Molecular studies in schizophrenia

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Evaluation of an educational programme for socially deprived asthma patients

The aim of this study was to evaluate the effectiveness of an asthma education programme in moderate and severe asthma patients in a longitudinal, prospective and randomized study with a control group. Fifty-three asthmatic patients were studied, 26 of whom were assigned to the educational group and 27 to the control group.The educational group attended the programme regularly for a period of 6 months. the programme included information about asthma, instruction on the appropriate use of medication and training in the metered dose inhaler (MDI) technique, and information about the identification and control of asthma attacks and the recognition of early signs of exacerbation. the control group was submitted to the routine tare provided at the Asthma Clinic, with no formal instruction regarding asthma control. the groups were identical with regard to severity parameters, skills, lung function and quality of Life at the beginning of the trial.At the end of the study, the education group showed significant differences when compared with the control group education/control (mean values) with respect to: visits to the asthma emergency room over the previous 6 months, 0.7/2 (p=0.03); nocturnal symptoms, 0.3/0.7 (p=0.04); score of symptoms, 1.3/2 (p=0.04). Improvements were also observed in skills and quality of life, knowledge of how to deal with attacks and how to control the environmental triggering factors, 73/35 (<0.05); correct use of the MDI, 8/4 (0.001); understanding of the difference between relief and antiinflammatory medication, 86/20 (<0.05); and in the global limitation quality of life score, 28/50 (0.02).It is concluded that the educational programme led to a significant improvement in asthma morbidity and that the implantation of educational programmes is possible for special populations when these programmes are adapted to the socioeconomic profile of the patients, with a significant gain in terms of the reduction of symptoms and improved pulmonary function and quality of life of asthmatics.Universidade Federal de São Paulo, Dept Med, Lund Div, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Med, Lund Div, São Paulo, BrazilWeb of Scienc

Escolha alimentar e fatores determinantes em idosos europeus

[resumo][abstract

Potential of mild torrefaction for upgrading the wood energy value of different Eucalyptus species

Torrefaction is a promising pre-treatment for improving the fuel quality of biomass. This study examined the effect of a mild torrefaction (from 160 to 230 C) on the heating value, elemental composition, and thermogravimetric analysis of wood from eight Eucalyptus species (E. botryoides Sm., E. globulus Labill., E. grandis W.Hill ex Maiden, E. maculata (Hook.) K.D. Hill & L.A.S.Johnson, E. propinqua Maiden Deane, E. rudis Endl., E. saligna Sm., and E. viminalis Labill.). The higher heating values (HHV) increased from the initial average of 19 MJ kg1 to 21 MJ kg1 in the torrefied samples. The carbon content increased from 48.2% to 53.3% and the C/O ratio from 1.08 to 1.35. The torrefied wood samples showed more thermal stability with a shift of the mass loss peaks to higher temperatures and a higher residual mass at 450 C of 36%, in comparison to 30% of the untreated samples. Torrefaction concentrated the biomass samples in the more energetic and thermal resistant components and decreased their sulfur and chlorine content, leading to a better combustion performance. The wood of the eight Eucalyptus species had a similar behavior and showed quality improvement. Therefore, torrefaction showed potential as a pre-treatment for eucalyptus biomass fuel improvementinfo:eu-repo/semantics/publishedVersio

Beyond comorbidities, sex and age have no effect on COVID-19 health care demand

Mendes, J. M., Baptista, H., Oliveira, A., Jardim, B., & De Castro Neto, M. (2022). Beyond comorbidities, sex and age have no effect on COVID-19 health care demand. Scientific Reports, 12(1), 1-12. [7356]. https://doi.org/10.1038/s41598-022-11376-5 -------------------------------- This research was supported by project Data4Covid19 (project ID: 62821), funded by the European Regional Development Fund, through the Operational Competitiveness Programme—COMPETE 2020, in the framework of 15/SI/2020—R&D Companies and Testing and Optimization Infrastructures (COVID-19). The authors acknowledge the editors and reviewers, whose comments and suggestions helped to improve the presentation of the paper.This paper explores the associations between sex, age and hospital health care pressure in the context of the COVID-19 pandemic in Portuguese mainland municipalities. To represent the impact of sex and age, we calculated COVID-19 standardised incidence ratios (SIR) in Portuguese mainland municipalities over fourteen months daily, especially focusing on the Porto metropolitan area. A daily novel indicator was devised for hospital health care pressure, consisting of an approximation to the ratio of hospitalisations per available hospital medical doctor (HPI). In addition, 14-day incidence rates were also calculated daily (DIR14), both as an approach and an alternative to the current national pandemic surveillance indicator (which is not calculated with such regularity). Daily maps were first visualised to evaluate spatial patterns. Pearson's correlation coefficients were then calculated between each proposed surveillance indicator (SIR and DIR14) and the HPI. Our results suggest that hospital pressure is not strongly associated with SIR (r = 0.34, p value = 0.08). However, DIR14 bears a stronger correlation with hospital pressure (r = 0.84, p value < 0.001). By establishing the importance of tackling sex and age through the inclusion of these factors explicitly in an epidemiological monitoring indicator, and assessing its relationship with a hospital pressure indicator, our findings have public policy implications that could improve COVID-19 incidence surveillance in Portugal and elsewhere, contributing to advancing the management of potential pandemics in the near future, with a particular focus on local and regional territorial scales.publishersversionepub_ahead_of_prin

Large-scale analyses of schizophrenia proteome

Valuable knowledge about schizophrenia has been recently generated for deciphering its pathobiology and revealing biomarkers. However, efforts are still needed, especially if we take in account that this debilitating mental disorder affects approximately 30 million people worldwide. Considering that schizophrenia is a result of a complex interaction among environmental factors altered gene function and systematic differential protein expression, proteomics is likely to be a suitable tool for studying this disorder. Here we synthetize the main findings by proteomic studies and further directions to be taken in order to better comprehend the biochemistry of schizophrenia as well as reveal biomarkers. In addition, we summarize proteomic methodologies used in such studies.Valioso conhecimento a respeito de esquizofrenia tem sido gerado recentemente para decifrar sua patobiologia e revelar biomarcadores. Entretanto, esforços ainda são necessários, especialmente se levarmos em conta que essa debilitante desordem mental afeta aproximadamente 30 milhões de pessoas ao redor do mundo. Considerando que esquizofrenia é resultado de uma complexa interação entre fatores ambientais, função genética alterada e expressão proteica diferencial sistemática, a proteômica é provavelmente uma ferramenta adequada ao estudo dessa desordem. Aqui sintetizamos os principais achados em estudos proteômicos e posteriores direções a serem tomadas de forma a melhor compreender a bioquímica da esquizofrenia, bem como revelar biomarcadores