420 research outputs found

    Flow Characteristics of Oil Film in Suction Line of Refrigeration Cycle

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    Produksi Kamus Kanhan500

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    Indonesian Kanji dictionaries that were found in the bookstore during this sequence only present way of writing and examples of using the Kanji letters. We have not found a dictionary that describes how to learn kanji effectively as a way to remember kanji. In addition, examples of using Kanji letters did not focus on vocabulary learning based on the level of the level of Japanese language learning, vocabulary should be memorized beforehand was also not included. Until now there are so many Indonesian Japanese language learners who have difficulties in learning kanji. Actually, studying Japanese kanji means we will be able to guess the vocabulary of the Korean language because a lot of similarities between Japanese and Korean vocabulary. Thus, the need for kanji dictionary compiled not only present how to write Kanji and examples of using Kanji letters but also how to remember the kanji, and division level based vocabulary. Therefore, we try to make the dictionary and have purpose of: 1 Provides media that can facilitate learners understand and remember Japanese kanji. 2 Provide instructional media can also enrich the science of Japanese language learners with vocabulary presented Sino Korea, making it easier to learn Korean vocabulary. 3 Adding references and resources kanji that have not featured in publications kanji dictionaries Indonesia. Method that was used to make this dictionary is a method of learning kanji by drawing the kanji origins and reminders words. The words made a principled reminder on the origins of Kanji is Shoukei Moji, Shiji Moji, Kai-I Moji, and Keisei moji. However, these reminders words also made based on our creativity to make it easier to remember the kanji learners. Thus, studying kanji in this way will definitely make kanji learners easily remember the form of starch

    Comparison of different methods of temporomandibular joint disc reconstruction - An animal model

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    The document attached has been archived with permission from the Australian Dental Association. An external link to the publisher’s copy is included. Article first published online: 12 MAR 2008The optimum method of temporomandibular joint (TMJ) reconstruction has not been defined despite numerous surgical treatments and several well controlled clinical trials. Animal models offer an experimental method allowing direct comparison of standardized surgical techniques. Advanced osteoarthrosis was induced bilaterally in 12 mature merino sheep. Three months later unilateral surgical reconstruction was performed. Four sheep had discectomy alone, four discectomy with fresh TMJ disc grafts, and four discectomy with fresh auricular grafts. All three surgical methods resulted in some reversal and repair of the osteoarthritic process, with the best result being from the auricular graft, next discectomy alone, next the disc graft, with the untreated osteoarthritic joint showing the most advanced pathosis. This study supports the role of surgical reconstruction in advanced degenerative disease of the temporomandibular joint, in particular, auricular graft reconstruction.Nobumi Ogi, Jun-Ichi Ishimaru, Kenichi Kurita, Yujiro Handa, Robert H.B. Jones, Alastair N. Gos

    Analisis dan Pengembangan Sistem Manajemen Pengetahuan Berbasis Perangkat Lunak Open Source (Studi Kasus)

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    Penelitian ini akan memaparkan proses identifikasi dan kategorisasi pengetahuan yang di miliki oleh PT XYZ sebagai objek penelitian, dimana Perusahaan ini membutuhkan wadah yang mendukung sharing knowledge untuk pendokumentasian dan pendistribusian pengetahuan yang ada pada Perusahaan tersebut, serta menerapkan sistem open source untuk mengelola pengetahuan secara mandiri dan terpusat. Metode penelitian yang dilakukan adalah dengan Inukshuk KM Model. Metode pengumpulan data yang digunakan adalah wawancara dan observasi. Hasil yang dicapai dari penelitian ini adalah tersedianya wadah untuk menyimpan dan mengelola pengetahuan yang mudah diakses oleh pengguna. Dengan pengimplementasian sistem manajemen pengetahuan ini diharapkan dapat meningkatan kualitas sharing knowledge antar karyawan, serta meningkatan kualitas knowledge content yang terdapat didalam Perusahaan

    Detection of a climatological short break in the polar night jet in early winter and its relation to cooling over Siberia

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    The polar night jet (PNJ) is a strong stratospheric westerly circumpolar wind at around 65°&thinsp;N in winter, and the strength of the climatological PNJ is widely recognized to increase from October through late December. Remarkably, the climatological PNJ temporarily stops increasing during late November. We examined this short break in terms of the atmospheric dynamical balance and the climatological seasonal march. We found that it results from an increase in the upward propagation of climatological planetary waves from the troposphere to the stratosphere in late November, which coincides with a maximum of the climatological Eliassen–Palm (EP) flux convergence in the lower stratosphere. The upward propagation of planetary waves at 100&thinsp;hPa, which is strongest over Siberia, is related to the climatological strengthening of the tropospheric trough over Siberia. We suggest that longitudinally asymmetric forcing by land–sea heating contrasts caused by their different heat capacities can account for the strengthening of the trough.</p

