13 research outputs found

    The evaluation of ventrikular function of newly diagnosed idiopatic generalized epileptic children with tissue Doppler imaging

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    Objective: Epileptic discharges spread all over central autonomic area, and may alter normal autonomic control over vital cardiac functions. In our study we aimed to evaluate left ventricular diastolic function of the yet untreated patients with newly diagnosed idiopathic generalized epilepsy using tissue Doppler imaging (TDI).& para;& para;Methods: Thirty-one yet untreated patients aged 1 month-18 years who were newly diagnosed as idiopathic generalized epilepsy based on 1981 ILAE classification were included in the study. Control group consisted of age-, and gender-matched 29 healthy children. Transthoracic two-dimensional and Doppler echocardiographic examinations of the patients were performed.& para;& para;Results: Median age of the cases was 7.42 (3.52) years. There were not significant differences between patients and control groups as assessed with conventional echocardiographic variables (p>0.05). Right ventricular isovolumic contraction times (IVCTs) of the case and control groups were estimated with tissue Doppler imaging, and shorter IVCTs were found in the patient group. A statistically significant difference existed between the patient, and the control groups in terms of IVCT values. Differences between the measurements of systolic peak velocities of the medial wall of the annulus, and also between IVCT values (p<0.05) were significant in case and control groups. More comprehensive studies should be conducted to interpret lower IVCT values regarding systolic dysfunction.& para;& para;Conclusion: In conclusion, diastolic dysfunction was not detected in the patient group, we think that diastolic functions of our patients may not yet altered because of smaller mean age of our newly diagnosed patients with longer time intervals between seizures. Therefore more comprehensive, and long-term studies with greater number of drug- resistant epileptic children should be conducted to show the effect of epilepsy on diastolic function in children

    Protective effect of grape seed extract against ischaemia/reperfusion injury in a rat epigastric flap model

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    Proanthocyanidins are potent natural antioxidants which belong to a class of polyphenols. Proanthocyanidin-rich extracts are prepared from grape seeds. The effect of grape seed proanthocyanidin extract (GSPE) on the viability of abdominal skin flaps exposed to warm ischaemia and subsequent reperfusion were studied in 40 male Wistar rats. In the control group (group I; n=20), rats were fed with standard, non-purified rat diet, and the study group received GSPE 100 mg kg(-1) per day 1 week prior to surgery and 1 week following surgery. Abdominal island flaps were elevated in both the groups and subjected to 8 h of warm ischaemia, followed by reperfusion. Mean flap survival areas in groups I (control group) and II (treatment group) were calculated to be 58.3% +/- 11.72 and 81.0% +/- 11.88, respectively. Flap survival on day 7 was significantly higher in group II compared to group I (p < 0.01). Histopathological semi-quantitative analysis of the specimens revealed infiltration by polymorphonuclear leucocytes, oedema formation and necrosis in group I, whereas neo-vascularisation and fibrosis were the prominent findings in group II. (C) 2009 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved

    The Effect of Reduction Mammaplasty on the Vertebral Column: A Radiologic Study

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    Some studies emphasized that anatomic mechanisms of vertebral aberrations could be associated with large breasts. The effect of mammaplasty operation on the vertebral column and body posture seems to be beneficial; in this trial, it was planned to investigate the objective radiologic effect of reduction mammaplasty on the posture of the vertebral column in a group of patients operated due to the large breasts. Thirty-four white women with large breasts were enrolled in this study. The patients were divided into three groups according to their breast cup sizes. Anteroposterior and lateral radiographs of the lumbosacral and thoracic spine were taken at baseline preoperatively, and the same radiographic images were taken in an average of 12 months later than the reduction mammaplasty operation. All were evaluated and compared for thoracic kyphosis angle and lumbar lordosis angle both preoperatively and postoperatively. The mean thoracic kyphosis angle was 40,53 preoperatively and 39,38 postoperatively. However, there was no statistically significant difference between the preoperative and postoperative measurements in all groups (P>0,05). The mean lumbar lordosis angle was 54,71 preoperatively and 53,18 postoperatively. Regarding the preoperative and postoperative measurements of lumbar lordosis angles, no statistically significant difference was found between the groups (P>0,05). Although breast size may be an important factor that affects body posture, reduction mammaplasty operations have little or no radiologic effect on the vertebral column

    Mu-Opioid Receptor Gene (Oprm1) Polymorphisms A118G And C17T In Alcohol Dependence: A Turkish Sample

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    Objectives: Previous investigations on opioid system genetics have identified polymorphisms of the OPRM1 gene expressing mu-opioid receptors to be significantly associated with some features of alcohol dependence (AD). In the present study, we evaluated the relationship between single nucleotide polymorphisms (SNP) in the OPRM1 gene, A118G (rs1799971, Asn40Asp) and C17T (rs1799972, Arg6Val), and AD diagnosis, level of alcohol consumption, and AD severity in a Turkish sample. Methods: 121 AD patients and 117 healthy male subjects were included in the study. OPRM1 A118G (N40D) and C17T (A6V) polymorphisms were evaluated using PCR - RFLP (polymerase chain reaction restriction fragment length polymorphism) method. We evaluated the association between the presence of SNPs and AD diagnosis, family history of AD, AD severity evaluated via the Michigan Alcoholism Screening Test (MAST), the daily average and maximum quantity of alcohol consumed. Results: There was no significant difference in OPRM1 A118G genotype frequencies between the AD and control groups. T allele frequency for the OPRM1 C17T SNP was very low (0.006) in the sample population. OPRM1 Al 18G SNP G118 allele carriers showed significantly higher levels of AD severity as indicated by the MAST. Conclusion: The OPRM1 G118 allele was significantly associated with more severe AD in the Turkish population. Similar to other European populations, the frequency of the OPRM1 T17 allele was very low.WoSScopu

    Treatment of chronic delta hepatitis with lamivudine vs lamivudine + interferon vs interferon

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    Chronic delta hepatitis is the most severe form of chronic viral hepatitis for which interferon (IFN) is the only available treatment. In 39 patients (25 were treatment-naive, 14 had previously used IFN), efficacy of 1-year treatment with IFN (9 MU, t.i.w.) or lamivudine (LAM; 100 mg, q.d.) alone was compared with IFN and LAM combination (2 months of LAM to be followed by combination treatment). IFN monotherapy was given only to treatment-naive patients. In both treatment-naive and previous IFN users, end of treatment virological and biochemical responses were similar with IFN-LAM combination and superior to LAM monotherapy (P < 0.05). Improvement in liver histology occurred more often with IFN +/- LAM than with LAM alone (P < 0.05). In treatment-naive patients, combination treatment was not superior to IFN monotherapy. After treatment discontinuation, virological and biochemical response rates decreased in LAM and IFN combination and IFN monotherapy. On treatment virological response at month 6 of treatment predicted sustained virological response. The results of this study suggest that addition of LAM to IFN for the treatment of delta hepatitis is of no additional value and that both treatment modalities are superior to LAM monotherapy

    Dealing with the gray zones in the management of gastric cancer: The consensus statement of the Istanbul Group

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    The geographical location and differences in tumor biology significantly change the management of gastric cancer. The prevalence of gastric cancer ranks fifth and sixth among men and women, respectively, in Turkey. The international guidelines from the Eastern and Western countries fail to manage a considerable amount of inconclusive issues in the management of gastric cancer. The uncertainties lead to significant heterogeneities in clinical practice, lack of homogeneous data collection, and subsequently, diverse outcomes
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