393 research outputs found
Synthesis of improved moisture resistant polymers
The use of difluoromaleimide-capped prepolymers to provide improved moisture resistant polymers was investigated. Six different prepolymer formulations were prepared by two different methods. One method utilized the PMR approach to polyimides and the second method employed the normal condensation route to provide fully imidized prepolymers. Polymer specimens cured at 450 F exhibited adequate long-term stability in air at 400 F. Moisture absorption studies were conducted on one polymer formulation. Neat Polymer specimens exhibited weight gains of up to 2% (w/w) after exposure to 100% relative humidity at 344K (160 F) for 400 hours
Sampled Policy Gradient for Learning to Play the Game Agar.io
In this paper, a new offline actor-critic learning algorithm is introduced:
Sampled Policy Gradient (SPG). SPG samples in the action space to calculate an
approximated policy gradient by using the critic to evaluate the samples. This
sampling allows SPG to search the action-Q-value space more globally than
deterministic policy gradient (DPG), enabling it to theoretically avoid more
local optima. SPG is compared to Q-learning and the actor-critic algorithms
CACLA and DPG in a pellet collection task and a self play environment in the
game Agar.io. The online game Agar.io has become massively popular on the
internet due to intuitive game design and the ability to instantly compete
against players around the world. From the point of view of artificial
intelligence this game is also very intriguing: The game has a continuous input
and action space and allows to have diverse agents with complex strategies
compete against each other. The experimental results show that Q-Learning and
CACLA outperform a pre-programmed greedy bot in the pellet collection task, but
all algorithms fail to outperform this bot in a fighting scenario. The SPG
algorithm is analyzed to have great extendability through offline exploration
and it matches DPG in performance even in its basic form without extensive
sampling
Development of autoclavable addition type polyimides
Two highly promising approaches to yield autoclavable addition-type polyimides were identified and evaluated in the program. Conditions were established for autoclave preparation of Hercules HMS graphite fiber reinforced composites in the temperature range of 473 K to 505 K under an applied pressure of 0.7 MN/m2 (100 psi) for time durations up to four hours. Upon oven postcure in air at 589 K, composite samples demonstrated high mechanical property retention at 561 K after isothermal aging in air for 1000 hours. Promise was shown for shorter term mechanical property retention at 589 K upon exposure in air at this temperature
Development of autoclavable polyimides
A poly(Diels-Alder) (PDA) resin approach was investigated as a means to achieve autoclavability of high temperature resistant resin/fiber composites under mild fabrication procedures. Low void content Type A-S graphite reinforced composites were autoclave fabricated from a PDA resin/fiber prepared from an acetone:methanol:dioxane varnish. Autoclave conditions were 477K (400F) and 0.7 MN/sq m (100 psi) for up to two hours duration. After postcure at temperatures up to 589K (600F), the composites demonstrated high initial mechanical properties at temperatures up to 561K (550F). The results from isothermal aging studies in air for 1000 hours indicated potential for long-term ( 1000 hours) use at 533K (500F) and shorter-term (up to 1000 hours) at 561K (550F)
Development of autoclave moldable addition-type polyimides
Chemistry and processing modifications of the poly(Diels Alder) polyimide (PDA) resin were performed to obtain structural composites suitable for 589 K (600 F) service. This work demonstrated that the PDA resin formulation is suitable for service at 589 K (600 F) for up to 125 hours when used in combination with Hercules HTS graphite fiber. Sandwich panels were autoclave molded using PDA/HTS skins and polyimide/glass honeycomb core. Excellent adhesion between honeycomb core and the facing skins was demonstrated. Fabrication ease was demonstrated by autoclave molding three-quarter scale YF-12 wing panels
The Genus viola in the Balearic Islands
S'ha dut a terme l'estudi del gènere Viola a les illes Balears. Es proposen dues noves combinacions nomenclaturals: Viola suavis Bieb. subsp. barceloi (Nyman) Orell & Romo, comb.
nova i Viola odorata L. subsp. stolonifera (RodrĂguez FemenĂas) Orell & Romo, comb. nova.
