among them are explored with Lattice QCD. Calculations are performed with n_f=2+1 clover fermion discretization in four lattice volumes, with spatial extent L ~ 2.0, 2.5, 3.0 and 3.9 fm, with an anisotropic lattice spacing of b_s ~ 0.123 fm in the spatial direction, and b_t = b_s/3.5 in the time direction, and at a pion mass of m_pi ~ 390 MeV. The typical precision of the ground-state baryon mass determination is ~0.2%, enabling a precise exploration of the volume dependence of the masses, the Gell-Mann--Okubo mass relation, and of other mass combinations. A comparison of the volume dependence with the predictions of heavy baryon chiral perturbation theory is performed in both the SU(2)_L X SU(2)_R and SU(3)_L X SU(3)_R expansions. Predictions of the three-flavor expansion for the hadron masses are found to describe the observed volume dependences reasonably well. Further, the Delta-N-pi axial coupling constant is extracted from the volume dependence of the nucleon mass in the two-flavor expansion, with only small modifications in the three-flavor expansion from the inclusion of kaons and etas. At a given value of m_pi L, the finite-volume contributions to the nucleon mass are predicted to be significantly smaller at m_pi ~ 140 MeV than at m_pi ~ 390 MeV due to a coefficient that scales as ~ m_pi^3. This is relevant for the design of future ensembles of lattice gauge-field configurations. Finally, the volume dependence of the pion and kaon masses are analyzed with two-flavor and three-flavor chiral perturbation theory.Comment: 34 pages, 45 figure

Meson and baryon spectrum for QCD with two light dynamical quarks

We present results of meson and baryon spectroscopy using the Chirally Improved Dirac operator on lattices of size 16**3 x 32 with two mass-degenerate light sea quarks. Three ensembles with pion masses of 322(5), 470(4) and 525(7) MeV and lattice spacings close to 0.15 fm are investigated. Results on ground and excited states for several channels are given, including spin two mesons and hadrons with strange valence quarks. The analysis of the states is done with the variational method, including two kinds of Gaussian sources and derivative sources. We obtain several ground states fairly precisely and find radial excitations in various channels. Excited baryon results seem to suffer from finite size effects, in particular at small pion masses. We discuss the possible appearance of scattering states in various channels, considering masses and eigenvectors. Partially quenched results in the scalar channel suggest the presence of a 2-particle state, however, in most channels we cannot identify them. Where available, we compare our results to results of quenched simulations using the same action.Comment: 27 pages, 29 figures, 11 table

Search for Fermion Actions on Hyperdiamond Lattices

Fermions moving in a two-dimensional honeycomb lattice (graphene) have, at low energies, chiral symmetry. Generalizing this construction to four dimensions potentially provides fermions with chiral symmetry and only the minimal fermion doubling demanded by the Nielsen-Ninomiya no-go theorem. The practical usefulness of such fermions hinges on whether the action has a necessary set of discrete symmetries of the lattice. If this is the case, one avoids the generation of dimension three and four operators which require fine tuning. We construct hyperdiamond lattice actions with enough symmetries to exclude fine tuning; however, they produce multiple doublings. The limit where the actions exhibit minimal doubling does not possess the requisite symmetry.Comment: 4 pages, 1 figur

RANK/RANKL/OPG pathway: genetic associations with stress fracture period prevalence in elite athletes

Context: The RANK/RANKL/OPG signalling pathway is important in the regulation of bone turnover, with single nucleotide polymorphisms (SNPs) in genes within this pathway associated with bone phenotypic adaptations. Objective: To determine whether four SNPs associated with genes in the RANK/RANKL/OPG signalling pathway were associated with stress fracture injury in elite athletes. Design, Participants, and Methods: Radiologically confirmed stress fracture history was reported in 518 elite athletes, forming the Stress Fracture Elite Athlete (SFEA) cohort. Data were analysed for the whole group, and were sub-stratified into male and cases of multiple stress fracture group. Genotypes were determined using proprietary fluorescence-based competitive allele-specific PCR assays. Results: SNPs rs3018362 (RANK) and rs1021188 (RANKL) were associated with stress fracture injury (p<0.05). 8.1% of stress fracture group and 2.8% of the non-stress fracture group were homozygote for the rare allele of rs1021188. Allele frequency, heterozygotes and homozygotes for the rare allele of rs3018362 were associated with stress fracture period prevalence (p<0.05). Analysis of the male only group showed 8.2% of rs1021188 rare allele homozygotes to have suffered a stress fracture while 2.5% of the non-stress fracture group were homozygous. In cases of multiple stress fractures, homozygotes for the rare allele of rs1021188, and individuals possessing at least one copy of the rare allele of rs4355801 (OPG) were shown to be associated with stress fracture injury (p<0.05). Conclusions: The data support an association between SNPs in the RANK/RANKL/OPG signalling pathway and the development of stress fracture injury. The association of rs3018362 (RANK) and rs1021188 (RANKL) with stress fracture injury susceptibility supports their role in the maintenance of bone health, and offers potential targets for therapeutic interventions

