Pasemos REVISTA. Publicaciones Periódicas

De un modo gráfico, se explica la gestión de Publicaciones Periódicas en Koha, el procedimiento de trabajo desde la adquisición hasta el registro de ejemplares, la visualización en OPAC desde el punto de vista del usuario y la conservación de los fondos en las distintas ubicaciones

Zinc(II), cobalt(II) and manganese(II) networks with phosphoserine ligand: Synthesis, crystal structures magnetic and conduction properties

A series of zinc(II), cobalt(II) and manganese(II) coordination networks with the phosphoserine ligand (Pser) is synthesized and characterized. Whereas in compounds 1 and 2 with the general formula [M(Pser)]n [M = Zn (1) and Co(2)], the metal(II) ion presents a tetrahedral geometry, in [Co(Pser)(H2O)2]n (3) and [Mn(Pser)(H2O)]n (4)], the metal(II) ions are in a distorted octahedral geometry. The 3D frameworks are formed by inorganic layers built up from MO4 or MO6 polyhedra and phosphate groups. These layers are linked by the carboxylate groups of the phosphoserine ligand. The presence of extended hydrogen bonding stabilizes the 3D network and favors the proton transfer leading to moderate proton conductors. The highest proton conductivity, 2.70·10−5 S cm−1 (at 80 ºC and 95% RH), is obtained for compound 3. Temperature dependent magnetic susceptibility measurements for 2−4 reveal predominant antiferromagnetic interactions between the paramagnetic metal(II) ions.Proyectos MAT2013-41836-R y MAT2016-77648-R del MINECO, y proyecto (P12-FQM-1656) de la Junta de Andalucía

Evaluation of the primitive fraction by functional in vitro assays at the RNA and DNA level represents a novel tool for complementing molecular monitoring in chronic myeloid leukemia

Quantification of BCR-ABL1 mRNA levels in peripheral blood of chronic myeloidleukemia patients is a strong indicator of response to tyrosine-kinase inhibitors (TKI)treatment. However, additional prognostic markers are needed in order to better classify patients. The hypothesis of leukemic stem cells (LSCs) heterogeneity and persistence, suggests that their functional evaluation could be of clinical interest. In this work, we assessed the primitive and progenitor fractions in patients at diagnosis and during TKI treatment using functional in vitro assays, defining a ?functional leukemic burden? (FLB). We observed that the FLB was reduced in vivo in both fractions upon treatment. However, different FLB levels were observed among patients according to their response to treatment, suggesting that quantification of the FLB could complement early molecular monitoring. Given that FLB assessment is limited by BCR-ABL1 mRNA expression levels, we developed a novel detection method of primitive cells at the DNA level, using patient-specific primers and direct nested PCR in colonies obtained from functional in vitro assays. We believe that this methodcould be useful in the context of discontinuation trials, given that it is unknown whether the persistent leukemic clone represents LSCs, able to resume the leukemia upon TKI removal.Fil: Ruiz, María Sol. Fundación Cáncer. Centro de Investigaciones Oncológicas; ArgentinaFil: Sanchez, María Belén. Fundación Cáncer. Centro de Investigaciones Oncológicas; Argentina. Argenomics; ArgentinaFil: Gutierrez, Leandro German. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Instituto Alexander Fleming, Bs. As.; ArgentinaFil: Koile, Daniel Isaac. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; ArgentinaFil: Yankilevich, Patricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; ArgentinaFil: Mosqueira, Celeste. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Cranco, Santiago. Fundaleu; ArgentinaFil: Custidiano, María del Rosario. Hospital Italiano de La Plata; ArgentinaFil: Freitas, Josefina. Provincia de Buenos Aires. Hospital Nacional Profesor A. Posadas; ArgentinaFil: Foncuberta, Cecilia. Instituto Alexander Fleming; ArgentinaFil: Moiraghi, Beatriz. Fundación Cáncer. Centro de Investigaciones Oncológicas; ArgentinaFil: Pavlovsky, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Pérez, Mariel Ana. Fundación Cáncer. Centro de Investigaciones Oncológicas; ArgentinaFil: Ventriglia, Verónica. Provincia de Buenos Aires. Hospital Nacional Profesor A. Posadas; Argentina; ArgentinaFil: Sánchez Ávalos, Julio César Américo. Instituto Alexander Fleming; ArgentinaFil: Mordoh, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Cáncer. Centro de Investigaciones Oncológicas; ArgentinaFil: Larripa, Irene Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Bianchini, Michele. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Cáncer. Centro de Investigaciones Oncológicas; Argentin

