The 15-43 GHz parsec-scale circular polarization of 41 active galactic nuclei

We present the results of parsec-scale circular-polarization measurements based on Very Long Baseline Array data for a number of radio-bright, core-dominated active galactic nuclei obtained simultaneously at 15, 22 and 43 GHz. The degrees of circular polarization m(c) for the Very Long Baseline Interferometry (VLBI) core region at 15 GHz are similar to the values reported earlier at this wavelength, with typical values of a few tenths of a per cent. We find that mc as often rises as falls with increasing frequency between 15 and 22 GHz, while the degree of circular polarization at 43 GHz is in all cases higher than at 22 and 15 GHz. This behaviour seems contrary to expectations, since the degree of circular polarization from both synchrotron radiation and the Faraday conversion of linear to circular polarization - the two main mechanisms considered thus far in the literature - should decrease towards higher frequencies if the source is homogeneous. The increase in mc at 43 GHz may be due to the presence of regions of both positive and negative circular polarization with different frequency dependences ( but decreasing with increasing frequency) on small scales within the core region; alternatively, it may be associated with the intrinsic inhomogeneity of a Blandford-Konigl like jet. In several objects, the detected circular polarization appears to be near, but not coincident with, the core, although further observations are needed to confirm this. We find several cases of changes in sign with frequency, most often between 22 and 43 GHz. We find tentative evidence for transverse structure in the circular polarization of 1055+018 and 1334-127, that is consistent with their being generated by either the synchrotron mechanism or the Faraday conversion in a helical magnetic field. Our results confirm the earlier finding that the sign of the circular polarization at a given observing frequency is generally consistent across epochs separated by several years or more, suggesting stability of the magnetic-field orientation in the innermost jets

Investigating organic aerosol loading in the remote marine environment

Aerosol loading in the marine environment is investigated using aerosol composition measurements from several research ship campaigns (ICEALOT, MAP, RHaMBLe, VOCALS and OOMPH), observations of total AOD column from satellite (MODIS) and ship-based instruments (Maritime Aerosol Network, MAN), and a global chemical transport model (GEOS-Chem). This work represents the most comprehensive evaluation of oceanic OM emission inventories to date, by employing aerosol composition measurements obtained from campaigns with wide spatial and temporal coverage. The model underestimates AOD over the remote ocean on average by 0.02 (21 %), compared to satellite observations, but provides an unbiased simulation of ground-based Maritime Aerosol Network (MAN) observations. Comparison with cruise data demonstrates that the GEOS-Chem simulation of marine sulfate, with the mean observed values ranging between 0.22 μg m−3 and 1.34 μg m−3, is generally unbiased, however surface organic matter (OM) concentrations, with the mean observed concentrations between 0.07 μg m−3 and 0.77 μg m−3, are underestimated by a factor of 2–5 for the standard model run. Addition of a sub-micron marine OM source of approximately 9 TgC yr−1 brings the model into agreement with the ship-based measurements, however this additional OM source does not explain the model underestimate of marine AOD. The model underestimate of marine AOD is therefore likely the result of a combination of satellite retrieval bias and a missing marine aerosol source (which exhibits a different spatial pattern than existing aerosol in the model)

Latent Stochastic Differential Equations for Modeling Quasar Variability and Inferring Black Hole Properties

Active galactic nuclei (AGN) are believed to be powered by the accretion of matter around supermassive black holes at the centers of galaxies. The variability of an AGN's brightness over time can reveal important information about the physical properties of the underlying black hole. The temporal variability is believed to follow a stochastic process, often represented as a damped random walk described by a stochastic differential equation (SDE). With upcoming wide-field surveys set to observe 100 million AGN in multiple bandpass filters, there is a need for efficient and automated modeling techniques that can handle the large volume of data. Latent SDEs are well-suited for modeling AGN time series data, as they can explicitly capture the underlying stochastic dynamics. In this work, we modify latent SDEs to jointly reconstruct the unobserved portions of multivariate AGN light curves and infer their physical properties such as the black hole mass. Our model is trained on a realistic physics-based simulation of ten-year AGN light curves, and we demonstrate its ability to fit AGN light curves even in the presence of long seasonal gaps and irregular sampling across different bands, outperforming a multi-output Gaussian process regression baseline.Comment: 10 pages, 5 figures, accepted at the ICLR 2023 Workshop on Physics for Machine Learnin

