The Ethical Dimensions of Dialogue Between Policymakers: Learning Through Interaction Over Migrant Integration Dilemmas

This article explores how dialogue between policymakers from different countries can help generate learning which responds to the dilemmas they face when seeking to integrate migrants more fully within local communities. These dilemmas include reducing prejudice and discrimination between those who don’t want to interact, and building collective belonging whilst valuing the complexity of diverse individual identities. The article highlights ways in which the ethical dimensions of the dialogue process can interact with the ethical dimensions of the issues under discussion within such policymakers’ dialogues. In the process, the article demonstrates how research which adopts dialogical approaches, whilst being critically aware of these ethical dimensions, can help to address the gaps and limitations in existing policymakers’ understandings, by generating improved exchanges of learning

Mixture effects at very low doses with combinations of anti-androgenic pesticides, antioxidants, industrial pollutant and chemicals used in personal care products

This article has been made available through the Brunel Open Access Publishing Fund.Many xenobiotics have been identified as in vitro androgen receptor (AR) antagonists, but information about their ability to produce combined effects at low concentrations ismissing. Such data can reveal whether joint effects at the receptor are induced at low levels andmay support the prioritisation of in vivo evaluations and provide orientations for the grouping of anti-androgens in cumulative risk assessment. Combinations of 30 AR antagonists from a wide range of sources and exposure routes (pesticides, antioxidants, parabens, UV-filters, synthetic musks, bisphenol-A, benzo(a)pyrene, perfluorooctane sulfonate and pentabromodiphenyl ether) were tested using a reporter gene assay (MDA-kb2). Chemicalswere combined at threemixture ratios, equivalent to single components' effect concentrations that inhibit the action of dihydrotesterone by 1%, 10% or 20%. Concentration addition (CA) and independent action were used to calculate additivity expectations. We observed complete suppression of dihydrotestosterone effects when chemicals were combined at individual concentrations eliciting 1%, 10% or 20% AR antagonistic effect. Due to the large number of mixture components, the combined AR antagonistic effects occurred at very low concentrations of individual mixture components. CA slightly underestimated the combined effects at all mixture ratios. In conclusion, large numbers of AR antagonists froma wide variety of sources and exposure routes have the ability of acting together at the receptor to produce joint effects at very low concentrations. Significant mixture effects are observed when chemicals are combined at concentrations that individually do not induce observable AR antagonistic effects. Cumulative risk assessment for AR antagonists should apply grouping criteria based on effects where data are available, rather than on criteria of chemical similarity

Source code patches from dynamic analysis

Dynamic analysis can identify improvements to programs that cannot feasibly be identified by static analysis; concurrency improvements are a motivating example. However, mapping these dynamic-analysis-based improvements back to patch-like source-code changes is non-trivial. We describe a system, Scopda, for generating source-code patches for improvements identified by execution-trace-based dynamic analysis. Scopda uses a graph-based static program representation (abstract program graph, APG), containing inter-procedural control flow and local data flow information, to analyse and transform static source-code. We demonstrate Scopda's ability to generate sensible source code patches for Java programs, though it is fundamentally language agnostic.The first author was funded by the Engineering and Physical Sciences Research Council (EPSRC), the Cambridge Trusts, and the University of Cambridge Department of Computer Science and Technology

Adolescent perceptions of singing: exploring gendered differences in musical confidence, identity and ambition

Previous research on adolescents and singing has focused on understanding the physiological changes in the voice during the age range 11–16 [Cooksey, J. M., and G. F. Welch. 2008. ‘Adolescence, singing development and national curricula design.’ British Journal of Music Education 15 (1): 99–119], and addressing the lack of male participation in singing [Ashley, M. R. 2013. ‘Broken voices or a broken curriculum? The impact of research on UK school choral practice with boys.’ British Journal of Music Education 30 (3): 311–327; Hall, C. 1999. ‘Gender and boys” singing in early childhood.’ British Journal of Music Education 22 (1): 5–20]. This study makes a new contribution by exploring adolescent girls’ perceptions of singing as compared with those of boys. Through an inductive, two-phase research design, the language of the students themselves is used to describe their perceptions of singing. The roles of motivation, confidence, self-efficacy and autonomy come through as strong influences on the students’ enjoyment of singing. Boys have a tendency to exhibit static ability evaluations in this age group, and demonstrate a lack of cognitive understanding of their changing voices. Girls, however, recognise that effort, ability and confidence interact in different ways depending on the social context for their singing. Recommendations for teachers are made, that could challenge boys’ fixed views of their vocal abilities, and strengthen the appeal of group singing for all adolescents

Refactoring traces to identify concurrency improvements

It is often difficult to analyse why a program executes more slowly than intended. This is particularly true for concurrent programs. We describe and evaluate a system, Rehype, which takes Java programs, performs low-overhead tracing of method calls, analyses the resulting trace-logs to detect inefficient uses of concurrency constructs, and suggests source-code-oriented improvements. Rehype deals with task-based concurrency, specifically a future-based model of tasks. Implementing the suggested improvements on an industrial API server more than doubled request-processing throughput.The first author was funded by the Engineering and Physical Sciences Research Council (EPSRC), the Cambridge Trusts, and the University of Cambridge Department of Computer Science and Technology

