3D hindlimb joint mobility of the stem-archosaur Euparkeria capensis with implications for postural evolution within Archosauria.

Triassic archosaurs and stem-archosaurs show a remarkable disparity in their ankle and pelvis morphologies. However, the implications of these different morphologies for specific functions are still poorly understood. Here, we present the first quantitative analysis into the locomotor abilities of a stem-archosaur applying 3D modelling techniques. μCT scans of multiple specimens of Euparkeria capensis enabled the reconstruction and three-dimensional articulation of the hindlimb. The joint mobility of the hindlimb was quantified in 3D to address previous qualitative hypotheses regarding the stance of Euparkeria. Our range of motion analysis implies the potential for an erect posture, consistent with the hip morphology, allowing the femur to be fully adducted to position the feet beneath the body. A fully sprawling pose appears unlikely but a wide range of hip abduction remained feasible-the hip appears quite mobile. The oblique mesotarsal ankle joint in Euparkeria implies, however, a more abducted hindlimb. This is consistent with a mosaic of ancestral and derived osteological characters in the hindlimb, and might suggest a moderately adducted posture for Euparkeria. Our results support a single origin of a pillar-erect hip morphology, ancestral to Eucrocopoda that preceded later development of a hinge-like ankle joint and a more erect hindlimb posture

Schroedinger operators with singular interactions: a model of tunneling resonances

We discuss a generalized Schr\"odinger operator in $L^2(\mathbb{R}^d), d=2,3$, with an attractive singular interaction supported by a $(d-1)$-dimensional hyperplane and a finite family of points. It can be regarded as a model of a leaky quantum wire and a family of quantum dots if $d=2$, or surface waves in presence of a finite number of impurities if $d=3$. We analyze the discrete spectrum, and furthermore, we show that the resonance problem in this setting can be explicitly solved; by Birman-Schwinger method it is cast into a form similar to the Friedrichs model.Comment: LaTeX2e, 34 page

A note on the differences of computably enumerable reals

We show that given any non-computable left-c.e. real α there exists a left-c.e. real β such that α≠β+γ for all left-c.e. reals and all right-c.e. reals γ. The proof is non-uniform, the dichotomy being whether the given real α is Martin-Loef random or not. It follows that given any universal machine U, there is another universal machine V such that the halting probability of U is not a translation of the halting probability of V by a left-c.e. real. We do not know if there is a uniform proof of this fact

The acquisition of Sign Language: The impact of phonetic complexity on phonology

Research into the effect of phonetic complexity on phonological acquisition has a long history in spoken languages. This paper considers the effect of phonetics on phonological development in a signed language. We report on an experiment in which nonword-repetition methodology was adapted so as to examine in a systematic way how phonetic complexity in two phonological parameters of signed languages — handshape and movement — affects the perception and articulation of signs. Ninety-one Deaf children aged 3–11 acquiring British Sign Language (BSL) and 46 hearing nonsigners aged 6–11 repeated a set of 40 nonsense signs. For Deaf children, repetition accuracy improved with age, correlated with wider BSL abilities, and was lowest for signs that were phonetically complex. Repetition accuracy was correlated with fine motor skills for the youngest children. Despite their lower repetition accuracy, the hearing group were similarly affected by phonetic complexity, suggesting that common visual and motoric factors are at play when processing linguistic information in the visuo-gestural modality

Dyeability of corona-treated fabrics

In this study, corona technology is applied in the wet processing of cotton fabrics. The properties of cotton, such as hydrophilicity, ionisation and mechanical properties, are evaluated and compared with previous results of cuticle oxidation and morphological changes. The results of dyeings of coronatreated materials under different conditions are compared with those of raw, bleached and desized cotton. The dyeings are carried out with three different commercial direct dyes. The classical method for the processing of cotton materials and the corona discharge method are discussed and compared in order to analyse the advantages of this innovative process

Potentially inappropriate medication in older participants of the Berlin Aging Study II (BASE-II) - Sex differences and associations with morbidity and medication use

