Dynamics of Snoring Sounds and Its Connection with Obstructive Sleep Apnea

Snoring is extremely common in the general population and when irregular may indicate the presence of obstructive sleep apnea. We analyze the overnight sequence of wave packets --- the snore sound --- recorded during full polysomnography in patients referred to the sleep laboratory due to suspected obstructive sleep apnea. We hypothesize that irregular snore, with duration in the range between 10 and 100 seconds, correlates with respiratory obstructive events. We find that the number of irregular snores --- easily accessible, and quantified by what we call the snore time interval index (STII) --- is in good agreement with the well-known apnea-hypopnea index, which expresses the severity of obstructive sleep apnea and is extracted only from polysomnography. In addition, the Hurst analysis of the snore sound itself, which calculates the fluctuations in the signal as a function of time interval, is used to build a classifier that is able to distinguish between patients with no or mild apnea and patients with moderate or severe apnea

ACTIVITY ANTI-C. TROPICALIS AND EFFECTS OF THE COMBINATION OF (S)-(-)-CITRONELLAL WITH FOUR ANTIFUNGAL APPLIED IN VULVOVAGINAL CANDIDIASIS

Objective: Assess the antifungal potential of the enantiomer (S)-(-)-citronellal [(S)-(-)-CT] isolated and associated to amphotericin B, fluconazole, itraconazole and miconazole against C. tropicalis from vulvovaginal secretions.Methods: The enantiomer was solubilized in Tween 80 and DMSO. Posteriorly diluted in sterile distilled water up to the concentration of 2048 µg/ml. The MIC of the product was determined by microdilution in RPMI-1640 obtaining dilutions of 1024-4 µg/ml. The MFC was determined by the SDA depletion technique from aliquots of 1 µl of the MIC, MIC × 2 and MIC × 4.Results: The antifungal susceptibility testing and the interfering effects of the association of the enantiomer with the standard drugs were determined by disk-diffusion in SDA. The MIC of (S)-(-)-CT was 64 µg/ml and the MFC 128 µg/ml. A high resistance of the strands C. tropicalis to amphotericin B, itraconazole and miconazole were observed. The combination test of the enantiomer with the amphotericin B, as well as with the itraconazole resulted in synergism 2 (66.6%) of the yeasts and in association with the fluconazole 1 (33.3%) and miconazole 3 (100%) of synergic effect.Conclusion: The (S)-(-)-CT alone is fungicide for the 3 fungal strains and in association with the four antifungals increased the inhibition zones, increasing the sensitivity

Doença renal crônica: explorando novas estratégias de comunicação para promoção da saúde

Objetivo: Descrever o desenvolvimento de novas estratégias de comunicação para promoção da saúde no âmbito da doença renal crônica (DRC). Métodos: Pesquisa de natureza aplicada, pois objetiva a produção de conhecimentos direcionados à solução de problemas específicos por meio de ferramentas práticas e da análise das hipóteses levantadas. As ferramentas foram desenvolvidas pela parceria entre o Programa de Pós-Graduação em Saúde Coletiva e o Núcleo de Aplicação em Tecnologia da Informação da Universidade de Fortaleza. O estudo intitulado “Renal Health” foi dividido em três fases consecutivas: Fase 1 - Desenvolvimento do aplicativo Renal Health; Fase 2 - Construção de conteúdos e plataformas digitais vinculadas ao aplicativo; e Fase 3 – Teste de impacto clínico e adesão ao aplicativo. No presente momento, o estudo encontra-se com a fase 1 concluída e com a fase 2 em andamento. Resultados: Foi desenvolvido o aplicativo Renal Health para uso em dispositivos móveis, em plataforma Android, com interfaces para a população geral, ou seja, pessoas que não fazem tratamento para DRC, pacientes renais crônicos em hemodiálise e transplantados renais. A fase 2 do estudo encontra-se em desenvolvimento, ocorrendo por meio de reuniões entre as equipes de pesquisadores e dos setores saúde e tecnologia para a compilação dos conteúdos e delineamento do projeto gráfico das plataformas digitais. Conclusão: A comunicação entre os profissionais de saúde e os portadores de DRC é passível de contínuo aperfeiçoamento, dada a variedade das modalidades de tratamento e suas peculiaridades. O aplicativo Renal Health e as plataformas digitais se propõem a apoiar ambos nesse processo

