The effect of Holstein-Friesian genotype and feeding system on selected performance parameters of dairy cows on grass-based systems of milk production in Ireland

End of project reportThe overall objective of this project was to assess, the effect of strain of Holstein-Friesian dairy cow, pasture-based feed system (FS) and their interaction on animal performance in terms of milk productivity and lactation profile, body weight (BW), body condition score (BCS), feed intake and energy balance (EB), reproductive performance and overall economic profitability

Effect of Teaching through Problem - Solving on Students’ Performance in Mathematics in Secondary School in Murang’a County, Kenya

Students’ are weak in curriculum outcomes in Mathematics at National examinations of secondary school education have been of concern to primary and secondary stakeholders. The concern was that result determines student’s participation in science oriented programmes at tertiary level. Many interventions have been put in place to avoid but performance persisted. Science programmes support Kenya development agenda as described in the current vision 2030 including social, economic, political technological and industrial development. The pedagogical interventions had been done in various Counties. The study examined effect of teaching through problem – solving on students’ achievements in Mathematics in secondary schools in Murang’a County, Kenya. This County was among 47 counties, but it was favoured because of climatic condition and assessable roads to schools. The study investigated students’ performance in Mathematics for those taught using problem - solving strategies with those taught using conventional strategies. The study employed quasi – experimental design using Solomon Four Group model. The target population was 28485 students in 340 secondary schools in Murang’a County. These schools were purposely stratified into four categories according to their performance in national examination past four years. Four schools from each stratum were randomly distributed into four groups. Two groups E1 and E2 were assigned as experimental groups whereas other two C1 and C2 as control groups. A total of 16 schools: 8 schools experimental and 8 schools, control. Sample size of 544 students and 16 teachers were involved in the study. Pretest and posttest Students’ Mathematics Achievement Questionnaire were constructed by national examiners and moderated by senior examiners not in sampled schools. Eight schools participated in pre-test in E1 and C1 and all 16 schools received post- test Mathematics achievements tests after intervention. In order to establish significance means difference between students taught through problem – solving and those taught through conventional strategies paired t –tests and Cohen’s d effect measure were used. Problem – solving method improved students’ performance and teachers should embrace facilitating Mathematics in an environment contributing to better achievement

Pilot scale implementation of a single-use, high intensity, integrated process system

Pfizer and Boehringer Ingelheim are developing pilot scale systems with entirely single-use flow paths that are fully integrated end-to-end under a single control system from bioreactor through downstream processing. These prototype systems are designed to run continuous processing from the bioreactor to downstream, and periodic processing to the end of the downstream system. This presentation shows the evolution of the systems including some novel single use technologies, details of some high-intensity run results, and offers future single use improvement ideas

Undergraduate Accounts of the Impact of Lockdown on Their Self-Managed Reflective Development of Graduate Abilities

This account is mostly written by students in the first year of their discipline-based study of civil engineering. It features their self-managed development of graduate abilities in the second semester of an undergraduate Irish course in problem-based civil engineering. The principal abilities were creativity, problem-solving, presentations and teamwork. The case-study paper concentrates upon four students’ reports and reflections on their experiences concerning their second (partially locked-down) semester. Their accounts complement the review of the early weeks of their first semester experience, that has already been published elsewhere. They are joined by the tutor who was an external facilitator of their early drafts of reviews. He suggested the compilation and structure of this paper, and has assisted with the assembly of the condensed individual contributions

Conceptualizing gratitude and appreciation as a unitary personality trait

Gratitude and appreciation are currently measured using three self-report instruments, the GQ6 (1 scale), the Appreciation Scale (8 scales), and the GRAT (3 scales). Two studies were conducted to test how these three instruments are interrelated, whether they exist under the same higher order factor or factors, and whether gratitude and appreciation is a single or multi-factorial construct. In Study 1 (N = 206) all 12 scales were subjected to an exploratory factor analysis. Both parallel analysis and the minimum average partial method indicated a clear one-factor solution. In Study 2 (N = 389) multigroup confirmatory factor analysis supported the one-factor structure, demonstrated the invariance of this structure across gender, and ruled out the confounding effect of socially desirable responding. We conclude gratitude and appreciation are a single-factor personality trait. We suggest integration of gratitude and appreciation literatures and provide a clearer conceptualization of gratitude

eDrama: Facilitating online role-play using emotionally expressive avatars.

