Individual and relational contributions to parallel and joint attention in infancy

Objective: This study examined the contributions of maternal bids for joint attention, relationship quality, and infant characteristics, to individual differences in infants’ parallel and joint attention. Method: Fifty-two 10-month-olds and their mothers were assessed in order to investigate concurrent predictors of infant parallel attention, responding to joint attention, and initiating joint attention. Results: Parallel attention was predicted by infants’ higher mental development, low expression of negative emotionality, and maternal entertaining behaviors. Responding to joint attention was marginally predicted by total maternal bids for joint attention. Initiating joint attention was predicted by the infants’ low expression of negative emotionality, as well as marginally predicted by fewer maternal teaching behaviors. Conclusion: These results further the understanding of the factors influencing infant parallel as well as joint attention.Fundação para a Ciência e a Tecnologia (FCT

A psychiatric perspective view of bariatric surgery patients

Background Bariatric surgery is the only procedure that has significant results in weight loss and improvements in medical comorbidities in morbid obese patients. Severely obese patients are also associated with a higher prevalence of psychiatric disorders and poor quality of life. Objective To evaluate specific areas of psychopathology in individuals undergoing bariatric surgery. Methods A review of the literature was conducted from January 2002 to March 2014 by researching PubMed database using the following query: “morbid AND obesity AND bariatric AND surgery AND (psychiatry OR psychology)”. Results Overall improvements in eating behaviors, mood disorders and body image are reported after bariatric surgery, and the mechanism is not enlightened. Risk of suicide and consumption of substances of abuse, especially alcohol, after gastric bypass surgery are problems that clinicians must be aware. Discussion Bariatric patients should be monitored after surgery to identify who did not show the expected benefits postoperatively and the ones who develop psychiatric symptoms after an initial positive response

Nationwide study of drug resistance mutations in HIV-1 infected individuals under antiretroviral therapy in Brazil

The success of antiretroviral treatment (ART) is threatened by the emergence of drug resistance mutations (DRM). Since Brazil presents the largest number of people living with HIV (PLWH) in South America we aimed at understanding the dynamics of DRM in this country. We analyzed a total of 20,226 HIV-1 sequences collected from PLWH undergoing ART between 2008–2017. Results show a mild decline of DRM over the years but an increase of the K65R reverse transcriptase mutation from 2.23% to 12.11%. This increase gradually occurred following alterations in the ART regimens replacing zidovudine (AZT) with tenofovir (TDF). PLWH harboring the K65R had significantly higher viral loads than those without this mutation (p p < 0.001) association of K65R with subtype C (11.26%) when compared with subtype B (9.27%). Nonetheless, evidence for K65R transmission in Brazil was found both for C and B subtypes. Additionally, artificial neural network-based immunoinformatic predictions suggest that K65R could enhance viral recognition by HLA-B27 that has relatively low prevalence in the Brazilian population. Overall, the results suggest that tenofovir-based regimens need to be carefully monitored particularly in settings with subtype C and specific HLA profiles.This work has been funded by Portuguese National funds, through the Foundation for Science and Technology (FCT) (project UIDB/50026/2020 and UIDP/50026/2020; by the projects NORTE-01-0145-FEDER-000013 and NORTE-01-0145-FEDER-000023, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) and by Gilead Génese PGG/009/2017. ASP and PMMA were funded by FCT PhD scholarships PD/BD/127827/2016, and PDE/BDE/113599/2015, respectively

Project Indigenous Parallel Lives : revealing the Fulni-ô people of Pernambuco, Brazil

