El Prácticum como enseñanza reflexiva: una propuesta de innovación didáctica realizada en la Escuela de Magisterio de la UAH

En este artículo presentamos una experiencia piloto de innovación referida al Prácticum, realizada en la E. de Magisterio de la UAH., durante los cursos 2006-07 y 2007-08. La experiencia, que parte de la premisa de formar un profesor crítico y con criterio, nos ha llevado a situarnos en el modelo del profesor refl exivo. Empezamos indicando el origen de la propuesta, y más tarde justifi camos las bases del modelo, explicamos la metodología que hemos empleado e indicamos las conclusiones que se derivan de la experiencia.                                                                                                                                  This article presents a pilot and innovative experience dealing with the Teaching Practice that has been carried out at the Teacher Training School of the University of Alcalá during the academic years 2006/07 and 2007/08. This experience is based on the premise of educating a teacher so that s/he can become a person of sound judgement and constructive criticism and it has made us choose the refl exive teacher model. Our study begins by indicating the background of our proposal and continues by reasoning the basis of that model. Then we explain the methodology we have used and we fi nally point out the conclusions we have reached from this innovative experience

Laforin, a dual specificity protein phosphatase involved in Lafora disease, is phosphorylated at Ser25 by AMP-activated protein kinase

Carlos Romá-Mateo et alt.Lafora progressive myoclonus epilepsy [LD (Lafora disease)] is a fatal autosomal recessive neurodegenerative disorder caused by loss-of-function mutations in either the EPM2A gene, encoding the dual-specificity phosphatase laforin, or the EPM2B gene, encoding the E3-ubiquitin ligase malin. Previously, we and others showed that laforin and malin form a functional complex that regulates multiple aspects of glycogen metabolism, and that the interaction between laforin and malin is enhanced by conditions activating AMPK (AMP-activated protein kinase). In the present study, we demonstrate that laforin is a phosphoprotein, as indicated by two-dimensional electrophoresis, and we identify Ser25 as the residue involved in this modification. We also show that Ser25 is phosphorylated both in vitro and in vivo by AMPK. Lastly, we demonstrate that this residue plays a critical role for both the phosphatase activity and the ability of laforin to interact with itself and with previously established binding partners. The results of the present study suggest that phosphorylation of laforin-Ser25 by AMPK provides a mechanism to modulate the interaction between laforin and malin. Regulation of this complex is necessary to maintain normal glycogen metabolism. Importantly, Ser25 is mutated in some LD patients (S25P), and our results begin to elucidate the mechanism of disease in these patientsThis work was supported the Spanish Ministry of Education and Science [grant number SAF2008-01907 (to P.S.)]; the Generalitat Valenciana [grant number Prometeo 2009/051 (to P.S.)]; the National Institutes of Health [grant numbers R00NS061803, P20RR020171, R01NS070899 (to M.S.G.)]; and the University of Kentucky College of Medicine startup funds (to M.S.G.)Peer reviewe

El Prácticum como enseñanza reflexiva: una propuesta de innovación didáctica realizada en la Escuela de Magisterio de la UAH

En este artículo presentamos una experiencia piloto de innovación referida al Prácticum, realizada en la E. de Magisterio de la UAH., durante los cursos 2006-07 y 2007-08. La experiencia, que parte de la premisa de formar un profesor crítico y con criterio, nos ha llevado a situarnos en el modelo del profesor refl exivo. Empezamos indicando el origen de la propuesta, y más tarde justifi camos las bases del modelo, explicamos la metodología que hemos empleado e indicamos las conclusiones que se derivan de la experiencia.This article presents a pilot and innovative experience dealing with the Teaching Practice that has been carried out at the Teacher Training School of the University of Alcalá during the academic years 2006/07 and 2007/08. This experience is based on the premise of educating a teacher so that s/he can become a person of sound judgement and constructive criticism and it has made us choose the refl exive teacher model. Our study begins by indicating the background of our proposal and continues by reasoning the basis of that model. Then we explain the methodology we have used and we finally point out the conclusions we have reached from this innovative experience

El Prácticum como enseñanza reflexiva: una propuesta de innovación didáctica realizada en la Escuela de Magisterio de la UAH

En este artículo presentamos una experiencia piloto de innovación referida al Prácticum, realizada en la E. de Magisterio de la UAH., durante los cursos 2006-07 y 2007-08. La experiencia, que parte de la premisa de formar un profesor crítico y con criterio, nos ha llevado a situarnos en el modelo del profesor refl exivo. Empezamos indicando el origen de la propuesta, y más tarde justifi camos las bases del modelo, explicamos la metodología que hemos empleado e indicamos las conclusiones que se derivan de la experiencia.This article presents a pilot and innovative experience dealing with the Teaching Practice that has been carried out at the Teacher Training School of the University of Alcalá during the academic years 2006/07 and 2007/08. This experience is based on the premise of educating a teacher so that s/he can become a person of sound judgement and constructive criticism and it has made us choose the refl exive teacher model. Our study begins by indicating the background of our proposal and continues by reasoning the basis of that model. Then we explain the methodology we have used and we finally point out the conclusions we have reached from this innovative experience

