Volume CXIV, Number 4, November 7, 1996

Objective: Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls. This study aimed to systematically investigate the key clinical features of TS in relationship to karyotype in a large pediatric Turkish patient population.Methods: Our retrospective study included 842 karyotype-proven TS patients aged 0-18 years who were evaluated in 35 different centers in Turkey in the years 2013-2014.Results: The most common karyotype was 45,X (50.7%), followed by 45,X/46,XX (10.8%), 46,X,i(Xq) (10.1%) and 45,X/46,X,i(Xq) (9.5%). Mean age at diagnosis was 10.2±4.4 years. The most common presenting complaints were short stature and delayed puberty. Among patients diagnosed before age one year, the ratio of karyotype 45,X was significantly higher than that of other karyotype groups. Cardiac defects (bicuspid aortic valve, coarctation of the aorta and aortic stenosis) were the most common congenital anomalies, occurring in 25% of the TS cases. This was followed by urinary system anomalies (horseshoe kidney, double collector duct system and renal rotation) detected in 16.3%. Hashimoto's thyroiditis was found in 11.1% of patients, gastrointestinal abnormalities in 8.9%, ear nose and throat problems in 22.6%, dermatologic problems in 21.8% and osteoporosis in 15.3%. Learning difficulties and/or psychosocial problems were encountered in 39.1%. Insulin resistance and impaired fasting glucose were detected in 3.4% and 2.2%, respectively. Dyslipidemia prevalence was 11.4%.Conclusion: This comprehensive study systematically evaluated the largest group of karyotype-proven TS girls to date. The karyotype distribution, congenital anomaly and comorbidity profile closely parallel that from other countries and support the need for close medical surveillance of these complex patients throughout their lifespa

The Role of Sports Participation in Hemispheric Dominance: Assessment by Electrodermal Activity Signals

This study aims at evaluating hemispheric differences between active sportsmen (n=17) and sedentary control subjects (n=21) using Electrodermal Activity (EDA), which is a physiologic measure of emotional sweating. Following the denoising of the acquired EDA records, feature extraction functions were utilized for each record to generate a feature vector, containing 14 parameters per record. Statistical significances of the differences and similarities between feature vectors were determined by unpaired t-test (p0.95). Findings from this study show that the agreement of hemispheric dominance test with hand preference is significantly lower for active sportsmen in comparison to control group. This implies that participation in sport activity may play a facilitative role in a more equally weighted development of both hemispheres by somewhat decreasing the hemispheric lateralization

Measuring electrodermal activity to determining sympathetic activity in sportsman and feature extraction with signal processing methods Sporcularda sempatik aktivitenin belirlenmesinde elektrodermal aktivitenin ölçülmesi ve sinyal işleme yöntemleriyle sinyal karakteristiklerinin çikarilmasi

© 2016 IEEE.Our study aimed to determine hemispheric differences using Galvanic Skin Response (GSR) which is measure to emotional sweating with signal processing and feature extraction methods. Active sportsmans (n=17) and non-sportsmans (n=21) who are student at university have been used in this study. The average of ages is 20±0.4. We worked on GSR records which have been denoise with signal processing method and include pure information. We applied feature extraction function to GSR signals and we compared from feature vector. Feature vector has 14 parameters. We chose parameters which are making difference. Acording to findings from group of volunteers which are sportsman, doing sport improves both of hemisphere

Crystal structure and photoluminescence properties of a new Cd-II coordination polymer catena-poly[bis[4-bromo-2-({[2-(pyrrolidin-1-yl)ethyl]imino}methyl)phenolato-kappa N-3,N ',O]di-mu(3)-chlorido-di-mu(2)-chlorido-bis(methanol-kappa O)tricadmium(II)]

Schiff base-metal complexes have been used widely as catalysts for many organic reactions, such as ring-opening polymerization and oxidation. In view of the importance of Cd-II coordination polymers and in an effort to enlarge the library of such complexes, the title novel polymeric Cd-II tridentate Schiff base complex, [Cd-3(C13H16BrN2O)(2)Cl-4(CH4O)(2)](n), has been synthesized and characterized by elemental analyses, UV and IR spectroscopies, and single-crystal X-ray diffraction. The complex crystallizes in the triclinic P space group with two symmetry-independent Cd-II atoms, one of which lies on an inversion centre, and analysis of the crystal structure shows that both Cd-II atoms are six-coordinated; the environment around one Cd-II atom can be described as distorted octahedral, while that around the second Cd-II atom is octahedral. The Cd-II atoms are linked by chloride ligands to form a one-dimensional coordination polymer. The nonbonding intermolecular Cd center dot center dot center dot Cd distances are 3.7009 (4) and 4.3563 (5) angstrom. Furthermore, the photoluminescence properties of the complex have been investigated and it displays a strong red emission in the solid state at room temperature

Surface dose and build-up region measurements with wedge filters for 6 and 18 MV photon beams

Purpose. High-energy photons are most commonly used in radiotherapy to treat cancer. Wedge filters are required to obtain homogeneous dose distribution in the patient. Different wedge filter types create different surface doses. In this study, the effect of the virtual and physical wedge filters on the surface and build-up region doses was examined for 6- and 18-MV high-energy photon beams

Synthesis and in Vitro Biological Evaluation of Aminonaphthoquinones and Benzo[ b ]phenazine-6,11-dione Derivatives as Potential Antibacterial and Antifungal Compounds

