The Senegalese Sole Mx gene promoter contains a variable microsatellite region involved in the transcriptional

Interferons (IFNs) play a key role against viral infections by stimulating the expression of IFN stimulated genes, such as Mx. The transcriptional regulation of these genes in fish are poorly understood. The sequencing of the Senegalese sole (Solea senegalensis) Mx gene promoter revealed the presence of a guanosine-citosine rich region that contains a microsatellite, sited close to the translation start codon. The aim of the current study has been to determine the functional role of this region and to study its variability.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Dynamical confirmation of a stellar-mass black hole in the transient X-ray dipping binary MAXI J1305-704

MAXI J1305-704 has been proposed as a high-inclination candidate black hole X-ray binary in view of its X-ray properties and dipping behaviour during outburst. We present photometric and spectroscopic observations of the source in quiescence that allow us to reveal the ellipsoidal modulation of the companion star and absorption features consistent with those of an early K-type star (Teff = 4610 +130 -160 K). The central wavelengths of the absorption lines vary periodically at Porb = 0.394 +- 0.004 d with an amplitude of K2 = 554 +- 8 km/s . They imply a mass function for the compact object of f(M1) = 6.9 +- 0.3 Msun, confirming its black hole nature. The simultaneous absence of X-ray eclipses and the presence of dips set a conservative range of allowed inclinations 60 deg < i < 82 deg, while modelling of optical light curves further constrain it to i = 72 +5 -8 deg. The above parameters together set a black hole mass of M1 = 8.9 +1.6 -1.0 Msun and a companion mass of M2=0.43 +- 0.16 Msun, much lower than that of a dwarf star of the observed spectral type, implying it is evolved. Estimates of the distance to the system (d = 7.5 +1.8 -1.4 kpc) and space velocity (vspace = 270 +- 60 km/s ) place it in the Galactic thick disc and favour a significant natal kick during the formation of the BH if the supernova occurred in the Galactic Plane.Comment: 14 pages, 6 figures. Submitted to MNRA

RETROCALCULATED LARVAL ABUNDANCE INDEX OF ATLANTIC BLUEFIN TUNA IN THE WESTERN MEDITERRANEAN SEA, 2001-2020

This document presents the update of the bluefin tuna retrocalculated larval abundance indices from the Balearic archipelago (western Mediterranean). The index has been calculated following methods presented in 2020 (SCRS/2020/067) and 2021 (SCRS/2021/033). The abundance index shows an increasing trend with a maximum value in 2020. A previous version of the index (SCRS/P/2019/055) is also provided for comparison.En prensa

The binary mass ratio in the black hole transient MAXI J1820+070

We present intermediate resolution spectroscopy of the optical counterpart to the black hole X-ray transient MAXI J1820+070 (=ASASSN-18ey) obtained with the OSIRIS spectrograph on the 10.4-m Gran Telescopio Canarias. The observations were performed with the source close to the quiescent state and before the onset of renewed activity in August 2019. We make use of these data and K-type dwarf templates taken with the same instrumental configuration to measure the projected rotational velocity of the donor star. We find $v_{rot} \sin i = 84 \pm 5$ km s$^{-1}$ ($1\!-\!\sigma$), which implies a donor to black-hole mass ratio $q = {M_2}/{M_1} = 0.072 \pm 0.012$ for the case of a tidally locked and Roche-lobe filling donor star. The derived dynamical masses for the stellar components are $M_1 = (5.95 \pm 0.22)\sin ^{-3}i$ $M_\odot$ and $M_2 = (0.43 \pm 0.08) \sin^{-3}i$ $M_\odot$. The use of $q$, combined with estimates of the accretion disk size at the time of the optical spectroscopy, allows us to revise our previous orbital inclination constraints to $66^{\circ} < i < 81^{\circ}$. These values lead to 95% confidence level limits on the masses of $5.73 <M_1(M_\odot) < 8.34$ and $0.28 < M_2(M_\odot) < 0.77$. Adopting instead the $63 \pm 3^{\circ}$ orientation angle of the radio jet as the binary inclination leads to $M_1 = 8.48^{+0.79}_{-0.72} M_\odot$ and $M_2 = 0.61^{+0.13}_{-0.12} M_\odot$ ($1\!-\!\sigma$).Comment: 8 pages, 2 figures. Accepted for publication in ApJ

