Volume CXIV, Number 4, November 7, 1996

Objective: Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls. This study aimed to systematically investigate the key clinical features of TS in relationship to karyotype in a large pediatric Turkish patient population.Methods: Our retrospective study included 842 karyotype-proven TS patients aged 0-18 years who were evaluated in 35 different centers in Turkey in the years 2013-2014.Results: The most common karyotype was 45,X (50.7%), followed by 45,X/46,XX (10.8%), 46,X,i(Xq) (10.1%) and 45,X/46,X,i(Xq) (9.5%). Mean age at diagnosis was 10.2±4.4 years. The most common presenting complaints were short stature and delayed puberty. Among patients diagnosed before age one year, the ratio of karyotype 45,X was significantly higher than that of other karyotype groups. Cardiac defects (bicuspid aortic valve, coarctation of the aorta and aortic stenosis) were the most common congenital anomalies, occurring in 25% of the TS cases. This was followed by urinary system anomalies (horseshoe kidney, double collector duct system and renal rotation) detected in 16.3%. Hashimoto's thyroiditis was found in 11.1% of patients, gastrointestinal abnormalities in 8.9%, ear nose and throat problems in 22.6%, dermatologic problems in 21.8% and osteoporosis in 15.3%. Learning difficulties and/or psychosocial problems were encountered in 39.1%. Insulin resistance and impaired fasting glucose were detected in 3.4% and 2.2%, respectively. Dyslipidemia prevalence was 11.4%.Conclusion: This comprehensive study systematically evaluated the largest group of karyotype-proven TS girls to date. The karyotype distribution, congenital anomaly and comorbidity profile closely parallel that from other countries and support the need for close medical surveillance of these complex patients throughout their lifespa

FREQUENCY OF POLYPHARMACY AND RISK FACTORS IN THE ELDERLYIN BURDUR

Introduction: Polypharmacy is common among the elderly. This study aimed to determine the frequency of polypharmacy and the risk factors in the elderly. Materials and Method: This cross-sectional study will be analysed in three stages (polypharmacy, drug characteristics and drug interaction). Herein, the first stage (polypharmacy) was conducted at Burdur city centre and the connected villages. A total of 400 of 11,360 subjects aged >= 65 years who were registered with family physicians in Burdur city centre were selected using a systematic sampling method. A questionnaire of 30 questions about socio-demographic variables and rational drug use was distributed among the subjects. Subsequently, the subjects were asked to bring their own drugs from home that they were actively using or not currently using, and their drug-using behaviour was analysed via specific questions. Results: The average number of different drugs possessed by the subjects at home was approximately 6 (5.95 +/- 4.30). A total of 64.9% of the drugs were used regularly, 21.3% were used occasionally and 13.8% were previously used but not currently used. The median number +/- standard deviation of the drugs that were used regularly, used occasionally and previously used but not currently used was 3.86 +/- 3.36, 1.27 +/- 1.75 and 0.82 +/- 1.82, respectively. According to the results of multivariate analysis, the presence of diabetes, hypertension, respiratory system or cardiovascular (except hypertension) diseases, visual impairment or hearing disorders significantly increased the total drug use (p<0.05). Conclusion: Chronic diseases and living in the city centre are the main risk factors leading to polypharmacy. Therefore, interventions must be undertaken by monitoring and reducing chronic diseases and providing training on rational drug use in the provincial centres

How does reimbursement status affect the smoking cessation interventions?

28th International Congress of the European-Respiratory-Society (ERS) -- SEP 15-19, 2018 -- Paris, FRANCEWOS: 000455567101295[No abstract available]European Respiratory So

How does reimbursement status affect smoking cessation interventions? A real-life experience from the Eastern Black Sea region of Turkey (vol 17, pg 1, 2019) - [Correction]

onal, ozgur/0000-0001-6514-2120WOS: 000491278300006PubMed: 31584567[No abstract available

Prevalence and determinants of smoking status among university students: Artvin Coruh University sample

onal, ozgur/0000-0001-6514-2120WOS: 000452644700001PubMed: 30532238Background and aim Smoking is still a public health concern in many countries, especially among young adults. Consequently, we determined what factors affect university students' smoking behavior in Turkey. Methods This cross-sectional study was conducted between March and June 2017 using a simple random sampling method. A self-administered questionnaire was used to collect information on participants' (N = 2,505; mean age = 20.9 +/- 2.5 years; 58.9% women) sociodemographic characteristics, cigarette smoking status, and related risk factors. Univariate analysis and multivariate logistic regression analysis were performed with the Backward likelihood-ratio method. Results Students were completing either two- or four-year degrees (45.6% and 54.4%, respectively). Regarding familial smoking behavior, 36.1% had a father who smoked, 10.3% had a mother who smoked, and 15.0% had siblings who smoked. Among participants, 27.9% were current smokers: 46% of the men and 15.3% of the women. Mean smoking onset age was 16.34 +/- 2.72 years (15.65 +/- 2.67 years for men and 16.34 +/- 2.72 for women (p < .05). Mean Fager-stromtest score was 4.43 +/- 1.82, and women had lower test scores than did men (p < .05). After controlling for potential confounders in multivariate analyses, five factors were significantly positively associated with current smoking: being a man (odds ratio (OR): 3.43; 95% confidence interval (CI): 2.75-4.28), studying in a two-year program (OR: 1.74; 95% CI: 1.39-2.18), having at least one immediate family member who smoked (OR: 1.63; 95% CI: 1.31-2.04), having all close friends who smoked (OR: 1.81; 95% CI: 1.40-2.33), and alcohol consumption (OR: 4.39; 95% CI: 3.51-5.49). Conclusion There was a higher smoking rate among our study population, both compared to similar national studies and Turkey's overall smoking rate. Underlying factors should be evaluated via qualitative studies and preventive strategies should be implemented accordingly

