Estudio epidemiológico descriptivo de las infecciones en las artroplastias de rodilla en el hospital Río Hortega de Valladolid.

La artroplastia total de rodilla (PTR) es un procedimiento quirúrgico que ha representado un avance significativo en el campo de la salud en los últimos tiempos. Sin embargo, las infecciones periprotésicas (IPP) surgen como una complicación grave que conlleva mayores riesgos de morbilidad y mortalidad. Cuando la infección se ha establecido, es crucial detectarla tempranamente, identificar de manera precisa los microorganismos responsables y seleccionar el tratamiento adecuado.Grado en Medicin

La traslación al crédito ects de la diplomatura en relaciones laborales : análisis y propuestas de mejora

El enfoque pedagógico del proceso de convergencia al Espacio Europeo de Educación Superior pretende una transformación superior de la docencia universitaria en la que el eje fundamental no sea la enseñanza sino el aprendizaje. De hecho, este principio básico promueve que sea necesario el cambio profundo de algunas de las directrices en las que se ha venido desenvolviendo dicha docencia hasta la actualidad. Desde el curso 2004/05, la Diplomatura de Relaciones Laborales de la Universidad de Huelva se encuentra inmersa en el proyecto piloto para la implantación del Sistema Europeo de Transferencia de Crédito. El trabajo realizado permite ofrecer una visión global de la influencia que ha tenido la puesta en marcha de la metodología ects en el alumnado. El presente estudio pretende analizar la percepción del alumnado sobre la experiencia piloto y la evolución de los resultados académicos de las diferentes asignaturas inmersas en dicho proyecto. Estas conclusiones permitirán ofrecer ciertas propuestas de mejora, teniendo en cuenta las aportaciones del alumnado como pieza clave en el proyecto.________________________________The pedagogical approach of the process of convergence to the European Space of Superior Education pretends a transformation of university teaching in which the fundamental axis is not the teaching but the learning. In fact, this basic principle promotes that a profound change is necessary of some of the directives in which this teaching has been developed up to the present time. From course 2004105, the Diploma in Labour Relations of the University of Huelva has been immersed in the Pilot project for the Implantation of the European System of Credit Transfer. The work realized allows a global vision of the influence that the start of the methodology ECTS has had in the pupils. The present study tries to analyze the perception of the pupils on the pilot experience and the evolution of the academic results of the different subjects immersed in this project. These conclusions will allow the offering of certain proposals for improvement, taking into consideration the contributions of the pupils as a key piece in the project

Comparison of Microcystis aeruginosa (PCC7820 and PCC7806) growth and intracellular microcystins content determined by liquid chromatography–mass spectrometry, enzyme-linked immunosorbent assay anti-Adda and phosphatase bioassay

Cyanobacteria are able to produce several metabolites that have toxic effects on humans and animals. Among these cyanotoxins, the hepatotoxic microcystins (MC) occur frequently. The intracellular MC content produced by two strains of Microcystis aeruginosa, PCC7806 and PCC7820, and its production kinetics during the culture time were studied in order to elucidate the conditions that favour the growth and proliferation of these toxic strains. Intracellular MC concentrations measured by liquid chromatography (LC) coupled to electrospray ionization mass spectrometer (MS) were compared with those obtained by enzyme-linked immunosorbent assay (ELISA) anti-Adda and protein phosphatase 2A (PP2A) inhibition assays. It has been demonstrated there are discrepancies in the quantification of MC content when comparing ELISA and LC-MS results. However, a good correlation has been obtained between PP2A inhibition assay and LC-MS. Three MC were identified using LC-MS in the PCC7806 strain: MC-LR, demethylated MC-LR and a new variant detected for the first time in this strain, [MeSer7] MC-LR. In PCC7820, MC-LR, D-Asp3-MCLR, Dglu(OCH3)-MCLR, MC-LY, MC-LW and MC-LF were identificated. The major one was MC-LR in both strains, representing 81 and 79% of total MC, respectively. The total MC content in M. aeruginosa PCC7820 was almost three-fold higher than in PCC7806 extracts.Centro de Investigaciones Cietíficas y Técnicas AGL 2006–06523/ AL

Red Eléctrica de España uses integer programming for annual salary revisions

In this paper, we present a mixed-integer linear programming model for determining salary-revision matrices for an organization based on that organization?s general strategies. The solution obtained from this model consists of salary increases for each employee; these increases consider the employee?s professional performance, salary level relative to peers within the organization, and professional group. In addition to budget constraints, we modeled other elements typical of compensation systems, such as equity and justice. Red Eléctrica de España (REE), the transmission agent and operator of the Spanish electricity system, used the model to revise its 2010 and 2011 salary policies, and achieved results that were aligned with the company strategy. REE incorporated the model into the salary management module within its information system, and plans to continue to use the model in revisions of the module

Interés de la elaboración de vídeos didácticos como material de prácticas en la asignatura de "Seguridad Química"

El presente trabajo tiene por objeto presentar el proceso seguido en la elaboración de una serie videográfica constituida por tres videos didácticos, que abordan los aspectos fundamentales de los riesgos derivados de la exposición a sustancias químicas y agentes biológicos en un labo - ratorio universitario. dicho material didáctico innovador, se utilizará en los seminarios teóricos de la asignatura seguridad Química, impartida por los profesores del área de toxicología de la universidad de sevilla. los objetivos fundamentales de dichos videos han sido despertar el mayor interés posible y favorecer la asimilación de conceptos básicos en el alumnado de dicha asignatura, haciendo especial hincapié en la correcta y segura manipulación, el adecuado almacenamiento y la correcta eliminación de las sustancias, contribuyendo en definitiva a la prevención de los riesgos derivados de su exposición.The present work aims to illustrate the process followed to elaborate a set of three didactic illustrate the process followed to elaborate a set of three didactic videos, which shows the main aspects of derived risks from the exposure to the chemical substances and biological agents present in a university laboratory. this innovator didactic material will be used in the subject “chemical security” seminaries lectured by the professors from toxicology area in the university of seville. the most important aims of these videos have been to implicate the students in their learning, making easier for them to assimilate the basic concepts of the subject, such as the correct and secure way of manipulate the chemical substances, its appropriate storage and its suitable elimination, contributing to the prevention of the risks derived from their exposure

