Historia empresarial del chef Jorge Rausch, sus restaurantes y la influencia que estos han generado en la difusión de la gastronomía colombiana

En los últimos años el chef Jorge Raush se ha convertido en una figura pública y visible en medios de comunicación colombianos posicionándose como un representante del sector de la gastronomía. Sin embargo, ¿Qué tanto ha influido este en la difusión de la gastronomía colombiana? Es por esto que a lo largo de la investigación se analizan temas como su historia de vida englobando su trayectoria laboral y vida personal, caso de éxito de sus restaurantes y marca, con el objetivo de identificar el nivel de influencia que este ha tenido en la difusión de la gastronomía colombiana. Mediante la implementación de herramientas de recolección de información sondeos de opinión, análisis de menús y de prensa se logró evidenciar que el actor en estudio no ha sido un participante activo en el desarrollo gastronómico del país.In recent years, chef Jorge Raush has become a public and visible figure in the Colombian media, positioning himself as a representative of the gastronomy sector. However, how much has he influenced the diffusion of Colombian gastronomy? That is why throughout the research we analyzed topics such as his life history, including his work and personal life, success stories of his restaurants and brand, with the purpose of identifying the level of influence he has had in the diffusion of Colombian gastronomy. Through the implementation of information collecting tools, opinion polls, menu and newspaper analysis, it was possible to show that the actor in the study has not been an active participant in the gastronomic development of the country.Administrador de Empresas Turísticas y HotelerasPregrad

Experimental pathology of local tissue damage induced by Bothrops asper snake venom

Envenomations by Bothrops asper are often associated with complex and severe local pathological manifestations, including edema, blistering, dermonecrosis, myonecrosis and hemorrhage. The pathogenesis of these alterations has been investigated at the experimental level. These effects are mostly the consequence of the direct action of zinc-dependent metalloproteinases (SVMPs) and myotoxic phospholipases A2 (PLA2s). SVMPs induce hemorrhage, blistering, dermonecrosis and general extracellular matrix degradation, whereas PLA2s induce myonecrosis and also affect lymphatic vessels. In addition, the prominent vascular alterations leading to hemorrhage and edema may contribute to ischemia and further tissue necrosis. The mechanisms of action of SVMPs and PLA2s are discussed in detail in this review. Venom-induced tissue damage plays also a role in promoting bacterial infection. A prominent inflammatory reaction develops as a consequence of these local pathological alterations, with the synthesis and release of abundant mediators, resulting in edema and pain. However, whether inflammatory cells and mediators contribute to further tissue damage is not clear at present. Muscle tissue regeneration after venom-induced pathological effects is often impaired, thus resulting in permanent tissue loss and dysfunction. SVMP-induced microvessel damage is likely to be responsible of this poor regenerative outcome. Antivenoms are only partially effective in the neutralization of B. asper-induced local effects, and the search for novel toxin inhibitors represents a potential avenue for improving the treatment of this serious aspect of snakebite envenomation.UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto Clodomiro Picado (ICP