282 research outputs found
TRAPPIST: a robotic telescope dedicated to the study of planetary systems
We present here a new robotic telescope called TRAPPIST (TRAnsiting Planets
and PlanetesImals Small Telescope). Equipped with a high-quality CCD camera
mounted on a 0.6 meter light weight optical tube, TRAPPIST has been installed
in April 2010 at the ESO La Silla Observatory (Chile), and is now beginning its
scientific program. The science goal of TRAPPIST is the study of planetary
systems through two approaches: the detection and study of exoplanets, and the
study of comets. We describe here the objectives of the project, the hardware,
and we present some of the first results obtained during the commissioning
phase.Comment: To appear in Detection and Dynamics of Transiting Exoplanets,
Proceedings of Haute Provence Observatory Colloquium (23-27 August 2010),
eds. F. Bouchy, R.F. Diaz & C.Moutou, Platypus press 201
Dissociative attachment in HCl, DCl, and F2
Resonant scattering models, using nonlocal decay widths, are developed for dissociative attachment of slow electrons to diatomic molecules. Cross sections are obtained for HCl and DCl in several initial rotational and vibrational states, and the dependence of the average attachment cross section upon the rotational and vibrational temperature is examined. For F_2 the cross section for ground state molecules agrees well with experiment above 0.2 eV but shows no zero energy peak. The attachment cross section is higher for vibrationally excited molecules, but the enhancement is much less than that found in H_2 and HCl
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Infant Serum and Maternal Milk Vitamin B-12 Are Positively Correlated in Kenyan Infant-Mother Dyads at 1-6 Months Postpartum, Irrespective of Infant Feeding Practice.
BackgroundVitamin B-12 is an essential nutrient required for many functions including DNA synthesis, erythropoiesis, and brain development. If maternal milk vitamin B-12 concentrations are low, infants may face elevated risks of deficiency when exclusively breastfed.ObjectiveWe evaluated cross-sectional associations between infant serum vitamin B-12 concentrations and maternal milk vitamin B-12 concentrations at 1-6 mo postpartum among an unsupplemented population in rural western Kenya, and assessed biological demographic, and dietary characteristics associated with adequate infant serum vitamin B-12.MethodsWe modeled 1) infant serum vitamin B-12 using maternal milk vitamin B-12 concentration with linear regression; and 2) adequate (>220 pmol/L) infant serum vitamin B-12 using hypothesized biological, demographic, and dietary predictors with logistic regression. In both models, we used generalized estimating equations to account for correlated observations at the cluster-level.ResultsThe median (quartile 1, quartile 3) infant serum vitamin B-12 concentration was 276 pmol/L (193, 399 pmol/L) and approximately one-third of infants had serum vitamin B-12 ≤220 pmol/L, indicating that they were vitamin B-12 depleted or deficient. There was a positive correlation between maternal milk and infant serum vitamin B-12 (r = 0.36, P < 0.001) and in multivariable analyses, maternal milk vitamin B-12 concentration was significantly associated with infant serum vitamin B-12 adequacy (P-trend = 0.03).ConclusionsDespite a high prevalence (90%) of maternal milk vitamin B-12 concentrations below the level used to establish the Adequate Intake (<310 pmol/L), there was a low prevalence of infant vitamin B-12 deficiency. We found few factors that were associated with infant vitamin B-12 adequacy in this population, including infant feeding practices, although maternal vitamin B-12 status was not measured. The contribution of maternal milk to infant vitamin B-12 status remains important to quantify across populations, given that maternal milk vitamin B-12 concentration is modifiable with supplementation. This trial was registered at clinicaltrials.gov as NCT01704105
COSMOGRAIL: the COSmological MOnitoring of GRAvItational Lenses IX. Time delays, lens dynamics and baryonic fraction in HE 0435-1223
We present accurate time delays for the quadruply imaged quasar HE 0435-1223.