Introduction: This paper describes the results of a user study of a multi-user role-playing environment ‘edrama’, which enables groups of people to converse online, in scenario driven virtual environments. Hi8us’ edrama system is a 2D graphical environment in which users are represented by static cartoon like avatars. An application has been developed to enable the integration of the existing edrama tool with several new software components to support avatars with emotionally expressive behaviours, rendered in a 3D environment. In this paper we describe a user trial that demonstrates that the changes made improve the quality of social interaction and users' sense of presence

Pleasure and meaningful discourse: an overview of research issues

The concept of pleasure has emerged as a multi-faceted social and cultural phenomenon in studies of media audiences since the 1980s. In these studies different forms of pleasure have been identified as explaining audience activity and commitment. In the diverse studies pleasure has emerged as a multi-faceted social and cultural concept that needs to be contextualized carefully. Genre and genre variations, class, gender, (sub-)cultural identity and generation all seem to be instrumental in determining the kind and variety of pleasures experienced in the act of viewing. This body of research has undoubtedly contributed to a better understanding of the complexity of audience activities, but it is exactly the diversity of the concept that is puzzling and poses a challenge to its further use. If pleasure is maintained as a key concept in audience analysis that holds much explanatory power, it needs a stronger theoretical foundation. The article maps the ways in which the concept of pleasure has been used by cultural theorists, who have paved the way for its application in reception analysis, and it goes on to explore the ways in which the concept has been used in empirical studies. Central to our discussion is the division between the ‘public knowledge’ and the ‘popular culture’ projects in reception analysis which, we argue, have major implications for the way in which pleasure has come to be understood as divorced from politics, power and ideology. Finally, we suggest ways of bridging the gap between these two projects in an effort to link pleasure to the concepts of hegemony and ideology

A combined clinical and biomarker approach to predict diuretic response in acute heart failure

Background: Poor diuretic response in acute heart failure is related to poor clinical outcome. The underlying mechanisms and pathophysiology behind diuretic resistance are incompletely understood. We evaluated a combined approach using clinical characteristics and biomarkers to predict diuretic response in acute heart failure (AHF). Methods and results: We investigated explanatory and predictive models for diuretic response—weight loss at day 4 per 40 mg of furosemide—in 974 patients with AHF included in the PROTECT trial. Biomarkers, addressing multiple pathophysiological pathways, were determined at baseline and after 24 h. An explanatory baseline biomarker model of a poor diuretic response included low potassium, chloride, hemoglobin, myeloperoxidase, and high blood urea nitrogen, albumin, triglycerides, ST2 and neutrophil gelatinase-associated lipocalin (r2 = 0.086). Diuretic response after 24 h (early diuretic response) was a strong predictor of diuretic response (β = 0.467, P < 0.001; r2 = 0.523). Addition of diuretic response after 24 h to biomarkers and clinical characteristics significantly improved the predictive model (r2 = 0.586, P < 0.001). Conclusions: Biomarkers indicate that diuretic unresponsiveness is associated with an atherosclerotic profile with abnormal renal function and electrolytes. However, predicting diuretic response is difficult and biomarkers have limited additive value. Patients at risk of poor diuretic response can be identified by measuring early diuretic response after 24 h

Recombinant Incretin-Secreting Microbe Improves Metabolic Dysfunction in High-Fat Diet Fed Rodents

peer-reviewedThe gut hormone glucagon-like peptide (GLP)-1 and its analogues represent a new generation of anti-diabetic drugs, which have also demonstrated propensity to modulate host lipid metabolism. Despite this, drugs of this nature are currently limited to intramuscular administration routes due to intestinal degradation. The aim of this study was to design a recombinant microbial delivery vector for a GLP-1 analogue and assess the efficacy of the therapeutic in improving host glucose, lipid and cholesterol metabolism in diet induced obese rodents. Diet-induced obese animals received either Lactobacillus paracasei NFBC 338 transformed to express a long-acting analogue of GLP-1 or the isogenic control microbe which solely harbored the pNZ44 plasmid. Short-term GLP-1 microbe intervention in rats reduced serum low-density lipoprotein cholesterol, triglycerides and triglyceride-rich lipoprotein cholesterol substantially. Conversely, extended GLP-1 microbe intervention improved glucose-dependent insulin secretion, glucose metabolism and cholesterol metabolism, compared to the high-fat control group. Interestingly, the microbe significantly attenuated the adiposity associated with the model and altered the serum lipidome, independently of GLP-1 secretion. These data indicate that recombinant incretin-secreting microbes may offer a novel and safe means of managing cholesterol metabolism and diet induced dyslipidaemia, as well as insulin sensitivity in metabolic dysfunction