How does reimbursement status affect smoking cessation interventions? A real-life experience from the Eastern Black Sea region of Turkey

onal, ozgur/0000-0001-6514-2120WOS: 000457575200005PubMed: 31582917INTRODUCTION in the last decade, outpatient smoking cessation clinics (SCCs) in Turkey have been extended countrywide. Initially, only counseling was covered under health insurance. in 2011 and 2015, free varenicline and bupropion preparations were distributed to SCCs, periodically. in the current study we aimed to compare outcomes between the free and paid medication periods. METHODS Patients applied to the local SCC in a secondary health care unit between June 2014 and June 2017. They were evaluated for SC interventions and had phone visits after their third month; these records were included in the study. Patients were grouped and evaluated according to medication's reimbursement status: free medication period (FP) and paid medication period (PMP). RESULTS in total, 733 patients applied to the SCC, 77.7% of them had applied during the FP. Analyses were made involving 417 patients who had records of third-month phone visit. Mean age of the patients was 44.0 +/- 13.7 years with the majority of patients (65%) being male. Sociodemographic characteristics of patients in both groups were not statistically different, while the percentage of patients with comorbid diseases was lower in the FP group (p<0.05). Treatment choices were different-the bupropion-prescribed group's rate was similar in both periods (53.5% in PMP vs 52.0% in FP), however varenicline was mostly prescribed in the FP (35.8% vs 14.1%) while nicotine replacement therapy was mostly prescribed in the PMP (32.4% vs 12.1%) (p<0.05). Patients who used the advised treatment for at least 30 days (treatment adherent) and the rate of quitters at the third month were higher in FP (p<0.05) from univariate analysis, however these differences were not statistically significant when a multivariate analysis was performed. CONCLUSIONS Our study showed that the free medication period increased the quit attempts but the increased in treatment adherence and quit success of the participating smokers was not obvious

Factors associated with current smoking in COPD patients: A cross-sectional study from the Eastern Black Sea region of Turkey

Introduction Even though smoking is a major reason for the development and progression of chronic obstructive pulmonary disease (COPD)-and quitting smoking is the only way to stop its progression-a significant number of smokers still continue to smoke after being diagnosed with COPD. The aim of this study is to compare the clinical and demographic characteristics of COPD patients who are current and former smokers and to find factors associated with their current smoking status. Methods For this study, data were collected between June 2015 and August 2016; COPD patients who had been regularly visiting Hopa State Hospital’s outpatient clinic over the last year or longer were included. Their demographic, clinical and functional data were recorded. Patients completed a pulmonary function test, six-minute walk test (6-MWT), COPD assessment test (CAT), and modified Medical Research Council (mMRC) dyspnea scale. Comparisons were then made according to their smoking status. Results In total 100 patients were included in the study; with a mean age of 63.4±10.7 years and mostly males (94%). Regarding smoking status, 49% were current smokers and 51% were former smokers. Multivariate logistic regression analysis revealed that current smoking was negatively associated with age (odds ratio, OR=0.93, 95% confidence interval, CI=0.88–0.96) and Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage (OR=0.32, 95% CI=0.13– 0.79), and was positively associated with six-minute walk distance (OR =1.005, 95% CI=1.001–1.009) and CAT score (OR=1.07, 95% CI=1.009–1.13). Conclusions Nearly half of the COPD patients in the study continued smoking even after having been diagnosed with COPD. The younger patients, with better lung function, better exercise capacity and poor quality of life were associated with current smoking

Prevalence and determinants of cigarette smoking among university students

28th International Congress of the European-Respiratory-Society (ERS) -- SEP 15-19, 2018 -- Paris, FRANCEWOS: 000455567106208[No abstract available]European Respiratory So

Expressions of p53, KAI1, PTEN and their use as prognostic markers in urothelial carcinoma of the bladder

Objectives: To determine the expression levels of p53, KAI1, PTEN and their relations with the clinicopathologic parameters in patients with urothelial carcinoma of the bladder Design: Retrospective study Setting: Department of Pathology, Ankara Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey Subjects: Seventy-eight patients with a diagnosis of urothelial carcinoma of the bladder at the Pathology Department of Ankara Diskapi Yildirim Beyazit Education and Research Hospital and who were followed up for two years Intervention: Archived pathology materials of all patients were reviewed and clinical data were collected from medical database records retrospectively. Main outcome measures: We considered the following parameters: age, gender, survivals and disease-free survivals of the patients, tumor-stage, lymphovascular-angiovascular invasions, expressions of KAI1, PTEN and p53 in tumorous tissues. Results: In non-metastatic-patients, 55.2% were p53 negative; however, 45.8% of the metastatic-patients had diffuse-strong p53-expressions. Hence, p53 positivity indicates that the tumor will metastase. In transurethral resection (TUR) materials, patients with positive KAI1-expression had better survival (p=0.0285). The tumor seemed to be more aggressive and invasive in patients with decreased KAI1-expressions because there was no KAI1 expression in 50% of the metastatic-patients, although it wasn't statistically significant (p=0.550). For PTEN expression, no statistically-significant relation was found with the tumor-stage (p=0.34) and survival/ disease-free-survival (TUR:p=0.9599/0.7576, radical cystectomy :p=0.8219/0.5790). Conclusions: The presence of metastasis dramatically decreases the overall survival in patients with urothelial carcinoma. Identification of these patients as early as possible would effect their therapies, follow-up intervals and surveys. p53 and KAI1 seem to be especially better indicators of the prognosis than PTEN.WOS:0005407622000082-s2.0-8509061040