Restoring the full velocity field in the gaseous disk ofthe spiral galaxy NGC 157

We analyse the line-of-sight velocity field of ionized gas in the spiral galaxy NGC 157 which has been obtained in the H\alpha emission at the 6m telescope of SAO RAS. The existence of systematic deviations of the observed gas velocities from pure circular motion is shown. A detailed investigation of these deviations is undertaken by applying a Fourier analysis of the azimuthal distributions of the line-of-sight velocities at different distances from the galactic center. As a result of the analysis, all the main parameters of the wave spiral pattern are determined: the corotation radius, the amplitudes and phases of the gas velocity perturbations at different radii, and the velocity of circular rotation of the disk corrected for the velocity perturbations due to spiral arms. At a high confidence level, the presence of the two giant anticyclones in the reference frame rotating with the spiral pattern is shown; their sizes and the localization of their centers are consistent with the results of the analytic theory and of numerical simulations. Besides the anticyclones, the existence of cyclones in residual velocity fields of spiral galaxies is predicted. In the reference frame rotating with the spiral pattern these cyclones have to reveal themselves in galaxies where a radial gradient of azimuthal residual velocity is steeper than that of the rotation velocity (abridged).Comment: 23 pages including 25 eps-figures. Accepted for publication in A&

Dynamic stabilization of non-spherical bodies against unlimited collapse

We solve equations, describing in a simplified way the newtonian dynamics of a selfgravitating nonrotating spheroidal body after loss of stability. We find that contraction to a singularity happens only in a pure spherical collapse, and deviations from the spherical symmetry stop the contraction by the stabilising action of nonlinear nonspherical oscillations. A real collapse happens after damping of the oscillations due to energy losses, shock wave formation or viscosity. Detailed analysis of the nonlinear oscillations is performed using a Poincar\'{e} map construction. Regions of regular and chaotic oscillations are localized on this map.Comment: MNRAS, accepted, 7 pages, 9 figure

A generic C1C^1 map has no absolutely continuous invariant probability measure

Let $M$ be a smooth compact manifold (maybe with boundary, maybe disconnected) of any dimension $d \ge 1$. We consider the set of $C^1$ maps $f:M\to M$ which have no absolutely continuous (with respect to Lebesgue) invariant probability measure. We show that this is a residual (dense $G_\delta) set in the$C^1$ topology. In the course of the proof, we need a generalization of the usual Rokhlin tower lemma to non-invariant measures. That result may be of independent interest.Comment: 12 page

Inner Polar Rings and Disks: Observed Properties

A list of galaxies with inner regions revealing polar (or strongly inclined to the main galactic plane) disks and rings is compiled from the literature data. The list contains 47 galaxies of all morphological types, from E to Irr. We consider the statistics of the parameters of polar structures known from observations. The radii of the majority of them do not exceed 1.5 kpc. The polar structures are equally common in barred and unbarred galaxies. At the same time, if a galaxy has a bar (or a triaxial bulge), this leads to the polar disk stabilization - its axis of rotation usually coincides with the major axis of the bar. More than two thirds of all considered galaxies reveal one or another sign of recent interaction or merging. This fact indicates a direct relation between the external environment and the presence of an inner polar structure.Comment: 12 pages, 3 figures, accepted to Astrophysical Bulletin. Minor changes and corrections are still possibl

The structure of cool accretion disc in semidetached binaries

We present the results of qualitative consideration of possible changes occurring during the transition from the hot accretion disc to the cool one. We argue the possible existence of one more type of spiral density waves in the inner part of the disc where gasdynamical perturbations are negligible. The mechanism of formation of such a wave as well as its parameters are considered. We also present the results of 3D gasdynamical simulation of cool accretion discs. These results confirm the hypothesis of possible formation of the spiral wave of a new, "precessional" type in the inner regions of the disc. Possible observational manifestations of this wave are discussed.Comment: LaTeX, 16 pages, 8 figures, to be published in Astron. Z

Electrification of wind-blown sand on Mars and its implications for atmospheric chemistry

Wind-blown sand, or 'saltation,' creates sand dunes, erodes geological features, and could be a significant source of dust aerosols on Mars. Moreover, the electrification of sand and dust in saltation, dust storms, and dust devils could produce electric discharges and affect atmospheric chemistry. We present the first calculations of electric fields in martian saltation, using a numerical model of saltation that includes sand electrification, plasma physics, and the adsorption of ions and electrons onto particulates. Our results indicate that electric discharges do not occur in martian saltation. Moreover, we find that the production of hydrogen peroxide and the dissociation of methane by electric fields are less significant than previously thought. Both these species are highly relevant to studies of past and present life on Mars.Comment: 5 journal pages, 3 figures, published in Geophysical Research Letter

