Visco-lelastic properties of four currently used tissue conditioners

About 60% of complete denture wearers experience a mostly painless inflammation of the palatal mucosal membrane. Especially prosthetic trauma and Candida albicans infection are assumed as aetiological factors. The treatment can be prosthetic or medicamentous, dependent on the cause. In this connection tissue conditioners could be very effective by their visco‐elastic properties. Four tissue conditioners have been examined (Coe Comfort, FITT, Ivoseal, Visco Gel) for their impression softness and elastic recovery. All tests have been done on 20 mm specimens. The length of the specimens was measured during a 10 min compression and a 60 min relaxation. Eight ageing times have been taken into consideration. From the results large differences appear between the various tissue conditioners. Two main groups can be distinguished. FITT and Ivoseal are harder materials, whereas Coe Comfort and Visco Gel are softer. The ageing time has a clear hardening influence especially on Visco Gel. Visco Gel appears to be the best tissue conditioner by its relative plasticity during the first hours and its elastic behaviour during a longer ageing period. The clinical relevance of these materials is certainly not proved by this study. Further research will show this. Copyright © 1984, Wiley Blackwell. All rights reservedSCOPUS: ar.jFLWNAinfo:eu-repo/semantics/publishe

Plasma plant sterols serve as poor markers of cholesterol absorption in man

<p>The validation of the use of plasma plant sterols as a marker of cholesterol absorption is frail. Nevertheless, plant sterol concentrations are routinely used to describe treatment-induced changes in cholesterol absorption. Their use has also been advocated as a clinical tool to tailor cholesterol-lowering therapy. Prior to wider implementation, however, the validity of plant sterols as absorption markers needs solid evaluation. Therefore, we compared plasma plant sterol concentrations to gold-standard stable isotope-determined cholesterol absorption. Plasma campesterol/ TC concentrations (camp/TC) were measured in a population of 175 mildly hypercholesterolemic individuals (age: 59.7 +/- 5.6 years; BMI: 25.5 +/- 2.9kg/m(2); LDL-C: 4.01 +/- 0.56 mmol/l). We compared cholesterol absorption according to the plasma dual-isotope method in subjects with the highest camp/TC concentrations (N = 41, camp/TC: 2.14 +/- 0.68 mu g/mg) and the lowest camp/TC concentrations (N = 39, camp/TC: 0.97 +/- 0.22 mu g/mg). Fractional cholesterol absorption did not differ between the groups (24 +/- 12% versus 25 +/- 16%, P = 0.60), nor was it associated with plasma camp/TC concentrations in the total population of 80 individuals (beta = 0.13; P = 0.30, adjusted for BMI and plasma triglycerides). Our findings do not support a relation between plasma plant sterol concentrations and true cholesterol absorption and, therefore, do not favor the use of these sterols as markers of cholesterol absorption. This bears direct consequences for the interpretation of earlier studies, as well as for future studies targeting intestinal regulation of cholesterol metabolism.-Jakulj, L., H. Mohammed, T. H. van Dijk, T. Boer, S. Turner, A. K. Groen, M. N. Vissers, and E. S. G. Stroes. Plasma plant sterols serve as poor markers of cholesterol absorption in man. J. Lipid Res. 2013. 54: 1144-1150.</p>