97 research outputs found
Aversion-related effects of kappa-opioid agonist U-50488 on neural activity and functional connectivity between amygdala, ventral tegmental area, prefrontal cortex, hippocampus, and nucleus accumbens
This paper aims to provide an understanding of the neural activity underlying the aversion-associated effects of the KOR agonist U-5048
Effects of kappa-opioid agonist U-50488 and p38 MAPK inhibitor SB203580 on the spike activity of pyramidal neurons in the basolateral amygdala
Our study found that the KOR agonist-induced spiking activity of the BLA pyramidal neurons is mediated by the beta-arrestin pathway and can be suppressed by the application of the p38 MAPK inhibitor SB20358
Effect of Clozapine and 5-NT2A-Antagonist RU-31 on electroencephalography and Motor Activity of Rats in a Model of Schizophrenia with Neonatal Destruction of the Ventral Hippocampus
Background. Schizophrenia is a socially signifi cant disease that takes a variety of forms. The form of the course determines prescribing antipsychotic drugs with a different range of clinical effects. The study of the pharmacological activity of neuroleptics involves an experimental model using animals which makes it possible to reproduce some aspects of schizophrenia.Objectives. The study is aimed at evaluating the antipsychotic activity of 5-HT2A— RU-31 antagonist and atypical neuroleptic clozapine in behavioral tests and electroencephalography (EEG).Methods. The research methodology involved a dysontogenetic model of schizophrenia, implemented via aspiration destruction of the ventral hippocampus of rats on day 7 of postnatal development. The study was carried out on white outbred male rats selected from the offspring of females, represented by a simple random sample, provided by Rappolovo animal breeding facility of the National Research Center “Kurchatov Institute”. Injection of the studied substances was initiated on day 35 of postnatal development. Motor activity was assessed on day 54 of postnatal development in the Open Field unit and included assessing vertical motor activity, measured as the number of acts of verticalization in 5 minutes, and horizontal motor activity of rats, recorded as the number of crossed squares in 5 minutes. EEG signals were recorded on day 55 of postnatal development; thereafter the spectral density was calculated in the delta- (д) (0.4–4 Hz), theta- (и) (4.8–8 Hz), alpha- (б) (8–12 Hz) and beta- (в) (12–30 Hz) frequency ranges and the effect of the “operation” and “substance” factors on spectral density was evaluated in comparison with control groups. Statistical data processing was performed using GraphPad Prism 9 (Insight Partners, USA).Results. The antipsychotic activity of 1-(2-diethylaminoethyl)-2-(4-methoxyphenyl)-imidazo[1,2-a] benzimidazole — RU-31 compound with 5-HT2A-antagonistic mechanism of action was evaluated. RU-31 compound (10 mg/kg, intraperitoneally (i.p.)) statistically signifi cantly reduced vertical and horizontal spontaneous locomotor activity in rats with psychotic disorder by 18.8% and 20.9%, while the atypical neuroleptic clozapine (2 mg/kg, i.p.) signifi cantly reduced these values by 41.15% and 27.67%, respectively. The 5-HT2A-receptor antagonist RU-31 increased EEG signal power in the delta range by 123.33% and decreased it in the alpha range by 41.86% in surgically operated animals (p < 0.05). Clozapine increased the EEG signal power in all studied frequency ranges: in delta — by 107.99%, theta — by 97.16%, alpha — by 41.86% and in beta — by 49.16% in animals with neonatal destruction of the ventral hippocampus (p < 0.05).Conclusion. The studied substances contributed to the correction of behavioural disturbances associated with hypermobility as well as electrophysiological changes induced by a surgical operation, while similar activity was not observed (or was observed to a lesser extent) in healthy animals
Virtual screening benzimidazole derivatives with the highest bioavailability
The purpose of the study was to identify benzimidazole derivatives with high oral bioavailability using SwissADME web-tool.Цель исследования - поиск биологически активных соединений среди производных бензимидазола с максимальной пероральной биодоступностью
Digital receivers for low-frequency radio telescopes UTR-2, URAN, GURT
This paper describes digital radio astronomical receivers used for decameter
and meter wavelength observations. This paper describes digital radio
astronomical receivers used for decameter and meter wavelength observations.
Since 1998, digital receivers performing on-the-fly dynamic spectrum
calculations or waveform data recording without data loss have been used at the
UTR-2 radio telescope, the URAN VLBI system, and the GURT new generation radio
telescope. Here we detail these receivers developed for operation in the strong
interference environment that prevails in the decameter wavelength range. Data
collected with these receivers allowed us to discover numerous radio
astronomical objects and phenomena at low frequencies, a summary of which is
also presented.Comment: 24 pages, 15 figure
Proton dripline studies at ISOLDE: Ar and C
In this contribution examples of the application of new technologies to disentangle the mechanism of -delayed multiparticle emission are given. In particular the mechanism of 2p-emission from Ar has been resolved and proved to be sequential, a preview of C-decay data is discussed
Spectroscopy of Na: Bridging the two-proton radioactivity of Mg
The unbound nucleus Na, the intermediate nucleus in the two-proton
radioactivity of Mg, was studied by the measurement of the resonant
elastic scattering reaction Ne(p,Ne)p performed at 4 A.MeV.
Spectroscopic properties of the low-lying states were obtained in a R-matrix
analysis of the excitation function. Using these new results, we show that the
lifetime of the Mg radioactivity can be understood assuming a sequential
emission of two protons via low energy tails of Na resonances
\b{eta}-delayed three-proton decay of 31Ar
The beta decay of 31Ar, produced by fragmentation of a 36Ar beam at 880
MeV/nucleon, was investigated. Identified ions of 31Ar were stopped in a
gaseous time projection chamber with optical readout allowing to record decay
events with emission of protons. In addition to \b{eta}-delayed emission of one
and two protons we have clearly observed the beta-delayed three-proton branch.
The branching ratio for this channel in 31Ar is found to be 0.07(2)%.Comment: 5 pages, 3 figures, submitted to Physical Rev.
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