Diseño, síntesis y caracterización de materiales híbridos de redes metal orgánicas de tierras raras y grafeno

La finalidad de este proyecto es obtener materiales híbridos de redes metal orgánicas de tierras raras y grafeno para aumentar la emisión de los lantánidos en sus respectivas longitudes de onda (verde y rojo). Los sistemas orgánometálicos estudiados fueron Terbio: Tenoltrifluoroacetona y Europio: Tenoltrifluoroacetona en una proporción de [1:3] respectivamente. Una vez realizada la síntesis se hizo un análisis de luminiscencia, con el objetivo de comparar la emisión de los orgánicos con y sin la incorporación de óxido de grafeno. Posteriormente se sintetizó el óxido de grafeno por el método de Hummer modificado y se caracterizó por Difracción de Rayos X para verificar la fase estructural. Para la formación del material hibrido se añadió el óxido de grafeno al material orgánico antes de la precipitación de este. Finalmente, se hicieron caracterizaciones de Luminiscencia, Difracción de Rayos X y Espectroscopia Infrarroja por Transformada de Fourier de los materiales híbridos.The purpose of this project is to obtain hybrid materials from rare earth and graphene organic metal networks to increase the emission of lanthanides in their respective wavelengths (green and red). The metalorganic systems studied were Terbio: Thenoyltrifluoroacetone and Europium: Thenoyltrifluoroacetone in a proportion of [1: 3] respectively. Once the synthesis was performed, a luminescence analysis was carried out, with the aim of comparing the emission of the organics with and without the incorporation of graphene oxide. Graphene oxide was subsequently synthesized by the modified Hummer method and characterized by X-ray Diffraction to verify the structural phase. For the formation of the hybrid material, graphene oxide was added to the organic material before its precipitation. Finally, characterizations of Luminescence, X-ray Diffraction and Fourier Transform Infrared Spectroscopy of the hybrid materials were made

Enfermera Gestora de Casos del Servicio Murciano de Salud: Un año de puesta en marcha del programa

The objectives of this paper are to describe the fundamental processes of the nurse case manager in a year of the program, to know the sociodemographic and clinical profile of the target population and the strain on the caregiver. Methodology: This observational, descriptive and transversal study has been made in the health area of Murcia IX from 1 June 2010 to 31 May 2011. It describes the process maps of the nurse case manager; patients are identified through OMI-AP software and CIVITAS. Home visits are conducted to measure the social and demographic patterns, to perform evaluation through M. Gordon functional patterns and to apply validated questionnaires. The number of people who enter into the program is 258 patients and 115 caregivers. The population with chronic obstructive pulmonary disease represents 22.9%; 63.9% of patients have made full assessment. Results: The functional pattern that measures activity and exercise is the most altered. Patients have a mean age of 74 ± 15 years. Women predominate in the overall target population 54.7%; 87.2% have some degree of dependence, there are a higher percentage of patients with severe dependence. The average age of caregivers is 59 ± 13 years, of which, 40 % of family caregivers are not overloaded. The target population represented 5.3% of the population more vulnerable. Since the introduction of case manager, registration of functional patterns in medical records of patients and caregivers has increased. The aging population is high, fragile, with a severe dependence level, preferably female, with family caregivers (women) without overloading conclusionsLos objetivos que se plantean son describir los procesos claves de la enfermera gestora de casos (EGC) en un año de puesta en marcha del programa. Conocer el perfil sociodemográfico y clínico de la  población diana y conocer la sobrecarga en el cuidador familiar. Método; El estudio es observacional descriptivo y transversal en el Área IX de salud Murcia desde el 1 de junio de 2010 hasta 31 mayo de 2011. Se realiza mapa de procesos de la EGC, identificación de pacientes con OMI-AP y CIVITAS, y se realiza visita en consulta y/o domiciliaria para valoración inicial con datos sociodemográficos, 11 patrones funcionales de M. Gordon, y cuestionarios validados. El número de personas captadas es de 258 pacientes y 115 cuidadoras. La población con EPOC representa un 22,9%. El 63,9% de pacientes tienen valoración completa realizada. Resultados: El patrón actividad y ejercicio es el más alterado. Los pacientes tienen una media de edad de 74 ± 15 años. Las mujeres predominan en la población diana general 54,7%. El 87,2% presenta algún grado de dependencia, existe un mayor porcentaje con dependencia severa. La media de edad de la cuidadora familiar, es  59 ± 13 años, de las cuales, el 40% de las cuidadoras familiares no tienen sobrecarga. La población captada supone un 5,3% de la población compleja. Desde la incorporación de la EGC, ha aumentado el registro de las valoraciones por patrones, tanto de pacientes como de cuidadoras. La población captada está envejecida, frágil, con un nivel de dependencia severo, preferentemente es mujer, con cuidadora familiar (mujer) donde son más frecuentes las que no tienen sobrecarga

