Volume CXIV, Number 4, November 7, 1996

Objective: Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls. This study aimed to systematically investigate the key clinical features of TS in relationship to karyotype in a large pediatric Turkish patient population.Methods: Our retrospective study included 842 karyotype-proven TS patients aged 0-18 years who were evaluated in 35 different centers in Turkey in the years 2013-2014.Results: The most common karyotype was 45,X (50.7%), followed by 45,X/46,XX (10.8%), 46,X,i(Xq) (10.1%) and 45,X/46,X,i(Xq) (9.5%). Mean age at diagnosis was 10.2±4.4 years. The most common presenting complaints were short stature and delayed puberty. Among patients diagnosed before age one year, the ratio of karyotype 45,X was significantly higher than that of other karyotype groups. Cardiac defects (bicuspid aortic valve, coarctation of the aorta and aortic stenosis) were the most common congenital anomalies, occurring in 25% of the TS cases. This was followed by urinary system anomalies (horseshoe kidney, double collector duct system and renal rotation) detected in 16.3%. Hashimoto's thyroiditis was found in 11.1% of patients, gastrointestinal abnormalities in 8.9%, ear nose and throat problems in 22.6%, dermatologic problems in 21.8% and osteoporosis in 15.3%. Learning difficulties and/or psychosocial problems were encountered in 39.1%. Insulin resistance and impaired fasting glucose were detected in 3.4% and 2.2%, respectively. Dyslipidemia prevalence was 11.4%.Conclusion: This comprehensive study systematically evaluated the largest group of karyotype-proven TS girls to date. The karyotype distribution, congenital anomaly and comorbidity profile closely parallel that from other countries and support the need for close medical surveillance of these complex patients throughout their lifespa

THE DESIGN AND IMPLEMENTATION OF A MEDICAL INJECTION SYSTEM PROVIDING SENSITIVE FLUID FLOW CONTROL USING MECHATRONICS DESIGN METHOD

This paper describes design and implementation of a medical injection device providing sensitive flow control using mechatronics design method. With the ever-increasing demand for sensitive fluid flow control in medical designs, and as fluid flow control technology falls further behind, sensitive fluid flow control is becoming critically important to various medical fluid injection systems. So there is a need to design a medical injection system providing sensitive fluid flow control. To fulfill this purpose, mechatronics design method has been used. There is a synergy in the integration of mechanical, electrical, and computer systems with information systems for the design and manufacture of products and processes in mechatronics design method. After design process the prototype is a system reducing mistakes depending on human, carried out pre-determined operating range, as a central management by the LabVIEW-based. The experimental results of the prototype show that the system has provided the expected design targets

Easy and industrially applicable impregnation process for preparation of diatomite-based phase change material nanocomposites for thermal energy storage

WOS: 000365053200076The high porosity, high oil and water absorption capacity and low density of diatomite make it ideal for industrial applications. The porous structure of diatomite protects phase change materials (PCMs) from environmental factors as a supporting matrix and phase changes occur in nanopores of diatomite. Previous research on diatomite/PCMs composites aimed optimal composite preparation but many methods were feasible only in laboratory scale. In large scale industrial fabrication, easy, continuous and steady state methods are need to be performed. The main purpose of this study was to prepare leakagefree, thermally stable nanocomposite PCMs (nanoCPCMs) by an easy, continuous and steady state method for high temperature thermal energy storage applications. A series of nanoCPCMs with different paraffin:diatomite mass ratios were prepared. The properties of nanoCPCMs have been characterized via scanning electron microscopy (SEM), differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (MR). The leak (exudation) test was performed on prepared composites at higher temperatures (95 degrees C) in comparison with literature. As the optimum composite for thermal energy storage applications, thermal reliability of nanoCPCM was evaluated after 400 cycles of melting and freezing. NanoCPCM melted at 36.55 degrees C with latent heat of 53.1 J/g. (C) 2015 Elsevier Ltd. All rights reserved.Scientific & Technical Research Council of Turkey (TUBITAK) [TUBITAK 115M525]We would like to thank The Scientific & Technical Research Council of Turkey (TUBITAK) (The Project Code: TUBITAK 115M525) for partly financial support for this study. The authors would like to extend special thanks to the editor and the anonymous reviewers for their constructive comments and suggestions in improving the quality of this paper

