Luminiscence dating of burial 3 and the bell beaker pottery from La Pijotilla (Badajoz, Spain)

La Pijotilla es uno de los mayores asentamientos (80 Ha) del III milenio A.N.E. de la Península Ibérica, siendo considerado un lugar central dentro de la red de poblamiento de Tierra de Barros (comarca de Tierra de Barros, Badajoz). Desde los años 70 se han excavado el poblado y la necrópolis, destacando la tumba T3, excavada en la roca donde se realizaron 300 inhumaciones en capas sucesivas generando una estratigrafía amplia y que contenía un variado y cuantioso ajuar. En el poblado se ha recuperado una colección de fragmentos campaniformes sin contexto estratigráfico, junto a una gran diversidad de estilos decorativos pertenecientes a la última fases del III milenio ANE. El objetivo propuesto en este trabajo ha sido datar diferentes niveles de la tumba T3 y compararlas con otras dataciones C14; al igual que datar la cerámica campaniforme de superficie del poblado y compararla con dataciones absolutas procedentes de contextos habitacionalesLa Pijotilla, one of the largest settlements through out all Iberian Peninsula, and is considered a central place of Tierra de Barros Copper Age settlement network (Comarca de Tierra de Barros, Badajoz). During the field works that has been going on since the 70’s, the settlement and the necropolis area have been located. Several tombs have been excavated, standing out tomb 3, build on the rock with 300 buried individuals and a great richness of funerary objects alternated in several layers. During survey works in the settlement a large amount of decorated pottery from III millennium BC including a great number of Bell Beaker pottery, without a stratigraphic context, have been found. The focus in this work is to date different layers of T3 using luminescence techniques and compare them with old and new radiocarbon dates, as well as to date the survey-collected Bell Beaker pottery and compare them with the settlement radiocarbon datesPlan Nacional de Materiales MAT 2005-000790GRICES-CSIC 2005-PT003

Diminished emotional expression in schizophrenia: An interdisciplinary approach based on behavioral interventions

Resumen tomado de la publicaciónExpresión emocional disminuida en la esquizofrenia: un abordaje interdisciplinar basado en intervenciones conductuales. Antecedentes: los síntomas negativos representan la principal causa de discapacidad en la esquizofrenia, habiendo sido agrupados recientemente en dos dimensiones: avolición y expresión emocional disminuida, que incluye el aplanamiento afectivo y la alogia. El objetivo del estudio fue explorar la respuesta de estos dos síntomas a un conjunto de intervenciones conductuales basadas en el manejo de contingencias en un contexto interdisciplinario. Método: se monitorizaron conductas de interés y realizaron medidas pre y post a 9 participantes con esquizofrenia negativa persistente ingresados en dispositivos de rehabilitación. El programa incluyó 12 sesiones grupales dobles dirigidas a trabajar la expresión facial y la comunicación verbal, y un plan de cuidados para fortalecer y generalizar estas conductas. Resultados: se obtuvieron diferencias relevantes en la expresión facial, que fueron menos claras para la alogia. La evaluación clínica mediante la PANSS-N no obtuvo diferencias notables a nivel de grupo, pero sí la valoración mediante indicadores NOC. Conclusiones: aunque difíciles de modificar, los síntomas negativos no son insensibles a la influencia de intervenciones conductuales. Resulta necesario potenciar intervenciones psicológicas específicas que aborden estos síntomas como un foco prioritario de atención y cuidado, considerando el papel crucial del contexto en su evolución.Universidad de Oviedo. Biblioteca de Psicología; Plaza Feijoo, s/n.; 33003 Oviedo; Tel. +34985104146; Fax +34985104126; [email protected]

Datación del recinto murado calcolítico de Las Mesas (La Fuente, España)

