Regional differences in spatial flexibility : long commutes and job related migration intentions in the Netherlands

Spatial flexibility of the workforce is important in clearing regional labour markets. Workers’ spatial flexibility is limited and many European countries are developing policies to enhance the spatial flexibility of the labour force. Using the 2002 Netherlands Housing Demand Survey and logistic regression models, this paper examines the determinants of both long commutes and intentions to migrate for a job. The results show that living in the highly urbanized western part of the Netherlands increases the probability that workers opt for long commutes. Living in the more peripheral regions increases the probability that workers think about moving residence. The results further show that workers with long commutes are more likely to have the intention to move residence in the near future than workers with short commutes. This indicates that long commutes are suboptimal at the individual level.Publisher PDFPeer reviewe

SLIDER: Mining correlated motifs in protein-protein interaction networks

Abstract—Correlated motif mining (CMM) is the problem to find overrepresented pairs of patterns, called motif pairs, in interacting protein sequences. Algorithmic solutions for CMM thereby provide a computational method for predicting binding sites for protein interaction. In this paper, we adopt a motif-driven approach where the support of candidate motif pairs is evaluated in the network. We experimentally establish the superiority of the Chi-square-based support measure over other support measures. Furthermore, we obtain that CMM is an NP-hard problem for a large class of support measures (including Chi-square) and reformulate the search for correlated motifs as a combinatorial optimization problem. We then present the method SLIDER which uses local search with a neighborhood function based on sliding motifs and employs the Chi-square-based support measure. We show that SLIDER outperforms existing motif-driven CMM methods and scales to large protein-protein interaction networks

A longitudinal study of migration propensities for mixed-ethnic unions in England and Wales

This research was funded by the ESRC under the Understanding Population Trends and Processes (UPTAP) programme (Award Ref: RES-163-25-0045).Most studies investigating residential segregation of ethnic minorities ignore the fact that the majority of adults live in couples. In recent years there has been a growth in the number of mixed-ethnic unions that involve a minority member and a white member. To our knowledge, hardly any research has been undertaken to explicitly examine whether the ethnic mix within households has an impact on the residential mobility of households in terms of the ethnic mix of destination neighbourhoods. Our study addresses this research gap and examines the tendencies of mobility among mixed-ethnic unions in comparison with their co-ethnic peers. We used data from the Longitudinal Study for England and Wales. Our statistical analysis supports the spatial assimilation theory; ethnic minorities move towards less deprived areas and to a lesser extent also towards less ethnically concentrated areas. However, the types of destination neighbourhood of minority people living in mixed-ethnic unions varied greatly with the ethnicity of the ethnic minority partner.PostprintPeer reviewe

Comparative aspects of pulmonary toxicity induced by cytotoxic agents with emphasis on lomustine, and a veterinary case report

In veterinary oncology the use of the nitrosourea compound lomustine is increasing. veterinary oncologists need to be aware of the pulmonary toxicity of this drug. Because of the lack of veterinary publications on this subject, the incidence and pathophysiology in human cancer patients of pulmonary toxicity induced by cytotoxic agents in general and by nitrosoureas in particular are discussed. Three clinical syndromes can be recognized, the most devastating of which is interstitial pneumonitis resulting in pulmonary fibrosis. Disturbances in the homeostatic mechanisms of the oxidant/antioxidant-, immunologic-, matrix repair-, proteolytic-, and central nervous systems are some of the major mechanisms of pulmonary injury in human medicine. Risk factors such as cumulative dose, age, radiation, oxygen administration and multi-drug regimens are recognized. For the first time in veterinarv medicine, a case report of a dog with pulmonary fibrosis, probably caused by chronic lomustine administration, is presented

PIXE and ToF-SIMS analysis of streaker samplers filters

This paper presents methodological innovations introduced in the characterisation of urban aerosol collected in Italy in a recent campaign. Two complementary ion beam analysis (IBA) techniques were used to analyse Nuclepore filters used in continuous streaker samplers to collect airborne particles in four Italian towns. Na to Pb elemental concentrations were obtained by particle induced X-ray emission (PIXE), while time of flight secondary ion mass spectrometry (ToF-SIMS) produced, on the same samples, time trends for several elements and molecular fragments. In addition, light attenuation measurements were used as a tracer for black carbon. The data produced by these three techniques was merged into a unique data set to address the characterisation of particulate matter sources. Correlations between elemental concentration trends (PIXE) and relative trends for molecular fragments (ToF-SIMS) and black carbon (light attenuation) have been studied by cluster and principal component analysis

Transitioning of final year nursing students to professional nurses: A best practice guideline

Abstract Background. The period of transition from student nurse to professional nurse in various healthcare contexts can be challenging. No best practice guideline could be found optimizing the transition of final year nursing students to professional nurses in the South African Military Health Service (SAMHS).Methods. A draft guideline was developed based on data from interviews with students and professional nurses, and an integrative literature review including guidelines on the transition of final year nursing students to professional nurses (content), using the AGREEII instrument (format), which was piloted using expert panel reviews.Results. The guideline covers four areas: support for new graduates, providing socialization and belonging, enhancing a positive clinical learning environment and ensuring retention of newly qualified professional nurses.Conclusion. The guideline provides a guide to best practices which can be used by nurse educators and managers but requires implementation to determine its impact on a successful transition period.

Trends in Computer Network Modeling Towards the Future Internet

This article provides a taxonomy of current and past network modeling efforts. In all these efforts over the last few years we see a trend towards not only describing the network, but connected devices as well. This is especially current given the many Future Internet projects, which are combining different models, and resources in order to provide complete virtual infrastructures to users. An important mechanism for managing complexity is the creation of an abstract model, a step which has been undertaken in computer networks too. The fact that more and more devices are network capable, coupled with increasing popularity of the Internet, has made computer networks an important focus area for modeling. The large number of connected devices creates an increasing complexity which must be harnessed to keep the networks functioning. Over the years many different models for computer networks have been proposed, and used for different purposes. While for some time the community has moved away from the need of full topology exchange, this requirement resurfaced for optical networks. Subsequently, research on topology descriptions has seen a rise in the last few years. Many different models have been created and published, yet there is no publication that shows an overview of the different approaches.

Concentrated Aqueous Piperazine as CO2 Capture Solvent: Detailed Evaluation of the Integration with a Power Plant☆

AbstractAn integrated energetic evaluation has been performed of a reference coal-fired power plant, a power plant with an advanced MEA-based post-combustion CO2 capture plant, and a power plant with a capture plant using concentrated piperazine (PZ) and high-pressure flash regeneration. This comparison shows that using a MEA-based capture plant reduces the net electric efficiency from 44.6% to 35.5%, while the PZ-based capture plant reduces it to 37.4%, corresponding to an efficiency penalty of only 7.2%