131 research outputs found
Degenerate ground state in the classical pyrochlore antiferromagnet NaMn(CO)Cl
In an ideal classical pyrochlore antiferromagnet without perturbations, an
infinite degeneracy at a ground state leads to absence of a magnetic order and
spin-glass transition. Here we present NaMn(CO)Cl as a new
candidate compound where classical spins are coupled antiferromagnetically on
the pyrochlore lattice, and report its structural and magnetic properties.The
temperature dependences of the magnetic susceptibility and heat capacity, and
the magnetization curve are consistent with those of an = 5/2 pyrochlore
lattice antiferromagnet with nearest-neighbor interactions of 2 K. Neither an
apparent signature of a spin-glass transition nor a magnetic order is detected
in magnetization and heat capacity measurements, or powder neutron diffraction
experiments. On the other hand, an antiferromagnetic short-range order from the
nearest neighbors is evidenced by the -dependence of the diffuse scattering
which develops around 0.85 \AA. A high degeneracy near the ground state
in NaMn(CO)Cl is supported by the magnetic entropy estimated as
almost 4 J K mol at 0.5 K.Comment: 9 pages, 7 figures, accepted to PR
The mean-field approximation model of company's income growth
We introduce a mean-field type approximation for description of company's
income statistics. Utilizing huge company data we show that a discrete version
of Langevin equation with additive and multiplicative noises can appropriately
describe the time evolution of a company's income fluctuation in statistical
sense. The Zipf's law of income distribution is shown to be hold in a
steady-sate widely, and country-dependence of income distribution can also be
nicely implemented in our numerical simulation.Comment: 10 pages, 7 figures, submitted to Physics
Disease-Association Analysis of an Inflammation-Related Feedback Loop
SummaryThe IL-6-triggered positive feedback loop for NFκB signaling (or the IL-6 amplifier/Inflammation amplifier) was originally discovered as a synergistic-activation signal that follows IL-17/IL-6 stimulation in nonimmune cells. Subsequent results from animal models have shown that the amplifier is activated by stimulation of NFκB and STAT3 and induces chemokines and inflammation via an NFκB loop. However, its role in human diseases is unclear. Here, we combined two genome-wide mouse screens with SNP-based disease association studies, revealing 1,700 genes related to the IL-6 amplifier, 202 of which showed 492 indications of association with ailments beyond autoimmune diseases. We followed up on ErbB1 from our list. Blocking ErbB1 signaling suppressed the IL-6 amplifier, whereas the expression of epiregulin, an ErbB1 ligand, was higher in patients with inflammatory diseases. These results indicate that the IL-6 amplifier is indeed associated with human diseases and disorders and that the identified genes may make for potential therapeutic targets
No Go Theorem for Kinematic Self-Similarity with A Polytropic Equation of State
We have investigated spherically symmetric spacetimes which contain a perfect
fluid obeying the polytropic equation of state and admit a kinematic
self-similar vector of the second kind which is neither parallel nor orthogonal
to the fluid flow. We have assumed two kinds of polytropic equations of state
and shown in general relativity that such spacetimes must be vacuum.Comment: 5 pages, no figures. Revtex. One word added to the title. Final
version to appear in Physical Review D as a Brief Repor
Prevalence of and risk factors for postoperative complications after lower third molar extraction : A multicenter prospective observational study in Japan
Lower third molar extraction is the most common surgical treatment among routine dental and oral surgical procedures. while the surgical procedures for lower third molar extraction are well established, the difficulty of tooth extraction and the frequency of postoperative complications differ depending on the patient’s background. To establish a management protocol for the lower third molars, the prevalence of and risk factors for postoperative complications after lower third molar extraction were investigated in a large number of Japanese patients in a multicenter prospective study. During 6 consecutive months in 2020, 1826 lower third molar extractions were performed at the 20 participating institutions. The medical records of the patients were reviewed, and relevant data were extracted. The prevalence of and risk factors for postoperative complications were analyzed. The prevalence of postoperative complications after lower third molar extraction was 10.0%. Multivariate analysis indicated that age (≤32 vs >32, odds ratio [OR]: 1.428, 95% confidence interval [95% CI]: 1.040–1.962, P < .05), the radiographic anatomical relationship between the tooth roots and mandibular canal (overlapping of the roots and canal vs no close anatomical relationship between the roots and the superior border of the canal, OR: 2.078, 95% CI: 1.333–3.238, P < .01; overlapping of the roots and canal vs roots impinging on the superior border of the canal, OR: 1.599, 95% CI: 1.050–2.435, P < .05), and impaction depth according to the Pell and Gregory classification (position C vs position A, OR: 3.7622, 95% CI: 2.079–6.310, P < .001; position C vs position B, OR: 2.574, 95% CI: 1.574–4.210, P < .001) are significant independent risk factors for postoperative complications after lower third molar extraction. These results suggested that higher age and a deeply impacted tooth might be significant independent risk factors for postoperative complications after lower third molar extraction
Local microbleeding facilitates IL-6– and IL-17–dependent arthritis in the absence of tissue antigen recognition by activated T cells
Local microbleeding induces the accumulation of Th17 cells and the development of IL-17– and IL-6–dependent arthritis in the absence of cognate antigen recognition by CD4+ T cells
Clinical practice guideline for drug-induced kidney injury in Japan 2016: digest version
Approximately one in eight adults has chronic kidney disease (CKD) in Japan, and the prevalence rate is expected to rise steeply due to the aging of the population in this country. In patients with CKD, quite a few medications require the dosage reduction or discontinuation because of their reduced urinary excretion and the increased risk of further renal impairment. Therefore, CKD patients are often treated by insufficient amounts of the medications, even though they may suffer from various complications. Moreover, it is empirically known that drug-induced kidney injury (DKI) accelerates the progression of renal failure, while it is not superficially ranked as a primary cause of kidney disease.In this context, the early detection, prevention, and treatment of DKI are very important issue in preventing the progression of CKD and the development of renal failure. However, there are no comprehensive and practical guideline on the diagnosis and treatment of DKI for CKD patients and on dosage adjustments for these patients.In response to this need, a clinical practice guideline for DKI was developed with the support of a Health and Labour Science Research Grant from the Ministry of Health, Labour, and Welfare (MHLW) and the Japan Agency for Medical Research and Development (AMED) for Practical Research Project for Renal Diseases, “Early detection and treatment of drug-induced kidney injury that aggravate chronic kidney disease.” This guideline was established by doing a clinical survey on DKIs, evaluating clinicopathological factors, investigating the methods of the early detection of the disease, and analyzing animal models. The present article represents a Committee of Clinical Practice Guideline for DKI. We collected supportive evidence and analyzed data, focusing on several clinical questions that have practical importance
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