Comparing field observations of sorting patterns along tidal sand waves with theoretical predictions

We present a site-by-site comparison between field observations and model predictions of grains size variations over tidal sand waves at six sites in the North Sea. To drive the model, at each location, local sediment characteristics are derived from the described field data, while hydrodynamic conditions are determined from a numerical model for tidal wave propagation in the North Sea. It is found that the theoretical model providesreasonable estimates of the occurring tidally generated bed forms. Moreover, at five of the six locations, the modeldescribes a sorting pattern which concurs with the observed sediment grain size variation, indicating that the model provides a fair description of the processes governing the phenomenon

On the difference between updating the mixing matrix and updating the separation matrix

Raw data for our paper: "Interrelated chemical-microstructural-nanomechanical variations in the structural units of the cuttlebone of Sepia officinalis" DOI: 10.1063/1.499320

Supply Chain Disruption Costs Study in International Containerised Maritime Transportation

The global economy relies highly on international trade, and the international maritime transport system acts as the lifeblood carrying and transporting materials and goods globally, realizing the economy globalization in an effective and efficient way. However, globalization increases the interdependence and complexity of global supply chains and drives it to be more vulnerable to disruptions. Meanwhile, the international marine transport system is a complex and intertwined system exposed to high risks and decreased safety due to its very accessibility and operational flexibility. Thereby, global supply chains integrated with international maritime transportation systems are inherently vulnerable to various disruptions. Studies of supply chain disruptions particularly quantifying transport related disruption costs are becoming increasingly important. However, research on maritime transport related supply chain disruptions, in particular, quantifying its disruption costs is under-represented in the transport literature, due largely to the features of supply chain disruptions, but also because of the complexity of maritime related supply chains. Current research in transportation has tended to concentrate on shippers’ transport mode choice and port selection. In the context of a global market, however, the behaviour of maritime containerised shippers has to be viewed as a complex decision and an integral element of the supply chain management strategy. Those shippers’ transportation choice decisions should be emphasized and studied to reveal their behaviour changes between normal operations and disruption circumstance. This research adds to the paucity work on investigating the maritime transport related supply chain disruptions and quantifying its disruption costs based on shippers’ maritime transportation choice behaviour. It presents the results of a microanalysis of freight transport choice decisions in an international containerised maritime transport chain context. The Latent Class Model (LCM) is applied to identify the key service attributes and its preference heterogeneity in maritime transportation and to estimate the marginal values for the quality of maritime transport service with and without a disruption, simultaneously, quantifying the disruption costs through comparing each attribute’s marginal value difference between normal and disruption operations. The Seemingly Unrelated Regression model (SURE) is utilized to explore the sources influencing shippers’ preference heterogeneities. In doing so, we are able to gain an understanding as to where and how much should be invested in order to facilitate recovery in the case of a disruption based on the view of the maritime participants’ perspectives. The research results confirm freight rate, transit time, reliability, damage rate, and frequency as the key service attributes influencing shippers’ transport choice. They also reveal shippers’ VOT increase by more than four-times, VOR nearly double, and VOD increase about twenty percent if a disruption takes place, and identify shippers’ transport decisions vary with its product, shipment, company and supply chain characteristics no matter with or without a disruption. This research quantifies the costs of supply chain disruption in containerised maritime transport context for the first time, and its results provide useful industrial implications for maritime transport chain related parties

Reproducibility and validity of a diet quality index for children assessed using a FFQ

The diet quality index (DQI) for preschool children is a new index developed to reflect compliance with four main food-based dietary guidelines for preschool children in Flanders. The present study investigates: (1) the validity of this index by comparing DQI scores for preschool children with nutrient intakes, both of which were derived from 3d estimated diet records; (2) the reproducibility of the DQI for preschoolers based on a parentally reported forty-seven-item FFQ DQI, which was repeated after 5 weeks; (3) the relative validity of the FFQ DQI with 3d record DQI scores as reference. The study sample included 510 and 58 preschoolers (2-5-6.5 years) for validity and reproducibility analyses, respectively. Increasing 3d record DQI scores were associated with decreasing consumption of added sugars, and increasing intakes of fibre, water, Ca and many micronutrients. Mean FFQ DQI test-retest scores were not significantly different: 72 (so 11) v. 71 (Si) 10) (P-=0-218) out of a maximum of 100. Mean 3d record DQI score (66 (so 10)) was significantly lower than mean FFQ DQI (71 (so 10);

A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity

Malaria is a global health concern and research efforts are ongoing to develop a superior vaccine to RTS,S/AS01. To guide immunogen design, we seek a comprehensive understanding of the protective humoral response against Plasmodium falciparum circumsporozoite protein (PfCSP). In contrast to the well-studied responses to the repeat region and the C-terminus, the antibody response against the N-terminal domain of PfCSP (N-CSP) remains obscure. Here, we characterized the molecular recognition and functional efficacy of the N-CSP-specific monoclonal antibody 5D5. The crystal structure at 1.85 Åresolution revealed that 5D5 binds an α-helical epitope in N-CSP with high affinity through extensive shape and charge complementarity, and the unusual utilization of an N-linked glycan. Nevertheless, functional studies indicated low 5D5 binding to live Pf sporozoites, and lack of sporozoite inhibition in vitro and in mosquitoes. Overall, our data on low recognition and inhibition of sporozoites do not support the inclusion of the 5D5 epitope into the next generation of CSP-based vaccines.Summary Statement The Plasmodium falciparum sporozoite surface protein, PfCSP, is an attractive vaccine target, but the antibody response against the CSP N-terminal domain has remained understudied. Here, to guide immunogen design, Thai et al. provide insights into the binding motif and functional efficacy of the N-terminal domain-specific monoclonal antibody, 5D5

