Defending the 'Negro Race': Lamine Senghor and Black Internationalism in Interwar France

This article examines the career of Lamine Senghor, a Senegalese veteran of the First World War, who emerged in the mid 1920s as the most influential black anti-colonial activist of the period. Senghor combined a communist-inspired critique of empire with an attempt to forge a transnational sense of black identity. Many of the questions facing Senghor remain relevant today: should the black community seek equality through its own independent pressure groups or through strategic alliances with mainstream political parties? And how does one engage with issues of racial (or religious) equality within the terms of the purportedly colour-blind and secular Republic

Host and environmental predictors of exhaled breath temperature in the elderly

BACKGROUND: Exhaled breath temperature has been suggested as a new method to detect and monitor pathological processes in the respiratory system. The putative mechanism of this approach is based upon changes in the blood flow. So far potential factors that influence breath temperature have not been studied in the general population. METHODS: The exhaled breath temperature was measured in 151 healthy non-smoking elderly (aged: 60–80 years) at room temperature with the X-halo device with an accuracy of 0.03°C. We related exhaled breath temperature by use of regression models with potential predictors including: host factors (sex, age) and environmental factors (BMI, physical activity, and traffic indicators). RESULTS: Exhaled breath temperature was lower in women than in men and was inversely associated with age, physical activity. BMI and daily average ambient temperature were positively associated with exhaled breath temperature. Independent of the aforementioned covariates, exhaled breath temperature was significantly associated with several traffic indicators. Residential proximity to major road was inversely associated with exhaled breath temperature: doubling the distance to the nearest major intense road was observed a decrease of 0.17°C (95% CI: -0.33 to -0.01; p = 0.036). CONCLUSIONS: Exhaled breath temperature has been suggested as a noninvasive method for the evaluation of airway inflammation. We provide evidence that several factors known to be involved in proinflammatory conditions including BMI, physical activity and residential proximity to traffic affect exhaled breath temperature. In addition, we identified potential confounders that should be taken into account in clinical and epidemiological studies on exhaled breath temperature including sex, age, and ambient temperature

Knowledge-based energy functions for computational studies of proteins

This chapter discusses theoretical framework and methods for developing knowledge-based potential functions essential for protein structure prediction, protein-protein interaction, and protein sequence design. We discuss in some details about the Miyazawa-Jernigan contact statistical potential, distance-dependent statistical potentials, as well as geometric statistical potentials. We also describe a geometric model for developing both linear and non-linear potential functions by optimization. Applications of knowledge-based potential functions in protein-decoy discrimination, in protein-protein interactions, and in protein design are then described. Several issues of knowledge-based potential functions are finally discussed.Comment: 57 pages, 6 figures. To be published in a book by Springe

Evaluation of the model representation of the evolution of convective systems using satellite observations of outgoing longwave radiation

We introduce a technique for assessing the diurnal development of convective storm systems based on outgoing longwave radiation fields. Using the size distribution of the storms measured from a series of images, we generate an array in the lengthscale-time domain based on the standard score statistic. It demonstrates succinctly the size evolution of storms as well as the dissipation kinematics. It also provides evidence related to the temperature evolution of the cloud tops. We apply this approach to a test case comparing observations made by the Geostationary Earth Radiation Budget instrument to output from the Met Office Unified Model run at two resolutions. The 12km resolution model produces peak convective activity on all lengthscales significantly earlier in the day than shown by the observations and no evidence for storms growing in size. The 4km resolution model shows realistic timing and growth evolution although the dissipation mechanism still differs from the observed data