A series of 2-arylamino-3-chloro-1,4-naphthoquinone derivatives (3a-h) by the reaction of 2,3-dichloro-1,4-naphthoquinone with aryl amines (2a-h) and benzo[b]phenazine-6,11-dione derivatives (4a-c) by the treatment of 2-arylamino-3-chloro-1,4-naphthoquinone derivatives (3a-h) with sodium azide were synthesized and tested for their in vitro antibacterial and antifungal activities. The results suggest that compounds 3d and 3g had potent antifungal activity against Candida albicans (MIC = 78.12 mu g/mL). All synthesized compounds (3a-h, 4a-c) possessed activity against E. faecalis with MIC values of between 312.5 and 1250 mu g/mL. Benzo[b]phenazine-6,11-dione derivatives (4a-c) were mostly active against Gram-positive bacteria. The structures of the new members of the series were established on the basis of their spectral properties (IR, H-1 NMR, C-13 NMR, and mass spectrometry)

Synthesis and In Vitro Biological Evaluation of Aminonaphthoquinones and Benzo[b]phenazine-6,11-dione Derivatives as Potential Antibacterial and Antifungal Compounds

A series of 2-arylamino-3-chloro-1,4-naphthoquinone derivatives (3a–h) by the reaction of 2,3-dichloro-1,4-naphthoquinone with aryl amines (2a–h) and benzo[b]phenazine-6,11-dione derivatives (4a–c) by the treatment of 2-arylamino-3-chloro-1,4-naphthoquinone derivatives (3a–h) with sodium azide were synthesized and tested for their in vitro antibacterial and antifungal activities. The results suggest that compounds 3d and 3g had potent antifungal activity against Candida albicans (MIC = 78.12 μg/mL). All synthesized compounds (3a–h, 4a–c) possessed activity against E. faecalis with MIC values of between 312.5 and 1250 μg/mL. Benzo[b]phenazine-6,11-dione derivatives (4a–c) were mostly active against Gram-positive bacteria. The structures of the new members of the series were established on the basis of their spectral properties (IR, 1H NMR, 13C NMR, and mass spectrometry)

Splenic Artery Embolization With Ankaferd Blood Stopper In A Sheep Model

PURPOSE Splenic artery embolization is a minimally invasive therapeutic procedure utilized in a number of disorders. Ankaferd blood stopper (ABS) is a novel hemostatic agent with a new mechanism of action independent of clotting factors. We aimed to investigate the safety and efficiency of ABS for splenic artery embolization in a sheep model. METHODS Seven adult female sheep were included in the study. Selective celiac angiography was performed using a 5F diagnostic catheter and then a 2.7F hydrophilic coating microcatheter was advanced coaxially to the distal part of the main splenic artery. Under fluoroscopic guidance, 6 mL mixture composed of half-and-half ABS and contrast agent was slowly injected. Fluoroscopy was used to observe the deceleration and stagnation of the flow. Control celiac angiograms were obtained immediately after the embolization. After the procedure, the animals were observed for one day and then sacrificed with intravenous sodium thiopental. RESULTS Technical success rate was 100%. None of the animals died or experienced a major systemic adverse event during the procedure. All of the spleens appeared dark on macroscopic examination due to excessive thrombosis. Microscopically, the majority of the splenic sinusoids (90%-95%) were necrotic. CONCLUSION In our study, splenic artery embolization by ABS was found to be safe and effective in the short-term. Further studies are needed to better understand the embolizing potential of this novel hemostatic agent

Nutritional status and calcium levels in serum and urine of primary hypertensives and normotensives

WOS: 000259602500040This research has been designed for the determination of the nutritional status, serum and urinary calcium (UCa) levels and correlation between UCa and blood pressure (BP). 31 Volunteers' patients with essential hypertension (HT) and 31 age- and gender-matched normotensive (NT) control subjects living in Ankara and Nigde from Turkey have participated in this study. 62 Subjects' 24 h urinary samples were collected. Besides, for determination of the correlation between 24 h UCa and overnight UCa (12 h UCa), 38 urine samples (9 patients and 29 control subjects) were collected. Nutritional status was evaluated according to their food consumption and physical examination. After analyzing the collected blood and urinary samples, the mineral status was also evaluated. Urinary and serum Ca levels were determined by flame atomic adsorption spectroscopy. The mean 24 h urinary Ca excretion rates (24 h UCaV) in hypertensive and normotensive subjects were 101 +/- 69 and 128 +/- 85 mg/day, respectively (n = 62, t = 1.378, p > 0.05). The mean serum Ca levels in HT was significantly decreased when compared with the controls (n = 26, t = 2.54, p < 0.05). In NT subjects systolic blood pressure (SBP) correlated positively with diastolic blood pressure (DBP) (r = 0.588) and UCaV (r = 0.516) and negatively with dietary Ca (r = -0.617, for all p < 0.05). In NT group DBP correlated positively with body mass index (BMI) (p < 0.05). In HT subjects, SBP correlated positively with DBP (r = 0.741) and negatively with serum Ca (r = -0.633), DBP also correlated negatively with serum Ca (r = 0.727). Among the 38 subjects, overnight calcium excretion rate (12 h UCaV) was correlated with the 24 h UCaV (y = 0.8279x + 42.735, r = 0.81, R-2 0.653, p < 0.05)