Efectividad de la funcionalidad familiar de persona que ha intentado suicidarse

RESUMENIntroducción: Para Friedemann toda familia se conforma para funcionar adecuadamente en las dimensiones que la autora ha identificado en su teoría, existiendo momentos críticos cuando uno de sus miembros intenta suicidarse.Objetivo: determinar y analizar la efectividad del funcionamiento familiar con la persona que ha intentado suicidar. Metodología: Se diseñó un estudio descriptivo transversal, con muestreo por conveniencia, con la utilización la ficha sociodemográfica de convivencia familiar y la Escala de Evaluación de la Efectividad de la Funcionalidad Familiar. En total fueron 23 familias donde una persona ha intentado suicidarse.Resultados: La efectividad de la funcionalidad familiar fue baja en el 60,9% de las familias, debido a que presentaron dificultades en su estabilidad y crecimiento familiar.Conclusiones: Las familias se resisten a modificar sus patrones y costumbres y tienen dificultades en la comunicación asertiva. Salud UIS 2011; 43(1): 33-37Palabras clave: Intento de suicidio, salud de la familia, relaciones familiaresABSTRACTIntroduction: For Friedemann a family is made up with the purpose of performing adequately in the dimensions that the author has identified in her theory, but some critical problems appears when one of the members of that family tries to commit suicide. Objective: To determine and analyze the way the individuals family works.Methodology: A transversal descriptive study was designed using a convenient sampling of the individuals family´s convenience social demographic form and the Evaluation Scale for the Effectiveness of the Family´s Function. Twenty three families had a person who had tried suicide.Results: The effectiveness of the family´s function was low in a 60.9% of the families because some difficulties appeared when trying to establish their stability and growth.Conclusions: The families refused to modify their patterns and customs and showed difficulties in their assertive communication. Salud UIS 2011; 43(1): 33-37Keywords: Suicide attempts, family health, family relation

Efectividad de la funcionalidad familiar de persona que ha intentado suicidarse

RESUMENIntroducción: Para Friedemann toda familia se conforma para funcionar adecuadamente en las dimensiones que la autora ha identificado en su teoría, existiendo momentos críticos cuando uno de sus miembros intenta suicidarse.Objetivo: determinar y analizar la efectividad del funcionamiento familiar con la persona que ha intentado suicidar. Metodología: Se diseñó un estudio descriptivo transversal, con muestreo por conveniencia, con la utilización la ficha sociodemográfica de convivencia familiar y la Escala de Evaluación de la Efectividad de la Funcionalidad Familiar. En total fueron 23 familias donde una persona ha intentado suicidarse.Resultados: La efectividad de la funcionalidad familiar fue baja en el 60,9% de las familias, debido a que presentaron dificultades en su estabilidad y crecimiento familiar.Conclusiones: Las familias se resisten a modificar sus patrones y costumbres y tienen dificultades en la comunicación asertiva. Salud UIS 2011; 43(1): 33-37Palabras clave: Intento de suicidio, salud de la familia, relaciones familiaresABSTRACTIntroduction: For Friedemann a family is made up with the purpose of performing adequately in the dimensions that the author has identified in her theory, but some critical problems appears when one of the members of that family tries to commit suicide. Objective: To determine and analyze the way the individuals family works.Methodology: A transversal descriptive study was designed using a convenient sampling of the individuals family´s convenience social demographic form and the Evaluation Scale for the Effectiveness of the Family´s Function. Twenty three families had a person who had tried suicide.Results: The effectiveness of the family´s function was low in a 60.9% of the families because some difficulties appeared when trying to establish their stability and growth.Conclusions: The families refused to modify their patterns and customs and showed difficulties in their assertive communication. Salud UIS 2011; 43(1): 33-37Keywords: Suicide attempts, family health, family relation

Efectividad de la funcionalidad familiar de personas con intento de suicidio

El estudio que se presenta a continuación, realizado durante el período 2006-2009, tuvo como objetivo determinar y analizar la efectividad de la funcionalidad familiar de personas que han intentado suicidarse en el municipio de San Gil.A través de la aplicación de instrumentos como la Ficha sociodemográfica de convivencia familiar (Facultad de Enfermería de la Universidad Nacional de Colombia) y la Escala de Evaluación de la Efectividad de la Funcionalidad Familiar (Friedemann), se obtuvieron los siguientes resultados: 23 fueron las familias con personas que han intentado suicidarse entre 2006 y 2009, de las cuales, 60.9% corresponde al género femenino. En cuanto al nivel educativo, el 39.1% tiene secundaria incompleta y el 21.7%, secundaria completa. El promedio de miembros de la familia es de 4-6 personas (65.2%). En cuanto a la efectividad de la funcionalidad familiar, ésta estuvo en nivel bajo con 60.9%

Laforin, the most common protein mutated in Lafora disease, regulates autophagy

Lafora disease (LD) is an autosomal recessive, progressive myoclonus epilepsy, which is characterized by the accumulation of polyglucosan inclusion bodies, called Lafora bodies, in the cytoplasm of cells in the central nervous system and in many other organs. However, it is unclear at the moment whether Lafora bodies are the cause of the disease, or whether they are secondary consequences of a primary metabolic alteration. Here we describe that the major genetic lesion that causes LD, loss-of-function of the protein laforin, impairs autophagy. This phenomenon is confirmed in cell lines from human patients, mouse embryonic fibroblasts from laforin knockout mice and in tissues from such mice. Conversely, laforin expression stimulates autophagy. Laforin regulates autophagy via the mammalian target of rapamycin kinase-dependent pathway. The changes in autophagy mediated by laforin regulate the accumulation of diverse autophagy substrates and would be predicted to impact on the Lafora body accumulation and the cell stress seen in this disease that may eventually contribute to cell death