Electrical neuroimaging of music processing reveals mid-latency changes with level of musical expertise

This original research focused on the effect of training intensity on cerebral and behavioral processing of complex music using high-density event-related potential (ERP) approaches. Recently we have been able to show progressive changes with training in grey and white matter and higher order brain functioning using (f)MRI ((functional) Magnetic Resonance Imaging), as well as changes in musical and general cognitive functioning. The current study investigated the same population of non-musicians, amateur pianists and expert pianists using spatio-temporal ERP analysis, by means of microstate analysis, and ERP source imaging. The stimuli consisted of complex musical compositions containing three levels of transgression of musical syntax at closure that participants appraised. ERP waveforms, microstates and underlying brain sources revealed gradual differences according to expertise in a 300-500 ms window after the onset of the terminal chords of the pieces. Within this time-window, processing seemed to concern context-based memory updating, indicated by a P3b-like component or microstate for which underlying sources were localized in right middle temporal gyrus, anterior cingulate and right parahippocampal areas. Given that the 3 expertise groups were carefully matched for demographic factors, these results provide evidence of the progressive impact of training on brain and behavior

Pretransplant malignancy in candidates and posttransplant malignancy in recipients of cardiac transplantation

Background: Malignancy is generally considered a contraindication for cardiac transplantation, whereas secondary malignancy has been described under chronic immunosuppression. Patients and methods: We report here the frequency of malignancy encountered among the 495 patients evaluated at our cardiac transplant centre as well as the incidence and the course of post-transplant malignancy among 129 consecutive patients who underwent cardiac transplantation, with a subsequent minimum follow-up of 6 months. Results: A total of 10 out of 495 patients (2%) evaluated for heart transplantation presented with a history of previous malignancy: 3 of them underwent transplantation (2 survive, 1 died) whereas in the remaining 7 patients neoplasia was considered a contraindication for cardiac transplantation, and all 7 died (4 cardiac, 3 tumor-related deaths). Post-transplant malignancy was diagnosed in 10 of 129 patients (9%) 35 ± 15 months after transplantation (6 skin cancers, 1 lymphoproliferative disease, 3 solid tumors). No significant association was found between post-transplant malignancy and primary prophylaxis with antithymocyte globulin (ATG) or murine antihuman T-cell monoclonal antibodies (OKT3). Conclusions: These results confirm that pre-transplant malignancy is not an absolute contraindication for cardiac transplantation and that post-transplant follow-up must include careful monitoring of post-transplant malignanc

Local simulations of the magnetized Kelvin-Helmholtz instability in neutron-star mergers

Context. Global MHD simulations show Kelvin-Helmholtz (KH) instabilities at the contact surface of two merging neutron stars. That region has been identified as the site of efficient amplification of magnetic fields. However, these global simulations, due to numerical limitations, were unable to determine the saturation level of the field strength, and thus the possible back-reaction of the magnetic field onto the flow. Aims. We investigate the amplification of initially weak fields in KH unstable shear flows, and the back-reaction of the field onto the flow. Methods. We use a high-resolution ideal MHD code to perform 2D and 3D local simulations of shear flows. Results. In 2D, the magnetic field is amplified in less than 0.01ms until it reaches locally equipartition with the kinetic energy. Subsequently, it saturates due to resistive instabilities that disrupt the KH vortex and decelerate the shear flow on a secular time scale. We determine scaling laws of the field amplification with the initial field strength and the grid resolution. In 3D, this hydromagnetic mechanism may be dominated by purely hydrodynamic instabilities limiting the amplification. We find maximum magnetic fields of 10^16 G locally, and r.m.s. maxima within the box of 10^15 G. However, such strong fields exist only for a short period. In the saturated state, the magnetic field is mainly oriented parallel to the shear flow for strong initial fields, while weaker initial fields tend to lead to a more balanced distribution of the field energy. In all models the flow shows small-scale features. The magnetic field is at most in equipartition with the decaying shear flow. (abridged)Comment: 26 pages, 22 figures (figure quality reduced); accepted for publication in Astronomy & Astrophysic

The Relationship of Left Ventricular Trabeculation to Ventricular Function and Structure Over a 9.5-Year Follow-Up The MESA Study

Left ventricular (LV) trabeculation is highly variable among individuals and is increased in some diseases (e.g., congenital heart disease or cardiomyopathies), but its significance in population-representative individuals is unknown

Left ventricular non-compaction: clinical features and cardiovascular magnetic resonance imaging

