Microwave ISM Emission in the Green Bank Galactic Plane Survey: Evidence for Spinning Dust

We observe significant dust-correlated emission outside of H II regions in the Green Bank Galactic Plane Survey (-4 < b < 4 degrees) at 8.35 and 14.35 GHz. The rising spectral slope rules out synchrotron and free-free emission as majority constituents at 14 GHz, and the amplitude is at least 500 times higher than expected thermal dust emission. When combined with the Rhodes (2.326 GHz), and WMAP (23-94 GHz) data it is possible to fit dust-correlated emission at 2.3-94 GHz with only soft synchrotron, free-free, thermal dust, and an additional dust-correlated component similar to Draine & Lazarian spinning dust. The rising component generally dominates free-free and synchrotron for \nu >~ 14 GHz and is overwhelmed by thermal dust at \nu > 60 GHz. The current data fulfill most of the criteria laid out by Finkbeiner et al. (2002) for detection of spinning dust.Comment: ApJ in press. 26 pages, 11 figures, figures jpeg compressed to save spac

Antioxidant Treatment Regulates the Humoral Immune Response during Acute Viral Infection

Generation of reactive oxygen intermediates (ROI) following antigen receptor ligation is critical to promote cellular responses. However, the effect of antioxidant treatment on humoral immunity during a viral infection was unknown. Mice were infected with lymphocytic choriomeningitis virus (LCMV) and treated with Mn(III)tetrakis(4-benzoic acid)porphyrin chloride (MnTBAP), a superoxide dismutase mimetic, from days 0 to 8 postinfection. On day 8, at the peak of the splenic response in vehicle-treated mice, virus-specific IgM and IgG antibody-secreting cells (ASC) were decreased 22- and 457-fold in MnTBAP-treated animals. By day 38, LCMV-specific IgG ASC were decreased 5-fold in the bone marrow of drug-treated mice, and virus-specific antibodies were of lower affinity. Interestingly, antioxidant treatment had no effect on the number of LCMV-specific IgG memory B cells. In addition to decreases in ASC, MnTBAP treatment decreased the number of functional virus-specific CD4+ T cells. The decreased numbers of ASC observed on day 8 in drug-treated mice were due to a combination of Bim-mediated cell death and decreased proliferation. Together, these data demonstrate that ROI regulate antiviral ASC expansion and have important implications for understanding the effects of antioxidants on humoral immunity during infection and immunization

A 1.1 to 1.9 GHz SETI Survey of the Kepler Field: I. A Search for Narrow-band Emission from Select Targets

We present a targeted search for narrow-band (< 5 Hz) drifting sinusoidal radio emission from 86 stars in the Kepler field hosting confirmed or candidate exoplanets. Radio emission less than 5 Hz in spectral extent is currently known to only arise from artificial sources. The stars searched were chosen based on the properties of their putative exoplanets, including stars hosting candidates with 380 K > T_eq > 230 K, stars with 5 or more detected candidates or stars with a super-Earth (R_p 50 day orbit. Baseband voltage data across the entire band between 1.1 and 1.9 GHz were recorded at the Robert C. Byrd Green Bank Telescope between Feb--Apr 2011 and subsequently searched offline. No signals of extraterrestrial origin were found. We estimate that fewer than ~1% of transiting exoplanet systems host technological civilizations that are radio loud in narrow-band emission between 1-2 GHz at an equivalent isotropically radiated power (EIRP) of ~1.5 x 10^21 erg s^-1, approximately eight times the peak EIRP of the Arecibo Planetary Radar, and we limit the the number of 1-2 GHz narrow-band-radio-loud Kardashev type II civilizations in the Milky Way to be < 10^-6 M_solar^-1. Here we describe our observations, data reduction procedures and results.Comment: Accepted to the Astrophysical Journa

Effects of circadian rhythm phase alteration on physiological and psychological variables: Implications to pilot performance (including a partially annotated bibliography)

