Association of invasive breast carcinoma and multicentric high grade astrocytoma: a case report with a review.

Breast cancer is the most common cancer in women. Multicentric gliomas are uncommon lesions of the central nervous system (CNS) with an unprecise rate of occurrence that diffusely infiltrate large portions of the brain. High grade astrocytoma is the most agressive form of gliomas and often has a distinct neuroimaging pattern with a poor prognosis. We report a case of a 29-year-old woman patient with primary breast carcinoma and high grade astrocytoma subsequently developed. The woman was treated by mastectomy and 20 months post-diagnosis of the cancer she exhibited a transient facial paralysis. Magnetic resonance imaging (MRI) revealed two cranial masses suspicious of metastasis. A complete tumor removal from the brain was performed. On histological examination, this tumor was a high grade astrocytoma

Geometric approach to nonlinear coherent states using the Higgs model for harmonic oscillator

In this paper, we investigate the relation between the curvature of the physical space and the deformation function of the deformed oscillator algebra using non-linear coherent states approach. For this purpose, we study two-dimensional harmonic oscillators on the flat surface and on a sphere by applying the Higgs modell. With the use of their algebras, we show that the two-dimensional oscillator algebra on a surface can be considered as a deformed one-dimensional oscillator algebra where the effect of the curvature of the surface is appeared as a deformation function. We also show that the curvature of the physical space plays the role of deformation parameter. Then we construct the associated coherent states on the flat surface and on a sphere and compare their quantum statistical properties, including quadrature squeezing and antibunching effect.Comment: 12 pages, 7 figs. To be appeared in J. Phys.

A new record of the puffer fish Takifugu oblongus (Bloch, 1786) from the northern Persian Gulf, Iran

The new record of a puffer fish “Takifugu oblongus Bloch, 1786” (Tetraodontiformes, Tetraodontidae) is recorded for the first time the muddy shores of the inter-tidal zone of Bandar-e-Abbas city, in the northern Persian Gulf, Iran in March 2011. The morphological features of Takifugu oblongus are described. This species has previously been recorded from Indo-West Pacific, South Africa to Indonesia, Japan, China, and Korea (locality type). This finding considerably extends our knowledge of the distribution of Takifugu oblongus

Operating Room Scheduling Optimization Based on a Fuzzy Uncertainty Approach and Metaheuristic Algorithms

Today, planning and scheduling problems are the most significant issues in the world and make a great impact on improving organizational productivity and serving systems such as medical and healthcare providers. Since operating room planning is a major problem in healthcare organizations, the optimization of medical staff and equipment plays an essential role. Thus, this study presents a multi-objective mathematical model with a new categorization (preoperative, intraoperative, and postoperative) to minimize operating room scheduling and the risk of using equipment. Time constraints in healthcare systems and medical equipment limited capacity are the most significant considered limitation in the present study. In this regard, since the duration of patient preparation and implementation of treatment processes occur in three states of optimistic, pessimistic, and normal, the introduced parameters are examined relying on a fuzzy uncertainty analysis of the problem. Hence, the model is measured in a real numerical solution sample in a medical center to evaluate and confirm the proposed mathematical model. Then, two meta-heuristic algorithms (NRGA and NSGAII) are implemented on the mathematical model to analyze the proposed model. Finally, the research results indicate that the NSGA-II is more efficient in the operating room scheduling problem

Influence of phonons on exciton-photon interaction and photon statistics of a quantum dot

In this paper, we investigate, phonon effects on the optical properties of a spherical quantum dot. For this purpose, we consider the interaction of a spherical quantum dot with classical and quantum fields while the exciton of quantum dot interacts with a solid state reservoir. We show that phonons strongly affect the Rabi oscillations and optical coherence on first picoseconds of dynamics. We consider the quantum statistics of emitted photons by quantum dot and we show that these photons are anti-bunched and obey the sub-Poissonian statistics. In addition, we examine the effects of detuning and interaction of quantum dot with the cavity mode on optical coherence of energy levels. The effects of detuning and interaction of quantum dot with cavity mode on optical coherence of energy levels are compared to the effects of its interaction with classical pulse

On drug-base incompatibilities during extrudate manufacture and fused deposition 3D printing

Aim: 3D printing can be applied for point-of-care personalized treatment. This study aimed to determine the manufacturability and characteristics of 3D printed, drug loaded implants for alcohol misuse. Materials & methods: Disulfiram was the drug substance used and polylactic acid (PLA) the base material. Implantable devices were designed in silico. Drug and PLA were placed into the extruder to produce a 5% blend at 1.75-mm diameter. Material characterization included differential scanning calorimetry, thermogravimetric analysis plus inverse GC-surface energy analyzer. Results: Implantable constructs from the PLA feedstock were acquired. The extrusion processes had a detrimental effect on the active pharmaceutical ingredient-base blend. differential scanning calorimetry and thermogravimetric analysis analysis indicated drug–base interactions. Thermal history was found to influence inverse GC probe interaction. Conclusion: Drug-base incompatibilities must be considered during 3D printing

A Comparison between Recombinant Activated Factor VII (Aryoseven) and Novoseven in Patients with Congenital Factor VII Deficiency

In order to establish the efficacy and biosimilar nature of AryoSeven to NovoSeven in the treatment of congenital factor VII (FVII) deficiency, patients received either agent at 30 1/4g/kg, intravenously per week for 4 weeks, in a randomized fashion. The primary aim was to compare FVII:coagulation activity (FVII:C), 20 minutes after recombinant activated FVII (rFVIIa) injection, in the 2 groups. A secondary measure was self-reported bleeding. The median interquartile baseline range of the plasma level of activated FVII (FVIIa) activity in the 2 groups was 1.6 (1.1-14.0) IU/dL and 5.0 (1.1-25.5) IU/dL. All patients achieved levels of FVIIa (FVII:C) >30 IU/dL, 20 minutes after the injection of rFVIIa. Bleeding was similar between the 2 groups, with a comparable decrease in severity and frequency compared to the last month prior to treatment. AryoSeven is similar to NovoSeven in increasing postinjection FVIIa activity as well as in clinical safety and efficacy. © The Author(s) 2014

A new sinusoidal shear deformation theory for bending, buckling, and vibration of functionally graded plates

A new sinusoidal shear deformation theory is developed for bending, buckling, and vibration of functionally graded plates. The theory accounts for sinusoidal distribution of transverse shear stress, and satisfies the free transverse shear stress conditions on the top and bottom surfaces of the plate without using shear correction factor. Unlike the conventional sinusoidal shear deformation theory, the proposed sinusoidal shear deformation theory contains only four unknowns and has strong similarities with classical plate theory in many aspects such as equations of motion, boundary conditions, and stress resultant expressions. The material properties of plate are assumed to vary according to power law distribution of the volume fraction of the constituents. Equations of motion are derived from the Hamilton’s principle. The closed-form solutions of simply supported plates are obtained and the results are compared with those of first-order shear deformation theory and higher-order shear deformation theory. It can be concluded that the proposed theory is accurate and efficient in predicting the bending, buckling, and vibration responses of functionally graded plates