Numerical Solutions of Matrix Differential Models using Cubic Matrix Splines II

This paper presents the non-linear generalization of a previous work on matrix differential models. It focusses on the construction of approximate solutions of first-order matrix differential equations Y'(x)=f(x,Y(x)) using matrix-cubic splines. An estimation of the approximation error, an algorithm for its implementation and illustrative examples for Sylvester and Riccati matrix differential equations are given.Comment: 14 pages; submitted to Math. Comp. Modellin

Characterization of the Burkholderia cenocepacia J2315 Surface-Exposed Immunoproteome

Infections by the Burkholderia cepacia complex (Bcc) remain seriously life threatening to cystic fibrosis (CF) patients, and no effective eradication is available. A vaccine to protect patients against Bcc infections is a highly attractive therapeutic option, but none is available. A strategy combining the bioinformatics identification of putative surface-exposed proteins with an experimental approach encompassing the “shaving” of surface-exposed proteins with trypsin followed by peptide identification by liquid chromatography and mass spectrometry is here reported. The methodology allowed the bioinformatics identification of 263 potentially surface-exposed proteins, 16 of them also experimentally identified by the “shaving” approach. Of the proteins identified, 143 have a high probability of containing B-cell epitopes that are surface-exposed. The immunogenicity of three of these proteins was demonstrated using serum samples from Bcc-infected CF patients and Western blotting, validating the usefulness of this methodology in identifying potentially immunogenic surface-exposed proteins that might be used for the development of Bcc-protective vaccines

Upconverting Carbon Nanodots from EDTA as Near-Infrared Activated Phototheranostic Agents

This work describes the synthesis of nitrogen-doped carbon nanodots (CNDs) synthesized from ethylene diamine tetra acetic acid (EDTA) as a precursor and their application as luminescent agents with a dual-mode theranostic role as near-infrared (NIR) triggered imaging and photodynamic therapy agents. Interestingly, these fluorescent CNDs are more rapidly and selectively internalized in tumor cells and exhibit no cytotoxicity until remotely activated with a NIR illumination source. These CNDs are excellent candidates for photo-theranostic purposes, i.e.: simultaneous imaging and therapy can be carried out on cancer cells using their luminescent properties and the in situ generation of reactive oxidative species (ROS) upon excitation in the NIR range. In the presence of CNDs NIR remote activation induces the in vitro killing of U251 MG cells. Through the use of flow imaging cytometry we have been able to successfully map and quantify the different type of cell deaths induced by the presence of intracellular superoxide anions (¿O2-) and hydrogen peroxide (H2O2) ROS species generated in situ upon NIR irradiation

CRC general comments on children's health, impact of the business sector and the right to rest, leisure and play.

In April 2013, the UN Committee on the Rights of the Child (CRC) published the three General Comments which had been adopted at its 62nd session. General comments 15, 16 and 17 relate to the right of the child to enjoyment of the highest attainable standard of health; on State obligations regarding the impact of the business sector on children’s’ rights; and the right of the child to rest, leisure, play, recreational activities, cultural life and the arts, respectively

Caractérisation électrocinétique et thermodynamique de l'interface polypropylène/acides humiques

