El tiempo fuera del tiempo. Anotaciones sobre la temporalidad insular en María Zambrano

According to María Zambrano’s work, the island temporality behaves in a distinctive way when contrasted to the pass of time in continents. The ideas that will serve as aid to define this concept can be traced back to the philosopher’s reflections on the subject during her stay in Cuba and Puerto Rico, which contributed to structure her idea of poetic reason.La temporalidad insular, dentro de la obra zambraniana, se comporta de manera distintiva en contraposición al tiempo que transcurre en los continentes. Las ideas que definirán este concepto se verán remitidas en gran medida al sistema de referencias desarrollado por la filósofa durante su estancia en Cuba y Puerto Rico y que contribuyeron a estructurar su idea de razón poética

Elaboración de una propuesta de aprendizaje en red para estudiantes de licenciatura en el ITESO

Como parte de una ruta de formación docente ofrecida por el Centro de Aprendizaje en Red del Instituto Tecnológico y de Estudios Superiores de Occidente (ITESO) se le presentó a una profesora el reto de elaborar una propuesta experimental de aprendizaje en red. Como encargada de la materia Actividad física y estilos de vida saludable, tuvo el desafío de diseñar una situación de aprendizaje de este tipo para ayudar a los estudiantes a reflexionar y mantener un estilo de vida sana. As part of a teacher training course offered by the Networked Learning Center of Instituto Tecnológico y de Estudios Superiores de Occidente (ITESO), a professor faced the challenge to develop an experimental approach of networked learning. As teacher of the "Physical activity and healthy lifestyles" class, she had the task to design a learning situation of such kind, to help students reflect and maintain a healthy lifestyle.ITESO, A.C

A Comprehensive Review of the Effect of Honey on Human Health

Honey is a nutritious, healthy, and natural food, to which antioxidant, anti-inflammatory, and antimicrobial properties have been attributed, mainly due to its content of phenolic compounds. The aim of this review is to analyze the available evidence of the effect of honey on humans. Fortyeight clinical trials published between 1985 and 2022 were analyzed, with a total of 3655 subjects. More beneficial effects of honey intake than no or negative effects on different cardiovascular and metabolic risk factors, glucose tolerance, mucositis caused by chemo-radiotherapy, cough in children and wound healing, among others have been observed. Although the number of studies conducted to date is limited and the different investigations are not standardized, beneficial effects of honey intake have been observed, especially when its intake replaces the intake of other sweeteners. In addition, honey could be a safe adjuvant to be administered alongside drugs used for certain diseases.Programa Operativo de Empleo Juvenil (Youth Employment Program)Junta de Andalucía-Consejería de Universidad, Investigación e Innovación Research Project: P21_00777 M.P.-M

El tiempo fuera del tiempo. Anotaciones sobre la temporalidad insular en María Zambrano

La temporalidad insular, dentro de la obra zambraniana, se comporta de manera distintiva en contraposición al tiempo que transcurre en los continentes. Las ideas que definirán este concepto se verán remitidas en gran medida al sistema de referencias desarrollado por la filósofa durante su estancia en Cuba y Puerto Rico y que contribuyeron a estructurar su idea de razón poética.According to María Zambrano’s work, the island temporality behaves in a distinctive way when contras- ted to the pass of time in continents. The ideas that will serve as aid to define this concept can be traced back to the philosopher’s reflections on the subject during her stay in Cuba and Puerto Rico, which contributed to structure her idea of poetic reason.

Fractionation and fluxes of metals and radionuclides during the recycling process of phosphogypsum wastes applied to mineral CO2 sequestration

The industry of phosphoric acid produces a calcium-rich by-product known as phosphogypsum, which is usually stored in large stacks of millions of tons. Up to now, no commercial application has been widely implemented for its reuse because of the significant presence of potentially toxic contaminants. This work confirmed that up to 96% of the calcium of phosphogypsum could be recycled for CO2 mineral sequestration by a simple two-step process: alkaline dissolution and aqueous carbonation, under ambient pressure and temperature. This CO2 sequestration process based on recycling phosphogypsum wastes would help to mitigate greenhouse gasses emissions. Yet this work goes beyond the validation of the sequestration procedure; it tracks the contaminants, such as trace metals or radionuclides, during the recycling process in the phosphogypsum. Thus, most of the contaminants were transferred from raw phosphogypsum to portlandite, obtained by dissolution of the phosphogypsum in soda, and from portlandite to calcite during aqueous carbonation. These findings provide valuable information for managing phosphogypsum wastes and designing potential technological applications of the by-products of this environmentally-friendly proposal.Junta de Andalucía P10-RNM-6300, P12- RNM-226

Detección de microRNAs extracelulares y su potencial como biomarcadores moleculares

