Catálogo actualizado de los briófitos de la Región de Murcia (Sureste de España)

An updated checklist of the bryophytes of the Region of Murcia is provided. Bryophyte diversity in Murcia consists of 200 especies and 15 infraespecific taxa (77 genera) of mosses and 32 species (20 genera) of liverworts. Grimmia tergestina is confirmed in the territory. Aschisma cuynetii, Brachytheciastrum dieckii, Brachythecium albicans, Brachythecium rutabulum, Brachythecium salebrosum, Bryum alpinum, Bryum elegans, Campyliadelphus chrysophyllus, Campylopus pilifer and Didymodon eckeliae are new reported for Murcia. Bryum tenuisetum, Entosthodon attenuatus and Fissidens bryoides are excluded from the check-list.Se actualiza el catálogo de los briófitos de la Región de Murcia. Para este territorio se aceptan 200 especies y 15 taxones infraespecíficos (77 géneros) de musgos y 32 especies de hepáticas (20 géneros). Grimmia tergestina se confirma en el territorio. Aschisma cuynetii, Brachytheciastrum dieckii, Brachythecium albicans, Brachythecium rutabulum, Brachythecium salebrosum, Bryum alpinum, Bryum elegans, Campyliadelphus chrysophyllus, Campylopus pilifer y Didymodon eckeliae son nuevas citas para Murcia. Bryum tenuisetum, Entosthodon attenuatus y Fissidens bryoides se excluyen del catálogo

MOCDroid: multi-objective evolutionary classifier for Android malware detection

Malware threats are growing, while at the same time, concealment strategies are being used to make them undetectable for current commercial Anti-Virus. Android is one of the target architectures where these problems are specially alarming, due to the wide extension of the platform in different everyday devices.The detection is specially relevant for Android markets in order to ensure that all the software they offer is clean, however, obfuscation has proven to be effective at evading the detection process. In this paper we leverage third-party calls to bypass the effects of these concealment strategies, since they cannot be obfuscated. We combine clustering and multi-objective optimisation to generate a classifier based on specific behaviours defined by 3rd party calls groups. The optimiser ensures that these groups are related to malicious or benign behaviours cleaning any non-discriminative pattern. This tool, named MOCDroid, achieves an ac-curacy of 94.6% in test with 2.12% of false positives with real apps extracted from the wild, overcoming all commercial Anti-Virus engines from VirusTotal

Water Stress Enhances the Progression of Branch Dieback and Almond Decline under Field Conditions

Branch dieback and tree decline have been described as a common complex disease worldwide in woody crops, with Botryosphaeriaceae and Diaporthaceae being considered the most frequent fungi associated with the disease symptoms. Their behaviour is still uncertain, since they are considered endophytes becoming pathogenic in weakened hosts when stress conditions, such as water deficiency occur. Therefore, the main goal of this study was to determine if water stress enhances general decline on weakened almond trees subjected to different irrigation treatments under natural field conditions. In parallel, the occurrence of fungal species associated with almond decline was also determined in relation to disease progression by fungal isolation, and morphological and molecular based-methods. The symptoms of branch dieback and general decline were observed over time, mainly in the experimental plots subjected to high water deficiency. Botryosphaeriaceae were the most consistently isolated fungi, and Botryosphaeria dothidea was the most frequent. Collophorina hispanica was the second most frequent species and Diaporthe and Cytospora species were isolated in a low frequency. Most of them were recovered from both asymptomatic and symptomatic trees, with their consistency of isolation increasing with the disease severity. This work reveals the need to elucidate the role of biotic and abiotic factors which increase the rate of infection of fungal trunk pathogens, in order to generate important knowledge on their life cycle

La interferencia retroactiva entre claves entrenadas por separado: evidencia empírica y enfoques teóricos

Retroactive interference between cues trained apart was long ago studied in the psychology of memory, within the paired associate tradition. Current theories of learning, however, predict that interference between cues should not occur if they are trained elementally. Here we review the available evidence on retroactive interference between cues trained apart and show that this effect is very similar to other, classical effects, in the area of learning, such as interference between outcomes and competition between cues. We suggest that a stronger connection between these research areas is important, as common mechanisms are quite possibly responsible for all these effects. Finally, we discuss whether associative or the causal inference mechanisms currently studied in the area of learning could provide a satisfactory explanation for these effects.La interferencia retroactiva entre claves entrenadas elementalmente fue en su día un fenómeno muy estudiado en la psicología de la memoria, dentro de la tradición de los pares asociados. Sin embargo, las teorías actuales del aprendizaje predicen que no debería ocurrir interferencia entre claves si estas se entrenan por separado. En este trabajo revisamos la evidencia disponible y mostramos que la interferencia entre claves tiene enormes similitudes con otros efectos clásicos del aprendizaje, especialmente con los efectos de interferencia entre resultados y de competición entre claves. Postulamos, por tanto, que tiene sentido establecer una mayor conexión entre todas estas áreas de investigación y plantear que es muy posible que todos estos efectos sean debidos a mecanismos comunes. Finalmente discutimos si los procesos asociativos o los procesos de inferencia causal que se estudian actualmente en la psicología del aprendizaje podrían dar cuenta de estos efectos