El yacimiento amurallado de media hectárea de Las Mesas se ubica en la margen oeste del río Guadiana (La Fuente, Badajoz, España). El análisis de la cultura material recuperada en prospecciones de superficie remite a un arco cronológico que va desde el Neolítico Final (ca. 3600-2900 AC) a la Edad del Cobre (III milenio AC). Las excavaciones han revelado una muralla polibastionada y un espacio habitacional en el centro del asentamiento con tres fases de uso, diferentes áreas funcionales y un hoyo votivo adscrito a la segunda fase. En un hoyo ritual efectuado en la segunda fase se ha recuperado una cornamenta de cérvido que ha sido datado mediante AMS-14C. Se analizaron por Luminiscencia Ópticamente Estimulada (OSL) muestras de un nivel de uso de suelo asignado a la segunda fase (UE-9/10) y de la base de un horno asociado a la primera fase (UE- 18). Se aplicó un procedimiento de Dosis Única Regenerativa (SAR) sobre la fracción de granos de cuarzo de 90-160 μm. Se efectuó también un análisis de 7 muestras tomadas de la estratigrafía para determinar las variaciones de la conducta luminiscente y la edad relativa a través de la secuencia estratigráfica en muestras polimi- nerales mediante luminiscencia estimulada infrarojaópticamente y térmicamente (IRSl, OSL, TSL). La datación y el perfil luminiscente indican que el nivel superior (UE-1B) pertenecería probablemente al Bronce Final (ca. 1000 AC), pero que el resto de la secuencia estratigráfica se corresponde con una ocupación del Neolítico Final-Edad del Cobre. Siendo lo más probable que la ocupación del sitio tuviera lugar entre el 3300 y el 2900 AC. Se detectan vacíos de ocupación entre la fase I y II, y entre la fase II y la ocupación del Bronce Final (fase III). Indicando que el asentamiento fue abandonado y reocupado en dos ocasiones, una en la Edad del Cobre y una en el Bronce Final. La fecha de 4254 ± 45 BP (3010-2675 cal AC) obtenida mediante AMS-14C coincide con las fechas luminiscente de la fase II, apuntando que el hoyo fue excavado al principio de la fase II. Las fechas luminiscentes y radiocarbónicas combinadas muestran que el asentamiento de Las Mesas fue ocupado durante la colonización agrícola del territorio que tuvo lugar en el Neolítico Final, abandonado durante la Edad del Cobre y reocupado en el Bronce Final. Los vacíos poblacionales registrados podrían relacionarse con las evidencias de quemado y destrucción parcial de la muralla del asentamiento, y su posterior reconstrucción y consolidación.The site of Las Mesas is located in the west bank of the Guadajira river (La Fuente, Badajoz, Spain). It covers a half hectare and is enclosed by a stone wall. Previous assessments based on site surveys suggested a general chronological span from Late Neolithic period (ca. 3600- 2900 BC) through the Copper Age (3rd millennium BC). Excavations revealed a well-constructed wall with bastions and a domestic space at the centre of the site with three occupational phases. Several functional areas and a votive pit are ascribed to the second phase. A deer antler located in a re-cut ritual pit associated to the second phase was dated by AMS-14C. Samples from a living floor assigned to the second phase (SU- 9/10) and the basement of a kiln associated with the first phase (SU-18) was dated by optically stimulated luminescence (OSL) using the single aliquot regenerative dose (SAR) protocol on 90-160 μm quartz grains. Luminescence profiling analysis of 7 samples taken throughout the archaeological stratigraphy was used to assess variations in luminescence behaviour and relative age through the sequence, using infrared-, optically –and thermally– stimulated luminescence (IRSL, OSL, TSL) on poly-mineral and etched samples. Luminescence dating and profiling indicates that the upper archaeological layer (SU-1B) probably dates to the Late Bronze Age (ca. 1000 BC), but that the sediments in the remainder of this section accumulated during the late Neolithic-Copper Age: the site was most probably inhabited between 3300 and 2900 BC. There were gaps in occupation between the Late Neolithic-Cooper Age phases (I & II), and between the Late Neolithic-Cooper Age phases and Late Bronze Age phase (II & III), indicating that the site was abandoned and reoccupied twice. The AMS-14C date on deer antler of 4254 ± 45 BP (3010- 2675 cal BC) is consisten with the OSL results for phase II, indicating that the pit was excavated at the beginning of the second occupational phase. Combined OSL and AMS-14C dating shows that Las Mesas site was first occupied during Late Neolithic farming colonization, abandoned during the Copper Age and occupied again during the Late Bronze Age. The occupational gap recorded during the Copper Age relates to evidence for burning of the site and the partial destruction of the wall, followed by its reconstruction and consolidation

