Good practices in school to educate critical citizens: the youth parliament programme from the perspective of secondary school teachers in training

ERPA International Congresses on Education 2018This paper refers to the European project Erasmus + ELEF (European Learning Environment Formats for Citizenship and Democracy, Reference number 580426). The aim of this project is to develop, implement, evaluate and replicate democratic and innovative learning environments (good practices) in both educational institutions and informal and community learning environments. In this context, over the course of a year, a number of experiences considered relevant have been selected, which constitute the sample of this research on good practices. This contribution presents the educational programme “Youth Parliament”. This is a project with a long history and whose main objective is to train responsible citizens, with the collaboration of various educational agents. The evaluation carried out by the Secondary Education teachers in training on the potentialities and limitations of the programme is shown, based on the experiences carried out in the participating educational centres during the academic year 2016-2017

Informe sobre avances en la informatización del Archivo Rubén Darío (www.ucm.es/info/rdario)

This brief text offers information on the progress that has been made in the computerisation of the nearly five thousand documents of the Archive Rubén Darío. It presents the Archive’s web page, comments some of the difficulties that have been faced, offers technical details on the computerisation and an index of the Archive’s contents so as to enable researchers to travel through the web page.Este breve texto ofrece información sobre los avances que se han hecho en la informatización de los casi cinco mil documentos del Archivo Rubén Darío. Presenta la página web del Archivo, comenta las dificultades experimentadas en la labor de informatización, ofrece detalles técnicos sobre la digitalización y transcribe un índice de los contenidos del Archivo para facilitar la labor del investigador

Ordered three-dimensional interconnected nanoarchitectures in anodic porous ​alumina

Three-dimensional (3D) nanostructures combine properties of nanoscale materials with the advantages of being macro-sized pieces when the time comes to manipulate, measure their properties or make a device. However, the amount of compounds with the ability to self-organize in ordered 3D nanostructures is limited. Therefore, template-based fabrication strategies become the key approach towards 3D nanostructures. Here we report the simple fabrication of a template based on anodic ¿aluminium oxide, having a well-defined, ordered, tunable, homogeneous 3D nanotubular network in the sub 100-nm range. The 3D templates are then employed to achieve 3D, ordered nanowire networks in ¿Bi2Te3 and polystyrene. Finally, we demonstrate the photonic crystal behaviour of both the template and the polystyrene 3D nanostructure. Our approach may establish the foundations for future high-throughput, cheap, photonic materials and devices made of simple commodity plastics, metals and semiconductors.We would like to acknowledge financial support from ERC 2008 Starting Grant ‘Nano-TEC’ number 240497.Peer Reviewe

Efectos del déficit hídrico en pre-envero sobre la composición de vinos tintos jóvenes ( Vi tis vini fera L., cv. Cabernet sauvignon) en Madrid. España.

Se estudiaron los efectos del riego en un viñedo de la variedad de uva Cabernet sauvignon en la región Madrid, España, con el fin de determinar el efecto del riego desde brotación hasta envero. Es habitual, en zonas cálidas y secas, que el crecimiento de la baya y su rendimiento se limiten, afectando a la composición de la uva y por lo tanto a la calidad de sus vinos. Este ensayo tuvo como objetivo atenuar dichos efectos, estimulando el metabolismo y crecimiento mediante aportes de agua previos al estado fenológico de envero y estudiar como este hecho afectó a la calidad final del vino y a su composición

Spanish forest firesetter profile: An application of inductive criminal profiling

La técnica del perfil criminológico, entendida como el proceso de inferir características identificativas de un delincuente analizando las evidencias obtenidas en la escena del delito que ha cometido, ha recibido críticas por su dudoso carácter científico y su falta de apoyo teórico y empírico. No obstante, en la actualidad ha surgido un modelo que trabaja en la profesionalización del análisis del comportamiento delictivo en los cuerpos policiales mediante la aplicación de los conocimientos de la psicología a la investigación criminal. Una línea de trabajo iniciada por Canter consiste en la aplicación de la estadística multivariante a hechos criminales esclarecidos para crear tipologías (perfilamiento inductivo), de modo que se pueda ver si existen tipos de personas que cometen con más probabilidad determinados tipos de hechos. En este trabajo se utilizó el análisis de conglomerados bietápico en una muestra de 117 incendios ocurridos durante el año 2011 que ofreció una solución de cinco tipos de incendio (perfiles). Dicho modelo mostraría consistencia con el de años anteriores y es fácilmente interpretable por los agentes policiales, por lo que podría utilizarse ante incendios nuevos cuando se desconozca la identidad de sus responsablesThe criminal profiling, understood as the process of inferring identifying offender features by analyzing evidences from the crime scene, has been criticized for its doubtful scientific nature, along with its lack of theoretical and empirical support. However, at present a model has emerged that works on the professionalization of the analysis of criminal behavior in police forces, through a rigorous application of the psychological knowledge to the criminal investigation. This line of working, initiated by Canter, involves the multivariate statistical application to solved criminal acts, thereby creating typologies (inductive profiling). Thus, it is possible to see if there are types of people most likely to commit certain sort of events. In this paper, a two-stage cluster analysis is used in a sample of 117 fires occurred in 2011. The results show five types of fire profiles. This model would show consistence with the results of previous years, and it is easily interpretable by police officers so that it could be used to new fires when the identity of perpetrators is unknow