El presente trabajo muestra resultados acerca del comportamiento de las propiedades eléctricas y de la energía libre superficial en los procesos de adsorción de ácidos húmicos (AH) y diferentes electrolitos sobre las fibras de polipropileno. El propósito de este trabajo es conocer las propiedades de la superficie del polipropileno (PP) y los cambios que éstas experimentan cuando las fibras están en contacto con diferentes concentraciones de ácido húmico y diferentes cationes que son comunes en los suelos. Estos resultados son de gran interés para las aplicaciones del PP como geotextil. Los resultados muestran que el potencial zeta del sistema PP/AH decrece con la concentración de AH en disolución. Este hecho puede ser atribuido a la presencia de grupos carboxílicos COO- y hidroxilfenolicos presentes en la molécula de AH. Por otro lado, el pH de las disoluciones de ácido húmico tiene gran efecto en el potencial electrocinético del PP, debido probablemente a la presencia de los grupos de AH adsorbidos sobre la superficie del polipropileno. El análisis de la energía libre superficial de los sistemas PP/AH/electrolitos nos lleva a la conclusión de que el polipropileno es un material monopolar. Los valores bajos de la componente electrón donante, γ - , de la energía libre superficial nos llevan a la conclusión de que el material es fuertemente hidrófobo y que este carácter se incrementa con la adsorción de ácido húmico sobre las fibras.We present results about the electrokinetic properties and the behaviour of the surface free energy in the adsorption process of humic acid and different electrolytes onto polypropylene fibres. The aim of this investigation is to know the surface properties of polypropylene and the changes in these properties when these fibres are in contact with different concentrations of humic acid and different cations which are present in the ground for the application of the polypropylene fibres as geotextiles. The negative zeta potential of the Polypropylene / humic acid system decreases with the concentration of humic acid in solution. This fact can be attributed to the presence of both carboxyl COO- and phenolic hydroxyl groups in the macromolecule of humic acid. On the other hand, the pH of the humic acid solution greatly affects the electrokinetic potential of polypropylene fibres. The above groups of humic acid are responsible for the variation in the zeta potential of the polypropylene fibre with the pH of the liquid phase. The analysis of the surface free energy of the polypropylene/humic acid/electrolytes systems, leads to the conclusion that the polypropylene fibres it is presented as a monopolar material. The low values of the electrondonor component, γ - , of the surface free energy in the adsorption processes of humic acid and different electrolyte lead to the conclusion that this material is strongly hydrophobic and this character is increased by the adsorption of the humic acid onto the fibre.Le présent travail montre des résultats sur le comportement des propriétés électriques et de l'énergie libre superficielle dans les processus d'adsorption d'acides humiques (AC) et différents électrolytes sur les fibres de polypropylène. Le but de ce travail est de connaître les propriétés de la surface du polypropylène (PP) et les changements que celles-ci expérimentent quand les fibres sont en contact avec de différentes concentrations d'acide humique et de différents cations qui sont communs dans les sols. Ces résultats sont de grand intérêt pour les applications du PP comme géotextile Les résultats montrent que le potentiel zêta du système PP/AH diminue avec la concentration d'AH en dissolution. Ce fait peut être attribué à la présence de groupes carboxiliques COO- et hidroxilfenoliques présents dans la molécule d'AH. D'autre part, le pH des dissolutions d'acide humique a un grand effet dans le potentiel électrocinétic du PP, dû probablement à la présence des groupes d'AH adsorbés sur la surface du polypropylène. L'analyse de l'énergie libre superficielle des systèmes PP/AH/électrolytes nous apporte à la conclusion que le polypropylène est un matériel monopolaire. Les valeurs basses de la composante électron donneuse, de l'énergie libre superficielle nous apportent à la conclusion que le matériel est hydrophobe de façon forte et que ce caractère est augmenté avec l'adsorption d'acide humique sur les fibres.Peer Reviewe

A competitive family to the Beta and Kumaraswamy generators: Properties, Regressions and Applications

Abstract We define two new flexible families of continuous distributions to fit real data by compoun-ding the Marshall–Olkin class and the power series distribution. These families are very competitive to the popular beta and Kumaraswamy generators. Their densities have linear representations of exponentiated densities. In fact, as the main properties of thirty five exponentiated distributions are well-known, we can easily obtain several properties of about three hundred fifty distributions using the references of this article and five special cases of the power series distribution. We provide a package implemented in R software that shows numerically the precision of one of the linear representations. This package is useful to calculate numerical values for some statistical measurements of the generated distributions. We estimate the parameters by maximum likelihood. We define a regression based on one of the two families. The usefulness of a generated distribution and the associated regression is proved empirically

Superficial radiotherapy as haemostatic treatment in breast cancer

Poster Session [EP-1661] Purpose or Objective Breast cancer is a common pathology in which o = 25% in tumor size and absence of bleeding was observed. Conclusion Surface radiotherapy is a treatment modality that should be taken into account in patients with breast cancer who present bleeding as a consequence of local tumor growth, given that this is a treatment comfortable for the patient, non invasive and increases the quality of patient’s life