    The role of Schizosaccharomyces pombe SUMO ligases in genome stability

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    SUMOylation is a post-translational modification that affects a large number of proteins, many of which are nuclear. While the role of SUMOylation is beginning to be elucidated, it is clear that understanding the mechanisms that regulate the process is likely to be important. Control of the levels of SUMOylation is brought about through a balance of conjugating and deconjugating activities, i.e. of SUMO (small ubiquitin-related modifier) conjugators and ligases versus SUMO proteases. Although conjugation of SUMO to proteins can occur in the absence of a SUMO ligase, it is apparent that SUMO ligases facilitate the SUMOylation of specific subsets of proteins. Two SUMO ligases in Schizosaccharomyces pombe, Pli1 and Nse2, have been identified, both of which have roles in genome stability. We report here on a comparison between the properties of the two proteins and discuss potential roles for the proteins

    Ray-Tracing Simulation and In-Orbit Performance of the ASTRO-H Hard X-Ray Telescope (HXT)

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    A ray-trace simulation code for the Hard X-ray Telescope (HXT) on board the Hitomi (ASTRO-H) satellite is beingdeveloped. The half power diameter and effective area simulated based on the code are consistent with groundmeasurements within 10%. The HXT observed the pulsar wind nebula G21.5-0.9 for 105 ksec. We confirmed that theencircled energy function and the half power diameter obtained from the data are consistent with the ground measurements

    Beyond translesion synthesis: polymerase κ fidelity as a potential determinant of microsatellite stability

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    Microsatellite DNA synthesis represents a significant component of human genome replication that must occur faithfully. However, yeast replicative DNA polymerases do not possess high fidelity for microsatellite synthesis. We hypothesized that the structural features of Y-family polymerases that facilitate accurate translesion synthesis may promote accurate microsatellite synthesis. We compared human polymerases κ (Pol κ) and η (Pol η) fidelities to that of replicative human polymerase δ holoenzyme (Pol δ4), using the in vitro HSV-tk assay. Relative polymerase accuracy for insertion/deletion (indel) errors within 2–3 unit repeats internal to the HSV-tk gene concurred with the literature: Pol δ4 >> Pol κ or Pol η. In contrast, relative polymerase accuracy for unit-based indel errors within [GT]10 and [TC]11 microsatellites was: Pol κ ≥ Pol δ4 > Pol η. The magnitude of difference was greatest between Pols κ and δ4 with the [GT] template. Biochemically, Pol κ displayed less synthesis termination within the [GT] allele than did Pol δ4. In dual polymerase reactions, Pol κ competed with either a stalled or moving Pol δ4, thereby reducing termination. Our results challenge the ideology that pol κ is error prone, and suggest that DNA polymerases with complementary biochemical properties can function cooperatively at repetitive sequences

    Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome

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    A homozygous mutational change in the Ataxia-Telangiectasia and RAD3 related (ATR) gene was previously reported in two related families displaying Seckel Syndrome (SS). Here, we provide the first identification of a Seckel Syndrome patient with mutations in ATRIP, the gene encoding ATR-Interacting Protein (ATRIP), the partner protein of ATR required for ATR stability and recruitment to the site of DNA damage. The patient has compound heterozygous mutations in ATRIP resulting in reduced ATRIP and ATR expression. A nonsense mutational change in one ATRIP allele results in a C-terminal truncated protein, which impairs ATR-ATRIP interaction; the other allele is abnormally spliced. We additionally describe two further unrelated patients native to the UK with the same novel, heterozygous mutations in ATR, which cause dramatically reduced ATR expression. All patient-derived cells showed defective DNA damage responses that can be attributed to impaired ATR-ATRIP function. Seckel Syndrome is characterised by microcephaly and growth delay, features also displayed by several related disorders including Majewski (microcephalic) osteodysplastic primordial dwarfism (MOPD) type II and Meier-Gorlin Syndrome (MGS). The identification of an ATRIP-deficient patient provides a novel genetic defect for Seckel Syndrome. Coupled with the identification of further ATR-deficient patients, our findings allow a spectrum of clinical features that can be ascribed to the ATR-ATRIP deficient sub-class of Seckel Syndrome. ATR-ATRIP patients are characterised by extremely severe microcephaly and growth delay, microtia (small ears), micrognathia (small and receding chin), and dental crowding. While aberrant bone development was mild in the original ATR-SS patient, some of the patients described here display skeletal abnormalities including, in one patient, small patellae, a feature characteristically observed in Meier-Gorlin Syndrome. Collectively, our analysis exposes an overlapping clinical manifestation between the disorders but allows an expanded spectrum of clinical features for ATR-ATRIP Seckel Syndrome to be define
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