Elections in Castile and Leon. Electoral changes without effects in government?

Con más del 27% de los municipios de España y siendo la Comunidad Autónoma más extensa en provincias y territorio, Castilla y León fue la región que más tardíamente se constituyó. Tras 32 años de Gobiernos del Partido Popular, las dinámicas electorales de 2019 han denotado un cambio en las preferencias políticas ciudadanas, pero, la política de pactos y los acuerdos alcanzados por diferentes partidos a nivel nacional pueden provocar que la voluntad ciudadana se vea puenteada por la suma de la mitad más uno de los representantes electos. En este trabajo se pretende realizar un análisis histórico y descriptivo que dibuje cómo ha evolucionado la participación electoral y los resultados de la Comunidad en todos los comicios, así como los casos más significativos de estos procesos electorales de cambio.Castile and Leon has more than 27% of the Spanish city councils and is the most extended region in both number of provinces and territory. This region was also the last one in becoming a part of the Spanish regional system. After 32 years of conservative Governments (Popular Party), electoral dynamics seem to have change and popular vote in 2019 show a different pattern. Even though, the national pacts and alliances provoked that the popular vote was overlapped by the addition of representatives getting more than half of them in the chambers. This research pretends to generate an historical and descriptive framework on how electoral behaviour and turnout change in the region in every electoral call and also the most significate issues that happened in 2019

Emotions, Leadership and Social Networks in Electoral Campaign Materials. A Measurement Proposal

El uso de emociones en la campaña electoral, el papel de los liderazgos en la misma y la presencia de contenido electoral en redes sociales son elementos que van adquiriendo un mayor peso en la ciencia política. Esta nota realiza una propuesta de medición de estos elementos en los materiales de campaña electoral. Así, se presentarán indicadores que cubren todos los planos destacados, tomando como prueba de medición las elecciones autonómicas de Castilla y León celebradas en febrero de 2022. Con ello, se establece cómo las emociones positivas son las más utilizadas por los partidos políticos y cómo la presencia de líderes autonómicos y el uso extensivo de redes sociales ha sido habitual en esta excepcional campaña.The use of emotions in electoral campaigns, the role of leadership in these campaigns and the presence of electoral content in social networks are relevant elements of Political Science. This work provides a proposal for the measurement of these elements in electoral campaign materials. Indicators covering the highlighted topics will be presented, using the regional elections of Castile and Leon from February 2022 as a measurement test. In this way, it is established that positive emotions are the most frequently used by political parties, and the presence of regional leaders and the extensive use of social networks has been common practice during this exceptional campaign

Comfort in trams

[EN] In the railway sector, one of the key aspects in the design phase of the vehicles is the passenger¿s comfort, for which is important to take into account the passengers¿ opinion. Biomechanics Institute of Valencia (IBV), at the request of Vossloh, has carried out a study to know the main factors that influence the comfort perceived by passengers¿ trams.[ES] En el sector ferroviario, uno de los aspectos clave en la fase de diseño de los vehículos es el confort de los pasajeros, para lo cual resulta clave tener en cuenta su opinión. El Instituto de Biomecánica (IBV), a petición de Vossloh, ha llevado a cabo un estudio cuyo objetivo ha consistido en conocer los principales factores que influyen en el confort de los viajeros del tranvía.Palomares Olivares, N.; Marzo Rosello, R.; Solaz Sanahuja, JS.; Signes Pérez, E.; Pérez Antón, S.; Marsilla Benlloch, M.; Chirivella Moreno, C.... (2013). Confort en el tranvía. Revista de biomecánica. 59:13-14. http://hdl.handle.net/10251/38775S13145

El sistema de traducción automática castellano-catalán interNOSTRUM

Este artículo describe interNOSTRUM, un sistema de traducción automática (TA) castellano-catalán actualmente en desarrollo que alcanza una gran velocidad mediante el uso de tecnología de estados finitos (lo que permite su integracion en navegadores de internet) y obtiene una precisión razonable utilizando una estrategia de transferencia morfológica avanzada (lo que permite producir rápidamente borradores de traducciones listos para una postedición ligera).Este trabajo ha sido financiado por la Caja de Ahorros del Mediterráneo y por el Vicerrectorado de Nuevas Tecnologías de la Universitat d'Alacant, y más recientemente por la Comisión Interministerial de Ciencia y Tecnología a través del proyecto TIC2000-1599-C02-02

