Lithium in the Symbiotic Mira V407 Cyg

We report an identification of the lithium resonance doublet LiI 6708A in the spectrum of V407 Cyg, a symbiotic Mira with a pulsation period of about 745 days. The resolution of the spectra used was R~18500 and the measured equivalent width of the line is ~0.34A. It is suggested that the lithium enrichment is due to hot bottom burning in the intermediate mass AGB variable, although other possible origins cannot be totally ruled out. In contrast to lithium-rich AGB stars in the Magellanic clouds, ZrO 5551A, 6474A absorption bands were not found in the spectrum of V407Cyg. These are the bands used to classify the S-type stars at low-resolution. Although we identified weak ZrO 5718A, 6412A these are not visible in the low-resolution spectra, and we therefore classify the Mira in V407 Cyg as an M type. This, together with other published work, suggests lithium enrichment can precede the third dredge up of s-process enriched material in galactic AGB stars.Comment: 4 pages, 2 figures, to be published in MNRA

Plasmon-enhanced internal photoemission for photovoltaics: Theoretical efficiency limits

Plasmon-enhanced internal photoemission in metal-semiconductor Schottky junctions has recently been proposed as an alternative photocurrent mechanism for solar cells. Here, we identify and discuss the requirements for efficient operation of such cells and analyze their performance limits under standard solar illumination. We show that the maximum efficiency limit is 20%.We acknowledge the Australian Research Council and the Australian Solar Institute for financial support

A retrospective study of the prevalence of the canine degenerative myelopathy associated superoxide dismutase 1 mutation (SOD1: c. 118G> A) in a referral population of German Shepherd dogs from the UK

BACKGROUND: Canine degenerative myelopathy (CDM) is an adult onset, progressive neurodegenerative disease of the spinal cord. The disease was originally described in the German Shepherd dog (GSD), but it is now known to occur in many other dog breeds. A previous study has identified a mutation in the superoxide dismutase 1 gene (SOD1:c.118G > A) that is associated with susceptibility to CDM. In the present study, restriction fragment length polymorphism (RFLP) analysis was used to genotype GSD for SOD1:c.118G > A in order to estimate the prevalence of the mutation in a referral population of GSD in the UK. RESULTS: This study demonstrated that the RFLP assay, based on use of PCR and subsequent digestion with the Eco571 enzyme, provided a simple genotyping test for the SOD1:c.118G > A mutation. In a young GSD population (i.e. dogs less than 6 years of age, before clinical signs of the disease usually become apparent), 8 of 50 dogs were found to be homozygous and a further 19 were heterozygous for the mutation. In dogs over 8 years of age, 21 of 50 dogs admitted to a tertiary referral hospital with pelvic limb ataxia as a major clinical sign were homozygous for the mutation, compared to none of 50 dogs of similar age, but where no neurological disease was reported on referral. CONCLUSIONS: This data suggests that genotyping for the SOD1:c.118G > A mutation is clinically applicable and that the mutation has a high degree of penetrance. Genotyping might also be useful for screening the GSD population to avoid mating of two carriers, but since the allele frequency is relatively high in the UK population of GSD, care should be taken to avoid reduction in genetic diversity within the breed

Recombinant canine single chain insulin analogues: Insulin receptor binding capacity and ability to stimulate glucose uptake

Virtually all diabetic dogs require exogenous insulin therapy to control their hyperglycaemia. In the UK, the only licensed insulin product currently available is a purified porcine insulin preparation. Recombinant insulin is somewhat problematic in terms of its manufacture, since the gene product (preproinsulin) undergoes substantial post-translational modification in pancreatic β cells before it becomes biologically active. The aim of the present study was to develop recombinant canine single chain insulin (SCI) analogues that could be produced in a prokaryotic expression system and which would require minimal processing. Three recombinant SCI constructs were developed in a prokaryotic expression vector, by replacing the insulin C-peptide sequence with one encoding a synthetic peptide (GGGPGKR), or with one of two insulin-like growth factor (IGF)-2 C-peptide coding sequences (human: SRVSRRSR; canine: SRVTRRSSR). Recombinant proteins were expressed in the periplasmic fraction of Escherichia coli and assessed for their ability to bind to the insulin and IGF-1 receptors, and to stimulate glucose uptake in 3T3-L1 adipocytes. All three recombinant SCI analogues demonstrated preferential binding to the insulin receptor compared to the IGF-1 receptor, with increased binding compared to recombinant canine proinsulin. The recombinant SCI analogues stimulated glucose uptake in 3T3-L1 adipocytes compared to negligible uptake using recombinant canine proinsulin, with the canine insulin/cIGF-2 chimaeric SCI analogue demonstrating the greatest effect. Thus, biologically-active recombinant canine SCI analogues can be produced relatively easily in bacteria, which could potentially be used for treatment of diabetic dogs

Theory of the circular closed loop antenna in the terahertz, infrared, and optical regions

