Antonio de Alfián y Juan de Oviedo el Viejo. El retablo de la Inmaculada de la Parroquia de Santa Ana de Sevilla (1573-1574)

En este artículo se documenta el retablo concertado conjuntamente por el pintor Antonio de Alfián y el entallador Juan de Oviedo el Viejo para el altar de Melchor de Horozco en la parroquia sevillana de Santa Ana. Del retablo sólo se han conservado en la actualidad las pinturas que formaron parte del conjunto, pinturas que, a pesar de haber sido atribuidas a diversos pintores, nunca se habían vinculado con el estilo de Alfián. A partir del estudio de éstas, es posible atribuirle otras obras, algunas de las cuales analizamos.This paper examines the painted and carved altarpiece made by the painter Antonio de Alfián and the “entallador” Juan de Oviedo the Elder for Melchor de Horozco in the parish church of Santa Ana in Seville. Only the paintings, however, are preserved. Never before linked to this master, these paintings allow a more complete understanding of Alfián’s somewhat unknown style. Thanks to the documentation of the altarpiece, it is now possible to attribute other works to this painter, some of which we study

Gastroesophageal reflux disease associated with diseases of the respiratory tract

The European community of gastroenterologists in 1997 recognized GERB as "illness of the 21st century". Diseases of a respiratory tract take the leading place among all extra esophageal implications of a gastroesophageal reflux disease. Among them bronchial asthma and a chronic obstructive pulmonary disease are the most widespread. The study of the features of the current and modern methods of diagnosing bronchial asthma, obstructive sleep apnea syndrome and chronic obstructive pulmonary disease associated with gastroesophageal reflux disease is of great importance for identifying potential obstacles to effective treatment and preventing an increase in the risk of hospitalizations of patients with this co-morbid pathology. The morbidity of the pathology of the respiratory tract, combined with gastroesophageal reflux disease, is steadily growing. There is a large number of publications concerning the relationship between gastroesophageal reflux disease and diseases of the bronchopulmonary system, but the etiopathogenesis and the cause-and-effect relationship of these diseases remain in question. 1t is interesting to note that the syndrome of obstructive sleep apnea is not included in the list of extra-oesophageal manifestations, both probably and reliably associated with gastroesophageal reflux disease (according to the Montreal Consensus, 2006), but is of great interest to researchers in recent years

Formation and Study of Properties of Ta and Mo Nanocluster Films

In this article, the results of studies of thin-film samples of nanoclusters of tantalum and molybdenum metals on the surface of silicon dioxide SiO2 /Si (001) at room temperature are presented. The chemical composition and electronic structure of the obtained nanocluster films of Ta and Mo were controlled in situ by X-ray photoelectron spectroscopy (XPS). Susceptibility to oxidation during the exposure to the atmosphere of then nanocluster films, as well as their thermal stability when heated in a vacuum to 600∘C were studied ex situ by the XPS method. The size and shape of the nanoclusters composing the film were estimated ex situ by analyzing images obtained with a scanning electron microscope. The band structure before and after oxidation was studied by measuring the bandgap of the formed Ta and Mo films by the method of electron energy loss characteristic spectroscopy (REELS). Conclusions about thermoelectric properties of the formed nanocluster films of Ta and Mo were made

The relationship between cellular and calcium responses of Aspergillus awamori to external influences

The cellular and Ca2+ responses to physiological stimuli of different nature were studied in the experiments with the strain Aspergillus awamori 66A containing recombinant aequorin, a Ca2+-dependent photosensitive protein. The relationship between the cellular response registered by changes in the development of the mycelial fungus (colony growth, hyphal branching, and the rate of spore formation) and the level and duration of calcium flares in the cytosol was assessed. The physical or chemical stimuli (mechanical effect, osmotic shock) inducing short-time calcium flares in the cytosol did not influence significantly the development of A. awamori grown in liquid or on solid nutrient media. The action on the 24-h A. awamori culture of the Ca2+-selective ionophore (A23187) inducing long-term changes in calcium homeostasis caused disorders in the fungus development and morphology (hyperbranching of mycelial hyphae, formation of spherical cells, and inhibition of colony growth and spore formation). Thus, it was established that the development of cellular response in the micromycete correlated with the duration of the calcium flare in the cytosol. © 2010 Pleiades Publishing, Ltd

ОКРЕМI ЕПIДЕМIОЛОГIЧНI РИЗИКИ ДЛЯ БIОЛОГIЧНОЇ БЕЗПЕКИ УКРАЇНИ

The article adduces the issues of epidemiological risks to Ukraine’s biosecurity and other relevant military threats. The authors predicted directions of possible changes in the biological situation regarding infectious morbidity in Ukraine and bioterrorism, raised questions about the necessity of carrying out anti-epidemic and preventive measures.Розглянуті питання епідеміологічних ризиків для біологічної безпеки України та інші актуальні воєнні загрози. Авторами спрогнозовані напрямки можливих змін біологічної ситуації щодо інфекційної захворюваності в Україні та біотероризму, порушені питання необхідності проведення протиепідемічних і профілактичних заходів

Features of model coronaviruses distribution in feline organs and tissues in the context of COVID-19 pathogenesis study

To date, the reisreason to believe that, unlike classical a cuterespiratory virusinfections caused by adenoviruses, rhinoviruses, orthomyxoviruses, COVID-19 behaves completely differently. Firstly, the pathological process esare likely to be immune-mediated and the immun esystem quites lowly ensurest heelimination of the virus from the organism. Secondly, the dynamics of the diseases ymptom development and the duration of intestinal virusshedding after recovery give reason to believe that theSARS-CoV-2 infection is mainly localizedin the intestine. A possible reason isthat in the presence of proteolyticenzymes, viral particlesmature, hydrophilic aminoacids are removed from the surface of the virion, making it more hydrophobic and able to ad here to cells due to hydrophobic interactions. The presence of the ACE2 recept or mainly in the enterocytes of the ileumdoes not exclude the accumulation of coronavirusin lymphocytes, given that there are more lymphocytes in the gastrointestinal tract than anywhere else, this fact can beconsidered as another justification for the predominant accumulation of coronaviruses, including SARS-CoV-2 in the intestine. A distinctive feature of feline coronavirus infection and, in particular, infectious feline peritonitis, from human COVID-19 infection was considered to be the presence of effusion peritonitis as the main complication leading to death, while respiratory and card iovascular in sufficiency is more characteristic for humans. Never the less, cases of serous peritonitis in humans infected with COVID-19 have already been described. In the context of the analyzed model, theclinical case describedin the study allows principal possibility of exacerbation of chronic coronavirus infection in caseof re-infection (superinfection) and development of apredominantlylocal infection

Measuring the Boltzmann constant by mid-infrared laser spectroscopy of ammonia

We report on our ongoing effort to measure the Boltzmann constant, $k_B,$ using the Doppler broadening technique on ammonia. This paper presents some of the improvements made to the mid-infrared spectrometer including the use of a phase-stabilized quantum cascade laser, a lineshape analysis based on a refined physical model and an improved fitting program 2 increasing the confidence in our estimates of the relevant molecular parameters, and a first evaluation of the saturation parameter and its impact on the measurement of k B. A summary of the systematic effects contributing to the measurement is given and the optimal experimental conditions for mitigating those effects in order to reach a competitive measurement of $k_B$ at a part per million accuracy level are outlined