Este relato de experiência se refere ao povo Fulni-ô, que habita a comunidade de Xixia-clá no município de Águas Belas, a 300 km de Recife, Estado de Pernambuco. O histórico se refere à união com a tribo Carijós, e ao declínio no uso da língua ancestral, o Yaathê, do tronco linguístico Macro-Jê. Enfatiza-se também o confito de terras, pois foi realizado um loteamento que relegou os índios a um espaço limitado, sendo a cidade fundada em território indígena. Descreve-se a liderança do Cacique e do Pajé, e a discussão em comunidade dos assuntos que dizem respeito aos indígenas. Apesar da totalidade declarar que professa a religião católica, conhecimentos ancestrais são transmitidos e a cerimônia do Ouricury é muito concurrida. Descreve-se a assistência à saúde, que conta com um posto de saúde, onde trabalham indígenas nos cargos compatíveis com sua educação em níveis fundamental e médio. Já os cargos de nível superior são ocupados por não indígenas. O saneamento básico ainda está em processo de implantação. A atenção básica depende do Programa de Saúde da Família Indígena (PSFI). __________________________________________________________________________________________________________________ RESUMENEste relato de experiencia se refere al grupo étnico Fulni-ô, que habita la comunidad de Xixia-clá en el municipio de Águas Belas, a 300 km de Recife, Estado de Pernambuco, Brasil. Con respecto a su historia, se relata la unión con la tribu Carijós, y el declinio en el uso de la lengua ancestral, el Yaathê, del tronco linguístico Macro-Jê. Se hace hincapié en el confito de tierras, pues fue realizada una división en lotes que dejó a los indígenas un espacio muy limitado, siendo la ciudad fundada en territorio indígena. Se describe el liderazgo del Cacique y del Pajé, y la discusión en comunidad de los asuntos que interesan a los indígenas. A pesar de que todos ellos declaran profesar la religión católica, conocimientos ancestrales son trasmitidos y la ceremonia del Ouricury es muy concurrida. Se describe la atención a la salud, que cuenta con un puesto de salud, en donde trabajan indígenas en cargos compatibles con la educación en los niveles fundamental y medio. Los cargos de nivel superior son ocupados por no indígenas. El saneamiento básico aún está en proceso de implantación. La atención básica depende del Programa de Salud de la Familia Indígena (PSFI). __________________________________________________________________________________________________________________ ABSTRACTThis experience report deals with the Fulni-ô ethnic group settled at the Xixia-clá community, in the municipality of Águas Belas, 190 miles from Recife, state of Pernambuco, Brazil. History narrates their union to the Carijós tribe and the decline in the use of their ancestral tongue, Yaathê of the Macro- Jê linguistic stock. This article underscores the land dispute resulting from the division of lots, which reduced the indigenous people to a very restricted space because the city was founded in indigenous territory. It describes the leadership of the Cacique and the Pajé and the discussions held in the community about the community’s concerns. Although everyonedeclares to profess the Catholic religion, ancestral knowledge is transferred and many people attend the Ouricury ceremony. This report describes the health care provided by a health unit where indigenous people have jobs compatible with basic and middle level education. Higher-level jobs are performed by non indigenous people. Basic sanitation implementation is in process. Basic assistance is subject to the Indigenous Family Health Program (PSFI in Portuguese)

Characterizing HIV-1 genetic subtypes and drug resistance mutations among children, adolescents and pregnant women in Sierra Leone

Human immunodeficiency virus (HIV) drug resistance (HIVDR) is widespread in sub-Saharan Africa. Children and pregnant women are particularly vulnerable, and laboratory testing capacity remains limited. We, therefore, used a cross-sectional design and convenience sampling to characterize HIV subtypes and resistance-associated mutations (RAMs) in these groups in Sierra Leone. In total, 96 children (age 2–9 years, 100% ART-experienced), 47 adolescents (age 10–18 years, 100% ART-experienced), and 54 pregnant women (>18 years, 72% ART-experienced) were enrolled. Median treatment durations were 36, 84, and 3 months, respectively, while the sequencing success rates were 45%, 70%, and 59%, respectively, among children, adolescents, and pregnant women. Overall, the predominant HIV-1 subtype was CRF02_AG (87.9%, 95/108), with minority variants constituting 12%. Among children and adolescents, the most common RAMs were M184V (76.6%, n = 49/64), K103N (45.3%, n = 29/64), Y181C/V/I (28.1%, n = 18/64), T215F/Y (25.0%, n = 16/64), and V108I (18.8%, n = 12/64). Among pregnant women, the most frequent RAMs were K103N (20.6%, n = 7/34), M184V (11.8%, n = 4/34), Y181C/V/I (5.9%, n = 2/34), P225H (8.8%, n = 3/34), and K219N/E/Q/R (5.9%, n = 2/34). Protease and integrase inhibitor-RAMs were relatively few or absent. Based on the genotype susceptibility score distributions, 73%, 88%, and 14% of children, adolescents, and pregnant women, respectively, were not susceptible to all three drug components of the WHO preferred first-line regimens per 2018 guidelines. These findings suggest that routine HIVDR surveillance and access to better ART choices may improve treatment outcomes in Sierra Leone.This research was funded by the Roe Green Travel Medicine and Global Health Award 2019 (Award Number J0628), University Hospitals Cleveland Medical Center (G.A.Y.), Instituto de Salud Carlos III and Fondo Europeo de Desarrollo Regional-FEDER, Red Española de Investigación en SIDA (RD16/0025/0026) (E.P.), Xunta Galicia-Fondo Social Europeo (IN606A-2016/023) (E.P.) and Fundación Biomédica Galicia Sur (E.P.)