Primary skin fibroblasts as a model of Parkinson's disease

Parkinson's disease is the second most frequent neurodegenerative disorder. While most cases occur sporadic mutations in a growing number of genes including Parkin (PARK2) and PINK1 (PARK6) have been associated with the disease. Different animal models and cell models like patient skin fibroblasts and recombinant cell lines can be used as model systems for Parkinson's disease. Skin fibroblasts present a system with defined mutations and the cumulative cellular damage of the patients. PINK1 and Parkin genes show relevant expression levels in human fibroblasts and since both genes participate in stress response pathways, we believe fibroblasts advantageous in order to assess, e.g. the effect of stressors. Furthermore, since a bioenergetic deficit underlies early stage Parkinson's disease, while atrophy underlies later stages, the use of primary cells seems preferable over the use of tumor cell lines. The new option to use fibroblast-derived induced pluripotent stem cells redifferentiated into dopaminergic neurons is an additional benefit. However, the use of fibroblast has also some drawbacks. We have investigated PARK6 fibroblasts and they mirror closely the respiratory alterations, the expression profiles, the mitochondrial dynamics pathology and the vulnerability to proteasomal stress that has been documented in other model systems. Fibroblasts from patients with PARK2, PARK6, idiopathic Parkinson's disease, Alzheimer's disease, and spinocerebellar ataxia type 2 demonstrated a distinct and unique mRNA expression pattern of key genes in neurodegeneration. Thus, primary skin fibroblasts are a useful Parkinson's disease model, able to serve as a complement to animal mutants, transformed cell lines and patient tissues

The simulation of molecular clouds formation in the Milky Way

Using 3D hydrodynamic calculations we simulate formation of molecular clouds in the Galaxy. The simulations take into account molecular hydrogen chemical kinetics, cooling and heating processes. Comprehensive gravitational potential accounts for contributions from the stellar bulge, two and four armed spiral structure, stellar disk, dark halo and takes into account self-gravitation of the gaseous component. Gas clouds in our model form in the spiral arms due to shear and wiggle instabilities and turn into molecular clouds after t\simgt 100 Myr. At the times $t\sim 100 - 300$ Myr the clouds form hierarchical structures and agglomerations with the sizes of 100 pc and greater. We analyze physical properties of the simulated clouds and find that synthetic statistical distributions like mass spectrum, "mass-size" relation and velocity dispersion are close to those observed in the Galaxy. The synthetic $l-v$ (galactic longitude - radial velocity) diagram of the simulated molecular gas distribution resembles observed one and displays a structure with appearance similar to Molecular Ring of the Galaxy. Existence of this structure in our modelling can be explained by superposition of emission from the galactic bar and the spiral arms at $\sim$3-4 kpc.Comment: 10 pages, 8 figure

Mutations in components of complement influence the outcome of Factor I-associated atypical hemolytic uremic syndrome

Genetic studies have shown that mutations of complement inhibitors such as membrane cofactor protein, Factors H, I, or B and C3 predispose patients to atypical hemolytic uremic syndrome (aHUS). Factor I is a circulating serine protease that inhibits complement by degrading C3b and up to now only a few mutations in the CFI gene have been characterized. In a large cohort of 202 patients with aHUS, we identified 23 patients carrying exonic mutations in CFI. Their overall clinical outcome was unfavorable, as half died or developed end-stage renal disease after their first syndrome episode. Eight patients with CFI mutations carried at least one additional known genetic risk factor for aHUS, such as a mutation in MCP, CFH, C3 or CFB; a compound heterozygous second mutation in CFI; or mutations in both the MCP and CFH genes. Five patients exhibited homozygous deletion of the Factor H-related protein 1 (CFHR-1) gene. Ten patients with aHUS had one mutation in their CFI gene (Factor I-aHUS), resulting in a quantitative or functional Factor I deficiency. Patients with a complete deletion of the CFHR-1 gene had a significantly higher risk of a bad prognosis compared with those with one Factor I mutation as their unique vulnerability feature. Our results emphasize the necessity of genetic screening for all susceptibility factors in patients with aHUS