1,171 research outputs found
Non-equilibrium Phase Transitions with Long-Range Interactions
This review article gives an overview of recent progress in the field of
non-equilibrium phase transitions into absorbing states with long-range
interactions. It focuses on two possible types of long-range interactions. The
first one is to replace nearest-neighbor couplings by unrestricted Levy flights
with a power-law distribution P(r) ~ r^(-d-sigma) controlled by an exponent
sigma. Similarly, the temporal evolution can be modified by introducing waiting
times Dt between subsequent moves which are distributed algebraically as P(Dt)~
(Dt)^(-1-kappa). It turns out that such systems with Levy-distributed
long-range interactions still exhibit a continuous phase transition with
critical exponents varying continuously with sigma and/or kappa in certain
ranges of the parameter space. In a field-theoretical framework such
algebraically distributed long-range interactions can be accounted for by
replacing the differential operators nabla^2 and d/dt with fractional
derivatives nabla^sigma and (d/dt)^kappa. As another possibility, one may
introduce algebraically decaying long-range interactions which cannot exceed
the actual distance to the nearest particle. Such interactions are motivated by
studies of non-equilibrium growth processes and may be interpreted as Levy
flights cut off at the actual distance to the nearest particle. In the
continuum limit such truncated Levy flights can be described to leading order
by terms involving fractional powers of the density field while the
differential operators remain short-ranged.Comment: LaTeX, 39 pages, 13 figures, minor revision
Electrochemistry at nanoscale electrodes : individual single-walled carbon nanotubes (SWNTs) and SWNT-templated metal nanowires
Individual nanowires (NWs) and native single-walled carbon nanotubes (SWNTs) can be readily used as well-defined nanoscale electrodes (NSEs) for voltammetric analysis. Here, the simple photolithography-free fabrication of submillimeter long Au, Pt, and Pd NWs, with sub-100 nm heights, by templated electrodeposition onto ultralong flow-aligned SWNTs is demonstrated. Both individual Au NWs and SWNTs are employed as NSEs for electron-transfer (ET) kinetic quantification, using cyclic voltammetry (CV), in conjunction with a microcapillary-based electrochemical method. A small capillary with internal diameter in the range 30–70 μm, filled with solution containing a redox-active mediator (FcTMA+ ((trimethylammonium)methylferrocene), Fe(CN)64–, or hydrazine) is positioned above the NSE, so that the solution meniscus completes an electrochemical cell. A 3D finite-element model, faithfully reproducing the experimental geometry, is used to both analyze the experimental CVs and derive the rate of heterogeneous ET, using Butler–Volmer kinetics. For a 70 nm height Au NW, intrinsic rate constants, k0, up to ca. 1 cm s–1 can be resolved. Using the same experimental configuration the electrochemistry of individual SWNTs can also be accessed. For FcTMA+/2+ electrolysis the simulated ET kinetic parameters yield very fast ET kinetics (k0 > 2 ± 1 cm s–1). Some deviation between the experimental voltammetry and the idealized model is noted, suggesting that double-layer effects may influence ET at the nanoscale
Algorithm and performance of a clinical IMRT beam-angle optimization system
This paper describes the algorithm and examines the performance of an IMRT
beam-angle optimization (BAO) system. In this algorithm successive sets of beam
angles are selected from a set of predefined directions using a fast simulated
annealing (FSA) algorithm. An IMRT beam-profile optimization is performed on
each generated set of beams. The IMRT optimization is accelerated by using a
fast dose calculation method that utilizes a precomputed dose kernel. A compact
kernel is constructed for each of the predefined beams prior to starting the
FSA algorithm. The IMRT optimizations during the BAO are then performed using
these kernels in a fast dose calculation engine. This technique allows the IMRT
optimization to be performed more than two orders of magnitude faster than a
similar optimization that uses a convolution dose calculation engine.Comment: Final version that appeared in Phys. Med. Biol. 48 (2003) 3191-3212.