Es descriuen tres noves notosubspècies de l'illa de Mallorca: Viola alba L. nothosubsp. neusii
Orell & Romo, nothosubsp. nova (=Viola alba subsp. dehnhardtii x V. jaubertiana); Viola alba L.
nothosubsp. bonaefidei Orell & Romo, nothosubsp. nova (=V. alba subsp. dehnhardtii x V. suavis
subsp. barceloi); i Viola suavis Bieb. nothosubsp. cardonae nothopsubsp. nova (=Viola suavis subsp. barceloi x V. jaubertiana).
S'exposen la corologia i l'ecologia dels tĂ xons de Viola presents a les Illes i es valoren algunes
citacions antigues, probablement errònies.Following the study of Balearic taxa of the genus Viola, two new nomenclatural combinations
are proposed: Viola suavis Bieb. subsp. barceloi (Nyman) Orell & Romo, comb. nova; and
Viola odorata L. subsp. stolonifera (RodrĂguez FemenĂas) Orell & Romo, comb. nova. Three new nothosubspecies from the island of Majorca are described: Viola alba L. nothosubsp. neusii Orell &
Romo, nothosusp. nova (= Viola alba subsp. dehnhardtii x V. jaubertiana); Viola alba L. nothosubsp. bonaefidei Orell & Romo, nothosubsp. nova (= V. Alba subsp. dehnhardtii x V. suavis subsp.
barceloi); and Viola suavis Bieb. nothosubsp. cardonae nothosubsp. nova (= Viola suavis subsp. barceloi x V. Jaubertiana). The chorology and ecology of the Balearic taxa of the genus Viola are
presented and some of the oldest reports, which are probably erroneous, are discussed
Improved high-temperature resistant matrix resins
A study was performed with the objective of developing matrix resins that exhibit improved thermo-oxidative stability over state-of-the-art high temperature resins for use at temperatures up to 644 K (700 F) and air pressures up to 0.7 MPa (100 psia). The work was based upon a TRW discovered family of polyimides currently licensed to and marketed by Ethyl Corporation as EYMYD(R) resins. The approach investigated to provide improved thermo-oxidative properties was to use halogenated derivatives of the diamine, 2, 2-bis (4-(4-aminophenoxy)phenyl) hexafluoropropane (4-BDAF). Polyimide neat resins and Celion(R) 12,000 composites prepared from fluorine substituted 4-BDAF demonstrated unexpectedly lower glass transition temperatures (Tg) and thermo-oxidative stabilities than the baseline 4-BDAF/PMDA polymer
Long-term safety and efficacy of subcutaneous immunoglobulin IgPro20 in CIDP PATH extension study
Objective To investigate the long-term safety and efficacy of weekly subcutaneous IgPro20 (Hizentra, CSL Behring) in chronic inflammatory demyelinating polyneuropathy (CIDP). Methods In a 48-week open-label prospective extension study to the PATH study, patients were initially started on 0.2 g/kg or on 0.4 g/kg weekly and-if clinically stable-switched to 0.2 g/kg weekly after 24 weeks. Upon CIDP relapse on the 0.2 g/kg dose, 0.4 g/kg was (re)initiated. CIDP relapse was defined as a deterioration by at least 1 point in the total adjusted Inflammatory Neuropathy Cause and Treatment score. Results Eighty-two patients were enrolled. Sixty-two patients initially received 0.4 g/kg, 20 patients 0.2 g/kg weekly. Seventy-two received both doses during the study. Sixty-six patients (81%) completed the 48-week study duration. Overall relapse rates were 10% in 0.4 g/kg-treated patients and 48% in 0.2 g/kg-treated patients. After dose reduction from 0.4 to 0.2 g/kg, 51% (27/53) of patients relapsed, of whom 92% (24 of 26) improved after reinitiation of the 0.4 g/kg dose. Two-thirds of patients (19/28) who completed the PATH study without relapse remained relapse-free on the 0.2 g/kg dose after dose reduction in the extension study. Sixty-two patients had adverse events (AEs) (76%), of which most were mild or moderate with no related serious AEs. Conclusions Subcutaneous treatment with IgPro20 provided long-term benefit at both 0.4 and 0.2 g/kg weekly doses with lower relapse rates on the higher dose. Long-term dosing should be individualized to find the most appropriate dose in a given patient. Classification of evidence This study provides Class IV evidence that for patients with CIDP, long-term treatment with SCIG beyond 24 weeks is safe and efficacious.Peer reviewe
Single nucleotide polymorphisms to discriminate different classes of hybrid between wild Atlantic salmon and aquaculture escapees
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