AIMSurv: First pan-European harmonized surveillance of Aedes invasive mosquito species of relevance for human vector-borne diseases

Human and animal vector-borne diseases, particularly mosquito-borne diseases, are emerging or re-emerging worldwide. Six Aedes invasive mosquito (AIM) species were introduced to Europe since the 1970s: Aedes aegypti, Ae. albopictus, Ae. japonicus, Ae. koreicus, Ae. atropalpus and Ae. triseriatus. Here, we report the results of AIMSurv2020, the first pan-European surveillance effort for AIMs. Implemented by 42 volunteer teams from 24 countries. And presented in the form of a dataset named “AIMSurv Aedes Invasive Mosquito species harmonized surveillance in Europe. AIM-COST Action. Project ID: CA17108”. AIMSurv2020 harmonizes field surveillance methodologies for sampling different AIMs life stages, frequency and minimum length of sampling period, and data reporting. Data include minimum requirements for sample types and recommended requirements for those teams with more resources. Data are published as a Darwin Core archive in the Global Biodiversity Information Facility- Spain, comprising a core file with 19,130 records (EventID) and an occurrences file with 19,743 records (OccurrenceID). AIM species recorded in AIMSurv2020 were Ae. albopictus, Ae. japonicus and Ae. koreicus, as well as native mosquito species

The Shark Alar Hypothalamus:Molecular Characterization of Prosomeric Subdivisions and Evolutionary Trends

The hypothalamus is an important physiologic center of the vertebrate brain involved in the elaboration of individual and species survival responses. To better understand the ancestral organization of the alar hypothalamus we revisit previous data on ScOtp, ScDlx2/5, ScTbr1, ScNkx2.1 expression and Pax6 immunoreactivity jointly with new data on ScNeurog2, ScLhx9, ScLhx5, and ScNkx2.8 expression, in addition to immunoreactivity to serotonin (5-HT) and doublecourtin (DCX) in the catshark Scyliorhinus canicula, a key species for this purpose since cartilaginous fishes are basal representatives of gnathostomes (jawed vertebrates). Our study revealed a complex genoarchitecture for the chondrichthyan alar hypothalamus. We identified terminal (rostral) and peduncular (caudal) subdivisions in the prosomeric paraventricular and subparaventricular areas (TPa/PPa and TSPa/PSPa, respectively) evidenced by the expression pattern of developmental genes like ScLhx5 (TPa) and immunoreactivity against Pax6 (PSPa) and 5-HT (PPa and PSPa). Dorso-ventral subdivisions were only evidenced in the SPa (SPaD, SPaV; respectively) by means of Pax6 and ScNkx2.8 (respectively). Interestingly, ScNkx2.8 expression overlap over the alar-basal boundary, as Nkx2.2 does in other vertebrates. Our results reveal evidences for the existence of different groups of tangentially migrated cells expressing ScOtp, Pax6 and ScDlx2. The genoarchitectonic comparative analysis suggests alternative interpretations of the rostral-most alar plate in prosomeric terms and reveals a conserved molecular background for the vertebrate alar hypothalamus likely acquired before/during the agnathan-gnathostome transition, on which Otp, Pax6, Lhx5, and Neurog2 are expressed in the Pa while Dlx and Nkx2.2/Nkx2.8 are expressed in the SPa

The European Court of Human Rights and international humanitarian law

Research shows that executive function and social–behavioral adjustment during the preschool years are both associated with the successful acquisition of academic readiness abilities. However, studies bringing these constructs together in one investigation are lacking. This study addresses this gap by testing the extent to which social and behavioral adjustment mediated the association between executive function and academic readiness. Sixty-nine 63–76month old children, enrolled in the last semester of the preschool year, participated in the present study. Tasks were administered to measure executive function and preacademic abilities, and teachers rated preschoolers' social–behavioral adjustment. Hierarchical regression analyses revealed that social–behavioral adaptation was a significant mediator of the effect of executive function on academic readiness, even after controlling for maternal education and child verbal ability. These findings extend prior research and suggest that executive function contributes to early academic achievement by influencing preschoolers' opportunities to be engaged in optimal social learning activities.Fundação para a Ciência e a tecnologia (FCT); Ministério da Educação e Ciência; FEDE

Joint attention with the mother and the father at 10 months of age

Joint attention capabilities were assessed in 52 10-month-olds observed independently with their mothers and fathers in a semi-structured toy-play condition. Mothers and fathers were indistinguishable in terms of total number of behaviours aimed at engaging their infant in joint attention. However, infants responded more to mothers' bids for attention than to fathers' bids. Contrastingly, infants tended to display more initiating joint attention behaviours while interacting with their fathers. Although parents did not differ in terms of sensitivity, fathers were less intrusive than mothers. Results are discussed in terms of the specificities of mother-infant and father-infant interaction and how the paternal role should be highlighted in the case of infant's joint attention development.info:eu-repo/semantics/publishedVersio