Self-regulation: differences by year and area in college students

Neste estudo procura-se analisar a existência de diferenças nas estratégias auto-regulatórias de alunos universitários em áreas de formação distintas. Participaram 518 alunos de três níveis (inicial, intermédio e final) das áreas de ciências e humanidades. Aplicou-se a escala “CHE – Comportamentos e hábitos de estudo e aprendizagem”, que avalia cinco dimensões: estratégias cognitivas de transformação e manipulação da informação, organização e planeamento de rotinas, gestão e monitorização, aquisição e selecção da informação, e reforço motivacional. Verificou-se uma maior utilização das estratégias cognitivas e metacognitivas de gestão e monitorização apesar dos resultados não indicarem diferenças substantivas entre os alunos diferenciados por nível e área. Os resultados podem indicar estabilidade nos comportamentos ou limitações no tipo de instrumento e amostra utilizada. O estudo de mudanças nestas estratégias deverá ser conduzido com recurso a delineamentos longitudinais. O impacto da estabilidade deverá ser ponderado na elaboração de projectos de intervenção.In this study we seek to analyze the existence of differences in self-regulating strategies of university students in distinct graduation areas. 518 students of three levels (initial, intermediate and final) of science and humanities fields participated. We used the scale “Behavior and study skill”, which evaluates five dimensions: cognitive strategies of transformation and manipulation of information, organization and planning of routines, management and monitoring, information acquisition and selection, and motivational reinforcement. A higher use of cognitive and metacognitive strategies of management and monitoring was noted although the results do not indicate major differences between students in different levels and graduation areas. The results can indicate stability in the behaviors or limitations in the type of instrument and in the sample used. The study of changes in these strategies must be carried out having in mind longitudinal outlines. The impact of the stability should be taken into account while elaborating intervention projects.(undefined

9. Las diversas facetas de El Niño y sus efectos en la costa del Perú

El fenómeno El Niño es el modo dominante de la variabilidad interanual en el Océano Pacífico, resultando de un proceso de interacción entre el océano y la atmósfera en el Pacífico Tropical, Las últimas Investigaciones demuestran que existen varias facetas de este fenómeno que varían según las modalidades de interacción entre el océano y la atmosfera así como sus ubicaciones. Existen por lo menos dos tipos de El Niño, con expresiones diferentes sobre la Temperatura Superficial del Mar en el Pacifico Tropical y en la costa de Perú: uno que se desarrolla en el Pacifico Central (tiende a estar asociado a condiciones oceánicas más frías que favorecen el estado árido de la costa peruana y condiciones oceánicas hypóxicas), y otro que se desarrolla en el Pacifico Este (que transforma la costa peruana en una “típica” zona tropical, caracterizada por aguas costeras calientes y oxigenadas, y una lluvia intensa). Hoy en día, los esfuerzos de investigación para entender los mecanismos involucrados en los diferentes tipos de El Niño han sido reforzados, dado que, en las últimas décadas, se ha incrementado la frecuencia de ocurrencia de estos eventos en el Pacifico Central, sugiriéndose que podría ser una consecuencia del cambio climático. El perfeccionamiento de los modelos regionales acoplados tanto océano - atmosfera como océano - biogeoquímlco, tiene como objetivo mejorar la comprensión de la vulnerabilidad de la biosfera peruana al cambio climático y proponer un paradigma que represente la bimodalidad de la variabilidad interanual en el Pacifico Tropical.El Niño est le mode dominant de la variabilité interannuelle dans l’océan Pacifique, résultant d’un processus d’interaction entre l’océan et l’atmosphére dans le Pacifique tropical. Les recherches récentes montrent qu’il existe plusieurs facettes de ce phénomène qui varient selon les modalités d’interaction entre l’océan et l’atmosphére et leurs emplacements. Il y a au moins deux types de El Niño, avec des expressions différentes sur la Température de surface dans le Pacifique tropical et le long de la cote du Pérou: un qui se déroule dans le Pacifique central (associé á des conditions océaniques froides qui favorisent l’état aride de la cote péruvienne et des conditions océaniques d’hypoxie), et un autre qui a lieu dans le Pacifique oriental (qui transforme la cote péruvienne en une zone tropicale «typique», caractérisé par des eaux cótiéres chaudes et oxygénées, et de fortes pluies). Aujourd’hui, les efforts de recherche pour comprendre les mécanismes impliqués dans les différents types de El Niño ont été renforcés, en raison de l’accroissement de la fréquence d’occurrence de ces événements dans le Pacifique central au cours des dernières décennies a accru, suggérant qu’ll pourrait s’agir d’une conséquence du changement dimatique. L’optimisation des modeles régionaux couplés océan - atmosphére et océan - blogéochimiques, vise à améliorer la compréhension de la vulnérabilité de la biosphére péruvienne au changement dimatique et de proposer un paradigme qui représente la bimodalité de la variabilité Interannuelle dans le Pacifique tropical.The El Niño phenomenon is the dominant mode of inter-annual variability in the Pacific Ocean, which results from the ¡nteraction between the ocean and atmosphere in the tropical Pacific. Recent research shows that there are several facets of this phenomenon, which vary according to the modalities of ¡nteraction between the ocean and atmosphere, as well as their locations. There are at least two types of El Niño with different expresslons on the sea surface temperature in the tropical Pacific and on the coast of Peru: one that takes place in the Central Pacific (which tends to be associated with colder oceanic conditions who favoring the aridity of the Peruvian coast and the ocean conditions hypoxic), and another that takes place in the Eastern Pacific (which transforms the Peruvian coast in a “typical” tropical zone, with warm and oxygenated Coastal waters, and heavy rain). Nowadays, research efforts to understand the mechanisms involved in the different types of El Niño have been strengthened, since in recent decades has increased the frequency of these events in the Central Pacific, suggesting that ¡t might be a result of climate change. The ¡mprovement of both regional models coupled ocean - atmosphere and ocean - biogeochemical aims to Improve the understanding of the vulnerability of the Peruvian biosphere to climate change, and propose a paradigm that represents the bimodality of the Inter-annual variability in the tropical Pacific