INTRODUCTION: Multimorbidity in advanced age and the need for drug treatment may lead to polypharmacy, while pharmacokinetic and pharmacodynamic changes may increase the risk of adverse drug events (ADEs). OBJECTIVE: The aim of this study was to determine the proportion of subjects using potentially inappropriate medication (PIM) in a cohort of older and predominantly healthy adults in relation to polypharmacy and morbidity. METHODS: Cross-sectional data were available from 1,382 study participants (median age 69 years, IQR 67-71, 51.3% females) of the Berlin Aging Study II (BASE-II). PIM was classified according to the EU(7)-PIM and German PRISCUS (representing a subset of the former) list. Polypharmacy was defined as the concomitant use of at least five drugs. A morbidity index (MI) largely based on the Charlson Index was applied to evaluate the morbidity burden. RESULTS: Overall, 24.1% of the participants were affected by polypharmacy. On average, men used 2 (IQR 1-4) and women 3 drugs (IQR 1-5). According to PRISCUS and EU(7)-PIM, 5.9% and 22.6% of participants received at least one PIM, while use was significantly more prevalent in females (25.5%) compared to males (19.6%) considering EU(7)-PIM (p = 0.01). In addition, morbidity in males receiving PIM according to EU(7)-PIM was higher (median MI 1, IQR 1-3) compared to males without PIM use (median MI 1, IQR 0-2, p<0.001). CONCLUSION: PIM use occurred more frequently in women than in men, while it was associated with higher morbidity in males. As expected, EU(7)-PIM identifies more subjects as PIM users than the PRISCUS list but further studies are needed to investigate the differential impact of both lists on ADEs and outcome. KEY POINTS: We found PIM use to be associated with a higher number of regular medications and with increased morbidity. Additionally, we detected a higher prevalence of PIM use in females compared to males, suggesting that women and people needing intensive drug treatment are patient groups, who are particularly affected by PIM use

Medicina, hombre y sociedad: adecuando el ingreso a medicina al modelo de competencias y al perfil de graduación

Introducción: “Introducción a las Ciencias Médicas” (ICM) fue hasta 2015 la primera asignatura de la carrera de Medicina. Con 400 horas, estructurada en áreas (Biología, Química y Formación Científica-Humanística-Técnica), enfocada en contenidos básicos, con modelo didáctico tradicional y evaluación escrita estructurada. Este contexto de ingreso poco adecuado al curriculum de la carrera orientado en competencias, motivó a reformular el programa y cambiar la denominación por “Medicina, hombre y sociedad” (MHS), respetando la carga horaria, contenidos mínimos y sistema de promoción de ICM.Propósitos: Adecuar los objetivos y las estrategias didácticas de la materia al modelo de competencias y enriquecer la formación de los estudiantes hacia la Medicina Familiar y Comunitaria (MFC) acorde al perfil de graduación.Desarrollo: Para el cursado 2016 de MHS, las áreas se reordenaron en cuatro ejes temáticos: Alimentación, Actividad Física, Ambiente, y Sistemas de Salud; y uno de Contenidos Transversales (formación científica, humanística, y metodológica). Para cada eje se formularon competencias y los contenidos se categorizaron en esenciales, necesarios y ampliatorios. Las actividades se desarrollaron en tres escenarios: áulicas presenciales (aula invertida y talleres), aula virtual (actividades, repositorio y comunicación) y trabajos en terreno (observaciones, encuestas, y entrevistas a la comunidad y equipos de salud). Las evaluaciones se agruparon por tramo, articulando diferentes instrumentos, pruebas escritas abiertas (integradores de ejes), evaluación de informes (trabajos en terreno); ejercicios en CV y e-portfolio (transversales), y preguntas de opción múltiple (integrador de tramo).Resultados: De los 1563 inscriptos a la carrera (2016), 285 abandonaron el cursado. De los 1277 que finalizaron, 495 (39 %) regularizaron la materia y 762 (61 %) no regularizaron. En los portfolios, los estudiantes expresaron su satisfacción con las estrategias didácticas, las evaluaciones y las interacciones en los trabajos grupales. Muchos cuestionaron la sobrecarga de tareas y la claridad de las consignas. El grado de aceptación y compromiso de los docentes fue bueno, varios objetaron algunas de las nuevas actividades desarrolladas.Conclusiones: Con MHS se logró adecuar el ingreso al modelo curricular por competencias, orientar la formación de los estudiantes hacia la MFC y enriquecer las estrategias didácticas de la carrera. El desafío es darle continuidad

A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease

Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association studies (GWAS) analysis of common SNPs. Leveraging phased haplotypes from the 1000 Genomes Project, we report a GWAS meta-analysis of 185 thousand CAD cases and controls, interrogating 6.7 million common (MAF>0.05) as well as 2.7 million low frequency (0.005<MAF<0.05) variants. In addition to confirmation of most known CAD loci, we identified 10 novel loci, eight additive and two recessive, that contain candidate genes that newly implicate biological processes in vessel walls. We observed intra-locus allelic heterogeneity but little evidence of low frequency variants with larger effects and no evidence of synthetic association. Our analysis provides a comprehensive survey of the fine genetic architecture of CAD showing that genetic susceptibility to this common disease is largely determined by common SNPs of small effect siz