Evolution Meets Disease: Penetrance and Functional Epistasis of Mitochondrial tRNA Mutations

About half of the mitochondrial DNA (mtDNA) mutations causing diseases in humans occur in tRNA genes. Particularly intriguing are those pathogenic tRNA mutations than can reach homoplasmy and yet show very different penetrance among patients. These mutations are scarce and, in addition to their obvious interest for understanding human pathology, they can be excellent experimental examples to model evolution and fixation of mitochondrial tRNA mutations. To date, the only source of this type of mutations is human patients. We report here the generation and characterization of the first mitochondrial tRNA pathological mutation in mouse cells, an m.3739G>A transition in the mitochondrial mt-Ti gene. This mutation recapitulates the molecular hallmarks of a disease-causing mutation described in humans, an m.4290T>C transition affecting also the human mt-Ti gene. We could determine that the pathogenic molecular mechanism, induced by both the mouse and the human mutations, is a high frequency of abnormal folding of the tRNAIle that cannot be charged with isoleucine. We demonstrate that the cells harboring the mouse or human mutant tRNA have exacerbated mitochondrial biogenesis triggered by an increase in mitochondrial ROS production as a compensatory response. We propose that both the nature of the pathogenic mechanism combined with the existence of a compensatory mechanism can explain the penetrance pattern of this mutation. This particular behavior can allow a scenario for the evolution of mitochondrial tRNAs in which the fixation of two alleles that are individually deleterious can proceed in two steps and not require the simultaneous mutation of both

Exploring deep learning for complex trait genomic prediction in polyploid outcrossing species

Genomic prediction (GP) is the procedure whereby the genetic merits of untested candidates are predicted using genome wide marker information. Although numerous examples of GP exist in plants and animals, applications to polyploid organisms are still scarce, partly due to limited genome resources and the complexity of this system. Deep learning (DL) techniques comprise a heterogeneous collection of machine learning algorithms that have excelled at many prediction tasks. A potential advantage of DL for GP over standard linear model methods is that DL can potentially take into account all genetic interactions, including dominance and epistasis, which are expected to be of special relevance in most polyploids. In this study, we evaluated the predictive accuracy of linear and DL techniques in two important small fruits or berries: strawberry and blueberry. The two datasets contained a total of 1,358 allopolyploid strawberry (2n=8x=112) and 1,802 autopolyploid blueberry (2n=4x=48) individuals, genotyped for 9,908 and 73,045 single nucleotide polymorphism (SNP) markers, respectively, and phenotyped for five agronomic traits each. DL depends on numerous parameters that influence performance and optimizing hyperparameter values can be a critical step. Here we show that interactions between hyperparameter combinations should be expected and that the number of convolutional filters and regularization in the first layers can have an important effect on model performance. In terms of genomic prediction, we did not find an advantage of DL over linear model methods, except when the epistasis component was important. Linear Bayesian models were better than convolutional neural networks for the full additive architecture, whereas the opposite was observed under strong epistasis. However, by using a parameterization capable of taking into account these non-linear effects, Bayesian linear models can match or exceed the predictive accuracy of DL. A semiautomatic implementation of the DL pipeline is available at https://github.com/lauzingaretti/deepGP/.info:eu-repo/semantics/publishedVersio

Chemical abundances of Seyfert 2 AGNs, I: comparing oxygen abundances from distinct methods using SDSS

