61 research outputs found
Autochthonous Case of Pulmonary Histoplasmosis, Switzerland.
In Europe, pulmonary histoplasmosis is rarely diagnosed except in travelers. We report a probable autochthonous case of severe chronic pulmonary histoplasmosis in an immunocompetent man in Switzerland without travel history outside of Europe. Diagnosis was achieved by histopathology, fungal culture, and serology, but the source of the infection remains speculative
Multi effect plants and ionic liquids for improved absorption chillers
Paper presented at the 9th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Malta, 16-18 July, 2012.State of the art absorption chillers using conventional working pairs still suffer from problems like crystallization, corrosiveness and a relatively low efficiency. To improve this technology, different working pairs as well as plant designs are investigated using the simulation tool AspenPlus. The simulation is validated by comparing the results of single effect absorption chillers using the current commercially applied working pairs water/lithium bromide and ammonia/water with literature data. To increase the efficiency, double effect absorption chillers are implemented and analyzed. The performance of two kinds of double effect cycles, series and parallel, is compared using the working pair water/lithium bromide. In addition, ionic liquids (ILs) are investigated as a sorbent in order to improve the technology. So far, ILs have not been implemented in AspenPlus yet. Therefore, a guideline for the implementation of ILs in AspenPlus is outlined and the accordant phase equilibria results are validated with literature data. Simulations of single effect cycles using the ILs 1,3-dimethylimidazolium dimethylphosphate ([MMIM][DMP]) and 1-ethyl-3-methylimidazolium dimethylphosphate ([EMIM][DMP]) in combination with water as a refrigerant are performed and the results are compared to conventional working pairs.dc201
Nanofiber Fabry-Perot microresonator for non-linear optics and cavity quantum electrodynamics
We experimentally realize a Fabry-Perot-type optical microresonator near the
cesium D2 line wavelength based on a tapered optical fiber, equipped with two
fiber Bragg gratings which enclose a sub-wavelength diameter waist. Owing to
the very low taper losses, the finesse of the resonator reaches F = 86 while
the on-resonance transmission is T = 11 %. The characteristics of our resonator
fulfill the requirements of non-linear optics and cavity quantum
electrodynamics in the strong coupling regime. In combination with its
demonstrated ease of use and its advantageous mode geometry, it thus opens a
realm of applications.Comment: 4 pages, 3 figure
A prognostic score for non-small cell lung cancer resected after neoadjuvant therapy in comparison with the tumor-node-metastases classification and major pathological response.
Studies validating the prognostic accuracy of the tumor-node-metastases (TNM) classification in patients with lung cancer treated by neoadjuvant therapy are scarce. Tumor regression, particularly major pathological response (MPR), is an acknowledged prognostic factor in this setting. We aimed to validate a novel combined prognostic score. This retrospective single-center study was conducted on 117 consecutive patients with non-small cell lung cancer resected after neoadjuvant treatment at a Swiss University Cancer Center between 2000 and 2016. All cases were clinicopathologically re-evaluated. We assessed the prognostic performance of a novel prognostic score (PRSC) combining T-category, lymph node status, and MPR, in comparison with the eighth edition of the TNM classification (TNM8), the size adapted TNM8 as proposed by the International Association for the Study of Lung Cancer (IASLC) and MPR alone. The isolated ypT-category and the combined TNM8 stages accurately differentiated overall survival (OS, stage p = 0.004) and disease-free survival (DFS, stage p = 0.018). Tumor regression had a prognostic impact. Optimal cut-offs for MPR emerged as 65% for adenocarcinoma and 10% for non-adenocarcinoma and were statistically significant for survival (OS p = 0.006, DFS p < 0.001). The PRSC differentiated between three prognostic groups (OS and DFS p < 0.001), and was superior compared to the stratification using MPR alone or the TNM8 systems, visualized by lower Akaike (AIC) and Bayesian information criterion (BIC) values. In the multivariate analyses, stage III tumors (HR 4.956, p = 0.003), tumors without MPR (HR 2.432, p = 0.015), and PRSC high-risk tumors (HR 5.692, p < 0.001) had significantly increased risks of occurring death. In conclusion, we support 65% as the optimal cut-off for MPR in adenocarcinomas. TNM8 and MPR were comparable regarding their prognostic significance. The novel prognostic score performed distinctly better regarding OS and DFS
