Overview of Hybrid Ventilation Control System and Full Scale Monitoring

Mix-mode or hybrid ventilation systems have been previously shown to reduce cooling and ventilation energy consumption. This paper presents a case study of a new ten story 83,700 ft² (7,780 m²) office building in downtown Tokyo with a hybrid ventilation system that uses only 1.7% of the building footprint for ventilation shafts. The control system design is presented as an example of balancing the comfort expectations of multiple tenants in a mix-mode system. On-site measurements are presented from a three week commissioning project to show: modest temperature differences within the occupied zone with a maximum difference of 1.5 °F (0.83 °C), large differences of up to 6.1 °F (3.4 °C) between the measured outdoor temperature in the control system and the actual inlet temperature for the natural ventilation system, the importance of smooth integration of various design teams, and the use of low-power fans, 1.2-0.60 hp (900-450 W), that leverage the low pressure drop through the building when natural driving forces are insufficient for pure natural ventilation. Practical lessons learned from the design and commissioning of the building are also shared.Hulic Co., Ltd

経頸静脈的肝内門脈大循環短絡術が著効した難治性腹水の1例

京都府立医科大学附属北部医療センター放射線科京都府立医科大学附属北部医療センター外科京都府立医科大学大学院医学研究科放射線診断治療学京都府立医科大学大学院医学研究科消化器外科学市立福知山市民病院腫瘍内科市立福知山市民病院放射線科Department of Radiology, North Medical Center, Kyoto Prefectural University of MedicineDepartment of Surgery, North Medical Center, Kyoto Prefectural University of MedicineDepartment of Radiology, Kyoto Prefectural University of MedicineDepartment of Digestive Surgery, Kyoto Prefectural University of MedicineDepartment of Medical Oncology, Fukuchiyama City HospitalDepartment of Medical Radiology, Fukuchiyama City Hospital切除不能肝内胆管癌の58 歳男性に難治性腹水を生じ、著明な腹部膨満感に対し頻回な穿刺排液を要した。腹水性状は漏出性で進行した肝病変による門脈圧亢進症に起因すると判断した。介入治療として経頸静脈的肝内門脈大循環短絡術を適用した。腹部膨満感のNRS は9 から1 に低下し、35 日後の原病死まで有害事象や症状再発なく経過した。難治性腹水に対する介入治療には、腹水の性状診断を含めて治療方針を決定することが重要である

Characterization of Nuclear Import of the Domain-Specific Androgen Receptor in Association with the Importin α/β and Ran-Guanosine 5′-Triphosphate Systems

Androgen induces androgen receptor (AR) nuclear import, which allows AR to act as a transcriptional factor and ultimately leads to biological activity. However, the mechanism of AR translocation to the nucleus is still unclear. In the present study, we assessed the nuclear import abilities of each domain of AR and their mechanisms related to Ran and importin α/β using green fluorescent protein real-time imaging. The localization of AR to the nucleus in the absence and presence of ligands was dependent upon a complex interplay of the amino terminal transactivation domain (NTD), the DNA binding domain (DBD), and the ligand binding domain (LBD). NTD and DBD showed ligand-independent nuclear import ability, whereas LBD had ligand-dependent transport. In addition, AR deletion mutant lacking DBD was distributed in the cytoplasm regardless of ligand existence, suggesting that the remaining domains, NTD and LBD, are responsible for AR cytoplasmic localization. Cotransfection with a dominant negative form of Ran dramatically inhibited the nuclear import of all AR domains, and a dominant negative form of importin α prevented AR and DBD import. Importin β-knockdown strongly blocked DBD import. These results indicate that there are two additional nuclear localization signals (NLSs) in the NTD and LBD, and there are distinct pathways used to attain domain-specific AR nuclear import: the NLS of DBD is Ran and importin α/β-dependent, whereas the NLSs of NTD and LBD are Ran dependent but importin α/β-independent. Our data suggest that the nuclear import of AR is regulated by the interplay between each domain of the AR