High thermal tolerance in high-elevation species and laboratory-reared colonies of tropical bumble bees

Bumble bees are key pollinators with some species reared in captivity at a commercial scale, but with significant evidence of population declines and with alarming predictions of substantial impacts under climate change scenarios. While studies on the thermal biology of temperate bumble bees are still limited, they are entirely absent from the tropics where the effects of climate change are expected to be greater. Herein, we test whether bees' thermal tolerance decreases with elevation and whether the stable optimal conditions used in laboratory-reared colonies reduces their thermal tolerance. We assessed changes in the lower (CTMin) and upper (CTMax) critical thermal limits of four species at two elevations (2600 and 3600 m) in the Colombian Andes, examined the effect of body size, and evaluated the thermal tolerance of wild-caught and laboratory-reared individuals of Bombus pauloensis. We also compiled information on bumble bees' thermal limits and assessed potential predictors for broadscale patterns of variation. We found that CTMin decreased with increasing elevation, while CTMax was similar between elevations. CTMax was slightly higher (0.84°C) in laboratory-reared than in wild-caught bees while CTMin was similar, and CTMin decreased with increasing body size while CTMax did not. Latitude is a good predictor for CTMin while annual mean temperature, maximum and minimum temperatures of the warmest and coldest months are good predictors for both CTMin and CTMax. The stronger response in CTMin with increasing elevation, and similar CTMax, supports Brett's heat-invariant hypothesis, which has been documented in other taxa. Andean bumble bees appear to be about as heat tolerant as those from temperate areas, suggesting that other aspects besides temperature (e.g., water balance) might be more determinant environmental factors for these species. Laboratory-reared colonies are adequate surrogates for addressing questions on thermal tolerance and global warming impacts

Mycophenolate mofetil in IgA nephropathy: Results of a 3-year prospective placebo-controlled randomized study

Mycophenolate mofetil in IgA nephropathy: Results of a 3-year prospective placebo-controlled randomized study.BackgroundBecause humoral immunity is believed to play a pivotal role in the pathogenesis of IgA nephropathy (IgAN), a prospective placebo-controlled randomized study was started in patients with IgAN using mycophenolate mofetil (MMF).MethodsA total of 34 patients with IgAN were treated with salt intake restriction, angiotensin-converting enzyme (ACE) inhibition and MMF 2g per day (N = 21) or placebo (N = 13). After 36months of follow-up clinical, biochemical, and radiologic data were analyzed using linear mixed models for longitudinal data and Kaplan-Meier survival analysis.ResultsTherapy had to be stopped prematurely in five patients. Two patients (MMF group) evolved to end-stage renal disease (ESRD). There was no difference between groups in the percentage of patients with a decrease of 25% or more in the inulin clearance or with a serum creatinine increase of 50% or more over 3years. There was also no significant difference between groups in annualized rate of change of serum creatinine, computed by linear regression analysis. No significant difference was noted between groups for inulin clearance, serum creatinine, proteinuria, blood pressure, or other parameters of renal function. Hemoglobin and C-reactive protein were significantly lower in the MMF group compared with the placebo group. As a function of time, a significant decline in both groups was noted of proteinuria, parenchymal thickness of the kidneys and C3d.ConclusionIn patients with IgAN at risk for progressive disease, no beneficial effect of 3-year treatment with MMF 2g per day could be demonstrated on renal function/outcome or proteinuria. However, larger randomized studies are needed to confirm or reject these results

In reaction to: Thuillier P, Benisvy D, Ansquer C, Corvilain B, Mirallie E, Taieb D, et al. Section 5: What is the role of functional imaging and isotopic treatment? Ann Endocrinol (Paris) 2022;83:401-6. https://doi.org/10.1016/j.ando.2022.10.008

Radiolog

Design features of the upcoming Coastal and Ocean Basin in Ostend, Belgium, for marine renewable energy applications

The new Coastal and Ocean Basin (COB) located at the Greenbridge Science Park in Ostend, Belgium is under construction since February 2017. The laboratory will provide a versatile facility that will make a wide range of physical modelling studies possible, including the ability to generate waves in combination with currents and wind at a wide range of model scales. The facility is serving the needs in Flanders, Belgium, in the fields of mainly offshore renewable energy and coastal engineering. The COB will allow users to conduct tests for coastal and offshore engineering research and commercial projects. The basin will have state-of-the-art generating and absorbing wavemakers, a current generation system, and a wind generator. It will be possible to generate waves and currents in the same, opposite and oblique directions. The basin is expected to be operational in 2019. This paper presents an overview of the basin’s capabilities, the ongoing work, and selected results from the design of the COB