Low Adherence to the Mediterranean Diet in Isolated Adolescents: The Mediation Effects of Stress

Loneliness perception during adolescence has been increased dramatically in recent years. Changes in lifestyle and difficulties in social interaction could explain this increased phenomenon. As described in previous research, this fact has been associated with the development of high stress levels and dysfunctional lifestyles, in which eating habits play a main role. In this regard, loneliness has been classically associated with poor eating habits, fundamentally the consumption of processed food with little nutritional value. However, the relationship between loneliness and healthy eating patterns, such as the Mediterranean Diet (MD), has not been previously analyzed. The main aim of the present study was to identify the relationship between perceived loneliness, stress, dietary habits, and adherence to the MD in a sample of 527 Spanish adolescents. The obtained results show a significant association between high perceived loneliness and high stress levels with lower MD adherence. Hence, adolescents with high perceived loneliness exhibit poor dietary habits in comparison to those counterparts with low perceived loneliness. Mediation analyses demonstrated an indirect effect of the loneliness on adherence to the MD through the mediation effect of stress. These findings point out a possible mechanism that underlies the classic association between loneliness and health deterioration, based on a poor adherence to a healthy dietary pattern, such as the MD.This work was supported by the Spanish State Research Agency (AEI) and the European Regional Development Fund (FEDER) under project TIN2017-89069-R

Proposta didáctica para o desenvolvimento da capacidade aeróbica através da Educação Física no terceiro ciclo do Ensino Básico

Introducción: La realización de una actividad física regular predice mantener una buena salud presente y futura. Asimismo, un factor relacionado con la actividad física es la condición física, la cual suele evaluarse en la población escolar a través de la capacidad aeróbica con el uso del test de Course Navette. Revisiones de la literatura recientes concluyen que resulta necesario mejorar los niveles de capacidad aeróbica en los escolares ya que se considera un factor importante para el mantenimiento y optimización de la salud. En consecuencia, el objetivo del presente escrito es realizar una propuesta didáctica para el desarrollo de la capacidad aeróbica desde la Educación Física en tercer ciclo de Educación Primaria. Desarrollo: La propuesta se basa en una sesión prototipo con la que se podría iniciar el trabajo de la capacidad aeróbica en clase de una manera lúdica. Está diseñada según la instrucción 12/2022 de 23 de junio, para 5º de Educación Primaria con un total de 26 estudiantes. Se basa en la temática “La vida en la selva” a partir de una historia que explica el contenido de cada actividad. La sesión consta de calentamiento, parte principal con 5 juegos y vuelta a la calma. Conclusión: Desde la comunidad educativa se debe prestar atención a la comunidad científica, con el fin de observar desde una base científica “qué está pasando” entre nuestros y nuestras escolares, detectar una cuestión con necesidad de solventar y poner una solución.Introduction: Regular physical activity is predictive of good current and future health. Also, a factor related to physical activity is physical fitness, which is often assessed in the school population through aerobic capacity using the Course Navette test. Recent literature reviews conclude that there is a need to improve aerobic capacity levels as it is considered an important factor for the maintenance and optimisation of health. Consequently, the aim of this paper is to make a didactic proposal to aerobic capacity development in physical education in third-year primary school student. Development: The proposal is based on a prototype session which could be used to start working on aerobic capacity in class in a playful way. It is designed according to instruction 12/2022 of 23 June, for 5th year of primary school with a total of 26 students. It is based on the topic "Life in the jungle" with a story that explains the content of each activity. This session consists of a warm-up, a main part with 5 games and a cool-down. Conclusion: The educational community should pay attention to the scientific community, in order to observe on a scientific basis "what is happening" among our students, to detect an issue that needs to be solved and to find a solution.Introdução: A actividade física regular é um indicador de boa saúde actual e futura. Além disso, um factor relacionado com a actividade física é a aptidão física, que é frequentemente avaliada na população escolar através da capacidade aeróbica utilizando o teste Course Navette. Revisões recentes da literatura concluem que é necessário melhorar os níveis de capacidade aeróbica em crianças em idade escolar, uma vez que esta é considerada um factor importante para a manutenção e optimização da saúde. Assim, o objectivo deste trabalho é desenvolver uma proposta didáctica para o desenvolvimento da capacidade aeróbia a partir da Educação Física no terceiro ciclo do Ensino Básico. Desenvolvimento: A proposta baseia-se numa sessão protótipo que pode ser utilizada para começar a trabalhar a capacidade aeróbica nas aulas de uma forma lúdica. Foi concebida de acordo com a instrução 12/2022 de 23 de Junho, para o 5º ano do Ensino Básico com um total de 26 alunos. Baseia-se no tema "A vida na selva" com uma história que explica o conteúdo de cada atividade. A sessão é composta por um aquecimento, uma parte principal com 5 jogos e um regresso à calma. Conclusão: A comunidade educativa deve prestar atenção à comunidade científica, a fim de observar numa base científica "o que está a acontecer" entre os nossos alunos, para detetar um problema que precisa de ser resolvido e encontrar uma solução

