CP Violation in Heavy Neutrino Mediated e−e−→W−W−e^- e^- \to W^- W^-

We consider the reaction $e^- e^- \rightarrow W^- W^-$ mediated by possible heavy neutrino exchange at future LINAC energies of $\sqrt{s}>> 2 m_W$. This reaction is sensitive to CP phases of the neutrino mixing matrices, even at the level of Born amplitudes. Certain integrated cross-sections are shown to have the power to resolve the CP phases when the experimental configurations are varied. Asymmetries sensitive to CP violation (involving initial QED phases) for $e^- e^-$ and $e^+ e^+$ reactions are constructed and their consequences considered.Comment: 9 pages plain Latex and 4 figures available separately as uuencoded figure

The 10th Biennial Hatter Cardiovascular Institute workshop: cellular protection—evaluating new directions in the setting of myocardial infarction, ischaemic stroke, and cardio-oncology

Due to its poor capacity for regeneration, the heart is particularly sensitive to the loss of contractile cardiomyocytes. The onslaught of damage caused by ischaemia and reperfusion, occurring during an acute myocardial infarction and the subsequent reperfusion therapy, can wipe out upwards of a billion cardiomyocytes. A similar program of cell death can cause the irreversible loss of neurons in ischaemic stroke. Similar pathways of lethal cell injury can contribute to other pathologies such as left ventricular dysfunction and heart failure caused by cancer therapy. Consequently, strategies designed to protect the heart from lethal cell injury have the potential to be applicable across all three pathologies. The investigators meeting at the 10th Hatter Cardiovascular Institute workshop examined the parallels between ST-segment elevation myocardial infarction (STEMI), ischaemic stroke, and other pathologies that cause the loss of cardiomyocytes including cancer therapeutic cardiotoxicity. They examined the prospects for protection by remote ischaemic conditioning (RIC) in each scenario, and evaluated impasses and novel opportunities for cellular protection, with the future landscape for RIC in the clinical setting to be determined by the outcome of the large ERIC-PPCI/CONDI2 study. It was agreed that the way forward must include measures to improve experimental methodologies, such that they better reflect the clinical scenario and to judiciously select combinations of therapies targeting specific pathways of cellular death and injury

Stripping experiments in carbon foils with heavy ions in the energy range of 0.4-0.9 mev/a

We studied the properties of heavy ions stripped by carbon foils. Ni, I and Au ions of 0.4 - 0.9 MeV/A were used to bombard foils of 5 - 200 μg/cm 2. In these measurements the ions were detected in a Browne-Buechner spectrometer. We measured the angular straggling of the ions and the energy straggling. We looked for the behaviour of the foils under impact of large beam densities (several μAp/cm2 on an area of 1-2 mm2). We observed the thickness variations of the foils during bombardment in a vacuum of ∼ 10-6 and 10-7 torr. We looked for the evolution of the energy straggling during exposure and conclude that this parameter does not change in an important way. This means that neither thickening nor sputtering affects the homogeneity of the foil. Results on the lifetime of the bombarded foils are reported

THE 18O + 12C FUSION-EVAPORATION REACTION

No abstract availabl

Vector boson pair production in e-e- collisions with polarized beams

The $W$-boson pair production in $e^-e^-$ collisions with polarized beams is investigated. The helicity amplitudes are derived for general couplings and the conditions for a good high-energy behaviour of the cross-section are given. The results are applied to the heavy vector boson production in the context of the left-right symmetric model. The Ward identities and the equivalence theorem are also discussed.Comment: 17 pages+ 8 figures(uuencoded compressed ps-file appended), HU-SEFT R 1994-09 (the original version of the file was unreproducable in some computers

On the quest for unification - simplicity and antisimplicity

The road towards unification of elementary interactions is thought to start on the solid ground of a universal local gauge principle. I discuss the different types of bosonic gauge symmetries in gravitational and nongravitational (standard model) interactions and their extensions both fermionic, bosonic and with respect to space-time dimensions. The apparently paradoxical size and nature of the cosmological constant is sketched, which at first sight does not readily yield a clue as to the envelopping symmetry structure of a unified theory. Nevertheless a tentative outlook is given encouraging to proceed on this road.Comment: 29 pages, 4 figure

One-loop chiral amplitudes of Moller scattering process

The high energy amplitudes of the large angles Moller scattering are calculated in frame of chiral basis in Born and 1-loop QED level. Taking into account as well the contribution from emission of soft real photons the compact relations free from infrared divergences are obtained. The expressions for separate chiral amplitudes contribution to the cross section are in agreement with renormalization group predictions.Comment: 15 pages, 3 figure

ESC Working Group Cellular Biology of the Heart: Position Paper: Improving the pre-clinical assessment of novel cardioprotective therapies

Ischemic heart disease (IHD) remains the leading cause of death and disability worldwide. As a result, novel therapies are still needed to protect the heart from the detrimental effects of acute ischemia-reperfusion injury, in order to improve clinical outcomes in IHD patients. In this regard, although a large number of novel cardioprotective therapies discovered in the research laboratory have been investigated in the clinical setting, only a few of these have been demonstrated to improve clinical outcomes. One potential reason for this lack of success may have been the failure to thoroughly assess the cardioprotective efficacy of these novel therapies in suitably designed pre-clinical experimental animal models. Therefore, the aim of this Position Paper by the European Society of Cardiology Working Group Cellular Biology of the Heart is to provide recommendations for improving the pre-clinical assessment of novel cardioprotective therapies discovered in the research laboratory, with the aim of increasing the likelihood of success in translating these new treatments into improved clinical outcomes