Measuring what is not seen—Transparency and good governance nonprofit indicators to overcome the limitations of accounting models

One of the most complex challenges currently faced by non-profit organizations (NPOs) is demonstrating that they manage resources with the highest levels of efficiency and excellence, and do not deviate from the accomplishment of their mission. Transparency and good governance are highly valuable issues for the survival of these organizations. However, empirical studies and models to measure these concepts are scarce and lack consensus. The objective of this article is to develop a uniform procedure for measuring the levels of transparency and good governance in NPOs, validated by experts, that integrates the most important contributions. The main proposals are supported by lists of indicators whose compliance they try to verify. Finally, we considered the experts’ preferences to obtain the indicator weights by means of the Best–Worst Method and Minimum Cost Consensus model. The result of our work is the development of a list of indicators, which integrates the existing battery of Spanish indicators. We contribute, with this work, to improving the credibility of the third sector from the perspective of donors, users, public administrations, and society. This is an essential issue for the survival of these NPOs.Universidad de Jaén, Instituto de Estudios Giennenses (Diputación de Jaén), Ministerio de Economía y Competitividad (Gobierno de España) a través del Proyecto de Investigación Nacional del Gobierno de España PGC2018-099402-B-I00 y el Contrato Postdoctoral Ramón y Cajal (RYC-2017-21978)

Neurotoxic assessment of Microcystin-LR, cylindrospermopsin andtheir combination on the human neuroblastoma SH-SY5Y cell line

Microcystin-LR (MC-LR) and Cylindrospermopsin (CYN) are produced by cyanobacteria. Although being considered as a hepatotoxin and a cytotoxin, respectively, different studies have revealed neurotoxic properties for both of them. The aim of the present work was to study their cytotoxic effects, alone and in combination, in the SH-SY5Y cell line. In addition, toxicity mechanisms such as oxidative stress and acetylcholinesterase (AChE) activity, and morphological studies were carried out. Results showed a cytotoxic response of the cells after their exposure to 0–100 μg/mL of MC-LR or 0–10 μg/mL CYN in both differentiated and undifferentiated cells. Thus, CYN resulted to be more toxic than MC-LR. Respect to their combination, a higher cytotoxic effect than the toxins alone in the case of undifferentiated cells, and almost a similar response to the presented by MC-LR in differentiated cells were observed. However, after analyzing this data with the isobolograms method, an antagonistic effect was mainly obtained. The oxidative stress study only showed an affectation of glutathione levels at the highest concentrations assayed of MC-LR and the combination in the undifferentiated cells. A significant increase in the AChE activity was observed after exposure to MC-LR in undifferentiated cells, and after exposure to the combination of both cyanotoxins on differentiated cells. However, CYN decreased the AChE activity only on differentiated cultures. Finally, the morphological study revealed different signs of cellular affectation, with apoptotic processes at all the concentrations assayed. Therefore, both cyanotoxins isolated and in combination, have demonstrated to cause neurotoxic effects in the SH-SY5Y cell line.Ministerio de Economía y Com-petitividad of Spain (AGL2015-64558-R, MINECO/FEDER, UE)Junta de Andalucia for the contact of María Gracia Hinojosa (USE-16667

Copper-Catalyzed Oxidation of Alkenes and Heterocycles

A variety of copper species catalyze the allylic oxidation of olefins and the introduction of an ester group at the α-position of a heterocycle. Both transformations are closely related in terms of reaction conditions and radical species involved. This short review highlights the progress made in these two types of oxidations, emphasizing work that has occurred within the last fifteen years

Research, teaching and social engagement for the meaningful learning of architecture

This article outlines the process and results of an experience of teaching/learning architecture in México. The purpose was to explore new learning scenarios in the context of the crisis in this profession and in a world where the human being is considered as the subject and object of sustainable development. The project was carried out in the town of Xico, Veracruz, and was organized with research, teaching and social engagement as basic premises, and habitability and sustainability as transverse themes. The data were obtained by observing the site and exploring the collective imaginary using participatory strategies. The learning obtained by the co-participants university, society and local government, showed the strengths of collaborative work as a necessary link for the permanence and development of the profession, and university training and education as a collective construction of society.Este artículo expone el proceso y los resultados de una experiencia de enseñanza/aprendizaje de la arquitectura. El propósito fue explorar nuevos escenarios de aprendizaje en el contexto de la crisis de la profesión y de considerar al ser humano, objeto y sujeto del desarrollo sostenible. El proyecto de intervención se estructuró tomando como ejes rectores la investigación, la docencia y la vinculación social, y como ejes transversales la habitabilidad y la sostenibilidad. Los datos se obtuvieron de la observación del sitio y de la exploración de los imaginarios colectivos, a través de estrategias participativas. El aprendizaje obtenido por los co-partícipes: universidad, sociedad y gobierno local, mostró las fortalezas del trabajo colaborativo como un vínculo necesario para la permanencia y desarrollo de la profesión, de la formación universitaria y de la educación como una construcción colectiva de la sociedad