Hadron Structure on the Lattice

A few chosen nucleon properties are described from a lattice QCD perspective: the nucleon sigma term and the scalar strangeness in the nucleon; the vector form factors in the nucleon, including the vector strangeness contribution, as well as parity breaking effects like the anapole and electric dipole moment; and finally the axial and tensor charges of the nucleon. The status of the lattice calculations is presented and their potential impact on phenomenology is discussed.Comment: 17 pages, 9 figures; proceedings of the Conclusive Symposium of the Collaborative Research Center 443 "Many-body structure of strongly interacting systems", Mainz, February 23-25, 201

Patient Acceptability of the Yorkshire Dialysis Decision Aid (YoDDA) Booklet: A Prospective Non-Randomized Comparison Study Across 6 Predialysis Services

Background: Patients are satisfied with their kidney care but want more support in making dialysis choices. Predialysis leaflets vary across services, with few being sufficient to enable patients’ informed decision making. We describe the acceptability of a patient decision aid and feasibility of evaluating its effectiveness within usual predialysis practice. Methods: Prospective non-randomized comparison design, Usual Care or Usual Care Plus Yorkshire Dialysis Decision Aid Booklet (+YoDDA), in 6 referral centers (Yorkshire-Humber, UK) for patients with sustained deterioration of kidney function. Consenting (C) patients completed questionnaires after predialysis consultation (T1), and 6 weeks later (T2). Measures assessed YoDDA’s utility to support patients’ decisions and integration within usual care. Results: Usual Care (n = 105) and +YoDDA (n = 84) participant characteristics were similar: male (62%), white (94%), age (mean = 62.6; standard deviation [SD] 14.4), kidney disease severity (glomerular filtration rate [eGFR] mean = 14.7; SD 3.7); decisional conflict was <25; choice-preference for home versus hospital dialysis approximately 50:50. Patients valued receiving YoDDA, reading it on their own (96%), and sharing it with family (72%). +YoDDA participants had higher scores for understanding kidney disease, reasoning about options, feeling in control, sharing their decision with family. Study engagement varied by center (estimated range 14 – 49%; mean 45%); participants varied in completion of decision quality measures. Conclusions: Receiving YoDDA as part of predialysis education was valued and useful to patients with worsening kidney disease. Integrating YoDDA actively within predialysis programs will meet clinical guidelines and patient need to support dialysis decision making in the context of patients’ lifestyle

Symmetries and Interactions from Lattice QCD

Precision experimental tests of the Standard Model of particle physics (SM) are one of our best hopes for discovering what new physics lies beyond the SM (BSM). Key in the search for new physics is the connection between theory and experiment. Forging this connection for searches involving low-energy hadronic or nuclear environments requires the use of a non-perturbative theoretical tool, lattice QCD. We present two recent lattice QCD calculations by the CalLat collaboration relevant for new physics searches: the nucleon axial coupling, $g_A$, whose precise value as predicted by the SM could help point to new physics contributions to the so-called "neutron lifetime puzzle", and hadronic matrix elements of short-ranged operators relevant for neutrinoless double beta decay searches.Comment: Plenary talk presented CIPANP2018. 11 pages, 3 figure

UK Renal Research Strategy

This is the first published UK Renal Research Strategy compiled by professional and patient stakeholders across the renal community to provide guidance and evidence to funders, policy makers and those helping to create and support the next generation of researchers. Two rounds of widely based consultation with contributions from major renal stakeholders, patients, clinicians, multi-disciplinary teams, researchers and funders contributed to the strategic vision and aims. The strategy calls for action and implementation of the strategy will be reviewed and monitored by an Implementation Board

Neutrinoless double beta decay from lattice QCD

While the discovery of non-zero neutrino masses is one of the most important accomplishments by physicists in the past century, it is still unknown how and in what form these masses arise. Lepton number-violating neutrinoless double beta decay is a natural consequence of Majorana neutrinos and many BSM theories, and many experimental efforts are involved in the search for these processes. Understanding how neutrinoless double beta decay would manifest in nuclear environments is key for understanding any observed signals. In these proceedings we present an overview of a set of one- and two-body matrix elements relevant for experimental searches for neutrinoless double beta decay, describe the role of lattice QCD calculations, and present preliminary lattice QCD results