Novedades corológicas para la flora briofítica ibérica. IV

This note continues the publication on new national and regional records based on the studies of Flora Briofítica Ibérica Project. Several field trips has been carried out during the years 2004-2010, which have provided new records.Con esta nota continuamos la publicación de novedades corológicas provinciales o nacionales detectadas en los estudios realizados dentro del Proyecto Flora Briofítica Ibérica. Se han llevado a cabo diversas prospecciones y recolecciones durante los años 2004 a 2010 que han revelado novedades de interés

Anti-IL-6 Receptor Tocilizumab in Refractory Graves? Orbitopathy: National Multicenter Observational Study of 48 Patients

Graves’ orbitopathy (GO) is the most common extrathyroidal manifestation of Graves’ disease (GD). Our aim was to assess the e cacy and safety of Tocilizumab (TCZ) in GO refractory to conventional therapy. This was an open-label multicenter study of glucocorticoid-resistant GO treated with TCZ. The main outcomes were the best-corrected visual acuity (BVCA), Clinical Activity Score (CAS) and intraocular pressure (IOP). These outcome variables were assessed at baseline, 1st, 3rd, 6th and 12th month after TCZ therapy onset. The severity of GO was assessed according to the European Group on Graves’ Orbitopathy (EUGOGO). We studied 48 (38 women and 10 men) patients (95 eyes); mean age standard deviation 51 11.8 years. Before TCZ and besides oral glucocorticoids, they had received IV methylprednisolone (n = 43), or selenium (n = 11). GO disease was moderate (n =29) or severe (n = 19) and dysthyroid optic neuropathy (DON) (n = 7). TCZ was used in monotherapy (n = 45) or combined (n = 3) at a dose of 8 mg/kg IV every four weeks (n = 43) or 162 mg/s.c. every week (n = 5). TCZ yielded a significant improvement in all of the main outcomes at the 1st month that was maintained at one year. Comparing the baseline with data at 1 year all of the variables improved; BCVA (0.78 0.25 vs. 0.9 0.16; p = 0.0001), CAS (4.64 1.5 vs. 1.05 1.27; p = 0.0001) and intraocular pressure (IOP) (19.05 4.1 vs. 16.73 3.4 mmHg; p = 0.007). After a mean follow-up of 16.1 2.1 months, low disease activity (CAS 3), was achieved in 88 eyes (92.6%) and TCZ was withdrawn in 29 cases due to low disease activity (n = 25) or ine cacy (n = 4). No serious adverse events were observed. In conclusion, TCZ is a useful and safe therapeutic option in refractory GO treatment.This work was also partially supported by RETICS Programs, RD08/0075 (RIER) and RD12/0009/0013 from “Instituto de Salud Carlos III” (ISCIII) (Spain)

RICORS2040 : The need for collaborative research in chronic kidney disease

Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still confuse CKD with chronic kidney insufficiency or failure. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. Thus health authorities may consider CKD a non-issue: very few persons eventually need KRT and, for those in whom kidneys fail, the problem is 'solved' by dialysis or kidney transplantation. However, KRT is the tip of the iceberg in the burden of CKD. The main burden of CKD is accelerated ageing and premature death. The cut-off points for kidney function and kidney damage indexes that define CKD also mark an increased risk for all-cause premature death. CKD is the most prevalent risk factor for lethal coronavirus disease 2019 (COVID-19) and the factor that most increases the risk of death in COVID-19, after old age. Men and women undergoing KRT still have an annual mortality that is 10- to 100-fold higher than similar-age peers, and life expectancy is shortened by ~40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth greatest global cause of death by 2040 and the second greatest cause of death in Spain before the end of the century, a time when one in four Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded Centres for Biomedical Research (CIBER) network structure in Spain. Realizing the underestimation of the CKD burden of disease by health authorities, the Decade of the Kidney initiative for 2020-2030 was launched by the American Association of Kidney Patients and the European Kidney Health Alliance. Leading Spanish kidney researchers grouped in the kidney collaborative research network Red de Investigación Renal have now applied for the Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) call for collaborative research in Spain with the support of the Spanish Society of Nephrology, Federación Nacional de Asociaciones para la Lucha Contra las Enfermedades del Riñón and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true

Ambiguity produces attention shifts in category learning

It has been suggested that people and nonhuman animals protect their knowledge from interference by shifting attention toward the context when presented with information that contradicts their previous beliefs. Despite that suggestion, no studies have directly measured changes in attention while participants are exposed to an interference treatment. In the present experiments, we adapted a dot-probe task to track participants’ attention to cues and contexts while they were completing a simple category learning task. The results support the hypothesis that interference produces a change in the allocation of attention to cues and contexts

SEOM clinical guidelines for diagnosis and treatment of metastatic colorectal cancer (2018)

Colorectal cancer (CRC) is the second cause of cancer death in Spain, the objective of this guide published by the Spanish Society of Medical Oncology is to develop a consensus for the diagnosis and management of metastatic disease. The optimal treatment strategy for patients with metastatic CRC should be discussed in a multidisciplinary expert team to select the most appropriate treatment, and integrate systemic treatment and other options such as surgery and ablative techniques depending on the characteristics of the tumour, the patient and the location of the disease and metastases