The delays were measured from 575 independent photometric points obtained in
the R-band between January 2004 and March 2010. With seven years of data, we
clearly show that quasar image A is affected by strong microlensing variations
and that the time delays are best expressed relative to quasar image B. We
measured Delta_t(BC) = 7.8+/-0.8 days, Delta_t(BD) = -6.5+/-0.7 days and
Delta_t_CD = -14.3+/-0.8 days. We spacially deconvolved HST NICMOS2 F160W
images to derive accurate astrometry of the quasar images and to infer the
light profile of the lensing galaxy. We combined these images with a stellar
population fitting of a deep VLT spectrum of the lensing galaxy to estimate the
baryonic fraction, , in the Einstein radius. We measured f_b =
0.65+0.13-0.10 if the lensing galaxy has a Salpeter IMF and f_b =
0.45+0.04-0.07 if it has a Kroupa IMF. The spectrum also allowed us to estimate
the velocity dispersion of the lensing galaxy, sigma_ap = 222+/-34 km/s. We
used f_b and sigma_ap to constrain an analytical model of the lensing galaxy
composed of an Hernquist plus generalized NFW profile. We solve the Jeans
equations numerically for the model and explored the parameter space under the
additional requirement that the model must predict the correct astrometry for
the quasar images. Given the current error bars on f_b and sigma_ap, we did not
constrain H0 yet with high accuracy, i.e., we found a broad range of models
with chi^2 < 1. However, narrowing this range is possible, provided a better
velocity dispersion measurement becomes available. In addition, increasing the
depth of the current HST imaging data of HE 0435-1223 will allow us to combine
our constraints with lens reconstruction techniques that make use of the full
Einstein ring that is visible in this object.Comment: 12 pages, 10 figures, final version accepted for publication by A&
COSMOGRAIL: the COSmological MOnitoring of GRAvItational Lenses VII. Time delays and the Hubble constant from WFI J2033-4723
Gravitationally lensed quasars can be used to map the mass distribution in
lensing galaxies and to estimate the Hubble constant H0 by measuring the time
delays between the quasar images. Here we report the measurement of two
independent time delays in the quadruply imaged quasar WFI J2033-4723 (z =
1.66). Our data consist of R-band images obtained with the Swiss 1.2 m EULER
telescope located at La Silla and with the 1.3 m SMARTS telescope located at
Cerro Tololo. The light curves have 218 independent epochs spanning 3 full
years of monitoring between March 2004 and May 2007, with a mean temporal
sampling of one observation every 4th day. We measure the time delays using
three different techniques, and we obtain Dt(B-A) = 35.5 +- 1.4 days (3.8%) and
Dt(B-C) = 62.6 +4.1/-2.3 days (+6.5%/-3.7%), where A is a composite of the
close, merging image pair. After correcting for the time delays, we find R-band
flux ratios of F_A/F_B = 2.88 +- 0.04, F_A/F_C = 3.38 +- 0.06, and F_A1/F_A2 =
1.37 +- 0.05 with no evidence for microlensing variability over a time scale of
three years. However, these flux ratios do not agree with those measured in the
quasar emission lines, suggesting that longer term microlensing is present. Our
estimate of H0 agrees with the concordance value: non-parametric modeling of
the lensing galaxy predicts H0 = 67 +13/-10 km s-1 Mpc-1, while the Single
Isothermal Sphere model yields H0 = 63 +7/-3 km s-1 Mpc-1 (68% confidence
level). More complex lens models using a composite de Vaucouleurs plus NFW
galaxy mass profile show twisting of the mass isocontours in the lensing
galaxy, as do the non-parametric models. As all models also require a
significant external shear, this suggests that the lens is a member of the
group of galaxies seen in field of view of WFI J2033-4723.Comment: 14 pages, 12 figures, published in A&
Multi-wavelength observations of afterglow of GRB 080319B and the modeling constraints
We present observations of the afterglow of GRB 080319B at optical, mm and
radio frequencies from a few hours to 67 days after the burst. Present
observations along with other published multi-wavelength data have been used to
study the light-curves and spectral energy distributions of the burst
afterglow. The nature of this brightest cosmic explosion has been explored
based on the observed properties and it's comparison with the afterglow models.