Pengembangan Media Pembelajaran Fisika Berbasis Multimedia Interaktif Terintegrasi Dengan Lks Pokok Bahasan Hukum Newton Tentang Gerak Kelas X Sma/ma

Penelitian ini bertujuan untuk: (1) mengembangkan media pembelajaran fisika berbasis multimedia interaktif dengan menggunakan software adobe flash dan XML pada pokok bahasan Hukum Newton tentang gerak; (2) mengetahui kelayakan media pembelajaran fisika berbasis multimedia interaktif menggunakan software adobe flash dan XML pada pokok bahasan Hukum Newton tentang gerak yang dikembangkan; (3) mengetahui pencapaian hasil belajar siswa setelah mengikuti proses pembelajaran menggunakan media pembelajaran fisika berbasis multimedia interaktif terintegrasi dengan lembar kerja siswa hasil pengembangan. Penelitian ini merupakan penelitian dan pengembangan (R&amp;D) yang mengacu pada model yang dikemukakan oleh Sugiyono. Kelayakan media divalidasi oleh ahli materi, ahli media dan praktisi. Subjek Ujicoba penelitian ini adalah siswa kelas X SMA N 3 Sukoharjo tahun akademik 2013/2014 sebanyak 43 siswa dengan rincian 10 siswa sebagai subjek ujicoba produk dan 33 siswa sebagai subjek ujicoba pemakaian. Berdasarkan hasil analisis data disimpulkan: (1) media pembelajaran fisika berbasis multimedia interaktif terintegrasi dengan lembar kerja siswa berhasil dikembangkan dengan menggunakan Software Adobe Flash dan XML dengan hasil produk dikemas dalam keping CD yang didalamnya berisi software utama media dan beberapa file pendukung dari media tersebut. Media disajikan dengan dua pembagian materi yaitu materi pembelajaran dan materi penjelasan yang diproteksi serta berisi bank soal yang dapat diupdate. Media pembelajaran dikembangkan dengan mengacu pada langkah yang diberikan oleh Sugiyono dan telah tervalidasi; (2) media pembelajaran fisika berbasis multimedia interaktif terintegrasi dengan lembar kerja siswa yang dikembangkan layak digunakan dengan kategori baik; (3) pencapaian hasil belajar peserta didik setelah mengikuti proses pembelajaran menggunakan media pembelajaran fisika berbasis multimedia interaktif terintegrasi dengan lembar kerja siswa mengalami peningkatan pada aspek pengetahuan

Equivalence regimes for geometric quantum discord and local quantum uncertainty

The concept of quantum discord aims at unveiling quantum correlations that go beyond those described by entanglement. Its original formulation [L. Henderson and V. Vedral, J. Phys. A: Math. Gen. 34, 6899 (2001); H. Ollivier and W. H. Zurek, Phys. Rev. Lett. 88, 017901 (2001)] is difficult to compute even for the simplest case of two-qubits systems. Alternative formulations have been developed to address this drawback, such as the geometric measure of quantum discord [L. Chang and S. Luo, Phys. Rev. A 87, 062303 (2013)] and the local quantum uncertainty [D. Girolami, T. Tufarelli, and G. Adesso, Phys. Rev. Lett. 110, 240402 (2013)] that can be evaluated in closed form for some quantum systems, such as two-qubit systems. We show here that these two measures of quantum discord are equivalent for 2×D dimensional bipartite quantum systems. By considering the relevant example of N00N states for phase estimation in lossy environments, we also show that both metrics of quantum discord quantify the decrease of quantum Fisher information of the phase estimation protocol. Given their ease of computation in 2×D bipartite systems, the geometric measure of quantum discord and the local quantum uncertainty demonstrate their relevance as computable measures of quantum discord.We acknowledge support from the Spanish Ministry of Economy and Competitiveness (“Severo Ochoa” program for Centres of Excellence in R&D No. SEV-2015-0522), from Fundacio Privada Cellex, from Fundacio Mir-Puig, and from Generalitat de Catalunya through the CERCA program. This work was partially funded through the EMPIR project 17FUN01-BeCOMe. The EMPIR initiative is cofunded by the European Union Horizon 2020 Research and Innovation Programme and the EMPIR participating states. A.V. acknowledges financial support from PREBIST that has received funding from the European Union Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie Grant Agreement No. 754558. J.R.A. acknowledges funding by the European Union Horizon 2020 Research and Innovation Programme (Marie Sklodowska- Curie 765075-LIMQUET). R.J.L.M. thankfully acknowledges financial support by CONACyT under the project CB-2016-01/284372, and by Direcci n General de Asuntos del Personal Acad mico, Universidad Nacional Aut noma de M xico (DGAPA-UNAM), under the project UNAM-PAPIIT IN102920.Peer ReviewedPostprint (author's final draft