Novel potential predictive markers of sunitinib outcomes in long-term responders versus primary refractory patients with metastatic clear-cell renal cell carcinoma

Background: several potential predictive markers of efficacy of targeted agents in patients with metastatic renal cell carcinoma (mRCC) have been identified. Interindividual heterogeneity warrants further investigation. Patients and methods: multicenter, observational, retrospective study in patients with clear-cell mRCC treated with sunitinib. Patients were classified in two groups: long-term responders (LR) (progression-free survival (PFS)≥22 months and at least stable disease), and primary refractory (PR) (progressive disease within 3-months of sunitinib onset). Objectives were to compare baseline clinical factors in both populations and to correlate tumor expression of selected signaling pathways components with sunitinib PFS. Results: 123 patients were analyzed (97 LR, 26 PR). In the LR cohort, overall response rate was 79% and median duration of best response was 30 months. Median PFS and overall survival were 43.2 (95% confidence intervals[CI]:37.2-49.3) and 63.5 months (95%CI:55.1-71.9), respectively. At baseline PR patients had a significantly lower proportion of nephrectomies, higher lactate dehydrogenase and platelets levels, lower hemoglobin, shorter time to and higher presence of metastases, and increased Fuhrman grade. Higher levels of HEYL, HEY and HES1 were observed in LR, although only HEYL discriminated populations significantly (AUC[ROC]=0.704; cut-off=34.85). Increased levels of hsa-miR-27b, hsa-miR-23b and hsa-miR-628-5p were also associated with prolonged survival. No statistical significant associations between hsa-miR-23b or hsa-miR-27b and the expression of c-Met were found. Conclusions: certain mRCC patients treated with sunitinib achieve extremely long-term responses. Favorable baseline hematology values and longer time to metastasis may predict longer PFS. HEYL, hsa-miR-27b, hsa-miR-23b and hsa-miR-628-5p could be potentially used as biomarkers of sunitinib response

Novel potential predictive markers of sunitinib outcomes in long-term responders versus primary refractory patients with metastatic clear-cell renal cell carcinoma

Background: Several potential predictive markers of efficacy of targeted agents in patients with metastatic renal cell carcinoma (mRCC) have been identified. Interindividual heterogeneity warrants further investigation. Patients and methods: Multicenter, observational, retrospective study in patients with clear-cell mRCC treated with sunitinib. Patients were classified in two groups: long-term responders (LR) (progression-free survival (PFS)=22 months and at least stable disease), and primary refractory (PR) (progressive disease within 3-months of sunitinib onset). Objectives were to compare baseline clinical factors in both populations and to correlate tumor expression of selected signaling pathways components with sunitinib PFS. Results: 123 patients were analyzed (97 LR, 26 PR). In the LR cohort, overall response rate was 79% and median duration of best response was 30 months. Median PFS and overall survival were 43.2 (95% confidence intervals[CI]:37.2-49.3) and 63.5 months (95%CI:55.1-71.9), respectively. At baseline PR patients had a significantly lower proportion of nephrectomies, higher lactate dehydrogenase and platelets levels, lower hemoglobin, shorter time to and higher presence of metastases, and increased Fuhrman grade. Higher levels of HEYL, HEY and HES1 were observed in LR, although only HEYL discriminated populations significantly (AUC[ROC]=0.704; cut-off=34.85). Increased levels of hsa-miR-27b, hsa-miR-23b and hsa-miR-628-5p were also associated with prolonged survival. No statistical significant associations between hsa-miR-23b or hsa-miR-27b and the expression of c-Met were found. Conclusions: Certain mRCC patients treated with sunitinib achieve extremely long-term responses. Favorable baseline hematology values and longer time to metastasis may predict longer PFS. HEYL, hsa-miR-27b, hsa-miR-23b and hsa-miR- 628-5p could be potentially used as biomarkers of sunitinib response

El grupu neandertal de la Cueva d'El Sidrón (Borines, Piloña).