Bioinformatics tools for analysing viral genomic data

The field of viral genomics and bioinformatics is experiencing a strong resurgence due to high-throughput sequencing (HTS) technology, which enables the rapid and cost-effective sequencing and subsequent assembly of large numbers of viral genomes. In addition, the unprecedented power of HTS technologies has enabled the analysis of intra-host viral diversity and quasispecies dynamics in relation to important biological questions on viral transmission, vaccine resistance and host jumping. HTS also enables the rapid identification of both known and potentially new viruses from field and clinical samples, thus adding new tools to the fields of viral discovery and metagenomics. Bioinformatics has been central to the rise of HTS applications because new algorithms and software tools are continually needed to process and analyse the large, complex datasets generated in this rapidly evolving area. In this paper, the authors give a brief overview of the main bioinformatics tools available for viral genomic research, with a particular emphasis on HTS technologies and their main applications. They summarise the major steps in various HTS analyses, starting with quality control of raw reads and encompassing activities ranging from consensus and de novo genome assembly to variant calling and metagenomics, as well as RNA sequencing

Investigating intra-host and intra-herd sequence diversity of foot-and-mouth disease virus

Due to the poor-fidelity of the enzymes involved in RNA genome replication, foot-and-mouth disease (FMD) virus samples comprise of unique polymorphic populations. In this study, deep sequencing was utilised to characterise the diversity of FMD virus (FMDV) populations in 6 infected cattle present on a single farm during the series of outbreaks in the UK in 2007. A novel RT–PCR method was developed to amplify a 7.6 kb nucleotide fragment encompassing the polyprotein coding region of the FMDV genome. Illumina sequencing of each sample identified the fine polymorphic structures at each nucleotide position, from consensus level changes to variants present at a 0.24% frequency. These data were used to investigate population dynamics of FMDV at both herd and host levels, evaluate the impact of host on the viral swarm structure and to identify transmission links with viruses recovered from other farms in the same series of outbreaks. In 7 samples, from 6 different animals, a total of 5 consensus level variants were identified, in addition to 104 sub-consensus variants of which 22 were shared between 2 or more animals. Further analysis revealed differences in swarm structures from samples derived from the same animal suggesting the presence of distinct viral populations evolving independently at different lesion sites within the same infected animal

Increasing Storm Tides in New York Harbor, 1844–2013

Three of the nine highest recorded water levels in the New York Harbor region have occurred since 2010 (March 2010, August 2011, and October 2012), and eight of the largest twenty have occurred since 1990. To investigate whether this cluster of high waters is a random occurrence or indicative of intensified storm tides, we recover archival tide gauge data back to 1844 and evaluate the trajectory of the annual maximum storm tide. Approximately half of long-term variance is anticorrelated with decadal-scale variations in the North Atlantic Oscillation, while long-term trends explain the remainder. The 10 year storm tide has increased by 0.28 m. Combined with a 0.44 m increase in local sea level since 1856, the 10 year flood level has increased by approximately 0.72 ± 0.25 m, and magnified the annual probability of overtopping the typical Manhattan seawall from less than 1% to about 20–25%

The Origin of Nitrogen on Jupiter and Saturn from the 15^{15}N/14^{14}N Ratio

The Texas Echelon cross Echelle Spectrograph (TEXES), mounted on NASA's Infrared Telescope Facility (IRTF), was used to map mid-infrared ammonia absorption features on both Jupiter and Saturn in February 2013. Ammonia is the principle reservoir of nitrogen on the giant planets, and the ratio of isotopologues ($^{15}$N/$^{14}$N) can reveal insights into the molecular carrier (e.g., as N$_2$ or NH$_3$) of nitrogen to the forming protoplanets, and hence the source reservoirs from which these worlds accreted. We targeted two spectral intervals (900 and 960 cm$^{-1}$) that were relatively clear of terrestrial atmospheric contamination and contained close features of $^{14}$NH$_3$ and $^{15}$NH$_3$, allowing us to derive the ratio from a single spectrum without ambiguity due to radiometric calibration (the primary source of uncertainty in this study). We present the first ground-based determination of Jupiter's $^{15}$N/$^{14}$N ratio (in the range from $1.4\times10^{-3}$ to $2.5\times10^{-3}$), which is consistent with both previous space-based studies and with the primordial value of the protosolar nebula. On Saturn, we present the first upper limit on the $^{15}$N/$^{14}$N ratio of no larger than $2.0\times10^{-3}$ for the 900-cm$^{-1}$ channel and a less stringent requirement that the ratio be no larger than $2.8\times10^{-3}$ for the 960-cm$^{-1}$ channel ($1\sigma$ confidence). Specifically, the data rule out strong $^{15}$N-enrichments such as those observed in Titan's atmosphere and in cometary nitrogen compounds. To the extent possible with ground-based radiometric uncertainties, the saturnian and jovian $^{15}$N/$^{14}$N ratios appear indistinguishable, implying that $^{15}$N-enriched ammonia ices could not have been a substantial contributor to the bulk nitrogen inventory of either planet, favouring the accretion of primordial N$_2$ from the gas phase or as low-temperature ices.Comment: 33 pages, 19 figures, manuscript accepted for publication in Icaru