Original EPS figures have been converted to PNG files due to size limi
Holder exponents of irregular signals and local fractional derivatives
It has been recognized recently that fractional calculus is useful for
handling scaling structures and processes. We begin this survey by pointing out
the relevance of the subject to physical situations. Then the essential
definitions and formulae from fractional calculus are summarized and their
immediate use in the study of scaling in physical systems is given. This is
followed by a brief summary of classical results. The main theme of the review
rests on the notion of local fractional derivatives. There is a direct
connection between local fractional differentiability properties and the
dimensions/ local Holder exponents of nowhere differentiable functions. It is
argued that local fractional derivatives provide a powerful tool to analyse the
pointwise behaviour of irregular signals and functions.Comment: 20 pages, Late
Water in massive star-forming regions: HIFI observations of W3 IRS5
We present Herschel observations of the water molecule in the massive
star-forming region W3 IRS5. The o-H17O 110-101, p-H18O 111-000, p-H2O 22
202-111, p-H2O 111-000, o-H2O 221-212, and o-H2O 212-101 lines, covering a
frequency range from 552 up to 1669 GHz, have been detected at high spectral
resolution with HIFI. The water lines in W3 IRS5 show well-defined
high-velocity wings that indicate a clear contribution by outflows. Moreover,
the systematically blue-shifted absorption in the H2O lines suggests expansion,
presumably driven by the outflow. No infall signatures are detected. The p-H2O
111-000 and o-H2O 212-101 lines show absorption from the cold material (T ~ 10
K) in which the high-mass protostellar envelope is embedded. One-dimensional
radiative transfer models are used to estimate water abundances and to further
study the kinematics of the region. We show that the emission in the rare
isotopologues comes directly from the inner parts of the envelope (T > 100 K)
where water ices in the dust mantles evaporate and the gas-phase abundance
increases. The resulting jump in the water abundance (with a constant inner
abundance of 10^{-4}) is needed to reproduce the o-H17O 110-101 and p-H18O
111-000 spectra in our models. We estimate water abundances of 10^{-8} to
10^{-9} in the outer parts of the envelope (T < 100 K). The possibility of two
protostellar objects contributing to the emission is discussed.Comment: Accepted for publication in the A&A HIFI special issu
Modular reorganization of the global network of gene regulatory interactions during perinatal human brain development.
BACKGROUND
During early development of the nervous system, gene expression patterns are known to vary widely depending on the specific developmental trajectories of different structures. Observable changes in gene expression profiles throughout development are determined by an underlying network of precise regulatory interactions between individual genes. Elucidating the organizing principles that shape this gene regulatory network is one of the central goals of developmental biology. Whether the developmental programme is the result of a dynamic driven by a fixed architecture of regulatory interactions, or alternatively, the result of waves of regulatory reorganization is not known.
RESULTS
Here we contrast these two alternative models by examining existing expression data derived from the developing human brain in prenatal and postnatal stages. We reveal a sharp change in gene expression profiles at birth across brain areas. This sharp division between foetal and postnatal profiles is not the result of pronounced changes in level of expression of existing gene networks. Instead we demonstrate that the perinatal transition is marked by the widespread regulatory rearrangement within and across existing gene clusters, leading to the emergence of new functional groups. This rearrangement is itself organized into discrete blocks of genes, each targeted by a distinct set of transcriptional regulators and associated to specific biological functions.