Our results show that the observed features of the afterglow fits equally good
with the Inter Stellar Matter and the Stellar Wind density profiles of the
circum-burst medium. In case of both density profiles, location of the maximum
synchrotron frequency is below optical and the value of cooling break
frequency is below rays, s after the burst. Also, the
derived value of the Lorentz factor at the time of naked eye brightness is
with the corresponding blast wave size of cm. The
numerical fit to the multi-wavelength afterglow data constraints the values of
physical parameters and the emission mechanism of the burst.Comment: 8 Pages, 3 Figures, Accepted for publication to Astronomy and
Astrophysics on 02/04/200
Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT
Ubiquitin-dependent mechanisms have emerged as essential regulatory elements controlling cellular levels of Smads and TGFß-dependent biological outputs such as epithelial–mesenchymal transition (EMT). In this study, we identify a HECT E3 ubiquitin ligase known as WWP2 (Full-length WWP2-FL), together with two WWP2 isoforms (N-terminal, WWP2-N; C-terminal WWP2-C), as novel Smad-binding partners. We show that WWP2-FL interacts exclusively with Smad2, Smad3 and Smad7 in the TGFß pathway. Interestingly, the WWP2-N isoform interacts with Smad2 and Smad3, whereas WWP2-C interacts only with Smad7. In addition, WWP2-FL and WWP2-C have a preference for Smad7 based on protein turnover and ubiquitination studies. Unexpectedly, we also find that WWP2-N, which lacks the HECT ubiquitin ligase domain, can also interact with WWP2-FL in a TGFß-regulated manner and activate endogenous WWP2 ubiquitin ligase activity causing degradation of unstimulated Smad2 and Smad3. Consistent with our protein interaction data, overexpression and knockdown approaches reveal that WWP2 isoforms differentially modulate TGFß-dependent transcription and EMT. Finally, we show that selective disruption of WWP2 interactions with inhibitory Smad7 can stabilise Smad7 protein levels and prevent TGFß-induced EMT. Collectively, our data suggest that WWP2-N can stimulate WWP2-FL leading to increased activity against unstimulated Smad2 and Smad3, and that Smad7 is a preferred substrate for WWP2-FL and WWP2-C following prolonged TGFß stimulation. Significantly, this is the first report of an interdependent biological role for distinct HECT E3 ubiquitin ligase isoforms, and highlights an entirely novel regulatory paradigm that selectively limits the level of inhibitory and activating Smads
On the evolution of environmental and mass properties of strong lens galaxies in COSMOS
Among the 100 strong lens candidates found in the COSMOS field, 20 with
redshifts in the range [0.34,1.13], feature multiple images of background
sources. Using the multi-wavelength coverage of the field and its spectroscopic
follow-up, we characterize the evolution with redshift of the environment and
of the dark-matter (DM) fraction of the lens galaxies. We present new redshift
of the strong lens candidates. The lens environment is characterized by the
projected 10 closest galaxies around each lens and by the number of galaxies
with a projected distance less than 1Mpc at the lens galaxy redshift. In both
cases, we perform similar measurements on a control sample of twin non-lens
early type galaxies (ETGs). In addition, we identify group members and field
galaxies in the X-ray and optical catalogs of galaxy groups. From those
catalogs, we measure the external shear contribution at the lens galaxy
positions. The systems are then modeled using a SIE plus the external shear due
to the groups. We observe that the average stellar mass of lens galaxies
increases with z and that the environment of lens galaxies is compatible with
that of the twins. During the lens modeling, we notice that, when let free, the
external shear points in a direction which is the mean direction of the
external shear due to groups and of the closest galaxy to the lens. We notice
that the DM fraction of the lens galaxies within the Einstein radius decreases
as the redshift increases. Given these, we conclude that, while the environment
of lens galaxies is compatible with that of non-lens ETGS, their mass
properties evolves significantly with redshift: it is still not clear whether
this advocates in favor of a stronger lensing bias toward massive objects at
high redshift or is simply representative of the high proportion of massive and
high stellar density galaxies at high redshift.Comment: Accepted for publication in A&A. Significant modifications in the
paper but similar conclusion
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