Prolonged treatment of genetically obese mice with conjugated linoleic acid improves glucose tolerance and lowers plasma insulin concentration: possible involvement of PPAR activation

BACKGROUND: Studies in rodents and some studies in humans have shown that conjugated linoleic acid (CLA), especially its trans-10, cis-12 isomer, reduces body fat content. However, some but not all studies in mice and humans (though none in rats) have found that CLA promotes insulin resistance. The molecular mechanisms responsible for these effects are unclear, and there are conflicting reports on the effects of CLA on peroxisomal proliferator-activated receptor-γ (PPARγ) activation and expression. We have conducted three experiments with CLA in obese mice over three weeks, and one over eleven weeks. We have also investigated the effects of CLA isomers in PPARγ and PPARα reporter gene assays. RESULTS: Inclusion of CLA or CLA enriched with its trans-10, cis-12 isomer in the diet of female genetically obese (lep(ob)/lep(ob)) mice for up to eleven weeks reduced body weight gain and white fat pad weight. After two weeks, in contrast to beneficial effects obtained with the PPARγ agonist rosiglitazone, CLA or CLA enriched with its trans-10, cis-12 isomer raised fasting blood glucose and plasma insulin concentrations, and exacerbated glucose tolerance. After 10 weeks, however, CLA had beneficial effects on glucose and insulin concentrations. At this time, CLA had no effect on the plasma TNFα concentration, but it markedly reduced the plasma adiponectin concentration. CLA and CLA enriched with either isomer raised the plasma triglyceride concentration during the first three weeks, but not subsequently. CLA enriched with its trans-10, cis-12 isomer, but not with its cis-9, trans-11 isomer, stimulated PPARγ-mediated reporter gene activity; both isomers stimulated PPARα-mediated reporter gene activity. CONCLUSIONS: CLA initially decreased but subsequently increased insulin sensitivity in lep(ob)/lep(ob )mice. Activation of both PPARγ and PPARα may contribute to the improvement in insulin sensitivity. In the short term, however, another mechanism, activated primarily by trans-10, cis-12-CLA, which probably leads to reduced adipocyte number and consequently reduced plasma adiponectin concentration, may decrease insulin sensitivity

Over-Tip Choking and Its Implications on Turbine Blade Tip Aerodynamic Performance

At engine representative flow conditions a significant portion of flow over a high pressure turbine blade tip is transonic. In the present work, the choking flow behavior and its implications on over-tip leakage flow loss generation are computationally analyzed. An extensively developed RANS code (HYDRA) is adopted. Firstly a high speed linear cascade validation case is introduced, and the computations are compared with the experimental data to identify and establish the capability of the code in predicting the aerodynamics losses for a transonic turbine blade tip. The computational studies are then carried out for the blading configuration at different flow conditions ranging from a nearly incompressible to a nominal transonic one, enabling to establish a qualitatively consistent trend of the tip leakage losses in relation to the exit Mach number conditions. The results clearly show that the local choking sets a limiter for the over tip leakage mass flow, leading to a different leakage flow structure compared to that in a low speed and/or unchoked condition. The existence of tip choking effectively blocks the influence of the suction surface side on the over-tip flow, and hence leads to a breakdown of the pressure-driven mechanism, conventionally used in tip treatment and designs. The decoupling between blade loading and over tip leakage mass flow is clearly identified and highlighted. Furthermore, the realization of the loading-leakage flow decoupling indicates a possibility of a high-load blading design with a relatively low tip leakage loss. A high load blading is generated and analyzed to demonstrate the feasibility of such designs with a reduced tip leakage loss

'Let me take care of you': what can healthcare learn from a high-end restaurant to improve the patient experience?

Background: The patient experience is associated with patient satisfaction and health outcomes, presenting a key challenge in healthcare. The objective of the study was to explore the principles of care in and beyond healthcare, namely in a three Michelin-starred restaurant, and consider what, if any, principles of care from the diners’ experience could be transferrable to healthcare. Methods: The principles of care were first explored as part of observational fieldwork in a healthcare day surgery unit and restaurant respectively, focusing on communication between the professionals and the patients or the diners. Care was subsequently explored in a series of public engagement events across the UK. The events used immersive simulation to recreate the healthcare and the dining experiences for the general public, and to stimulate discussion. Results: A thematic analysis of the engagement discussions identified overarching themes in how care was experienced in and through communication; “informed, not bombarded”, “conversation, not interrogation”, “environment is communication”, and “being met as a person”. The themes suggested how the participants in simulation felt about the care they received in real time and provided recommendations for improved clinical practice. Conclusions: While practice improvements in healthcare are challenging, the patient experience could be enhanced by learning relational aspects of care from other sectors, including the high-end restaurant industry that focuses on meeting persons’ needs. Simulation provides a new kind of opportunity to bring professionals and patients together for focused discussions, prompted by immersive experiences of care and communication