CONCLUSIONS
Our results provide evidence of an acute modular reorganization of the regulatory architecture of the brain transcriptome occurring at birth, reflecting the reassembly of new functional associations required for the normal transition from prenatal to postnatal brain development
Immunologic monitoring and immunotherapy in Ewing's sarcoma
Serial immunological monitoring was performed on 31 patients with Ewing's sarcoma who were on a randomized immunotherapy trial with BCG administered by dermal scarification with a Heaf gun. Patients were skin-tested for delayed hypersensitivity reactions (DCHR) to recall antigens and extracts of tumor cells, and with keyhole limpet hemocyanin (KLH). In vitro testing consisted of lymphocyte counts, percentages of cells forming rosettes with sheep erythrocytes at 29° C and at 4° C, and leukocyte migration inhibition to tuberculin (PPD) and to 3 M KCl extracts of tumor cells. At the time of diagnosis, nearly all patients had positive DCHR to mumps and streptococcal antigens and were negative to PPD. Neither the skin tests nor the lymphocyte counts at this time gave useful prognostic information. In tests during and after therapy, the patients who responded and remained free of detectable disease had a higher incidence of DCHR to KLH and of rosette values in the normal range than did the patients who developed recurrent disease. The BCG immunotherapy had no apparent effect on immunologic parameters except for conversion of reactions to PPD.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46861/1/262_2004_Article_BF00200108.pd
Fractional Levy motion through path integrals
Fractional Levy motion (fLm) is the natural generalization of fractional
Brownian motion in the context of self-similar stochastic processes and stable
probability distributions. In this paper we give an explicit derivation of the
propagator of fLm by using path integral methods. The propagators of Brownian
motion and fractional Brownian motion are recovered as particular cases. The
fractional diffusion equation corresponding to fLm is also obtained.Comment: 9 pages, minor changes, published versio
Solar System Processes Underlying Planetary Formation, Geodynamics, and the Georeactor
Only three processes, operant during the formation of the Solar System, are
responsible for the diversity of matter in the Solar System and are directly
responsible for planetary internal-structures, including planetocentric nuclear
fission reactors, and for dynamical processes, including and especially,
geodynamics. These processes are: (i) Low-pressure, low-temperature
condensation from solar matter in the remote reaches of the Solar System or in
the interstellar medium; (ii) High-pressure, high-temperature condensation from
solar matter associated with planetary-formation by raining out from the
interiors of giant-gaseous protoplanets, and; (iii) Stripping of the primordial
volatile components from the inner portion of the Solar System by super-intense
solar wind associated with T-Tauri phase mass-ejections, presumably during the
thermonuclear ignition of the Sun. As described herein, these processes lead
logically, in a causally related manner, to a coherent vision of planetary
formation with profound implications including, but not limited to, (a) Earth
formation as a giant gaseous Jupiter-like planet with vast amounts of stored
energy of protoplanetary compression in its rock-plus-alloy kernel; (b) Removal
of approximately 300 Earth-masses of primordial gases from the Earth, which
began Earth's decompression process, making available the stored energy of
protoplanetary compression for driving geodynamic processes, which I have
described by the new whole-Earth decompression dynamics and which is
responsible for emplacing heat at the mantle-crust-interface at the base of the
crust through the process I have described, called mantle decompression
thermal-tsunami; and, (c)Uranium accumulations at the planetary centers capable
of self-sustained nuclear fission chain reactions.Comment: Invited paper for the Special Issue of Earth, Moon and Planets
entitled Neutrino Geophysics Added final corrections for publicatio
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults.
New neurons continue to be generated in the subgranular zone of the dentate gyrus of the adult mammalian hippocampus. This process has been linked to learning and memory, stress and exercise, and is thought to be altered in neurological disease. In humans, some studies have suggested that hundreds of new neurons are added to the adult dentate gyrus every day, whereas other studies find many fewer putative new neurons. Despite these discrepancies, it is generally believed that the adult human hippocampus continues to generate new neurons. Here we show that a defined population of progenitor cells does not coalesce in the subgranular zone during human fetal or postnatal development. We also find that the number of proliferating progenitors and young neurons in the dentate gyrus declines sharply during the first year of life and only a few isolated young neurons are observed by 7 and 13 years of age. In adult patients with epilepsy and healthy adults (18-77 years; n = 17 post-mortem samples from controls; n = 12 surgical resection samples from patients with epilepsy), young neurons were not detected in the dentate gyrus. In the monkey (Macaca mulatta) hippocampus, proliferation of neurons in the subgranular zone was found in early postnatal life, but this diminished during juvenile development as neurogenesis decreased. We conclude that recruitment of young neurons to the primate hippocampus decreases rapidly during the first years of life, and that neurogenesis in the dentate gyrus does not continue, or is extremely rare, in adult humans. The early decline in hippocampal neurogenesis raises questions about how the function of the dentate gyrus differs between humans and other species in which adult hippocampal neurogenesis is preserved
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