We compare the oxygen abundance (O/H) of the narrow-line regions (NLRs) of Seyfert 2 AGNs obtained through strong-line methods and from direct measurements of the electron temperature (Te-method). The aim of this study is to explore the effects of the use of distinct methods on the range of metallicity and on the mass-metallicity relation of active galactic nuclei (AGNs) at low redshifts (z<~0.4). We used the Sloan Digital Sky Survey (SDSS) and NASA/IPACExtragalactic Database (NED) to selected optical (3000Fil: Dors, Oli L.. Universidade Do Vale Do Paraiba; BrasilFil: de Freitas Rosa, Morsyleide. Universidade Do Vale Do Paraiba; BrasilFil: Amores, E. B.. Universidade Estadual de Feira de Santana; BrasilFil: Almarcha Pérez, Martha Ayelén. Instituto de Astrofísica de Andalucía - Csic; EspañaFil: Cardaci, Monica Viviana. Instituto de Astrofísica de la Plata (conicet- Universidad Nacional de la Plata); Argentina. Universidad Nacional de La Plata; ArgentinaFil: Hägele, Guillermo Federico. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Armah, M.. Universidade Do Vale Do Paraiba; BrasilFil: Krabbe, A. C.. Universidade Do Vale Do Paraiba; BrasilFil: Ruiz Faúndez, Giovanni Patricio. Laboratorio Nacional de Astrofisica, Itajuba; Brasi

Reseñas

EZEQUIEL LUDUEÑA, Eriúgena. VALERIA BUFFON / CLAUDIA D’AMICO (comps.), Hermes Platonicus. Hermetismo y platonismo en el Medioevo y la Modernidad Temprana.&nbsp;IRVEN M. RESNICK (ed.), A companion to Albert the Great. Theology, Philosophy and the Sciences. MARIANO ÁLVAREZ-GÓMEZ (ed.), Nicolás de Cusa, La caza de la sabiduría. CHRISTIANE BACHER, Philosophische Waagschalen. Experimentelle Mystik bei Nikolaus von Kues mit Blick auf die Moderne. DAVIDE MONACO, Nicholas of Cusa: Trinity, Freedom and Dialogue. NICCOLÒ CUSANO, Opere filosofiche, teologiche e matematiche, a cura di ENRICO PEROLÌ. GREGORIO PIALA, Sapienza e follia: Per una storia intellettuale del Rinascimento europeo. HANS G. SENGER, Nikolaus von Kues. Leben, Lehre, Wirkungsgeschichte. JOCELYNE SFEZ, L’Art des conjectures de Nicolás de Cues. CHRISTIAN STRÖBELE, Performanz und Diskurs. Religiöse Sprache und negative Theologie bei Cusanus. KIRSTIN ZEYER, Cusanus in Marburg. Hermann Cohens und Ernst Cassirers produktive Form der Philosophiegeschichtsaneigun

Transcriptome profiling of grapevine seedless segregants during berry development reveals candidate genes associated with berry weight

Indexación: Web of Science; PubMedBackground Berry size is considered as one of the main selection criteria in table grape breeding programs. However, this is a quantitative and polygenic trait, and its genetic determination is still poorly understood. Considering its economic importance, it is relevant to determine its genetic architecture and elucidate the mechanisms involved in its expression. To approach this issue, an RNA-Seq experiment based on Illumina platform was performed (14 libraries), including seedless segregants with contrasting phenotypes for berry weight at fruit setting (FST) and 6–8 mm berries (B68) phenological stages. Results A group of 526 differentially expressed (DE) genes were identified, by comparing seedless segregants with contrasting phenotypes for berry weight: 101 genes from the FST stage and 463 from the B68 stage. Also, we integrated differential expression, principal components analysis (PCA), correlations and network co-expression analyses to characterize the transcriptome profiling observed in segregants with contrasting phenotypes for berry weight. After this, 68 DE genes were selected as candidate genes, and seven candidate genes were validated by real time-PCR, confirming their expression profiles. Conclusions We have carried out the first transcriptome analysis focused on table grape seedless segregants with contrasting phenotypes for berry weight. Our findings contributed to the understanding of the mechanisms involved in berry weight determination. Also, this comparative transcriptome profiling revealed candidate genes for berry weight which could be evaluated as selection tools in table grape breeding programs.http://bmcplantbiol.biomedcentral.com/articles/10.1186/s12870-016-0789-

Recensiones [Revista de Historia Económica Año VII Primavera-Verano 1989 n. 2 pp. 489-536]