Spitzer IRS Spectral Mapping of the Toomre Sequence: Spatial Variations of PAH, Gas, and Dust Properties in Nearby Major Mergers

We have mapped the key mid-IR diagnostics in eight major merger systems of the Toomre Sequence (NGC4676, NGC7592, NGC6621, NGC2623, NGC6240, NGC520, NGC3921, and NGC7252) using the Spitzer Infrared Spectrograph (IRS). With these maps, we explore the variation of the ionized-gas, PAH, and warm-gas (H_2) properties across the sequence and within the galaxies. While the global PAH interband strength and ionized gas flux ratios ([Ne III]/[Ne II]) are similar to those of normal star forming galaxies, the distribution of the spatially resolved PAH and fine structure line flux ratios is significant different from one system to the other. Rather than a constant H_2/PAH flux ratio, we find that the relation between the H_2 and PAH fluxes is characterized by a power law with a roughly constant exponent (0.61+/-0.05) over all merger components and spatial scales. While following the same power law on local scales, three galaxies have a factor of ten larger integrated (i.e. global) H_2/PAH flux ratio than the rest of the sample, even larger than what it is in most nearby AGNs. These findings suggest a common dominant excitation mechanism for H_2 emission over a large range of global H_2/PAH flux ratios in major mergers. Early merger systems show a different distribution between the cold (CO J=1-0) and warm (H_2) molecular gas component, which is likely due to the merger interaction. Strong evidence for buried star formation in the overlap region of the merging galaxies is found in two merger systems (NGC6621 and NGC7592) as seen in the PAH, [Ne II], [Ne III], and warm gas line emission, but with no apparent corresponding CO (J=1-0) emission. Our findings also demonstrate that the variations of the physical conditions within a merger are much larger than any systematic trends along the Toomre Sequence.Comment: 35 pages, accepted for publication in ApJ

Learning from a Rapid Health Impact Assessment of a proposed maternity service reconfiguration in the English NHS

<p>Abstract</p> <p>Background</p> <p>Within many parts of the country, the NHS is undertaking reconfiguration of services. Such proposals can prove a tipping point and provoke public protest, often with significant involvement of local and national politicians. We undertook a rapid Health Impact Assessment (HIA) of a proposed reconfiguration of maternity services in Huddersfield and Halifax in England. The aim of the HIA was to help the PCT Boards to assess the reconfiguration's possible consequences on access to maternity services, and maternal and infant health outcomes across different socio-economic groups in Kirklees. We report on the findings of the HIA and the usefulness of the process to decision making.</p> <p>Methods</p> <p>This HIA used routine maternity data for 2004–2005 in Huddersfield, in addition to published evidence. Standard HIA techniques were used.</p> <p>Results</p> <p>We re-highlighted the socio economic differences in smoking status at booking and quitting during pregnancy. We focused on the key concerns of the public, that of adverse obstetric events on a Midwife Led Unit (MLU) with distant obstetric cover. We estimate that twenty percent of women giving birth in a MLU may require urgent transfer to obstetric care during labour. There were no significant socio economic differences. Much of the risk can be mitigated though robust risk management policies. Additional travelling distances and costs could affect lower socio-economic groups the greatest because of lower car ownership and geographical location in relation to the units. There is potential that with improved community antenatal and post natal care, population outcomes could improve significantly, the available evidence supports this view.</p> <p>Conclusion</p> <p>Available evidence suggests that maternity reconfiguration towards enhanced community care could have many potential benefits but carries risk. Investment is needed to realise the former and mitigate the latter.</p> <p>The usefulness of this Health Impact Assessment may have been impeded by its timing, and the politically charged environment of the proposals. Nonetheless, the methods used are readily applicable to assess the impact of other service reconfigurations. The analysis was simple, not time intensive and used routinely available data. Careful consideration should be given to both the timing and the political context in which an analysis is undertaken.</p