23 research outputs found
Eco-engineering of coastal infrastructure: A design for life
Relevant publication from this thesis:
OâShaughnessy K. A., Hawkins, S. J., Evans, A. J., Hanley, M. E., Lunt, P., Thompson, R. C., Francis, R. A., Hoggart, S., Moore, P., Iglesias, G., Simmonds, D., Ducker, J. and Firth, L. B. 2019. Design catalogue for eco-engineering of coastal artificial structures: a multifunctional approach for stakeholders and end-users. Urban Ecosystems. DOI: 10.1007/s11252-019-00924-z.
OâShaughnessy K.A., Hawkins, S.J., Yunnie, A.L.E., Hanley, M.E., Lunt, P., Thompson, R.C. and Firth, L.B. 2020. Occurrence and assemblage composition of intertidal non-native species may be influenced by shipping patterns and artificial structures. Marine Pollution Bulletin.Coastal urbanisation has driven humans to build artificial defences to protect infrastructure from rising sea level, erosion and stormier seas. Artificial structures are proliferating in the coastal and marine environments (âocean sprawlâ), resulting in a loss of natural habitat, species diversity and ecosystem services. To mitigate the impacts of ocean sprawl, the practice of eco-engineering of coastal infrastructure has been developed. A strong evidence base in support of eco-engineering is growing, yet there remain critical knowledge gaps. This work investigated the ecology of artificial structures and their ability to be enhanced in order to increase species diversity, addressing five knowledge gaps in the eco-engineering literature: (1) understanding of occurrence of non-native species in intertidal natural and artificial habitats along the south coasts of England; (2) looking beyond conventional measures of species diversity to better understand the differences in communities between natural and artificial habitats at multiple spatial scales; (3) comparing how topographic complexity shapes species diversity in both intertidal and subtidal habitats; (4) seeking generality of patterns of eco-engineering interventions across geographic localities; and (5) making the outcomes of eco-engineering research accessible in a practitioner-focused format for stakeholders. To address the first knowledge gap, Rapid Assessment Surveys (RAS) were conducted along the south coast of England. The central region of the south of England supported the most non-native species, while artificial and natural habitats differed in their assemblages of non-native species. Biological surveys in Plymouth Sound (UK) were conducted to address the second knowledge gap. α-diversity (taxon richness) was greater in natural compared to artificial habitats at multiple spatial scales, but ÎČ-diversity was greater in artificial compared to natural habitats at the larger spatial scale (m-km). To address the third and fourth knowledge gaps, habitat enhancement eco-engineering trials in Plymouth Sound in intertidal and subtidal habitats were conducted. Results were informally compared to those from equivalent experiments done along the Mediterranean coast of Israel. In general, habitat complexity had an effect on species diversity, but results were dependent on habitat and location. Lastly, an eco-engineering âuser-guideâ for practitioners was created that can serve as a template for future guides and frameworks as the science evolves and becomes freely accessible to end-users. This thesis evaluates outcomes in the context of their application to the management of eco-engineering in order to mitigate the negative effects of ocean sprawl
Greening of grey infrastructure should not be used as a Trojan horse to facilitate coastal development
Climate change and coastal urbanization are driving the replacement of natural habitats with artificial structures and reclaimed land globally. These novel habitats are often poor surrogates for natural habitats. The application of integrated greening of grey infrastructure (IGGI) to artificial shorelines demonstrates how multifunctional structures can provide biodiversity benefits whilst simultaneously serving their primary engineering function. IGGI is being embraced globally, despite many knowledge gaps and limitations. It is a management tool to compensate anthropogenic impacts as part of the Mitigation Hierarchy. There is considerable scope for misuse and âgreenwashingâ however, by making new developments appear more acceptable, thus facilitating the regulatory process. We encourage researchers to exercise caution when reporting on small-scale experimental trials. We advocate that greater attention is paid to when experiments âfailâ or yield unintended outcomes. We advise revisiting, repeating and expanding on experiments to test responses over broader spatio-temporal scales to improve the evidence base. Synthesis and applications. Where societal and economic demand makes development inevitable, particular attention should be paid to avoiding, minimizing and rehabilitating environmental impacts. Integrated greening of grey infrastructure (IGGI) should be implemented as partial compensation for environmental damage. Mutual benefits for both humans and nature can be achieved when IGGI is implemented retrospectively in previously developed or degraded environments. We caution, however, that any promise of net biodiversity gain from new developments should be scrutinized and any local ecological benefits set in the context of the wider environmental impacts. A âgreenedâ development will always impinge on natural systems, a reality that is much less recognized in the sea than on land.</p
Design catalogue for eco-engineering of coastal artificial structures:a multifunctional approach for stakeholders and end-users