RESUMEN Los microRNAs (miRNAs) son moléculas de RNA de 18 a 24 nucleótidos de longitud involucrados en la regulación de la expresión génica a nivel postranscripcional en la célula. En este trabajo analizamos la expresión de miRNAs en muestras de tejido y suero de pacientes con cáncer mamario, y este perfil permite distinguir pacientes con cáncer de mama y mujeres sanas con alta sensibilidad, especificidad y eficiencia. La combinación de dos miRNAs para tejido y tres para suero, usados en conjunto como un solo grupo, eleva significativamente la eficiencia de la prueba, y demuestra que los miRNAs tienen gran potencial como nuevos biomarcadores no invasivos en cáncer de mama. Adicionalmente, se realizó la búsqueda de miRNAs en el protozoario Entamoeba histolytica, por secuenciación profunda, lo que permitió realizar la primera descripción de miRNAs en este parásito. Se identificaron 199 miRNAs exclusivos para este parásito, que servirán de base para el estudio de la regulación génica en E. histolytica y el establecimiento de nuevos biomarcadores para la amibiasis. ABSTRACT MicroRNAs (miRNAs) are 18 to 24 nucleotide-long RNA molecules responsible for the regulation of gene expression at the post-transcriptional level in the cell. In this work, we analyzed the expression of miRNAs in tissue samples and serum of patients with breast cancer and we found that miRNA expression patterns distinguish patients with breast cancer from healthy women with high sensitivity, specificity, and efficiency. The combination of 2 and 3 miRNAs used as a group in tissue and serum respectively, significantly increases the efficiency of the test and shows that miRNAs have potential as novel noninvasive biomarkers in breast cancer detection. Additionally, miRNAs were detected by deep sequence in the protozoan parasite Entamoeba histolytica, which allowed the first description of miRNAs in this parasite. We identified 199 new miRNAs in E. histolytica, which are the base for the study of gene regulation and the establishment of new biomarkers for amoebiasis

Topological structural alerts modulations of mammalian cell mutagenicity for halogenated derivatives

Genotoxicity is a key toxicity endpoint for current regulatory requirements regarding new and existing chemicals. However, genotoxicity testing is time-consuming and costly, and involves the use of laboratory animals. This has motivated the development of computational approaches, designed to predict genotoxicity without the need to conduct laboratory tests. Currently, many existing computational methods, like quantitative structure–activity relationship (QSAR) models, provide limited information about the possible mechanisms involved in mutagenicity or predictions based on structural alerts (SAs) do not take statistical models into account. This paper describes an attempt to address this problem by using the TOPological Substructural MOlecular Design (TOPS-MODE) approach to develop and validate improved QSAR models for predicting the mutagenicity of a range of halogenated derivatives. Our most predictive model has an accuracy of 94.12%, exhibits excellent cross-validation and external set statistics. A reasonable interpretation of the model in term of SAs was achieved by means of bond contributions to activity. The results obtained led to the following conclusions: primary halogenated derivatives are more mutagenic than secondary ones; and substitution of chlorine by bromine increases mutagenicity while polyhalogenation decreases activity. The paper demonstrates the potential of the TOPS-MODE approach in developing QSAR models for identifying structural alerts for mutagenicity, combining high predictivity with relevant mechanistic interpretation.Ciencias AmbientalesCiencias de la AlimentaciónFarmaciaIngeniería, Industria y ConstrucciónMedicin

Nuevo método para acelerar la curación de la enfermedad de Perthes

Se presenta el caso de un paciente de 13 años de edad, con el diagnóstico de enfermedad de Perthes avanzada, atendido en el servicio de Ortopedia y Traumatología del Hospital Universitario Celia Sánchez Manduley, en el que se empleó por primera vez el tratamiento quirúrgico convencional asociado al empleo de la oxigenación hiperbárica. La evolución del paciente fue satisfactoria, la nueva combinación de tratamientos, logró reducir el período de evolución de la enfermedad en seis meses.A case of 13 years old patient with advanced Perthes disease is presented. The child was admitted to the orthopedics and traumathology service of the University Hospital Celia Sánchez Manduley. Surgical treatment was associated to hiperbaric oxynation therapy. The patient's outcome was satisfactory. The new treatment combination was able to reduce the evolution's period of disease in six months

Self-assembled high molecular weight inulin nanoparticles: Enzymatic synthesis, physicochemical and biological properties

Inulin has interesting physicochemical and functional properties, and therefore a wide range of applications in the food and medical industries. It has gained great traction due to its ability to form nanoparticles and its possible application as nanovehicle for drug delivery. In this work, we demonstrated that the enzymatically-synthesized high molecular weight (HMW) inulin forms stable spherical nanoparticles with an average diameter of 112 ± 5 nm. The self-assemblage of HMW inulin nanoparticles is carried out during enzymatic synthesis of the polymer, and become detectable after a certain critical aggregation concentration (CAC) is reached. Both, the CAC and nanoparticle size are influenced by the reaction temperature. These nanoparticles are not toxic for peripheral blood mononuclear cells, at concentrations below 200 μg/mL; no significant prebiotic potential was detected in cultures of 13 probiotic strains. This work contributes to a better understanding of the formation of HMW inulin nanoparticles and their biological properties

Stability of excited states of a Bose-Einstein condensate in an anharmonic trap

We analyze the stability of non-ground nonlinear states of a Bose-Einstein condensate in the mean field limit in effectively 1D (``cigar-shape'') traps for various types of confining potentials. We find that nonlinear states become, in general, more stable when switching from a harmonic potential to an anharmonic one. We discuss the relation between this fact and the specifics of the harmonic potential which has an equidistant spectrum