Alfred W. Crosby. Imperialismo ecológico. La expansión biológica de Europa, 900-1900 (Por Tomás Pérez Vejo).-- Pedro Pérez Herrero. Plata y libranzas: La articulación comercial del México borbónico (Por Carlos Marichal).-- Ramón Lanza García. Población y familia campesina en el Antiguo Régimen (Por Miguel Ángel Melón Jiménez).-- Fernando Cortés Cortés. Esclavos en la Extremadura Meridional en el Siglo XVII (Por Alfonso Rodríguez Grajera).-- Rafael Domínguez Martín. Actividades comerciales Y transformaciones agrarias en Cantabria: 1750-1850 (Por Patricio Pérez).-- Ll. Ferrer Alos. Pagesos, rebassaires i industriáisa la Catalunya central (Segles XVIII i XIX) (Por Josep Pujol Andreu).-- Ramón Garrabou (ed.). La crisis agraria de fines del Siglo XIX (Por Fausto Dopico).-- Actas del II Congreso sobre Archivos Económicos de entidades privadas; Fuentes para la historia de la banca y del comercio en España (Por Santiago M. López).-- Mario Rapoport (comp.). Economía e historia. Contribuciones a la Historia Económica Argentina (Por Carlos Rodríguez Braun).-- Vicente Pérez Moreda y David-Sven Reher (eds.). Demografía histórica en España (Por Josune Aguinaga Roustan).-- Leandro Prados de la Escosura. De Imperio a Nación: Crecimiento y atraso económico en España (1780-1930) (Por Eugene N. White).-- M. Teresa González Calbet. La Dictadura de Primo De Rivera. El directorio Militar (Por Eloy Fernández Clemente)Publicad

Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin

Inflammatory caspase sensing of cytosolic lipopolysaccharide (LPS) triggers pyroptosis and the concurrent release of damage-associated molecular patterns (DAMPs). Collectively, DAMPs are key determinants that shape the aftermath of inflammatory cell death. However, the identity and function of the individual DAMPs released are poorly defined. Our proteomics study revealed that cytosolic LPS sensing triggered the release of galectin-1, a β-galactoside-binding lectin. Galectin-1 release is a common feature of inflammatory cell death, including necroptosis. In vivo studies using galectin-1-deficient mice, recombinant galectin-1 and galectin-1-neutralizing antibody showed that galectin-1 promotes inflammation and plays a detrimental role in LPS-induced lethality. Mechanistically, galectin-1 inhibition of CD45 (Ptprc) underlies its unfavorable role in endotoxin shock. Finally, we found increased galectin-1 in sera from human patients with sepsis. Overall, we uncovered galectin-1 as a bona fide DAMP released as a consequence of cytosolic LPS sensing, identifying a new outcome of inflammatory cell death.Fil: Russo, Ashley J.. UConn Health School of Medicine; Estados UnidosFil: Vasudevan, Swathy O.. UConn Health School of Medicine; Estados UnidosFil: Mendez Huergo, Santiago Patricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Kumari, Puja. UConn Health School of Medicine; Estados UnidosFil: Menoret, Antoine. UConn Health School of Medicine; Estados UnidosFil: Duduskar, Shivalee. Jena University Hospital; AlemaniaFil: Wang, Chengliang. UConn Health School of Medicine; Estados UnidosFil: Pérez Sáez, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Fettis, Margaret M.. University of Florida; Estados UnidosFil: Li, Chuan. UConn Health School of Medicine; Estados UnidosFil: Liu, Renjie. University of Florida; Estados UnidosFil: Wanchoo, Arun. University of Florida; Estados UnidosFil: Chandiran, Karthik. UConn Health School of Medicine; Estados UnidosFil: Ruan, Jianbin. UConn Health School of Medicine; Estados UnidosFil: Vanaja, Sivapriya Kailasan. UConn Health School of Medicine; Estados UnidosFil: Bauer, Michael. Jena University Hospital; AlemaniaFil: Sponholz, Christoph. Jena University Hospital; AlemaniaFil: Hudalla, Gregory A.. University of Florida; Estados UnidosFil: Vella, Anthony T.. UConn Health School of Medicine; Estados UnidosFil: Zhou, Beiyan. UConn Health School of Medicine; Estados UnidosFil: Deshmukh, Sachin D.. Jena University Hospital; AlemaniaFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Rathinam, Vijay A.. UConn Health School of Medicine; Estados Unido