All-optical switching and strong coupling using tunable whispering-gallery-mode microresonators
We review our recent work on tunable, ultrahigh quality factor
whispering-gallery-mode bottle microresonators and highlight their applications
in nonlinear optics and in quantum optics experiments. Our resonators combine
ultra-high quality factors of up to Q = 3.6 \times 10^8, a small mode volume,
and near-lossless fiber coupling, with a simple and customizable mode structure
enabling full tunability. We study, theoretically and experimentally, nonlinear
all-optical switching via the Kerr effect when the resonator is operated in an
add-drop configuration. This allows us to optically route a single-wavelength
cw optical signal between two fiber ports with high efficiency. Finally, we
report on progress towards strong coupling of single rubidium atoms to an
ultra-high Q mode of an actively stabilized bottle microresonator.Comment: 20 pages, 24 figures. Accepted for publication in Applied Physics B.
Changes according to referee suggestions: minor corrections to some figures
and captions, clarification of some points in the text, added references,
added new paragraph with results on atom-resonator interactio
A Nanofiber-Based Optical Conveyor Belt for Cold Atoms
We demonstrate optical transport of cold cesium atoms over millimeter-scale
distances along an optical nanofiber. The atoms are trapped in a
one-dimensional optical lattice formed by a two-color evanescent field
surrounding the nanofiber, far red- and blue-detuned with respect to the atomic
transition. The blue-detuned field is a propagating nanofiber-guided mode while
the red-detuned field is a standing-wave mode which leads to the periodic axial
confinement of the atoms. Here, this standing wave is used for transporting the
atoms along the nanofiber by mutually detuning the two counter-propagating
fields which form the standing wave. The performance and limitations of the
nanofiber-based transport are evaluated and possible applications are
discussed
Optical microbubble resonator
We develop a method for fabricating very small silica microbubbles having a micrometer-order wall thickness and demonstrate the first optical microbubble resonator. Our method is based on blowing a microbubble using stable radiative CO2 laser heating rather than unstable convective heating in a flame or furnace. Microbubbles are created along a microcapillary and are naturally opened to the input and output microfluidic or gas channels. The demonstrated microbubble resonator has 370 µm diameter, 2 µm wall thickness, and a Q factor exceeding 10
Super FSR tunable optical microbubble resonator
An optical resonator is often called fully tunable if its tunable range
exceeds the spectral interval that contains the resonances at all the
characteristic modes of this resonator. For the high Q-factor spheroidal and
toroidal microresonators, this interval coincides with the azimuthal free
spectral range. In this Letter, we demonstrate the first mechanically fully
tunable spheroidal microresonator created of a silica microbubble having a 100
micron order radius and a micron order wall thickness. The tunable bandwidth of
this resonator is more than two times greater than its azimuthal free spectral
range
Microscopic optical buffering in a harmonic potential
In the early days of quantum mechanics, Schrödinger noticed that oscillations of a wave packet in a one-dimensional harmonic potential well are periodic and, in contrast to those in anharmonic potential wells, do not experience distortion over time. This original idea did not find applications up to now since an exact one-dimensional harmonic resonator does not exist in nature and has not been created artificially. However, an optical pulse propagating in a bottle microresonator (a dielectric cylinder with a nanoscale-high bump of the effective radius) can exactly imitate a quantum wave packet in the harmonic potential. Here, we propose a tuneable microresonator that can trap an optical pulse completely, hold it as long as the material losses permit, and release it without distortion. This result suggests the solution of the long standing problem of creating a microscopic optical buffer, the key element of the future optical signal processing devices
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