Preoperative Differentiation Between Malignant and Benign Ovarian Masses in Patients with Normal CA-125 Levels

OBJECTIVE: We aimed to determine the diagnostic values of some clinical and ultrasonographic features for predicting ovarian malignancies in patients with normal serum CA-125 levels. STUDY DESIGN: All of the 84 patients who were diagnosed with ovarian malignancy and 168 patients with benign adnexal mass had normal CA-125 levels, and recruited as study and control groups, respectively. Individual characteristics, ultrasonographic features, and risk of malignancy index (RMI) values of the groups were compared retrospectively. RESULTS: The ages, mean postmenopausal period of the postmenopausal women in the malignant group were significantly higher than the benign group. Nulliparity rates were similar between the two groups. The number of postmenopausal patients was significantly higher in the malignant group. Median cyst diameter and RMI values were significantly higher, and bilaterality and presence of solid area were more frequent in this group. Logistic regression model showed that ovarian cysts larger than 8 cm [Odds ratio (OR): 7.012; p<0.001; 95% Confidence interval (CI): 3.463-14.198], presence of solid area within the cyst [OR: 7.43; p<0.001; 95% CI: 3.799-14.532], and postmenopausal state [OR: 2.893; p=0.027; 95% CI: 1.129-7.412] were found to be significant factors to predict malignancy. CONCLUSION: Ovarian cysts larger than 8 cm, presence of solid area within the cyst, and postmenopausal status are the most important risk factors for ovarian malignancies in these patients with normal CA-125 levels

Is Striae Gravidarum related to Cesarean Scar and Peritoneal Adhesions?

Objective: To evaluate the relationship between striae gravidarum (SG) score and abdominal scar characteristics together with intraperitoneal adhesion (IPA) grades of patients who were hospitalized for second cesarean delivery

Is it possible to prevent striae gravidarum?

Background: Striae gravidarum (SG), commonly called stretch marks, is an important cosmetic problem which is not treatable, although preventive measures might be effective. The aim of this study was to determine individual risk factors causing SG and the degree to which preventive measures could be effective. Methods: This prospective observational study included 211 singleton primiparous pregnant women who were hospitalized for birth and who did not have systemic diseases or other risk factors, like drug use or polyhydramnios. Patients were examined and divided into two groups with respect to whether or not they had striae. Individual features were compared between the two groups. Results: While 159 patients (75.4%) had SG, 52 (24.6%) did not. Patients with striae had a significantly lower mean age and higher mean preconceptional body mass indices than ones without striae (p < 0.001 and p = 0.001, respectively). Family history (p = 0.002), having a male baby (p = 0.042), and lower educational level (p = 0.033) were also statistically significant in predicting striae. Use of preventive oil or drugs, smoking status, skin type, water intake, and level of financial income did not significantly predict SG. Conclusion: Informing women preconceptionally on the importance of modifiable risk factors, such as body weight and maternal age before pregnancy, can be useful, considering that stretch marks are carried for a lifetime and there is no conclusive treatment

THE EFFECT OF APPLICATION OF LOCAL OXIDISED CELLULOSE POWDER ON HEMOSTASIS TIME IN A RAT MODEL WITH FEMORAL ARTERY BLEEDING

Aims: Whether pre-hospital area or emergency department, the early diagnosis and control of bleeding is the first critical step in the treatment of trauma patients. This becomes increasingly critical as the victim-to-medical-personnel or equipment ratio becomes higher (disasters, wars and/or mass casualty events e.g.). We purposed to investigate the hemostatic effect of application of local oxidised cellulose powder on time to hemostasis time in a rat model with severe femoral artery bleeding

Successful liver and kidney transplantations from a donor with left ventricular assist device.

Int Soc Organ Donat & Procuremen