A label-free optical system with a nanohole array biosensor for discriminating live single cancer cells from normal cells

Developing a simple, fast, and label-free method for discrimination between live cancer cells and normal cells in biological samples still remains a challenge. Here, a system is described that fulfills these features to analyze individual living cells. The system consists of a gold nanohole array biosensor plus a microscope optical design to isolate the spectral response of a single cell. It is demonstrated that differences in the spectral behavior between tumor (colorectal cancer cell lines and primary cells from colorectal cancer tissue) and non-tumor cells (peripheral blood mononuclear cells, skin fibroblasts and colon epithelial cells) are influenced by the actin cortex, which lies within the short penetration depth of the surface plasmon electromagnetic field. The efficacy of this system was assessed by the analysis of about one thousand single cells showing the highest discrimination capacity between normal colon epithelial cells and colorectal cancer cells from surgical specimens, with values of sensitivity and specificity ranging 80-100% and 87-100%, respectively. It is also demonstrated that cell discrimination capacity of the system is highly reduced by disrupting the formation of actin cortex. This plasmonic system may find wide applications in biomedicine and to study key cellular processes that involve the actin cortex, including proliferation, differentiation, and migration.This work was supported by the Instituto de Salud Carlos III through grant DTS18/00141, co-funded by European Regional Development Fund/ European Social Fund “A way to make Europe/Investing in your future” and Instituto de Investigación Valdecilla (IDIVAL) (APG/03)

CRISPR-Cas, a Revolution in the Treatment and Study of ESKAPE Infections: Pre-Clinical Studies

This article belongs to the Special Issue Non-antimicrobial Agents as Adjuvants against Bacterial Infections[Abstract] One of the biggest threats we face globally is the emergence of antimicrobial-resistant (AMR) bacteria, which runs in parallel with the lack in the development of new antimicrobials. Among these AMR bacteria pathogens belonging to the ESKAPE group can be highlighted (Enterococcus spp., Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) due to their profile of drug resistance and virulence. Therefore, innovative lines of treatment must be developed for these bacteria. In this review, we summarize the different strategies for the treatment and study of molecular mechanisms of AMR in the ESKAPE pathogens based on the clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins’ technologies: loss of plasmid or cellular viability, random mutation or gene deletion as well directed mutations that lead to a gene’s loss of function.This study was funded by grants PI16/01163 and PI19/00878 awarded to M. Tomás within the State Plan for R+D+I 2013–2016 (National Plan for Scientific Research, Technological Development and Innovation 2008–2011) and cofinanced by the ISCIII-Deputy General Directorate for Evaluation and Promotion of Research-European Regional Development Fund “A way of Making Europe” and Instituto de Salud Carlos III FEDER, Spanish Network for the Research in Infectious Diseases (REIPI, RD16/0016/0006) and by the Study Group on Mechanisms of Action and Resistance to Antimicrobials, GEMARA (SEIMC, http://www.seimc.org/, Accessed on 21 June 2021). I. Bleriot was financially supported by pFIS program (ISCIII, FI20/00302). O. Pacios and M. López was financially supported by a grant IN606A-2020/035 and IN606B-2018/008, respectively, (GAIN, Xunta de Galicia), and M. Gonzalez-Bardanca was financially supported by the Rio Hortega program (ISCIII, CM20/00198)Xunta de Galicia; IN606A-2020/035Xunta de Galicia; IN606B-2018/00

A convenient synthesis of new 6-substituted purinylcarbanucleosides on cyclopenta[b]thiophene

The 12th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic Chemistry and Natural ProductsThe first members of a new family of heterocarbobicyclic nucleoside analogues have been synthesized from the cis/trans mixture of (4-amino-5,6-dihydro-4H-cyclopenta[b]thiophen-6-yl)methanols cis/trans-7. The separation of cis and trans intermediates during preparation of the 6-chloropurine derivatives allowed separate preparation of the purine heterocarbanucleosides cis-10 and trans-11, from which cis-(12-14) and trans-(16-18) were obtained by replacement of the 6-chloro substituent with amino, hydroxy and cyclopropylamino groups. Additionally, the 6-phenyl-purinyl analogues cis-15 and trans-19 were prepared from cis-10 and trans-11 using Suzuki-Miyaura methodologyThe authors thank the Xunta de Galicia for financial support under project PGIDIT02BTF20305P