The effects of environmental synchronizers upon circadian rhythmic stability in man and the deleterious alterations in performance and which result from changes in this stability are points of interest in a review of selected literature published between 1972 and 1980. A total of 2,084 references relevant to pilot performance and circadian phase alteration are cited and arranged in the following categories: (1) human performance, with focus on the effects of sleep loss or disturbance and fatigue; (2) phase shift in which ground based light/dark alteration and transmeridian flight studies are discussed; (3) shiftwork; (4)internal desynchronization which includes the effect of evironmental factors on rhythmic stability, and of rhythm disturbances on sleep and psychopathology; (5) chronotherapy, the application of methods to ameliorate desynchronization symptomatology; and (6) biorythm theory, in which the birthdate based biorythm method for predicting aircraft accident susceptability is critically analyzed. Annotations are provided for most citations

G28.17+0.05: An unusual giant HI cloud in the inner Galaxy

New 21 cm HI observations have revealed a giant HI cloud in the Galactic plane that has unusual properties. It is quite well defined, about 150 pc in diameter at a distance of 5 kpc, and contains as much as 100,000 Solar Masses of atomic hydrogen. The outer parts of the cloud appear in HI emission above the HI background, while the central regions show HI self-absorption. Models which reproduce the observations have a core with a temperature <40 K and an outer envelope as much as an order of magnitude hotter. The cold core is elongated along the Galactic plane, whereas the overall outline of the cloud is approximately spherical. The warm and cold parts of the HI cloud have a similar, and relatively large, line width of approximately 7 km/s. The cloud core is a source of weak, anomalously-excited 1720 MHz OH emission, also with a relatively large line width, which delineates the region of HI self-absorption but is slightly blue-shifted in velocity. The intensity of the 1720 MHz OH emission is correlated with N(H) derived from models of the cold core. There is 12CO emission associated with the cloud core. Most of the cloud mass is in molecules, and the total mass is > 200,000 Solar Masses. In the cold core the HI mass fraction may be 10 percent. The cloud has only a few sites of current star formation. There may be about 100 more objects like this in the inner Galaxy; every line of sight through the Galactic plane within 50 degrees of the Galactic center probably intersects at least one. We suggest that G28.17+0.05 is a cloud being observed as it enters a spiral arm and that it is in the transition from the atomic to the molecular state.Comment: 35 pages, inludes 12 figure

Receptor for advanced glycation endproducts (RAGE) deficiency protects against MPTP toxicity

Copyright © 2011 Elsevier Inc. All rights reserved.Peer reviewedPublisher PD

Statistics of highly heterogeneous flow fields confined to three-dimensional random porous media

We present a strong relationship between the microstructural characteristics of, and the fluid velocity fields confined to, three-dimensional random porous materials. The relationship is revealed through simultaneously extracting correlation functions R-uu (r) of the spatial (Eulerian) velocity fields and microstructural two-point correlation functions S-2(r) of the random porous heterogeneous materials. This demonstrates that the effective physical transport properties depend on the characteristics of complex pore structure owing to the relationship between R-uu (r) and S-2(r) revealed in this study. Further, the mean excess plot was used to investigate the right tail of the streamwise velocity component that was found to obey light-tail distributions. Based on the mean excess plot, a generalized Pareto distribution can be used to approximate the positive streamwise velocity distribution

Quasi-simultaneous multi-frequency observations of inverted-spectrum GPS candidate sources

Gigahertz-Peaked Spectrum (GPS) sources are probably the precursors of local radio galaxies.Existing GPS source samples are small (<200). It is necessary to extend the availabe sample of the Gigahertz-Peaked Spectrum (GPS) and High Frequency Peaker (HFP) sources in order to study their nature with greater details and higher statistical significance. A sample of 214 radio sources, which were extracted from the SPECFIND catalog and show an inverted radio spectrum, were observed quasi-simultaneously at 4.85, 10.45, and 32GHz with the 100-m Effelsberg radio telescope. Using the VLBA calibrator survey (VCS) we have investigated the parsec-scale morphology of the sources. About 45% of the sources in our sample are classified as GPS or HFP candidates. We add 65 new GPS/HFP candidates to existing samples. We confirm the expected tendency that HFP are more compact on milliarcsecond scale than the 'classical' GPS sources, which peak at lower frequencies. The data mining of the SPECFIND database represents a promising tool for the discovery of new GPS/HFP sources.Comment: 16 pages, 7 figures, accepted for publication in A&