Equiparação dos salários dos professores das redes públicas aos dos demais profissionais com escolaridade equivalente: uma análise das desigualdades regionais

This paper aims to analyze the appreciation of public K-12 education teachers by means of the equalization of their average income to other professionals with equivalent educational level, the central axis of Target 17 of the National Education Plan (PNE). The article presents a brief overview of the average income of public school teachers in relation to other professionals, disaggregated by Federative Unit (UF), sex and race/skin color.Este trabalho tem como objetivo principal analisar a valorização dos profissionais do magistério das redes públicas de educação básica por meio da equiparação de seu rendimento médio ao dos demais profissionais com escolaridade equivalente, eixo central da Meta 17 do Plano Nacional de Educação (PNE). Nesse sentido, o trabalho traz um breve panorama sobre o rendimento médio dos professores da rede pública em relação ao dos demais profissionais, desagregado por Unidade Federativa (UF), sexo e raça/cor

Gestão de acidentes com produtos químicos (APQ): resposta

A Unidade 03 do módulo 02 do Curso de Capacitação a Distância em Saúde, Desastres e Desenvolvimento do IESC/UFRJ é a última unidade deste módulo e abordará as ações de resposta aos acidentes com produtos químicos (APQ) e o papel do setor de saúde nestas ações.1. ed.Fundo Nacional de Saúd

Acute kidney injury due to excessive and prolonged intramuscular injection of veterinary supplements containing vitamins A, D and E: A series of 16 cases

AbstractBackgroundDespite well-documented risks, injectable supplements containing high doses of vitamins are commonly used.ObjectivesTo describe acute kidney injury (AKI) as a complication of vitamin intoxication.MethodsOur series consisted of 16 patients with kidney complications resulting from the use of veterinary intramuscular injection supplements of vitamin A, D and E. The patients were admitted to two referral hospitals in Fortaleza (Brazil) between January 2010 and January 2015.ResultsPatients’ mean age was 28.3±8.9 years (19–53 years), and 11 (68.7%) were male. Main signs and symptoms upon admission were nausea (68.7%), vomiting (62.5%), weight loss (43.7%), epigastric pain (31.2%) and headache (31.2%). At hospital admission the mean laboratory values were: hemoglobin 10±2.0g/dL (6.1–14.2), leukocytes 10,542±4871/mm3 (4100–15,100), creatinine 3.9±5.2mg/dL (0.7–22) and urea 91±88mg/dL (22–306), respectively. Serum calcium was 12±2.2mg/dL (8.8–15.5), 24-h urine calcium was 575±329mg (10.7–1058), serum PTH was 55±141pg/mL (2–406), and serum vitamin D concentration was 135±75ng/mL (22–265). Using KDIGO criteria, AKI was diagnosed in 13 patients (81.2%), classified as stage 1 (n=3), stage 2 (n=3) or stage 3 (n=7). No deaths occurred in the study period.ConclusionsExcessive use of veterinary vitamin supplements containing high doses of vitamin A, D and E was associated with AKI. Hypercalcaemia, which was a common finding, appears to be a contributing factor to the development of this type of AKI

Charge localization and hopping in a topologically engineered graphene nanoribbon

Graphene nanoribbons (GNRs) are promising quasi-one-dimensional materials with various technological applications. Recently, methods that allowed for the control of GNR’s topology have been developed, resulting in connected nanoribbons composed of two distinct armchair GNR families. Here, we employed an extended version of the Su-Schrieffer-Heeger model to study the morphological and electronic properties of these novel GNRs. Results demonstrated that charge injection leads to the formation of polarons that localize strictly in the 9-AGNRs segments of the system. Its mobility is highly impaired by the system’s topology. The polaron displaces through hopping between 9-AGNR portions of the system, suggesting this mechanism for charge transport in this material