Background: It is apparent that despite lack of family history, patients with the morphological characteristics of left ventricular non-compaction develop arrhythmias, thrombo-embolism and left ventricular dysfunction. METHODS: Forty two patients, aged 48.7 +/- 2.3 yrs (mean +/- SEM) underwent cardiovascular magnetic resonance (CMR) for the quantification of left ventricular volumes and extent of non-compacted (NC) myocardium. The latter was quantified using planimetry on the two-chamber long axis LV view (NC area). The patients included those referred specifically for CMR to investigate suspected cardiomyopathy, and as such is represents a selected group of patients. RESULTS: At presentation, 50% had dyspnoea, 19% chest pain, 14% palpitations and 5% stroke. Pulmonary embolism had occurred in 7% and brachial artery embolism in 2%. The ECG was abnormal in 81% and atrial fibrillation occurred in 29%. Transthoracic echocardiograms showed features of NC in only 10%. On CMR, patients who presented with dyspnoea had greater left ventricular volumes (both p < 0.0001) and a lower left ventricular ejection fraction (LVEF) (p < 0.0001) than age-matched, healthy controls. In patients without dyspnoea (n = 21), NC area correlated positively with end-diastolic volume (r = 0.52, p = 0.0184) and end-systolic volume (r = 0.56, p = 0.0095), and negatively with EF (r = -0.72, p = 0.0001). CONCLUSION: Left ventricular non-compaction is associated with dysrrhythmias, thromboembolic events, chest pain and LV dysfunction. The inverse correlation between NC area and EF suggests that NC contributes to left ventricular dysfunction

Cardiac outcomes in adults with supravalvar aortic stenosis

Aims Supravalvar aortic stenosis is a rare form of left ventricular outflow tract obstruction that is often progressive in childhood. Little data are available on outcomes in the adult population. Our aim was to define cardiac outcomes in adults with supravalvar aortic stenosis. Methods and results This is a multicentre retrospective study of cardiac outcomes in adults (≥18 years) with supravalvar aortic stenosis. We examined: (i) adverse cardiac events (cardiovascular death, myocardial infarction, stroke, heart failure, sustained arrhythmias, and infective endocarditis) and (ii) the need for cardiac surgery in adulthood. One hundred and thirteen adults (median age at first visit 19 years; 55% with Williams-Beuren syndrome; 67% with surgical repair in childhood) were identified. Adults without Williams-Beuren syndrome had more severe supravalvar aortic stenosis and more often associated left ventricular outflow tract obstructions (P < 0.001). In contrast, mitral valve regurgitation was more common in patients with Williams-Beuren syndrome. Eighty-five per cent of adults (96/113) had serial follow-up information (median follow-up 6.0 years). Of these patients, 13% (12/96) had an adverse cardiac event and 13% (12/96) had cardiac operations (7 valve repair or replacements, 4 supravalvar aortic stenosis repairs, 1 other). Cardiac surgery was more common in adults without Williams-Beuren syndrome (P = 0.007). Progression of supravalvar aortic stenosis during adulthood was rare. Conclusion Adults with supravalvar aortic stenosis remain at risk for cardiac complications and reoperations, while progression of supravalvar aortic stenosis in adulthood is rare. Valve surgery is the most common indication for cardiac surgery in adulthoo

Neutron-Rich Freeze-Out in Viscously Spreading Accretion Disks Formed from Compact Object Mergers

Accretion disks with masses ~0.001-0.1 Msun form during the merger of neutron star (NS)-NS and black hole-NS binaries. Initially, such hyper-accreting disks cool efficiently by neutrino emission and their composition is driven neutron-rich by pair captures under degenerate conditions. However, as the disk viscously spreads and its temperature drops, cooling becomes inefficient and the disk becomes advective. Analytic arguments and numerical simulations suggest that once this occurs, powerful winds likely drive away most of the disk's remaining mass. We calculate the thermal evolution and nuclear composition of viscously spreading accretion disks formed from compact object mergers using one-dimensional height-integrated simulations. We show that freeze-out from weak equilibrium necessarily accompanies the disk's late-time transition to an advective state. As a result, hyper-accreting disks generically freeze out neutron-rich (with electron fraction Ye ~ 0.2-0.4), and their late-time outflows robustly synthesize rare neutron-rich isotopes. Using the measured abundances of these isotopes in our solar system, we constrain the compact object merger rate in the Milky Way to be < 1e-5 (M_d,0/0.1 Msun)^(-1) per year, where M_d,0 is the average initial mass of the accretion disk. Thus, either the NS-NS merger rate is at the low end of current estimates or the average disk mass produced during a typical merger is << 0.1 Msun. We also show that if most short duration gamma-ray bursts (GRBs) are produced by compact object mergers, their beaming fraction must exceed f_b ~ 0.13(M_d,0/0.1 Msun), corresponding to a jet half-opening angle > 30(M_d,0/0.1 Msun)^(1/2) degrees. This is consistent with other evidence that short duration GRB outflows are less collimated than those produced in long duration GRBs.Comment: 12 pages, 9 figures, 1 table; accepted to MNRAS; minor changes to text and figure