Modern antenna theory forms the bulwark of our knowledge of how radiation and metallic structures interact in the radio frequency (RF) and microwave (MW) regions. The theory has not yet penetrated the terahertz, infrared, and optical regions to the same degree. In this paper, we provide a rigorous analysis of closed circular loop antennas from first principles. Using antenna theory, we tie together their long wavelength behavior with their behavior at short wavelengths through the visible region. We provide analytic forms for the input impedance, current, quality factor, radiation resistance, ohmic loss, and radiation efficiency. We provide an exact circuit model for the closed loop in the RF and MW regions, and extend it through the optical region. We also provide an implicit analytic form for the determination of all modal resonances, allowing prediction of the resonance saturation wavelength for loops. Through simulations, we find that this behavior extends to hexagonal and square loops. All results are applicable to loop circumferences as short as 350 nm. Finally, we provide a precise analytic model of the index of refraction, as a tool in these computations, which works equally well for metals and semi-conductors.This work has been partially supported by the Australian Research Council and the Australian Solar Institute

Constraining the Nature of the Galactic Center X-ray Source Population

We searched for infrared counterparts to the cluster of X-ray point sources discovered by Chandra in the Galactic Center Region (GCR). While the sources could be white dwarfs, neutron stars, or black holes accreting from stellar companions, their X-ray properties are consistent with magnetic Cataclysmic Variables, or High Mass X-ray Binaries (HMXB) at low accretion-rates. A direct way to decide between these possibilities and hence between alternative formation scenarios is to measure or constrain the luminosity distribution of the companions. Using infrared (J, H, K, Br-gamma) imaging, we searched for counterparts corresponding to typical HMXB secondaries: spectral type B0V with K<15 at the GCR. We found no significant excess of bright stars in Chandra error circles, indicating that HMXBs are not the dominant X-ray source population, and account for fewer than 10% of the hardest X-ray sources.Comment: 4 pages, 3 figures, 1 table, accepted in ApJ Letters for publicatio

The analytical basis for the resonances and anti-resonances of loop antennas and meta-material ring resonators

Interest in the electromagnetic properties of loop structures has surged with the recent appearance of split-ring resonator meta-materials (SRRs) and nano-antennas. Understanding the resonances, anti-resonances, and harmonics of these loops is key to understanding their response to a wide range of excitation wavelengths. We present the classical analytical solution for the input impedance of a loop structure with circumference on the order of the wavelength, and we show how to identify these resonances from the function. We transform the classical solution into a new RLC formulation and show that each natural mode of the loop can be represented as a series resonant circuit, such that the full response function can be resolved by placing all of these circuits in parallel. We show how this formulation applies to SRRs.This work has been partially supported by the Australian Research Council and the Australian Solar Institute

Insights on adaptive and innate immunity in canine leishmaniosis

Canine leishmaniosis (CanL) is caused by the parasite Leishmania infantum and is a systemic disease, which can present with variable clinical signs, and clinicopathological abnormalities. Clinical manifestations can range from subclinical infection to very severe systemic disease. Leishmaniosis is categorized as a neglected tropical disease and the complex immune responses associated with Leishmania species makes therapeutic treatments and vaccine development challenging for both dogs and humans. In this review, we summarize innate and adaptive immune responses associated with L. infantum infection in dogs, and we discuss the problems associated with the disease as well as potential solutions and the future direction of required research to help control the parasite

Evaporation of Compact Young Clusters near the Galactic Center

We investigate the dynamical evolution of compact young clusters (CYCs) near the Galactic center (GC) using Fokker-Planck models. CYCs are very young (< 5 Myr), compact (< 1 pc), and only a few tens of pc away from the GC, while they appear to be as massive as the smallest Galactic globular clusters (~10^4 Msun). A survey of cluster lifetimes for various initial mass functions, cluster masses, and galactocentric radii is presented. Short relaxation times due to the compactness of CYCs, and the strong tidal fields near the GC make clusters evaporate fairly quickly. Depending on cluster parameters, mass segregation may occur on a time scale shorter than the lifetimes of most massive stars, which accelerates the cluster's dynamical evolution even more. When the difference between the upper and lower mass boundaries of the initial mass function is large enough, strongly selective ejection of lighter stars makes massive stars dominate even in the outer regions of the cluster, so the dynamical evolution of those clusters is weakly dependent on the lower mass boundary. The mass bins for Fokker-Planck simulations were carefully chosen to properly account for a relatively small number of the most massive stars. We find that clusters with a mass <~ 2x10^4 Msun evaporate in <~ 10 Myr. A simple calculation based on the total masses in observed CYCs and the lifetimes obtained here indicates that the massive CYCs comprise only a fraction of the star formation rate (SFR) in the inner bulge estimated from Lyman continuum photons and far-IR observations.Comment: 20 pages in two-column format, accepted for publication in Ap

Syndromic surveillance to assess the potential public health impact of the Icelandic volcanic ash plume across the United Kingdom, April 2010

The Eyjafjallajökull volcano in Iceland erupted on 14 April 2010 emitting a volcanic ash plume that spread across the United Kingdom and mainland Europe. The Health Protection Agency and Health Protection Scotland used existing syndromic surveillance systems to monitor community health during the incident: there were no particularly unusual increases in any of the monitored conditions. This incident has again demonstrated the use of syndromic surveillance systems for monitoring community health in real time