Acute kidney disease and renal recovery : consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup

Consensus definitions have been reached for both acute kidney injury (AKI) and chronic kidney disease (CKD) and these definitions are now routinely used in research and clinical practice. The KDIGO guideline defines AKI as an abrupt decrease in kidney function occurring over 7 days or less, whereas CKD is defined by the persistence of kidney disease for a period of > 90 days. AKI and CKD are increasingly recognized as related entities and in some instances probably represent a continuum of the disease process. For patients in whom pathophysiologic processes are ongoing, the term acute kidney disease (AKD) has been proposed to define the course of disease after AKI; however, definitions of AKD and strategies for the management of patients with AKD are not currently available. In this consensus statement, the Acute Disease Quality Initiative (ADQI) proposes definitions, staging criteria for AKD, and strategies for the management of affected patients. We also make recommendations for areas of future research, which aim to improve understanding of the underlying processes and improve outcomes for patients with AKD

Promiscuous Aggregate-Based Inhibitors Promote Enzyme Unfolding

One of the leading sources of false positives in early drug discovery is the formation of organic small molecule aggregates, which inhibit enzymes nonspecifically at micromolar concentrations in aqueous solution. The molecular basis for this widespread problem remains hazy. To investigate the mechanism of inhibition at a molecular level, we determined changes in solvent accessibility that occur when an enzyme binds to an aggregate using hydrogen-deuterium exchange mass spectrometry. For AmpC beta-lactamase, binding to aggregates of the small molecule rottlerin increased the deuterium exchange of all 10 reproducibly detectable peptides, which covered 41% of the sequence of beta-lactamase. This suggested a global increase in proton accessibility upon aggregate binding, consistent with denaturation. We then investigated whether enzyme-aggregate complexes were more susceptible to proteolysis than uninhibited enzyme. For five aggregators, trypsin degradation of beta-lactamase increased substantially when beta-lactamase was inhibited by aggregates, whereas uninhibited enzyme was generally stable to digestion. Combined, these results suggest that the mechanism of action of aggregate-based inhibitors proceeds via partial protein unfolding when bound to an aggregate particle