The dynamical mass of the white dwarf in XY Ari questions intermediate polar X-ray spectral models

We present a dynamical study of the eclipsing intermediate polar XY Ari based on time-resolved near-infrared spectroscopy obtained with the EMIR spectrograph on the 10.4-m Gran Telescopio Canarias. Using main sequence template spectra taken with the same instrument setup as the target spectra, we measure a radial velocity amplitude of the late K-type donor star $K_2=256 \pm 2$ km s$^{-1}$. We also obtain the rotational broadening of its photospheric lines $v_\mathrm{rot} \sin i = 141 \pm 3$ km s$^{-1}$. From these and the eclipse geometry, we derive a donor-to-white dwarf mass ratio $q = M_2/M_1 = 0.62 \pm 0.02$, an orbital inclination $i = 80.8^{\circ} \pm 0.5^{\circ}$ and dynamical masses $M_{1} = 1.21 \pm 0.04 \, \mathrm{M}_{\odot}$ and $M_2 = 0.75 \pm 0.04 \, \mathrm{M}_{\odot}$ ($1 \sigma$). This result places the white dwarf in XY Ari as one of the three most massive known in a cataclysmic variable. Comparison with a number of white dwarf mass estimates from X-ray spectral modelling indicates the necessity of a major revision of the cooling models currently assumed for magnetic accretion in intermediate polars, as most of the X-ray white dwarf masses lie significantly below the dynamical mass value.Comment: 9 pages, 4 figures, 5 tables, submitted for publication in MNRA

Uso de escáner láser 3D para el registro del estado previo a la intervención de la Fuente de los Leones de La Alhambra