Na monografía clásica de Puig y Larraz (1896: 250-252) amiéntense delles cavidaes del Conceyu de Piloña2 , pero non la Cueva d’El Sidrón (Fig. 1). Esta conocíase, ensin dulda, dende la Guerra Civil y el maquis al servir d’abellugu a persiguíos políticos, y guarda una alcordanza imborrable nuna de les sos múltiples entraes, yá qu’ellí ta enterrada Olvido Otero González (1908-1938). Per El Sidrón pasaron munches persones a lo llargo de los años, pero en 1994 prodúxose’l descubrimientu per parte d’unos espeleólogos xixoneses d’unos güesos humanos que dieron un importante xiru a la conocencia de los nuesos antepasaos neandertale

ClinPrior: an algorithm for diagnosis and novel gene discovery by network-based prioritization

BackgroundWhole-exome sequencing (WES) and whole-genome sequencing (WGS) have become indispensable tools to solve rare Mendelian genetic conditions. Nevertheless, there is still an urgent need for sensitive, fast algorithms to maximise WES/WGS diagnostic yield in rare disease patients. Most tools devoted to this aim take advantage of patient phenotype information for prioritization of genomic data, although are often limited by incomplete gene-phenotype knowledge stored in biomedical databases and a lack of proper benchmarking on real-world patient cohorts.MethodsWe developed ClinPrior, a novel method for the analysis of WES/WGS data that ranks candidate causal variants based on the patient's standardized phenotypic features (in Human Phenotype Ontology (HPO) terms). The algorithm propagates the data through an interactome network-based prioritization approach. This algorithm was thoroughly benchmarked using a synthetic patient cohort and was subsequently tested on a heterogeneous prospective, real-world series of 135 families affected by hereditary spastic paraplegia (HSP) and/or cerebellar ataxia (CA).ResultsClinPrior successfully identified causative variants achieving a final positive diagnostic yield of 70% in our real-world cohort. This includes 10 novel candidate genes not previously associated with disease, 7 of which were functionally validated within this project. We used the knowledge generated by ClinPrior to create a specific interactome for HSP/CA disorders thus enabling future diagnoses as well as the discovery of novel disease genes.ConclusionsClinPrior is an algorithm that uses standardized phenotype information and interactome data to improve clinical genomic diagnosis. It helps in identifying atypical cases and efficiently predicts novel disease-causing genes. This leads to increasing diagnostic yield, shortening of the diagnostic Odysseys and advancing our understanding of human illnesses

El grupu neandertal de la Cueva d' El Sidrón (Borines, Piloña)

El artículo está en la lengua asturianaPeer reviewe

Healthcare workers hospitalized due to COVID-19 have no higher risk of death than general population. Data from the Spanish SEMI-COVID-19 Registry

Aim To determine whether healthcare workers (HCW) hospitalized in Spain due to COVID-19 have a worse prognosis than non-healthcare workers (NHCW). Methods Observational cohort study based on the SEMI-COVID-19 Registry, a nationwide registry that collects sociodemographic, clinical, laboratory, and treatment data on patients hospitalised with COVID-19 in Spain. Patients aged 20-65 years were selected. A multivariate logistic regression model was performed to identify factors associated with mortality. Results As of 22 May 2020, 4393 patients were included, of whom 419 (9.5%) were HCW. Median (interquartile range) age of HCW was 52 (15) years and 62.4% were women. Prevalence of comorbidities and severe radiological findings upon admission were less frequent in HCW. There were no difference in need of respiratory support and admission to intensive care unit, but occurrence of sepsis and in-hospital mortality was lower in HCW (1.7% vs. 3.9%; p = 0.024 and 0.7% vs. 4.8%; p<0.001 respectively). Age, male sex and comorbidity, were independently associated with higher in-hospital mortality and healthcare working with lower mortality (OR 0.211, 95%CI 0.067-0.667, p = 0.008). 30-days survival was higher in HCW (0.968 vs. 0.851 p<0.001). Conclusions Hospitalized COVID-19 HCW had fewer comorbidities and a better prognosis than NHCW. Our results suggest that professional exposure to COVID-19 in HCW does not carry more clinical severity nor mortality