Herramienta de apoyo para la adquisición de competencias profesionales en nutrición humana y dietética

Es prioritario para el desarrollo de las competencias profesionales de los futuros Dietistas-Nutricionistas, conocer y saber utilizar los principales recursos tanto de información como de aplicaciones informáticas disponibles en la actualidad en esta área de estudio. La creación de repositorios en los que el alumnado de esta titulación pueda disponer de estos recursos de una manera simplificada y unificada puede contribuir a la mejora de su proceso de enseñanza-aprendizaje. El objetivo de este trabajo es crear un repositorio de información y recursos educativos que ayuden a desarrollar las competencias profesionales en estudiantes del Grado en Nutrición Humana y Dietética. Ha participado en nuestro estudio una muestra disponible y significativa de estudiantes de esta titulación. Se describe el proceso de creación del repositorio, la información y recursos educativos incorporados en el mismo, el análisis del funcionamiento de la propia herramienta, así como los resultados obtenidos sobre la satisfacción de los estudiantes con esta experiencia piloto mediante un cuestionario elaborado ad hoc

Age-dependent association of clonal hematopoiesis with COVID-19 mortality in patients over 60 years.

Clonal hematopoiesis, especially that of indeterminate potential (CHIP), has been associated with age-related diseases, such as those contributing to a more severe COVID-19. Four studies have attempted to associate CHIP with COVID-19 severity without conclusive findings. In the present work, we explore the association between CHIP and COVID-19 mortality. Genomic DNA extracted from peripheral blood of COVID-19 patients (n = 241 deceased, n = 239 survivors) was sequenced with the Myeloid Solutions™ panel of SOPHiA Genetics. The association between clonality and age and clonality and mortality was studied using logistic regression models adjusted for sex, ethnicity, and comorbidities. The association with mortality was performed with patients stratified into four groups of age according to the quartiles of the distribution: 60–74 years, 75–84 years, 85–91 years, and 92–101 years. Clonality was found in 38% of the cohort. The presence of CHIP variants, but not the number, significantly increased with age in the entire cohort of COVID-19 patients, as well as in the group of survivors (p < 0.001). When patients were stratified by age and the analysis adjusted, CHIP classified as pathogenic/likely pathogenic was significantly more represented in deceased patients compared with survivors in the group of 75–84 years (34.6% vs 13.7%, p = 0.020). We confirmed the well-established linear relationship between age and clonality in the cohort of COVID-19 patients and found a significant association between pathogenic/likely pathogenic CHIP and mortality in patients from 75 to 84 years that needs to be further validated.post-print1034 K