Coastal urbanisation, energy extraction, food production, shipping and transportation have led to the global proliferation of artificial structures within the coastal and marine environments (sensu âocean sprawlâ), with subsequent loss of natural habitats and biodiversity. To mitigate and compensate impacts of ocean sprawl, the practice of ecoengineering of artificial structures has been developed over the past decade. Eco-engineering aims to create sustainable ecosystems that integrate human society with the natural environment for the benefit of both. The science of eco-engineering has grown markedly, yet synthesis of research into a user-friendly and practitioner-focused format is lacking. Feedback from stakeholders has repeatedly stated that a âphoto user guideâ or âmanualâ covering the range of eco-engineering options available for artificial structures would be beneficial. However, a detailed and structured âuser guideâ for eco-engineering in coastal and marine environments is not yet possible; therefore we present an accessible review and catalogue of trialled eco-engineering options and a summary of guidance for a range of
different structures tailored for stakeholders and end-users as the first step towards a structured manual. This work
can thus serve as a potential template for future eco-engineering guides. Here we provide suggestions for potential eco-engineering designs to enhance biodiversity and ecosystem functioning and services of coastal artificial structures with the following structures covered: (1) rock revetment, breakwaters and groynes composed of armour stones or concrete units; (2) vertical and sloping seawalls; (3) over-water structures (i.e., piers) and associated support structures; and (4) tidal river walls
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Functional redundancy between RAP1 isoforms in murine platelet production and function
RAP GTPases, important regulators of cellular adhesion, are abundant signaling
molecules in the platelet/megakaryocytic lineage. However, mice lacking the predominant isoform, RAP1B, display a partial platelet integrin activation defect and have a normal platelet count, suggesting the existence of a RAP1-independent pathway to integrin activation in platelets and a negligible role for RAP GTPases in megakaryocyte biology. To determine the importance of individual RAP isoforms on platelet production and on platelet activation at sites of mechanical injury or vascular leakage, we conditionally deleted Rap1a and/or Rap1b in the megakaryocytic lineage (mKO). Interestingly, Rap1a/b-mKO mice displayed a marked macrothrombocytopenia due to impaired pro- platelet formation by megakaryocytes. In platelets, RAP isoforms had both redundant and
isoform-Ëspecific functions. Deletion of RAP1B, but not RAP1A, significantly reduced α- granule secretion and activation of the cytoskeleton regulator RAC1. Both isoforms significantly contributed to thromboxane A2 generation and the inside-out activation of platelet integrins. Combined deficiency of RAP1A and RAP1B markedly impaired platelet aggregation, spreading and clot retraction. Consistently, thrombus formation in physiological flow conditions was abolished in Rap1a/b-mKO, but not Rap1a-mKO or Rap1b-mKO platelets. Rap1a/b-mKO mice were strongly protected from experimental thrombosis and exhibited a severe defect in hemostasis after mechanical injury. Surprisingly, Rap1a/b-mKO platelets were indistinguishable from controls in their ability to prevent blood-lymphatic mixing during development and hemorrhage at sites of inflammation.
In summary, our studies demonstrate an essential role for RAP1 signaling in platelet
integrin activation and a critical role in platelet production. While important for
hemostatic/thrombotic plug formation, platelet RAP1 signaling is dispensable for vascular integrity during development and inflammation
Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial
Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes. Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18â85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR)25â75 mL/min per 1·73 m 2 of body surface area, and a urine albumin-to-creatinine ratio (UACR)of 300â5000 mg/g who had received maximum labelled or tolerated reninâangiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0·75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders)were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0·75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for â„30 days)or end-stage kidney disease (eGFR <15 mL/min per 1·73 m 2 sustained for â„90 days, chronic dialysis for â„90 days, kidney transplantation, or death from kidney failure)in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials.gov, number NCT01858532. Findings: Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325)or placebo group (n=1323). Median follow-up was 2·2 years (IQR 1·4â2·9). 79 (6·0%)of 1325 patients in the atrasentan group and 105 (7·9%)of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR]0·65 [95% CI 0·49â0·88]; p=0·0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3·5%)of 1325 patients in the atrasentan group and 34 (2·6%)of 1323 patients in the placebo group (HR 1·33 [95% CI 0·85â2·07]; p=0·208). 58 (4·4%)patients in the atrasentan group and 52 (3·9%)in the placebo group died (HR 1·09 [95% CI 0·75â1·59]; p=0·65). Interpretation: Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Funding: AbbVie
The James Webb Space Telescope Mission
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least .
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
Invasiveness risks of naked goby, Gobiosoma bosc, to North Sea transitional waters
In recent decades, gobies have dispersed or introduced from the Ponto-Caspian region of eastern Europe in a westerly direction to North American and western European waters. By contrast, the naked goby, Gobiosoma bosc, is the only known gobiid species to have been introduced in an easterly direction from North American to western Europe. The potential invasiveness of G. bosc was assessed using the Aquatic Species Invasiveness Screening Kit (AS-ISK) for rivers and transitional waters for the western and eastern sides of the North Sea. Using globally-derived thresholds, G. bosc was assessed as low-medium invasiveness risk for both sides of the North Sea under current climate conditions. Under future climate conditions, potential invasiveness will increase for both risk assessment areas. Environmental suitability assessment indicated an increase in environmental suitability for G. bosc on the eastern coastline of the North Sea under climate change scenarios and suitability remained unchanged on the western coastline, reflecting the authors' expectations of invasiveness risk