[ES] En el proceso de restauración y conservación del patrimonio histórico se hace necesaria la utilización de todas las técnicas disponibles que puedan aportar un adecuado conocimiento del proceso que se realice. En este artículo presentamos los trabajos realizados mediante el uso de escáner láser 3D para el registrado y documentación del estado de la Fuente de los Leones de La Alhambra, previos a las intervenciones de restauración que se están realizando. En primer lugar presentamos las técnicas clásicas usadas para el registro gráfico de las actuaciones, describiendo cómo se ha hecho hasta ahora, para después mostrar el nuevo proceso implantado con la utilización del escáner láser, y ver los resultados obtenidos. Para finalizar, describiremos algunas de las aplicaciones en las que se pretende utilizar el registrado obtenido.[EN] In the process of restoration and conservation of cultural heritage it’s necessary to use all available techniques that can contribute to a suitable knowledge of the process. In this paper we present the use of the 3D laser scanner for documenting the state of the Fuente de los Leones of the Alhambra, previous to the interventions of restoration that are being carried out at the moment. First, we present the classic techniques used for the graphical registry of the activities, describing how they have been used until now. Then, we describes the new process implanted with the use of the laser scanner, and show some results obtained. Finally, we describe some of the applications for which we plan to use the obtained models.Patronato de la Alhambra y Generalife, Ministerio de Ciencia y Tecnología y los fondos FEDER, a través del proyecto TIN2007-67474-C03-02, Consejería de innovación Ciencia y Empresa de la Junta de Andalucía a través del proyecto de excelencia TIC-401.Cano, P.; Lamolda Álvarez, F.; Torres, JC.; Villafranca, MDM. (2010). Uso de escáner láser 3D para el registro del estado previo a la intervención de la Fuente de los Leones de La Alhambra. Virtual Archaeology Review. 1(2):89-94. https://doi.org/10.4995/var.2010.4695OJS899412VALLE, J. M. (2006): Reflexiones sobre la Documentación Geométrica del Patrimonio. Papeles del Partal, núm. 3. [http://www.academiadelpartal.org/revista/revista_03/n3_8.pdf ]PAG (2004): Memoria de Intervención en el León nº 4 de la Fuente de los Leones. 2002-2004. Patronato de la Alhambra y Generalife.ALMAGRO, A. (1996): Realización de mapas de daños y de volumen: Fotogrametría. Curso: "Técnicas de diagnostico aplicadas a la conservación de bienes muebles".TIENZA, C. (2007): Proyecto integral de conservación-restauración en la Fuente de los Leones. Palacio y Patio de los Leones de la Alhambra. Informes de seguimiento de la intervención. Documento de trabajo del Servicio de Conservación, Patronato de la Alhambra y Generalife.GONZÁLEZ, A. (2006). Aportaciones de los sistemas de tratamiento digital de imagen en el estudio de las obras de arte. Innovación tecnológica en la Conservación y Restauración del patrimonio. U.A. MadridMINOLTA (2008): Escáner 3D Konica Minolta Vivid 910. [ http://www.minolta3d.com ]TORRES, J.C.; MELERO, F.J.; CANO, P.; MARTÍN, D.; LEÓN, A. (2007): Generación automatizada de modelado 3D para difusión y documentación del patrimonio histórico". En: Hernández, L. y Flores, J. (eds.) "Informática Gráfica y Patrimonio Histórico". pp: 111- 120.ESPAÑA, M.; MORENO, J.J.; MARTIN, D.; CANO, P. (2008): Herramientas para la triangulación y registrado inicial de modelos 3D a partir de nubes de puntos. Congreso Español de Informática Gráfica, pp: 261-264.SCHROEDER, W.J.; ZARGE, J. A.; LORENSEN, W. E. (1992): Decimation of Triangle Meshes. Proceedings of the 19th annual conference on Computer graphics and interactive techniques, pp. 65-70. http://dx.doi.org/10.1145/133994.134010http://dx.doi.org/10.1145/142920.134010HOPPE, H. ; DEROSE, T.; DUCHAMP, T.; MCDONALD, J.; STUELZLE, W. (1993): Mesh Optimization. ACM SIGGRAPH 1993, pp. 19-26. http://dx.doi.org/10.1145/166117.16611

Agreement between a simple dyspnea-guided treatment algorithm for stable COPD and the GOLD guidelines: A pilot study

Introduction: Guidelines recommendations for the treatment of COPD are poorly followed. This could be related to the complexity of classification and treatment algorithms. The purpose of this study was to validate a simpler dyspnea-based treatment algorithm for inhaled pharmacotherapy in stable COPD, comparing its concordance with the current Global Initiative for Obstructive Lung Disease (GOLD) guideline. Methods: We enrolled patients who had been diagnosed with COPD in three primary care facilities and two tertiary hospitals in Spain. We determined anthropometric data, forced expiratory volume in the 1st second (percent), exacerbations, and dyspnea based on the modified Medical Research Council scale. We evaluated the new algorithm based on dyspnea and exacerbations and calculated the concordance with the current GOLD recommendations. Results: We enrolled 100 patients in primary care and 150 attending specialized care in a respiratory clinic. There were differences in the sample distribution between cohorts with 41% vs 26% in grade A, 16% vs 12% in grade B, 16% vs 22% in grade C, and 27% vs 40% in grade D for primary and respiratory care, respectively (P=0.005). The coincidence of the algorithm with the GOLD recommendations in primary care was 93% and 91.8% in the respiratory care cohort. Conclusion: A simple dyspnea-based treatment algorithm for inhaled pharmacotherapy of COPD could be useful in the management of COPD patients and concurs very well with the recommended schema suggested by the GOLD initiative