Evaluation of Overall Survival (OS) and Event-Free Survival (EFS) of paediatric sarcoma patients at a single institution

Aims: To evaluate OS and EFS of paediatric sarcoma patients with an interest in comparing metastatic cases with non-metastatic cases, and compiling statistics on treatment methods. Methods: Information was obtained from patient notes in the Schiehallion ward. These contained information about diagnosis, treatment, prognostic indicators, and outcomes for each patient. Results: 56 patients, 2001-2008. Osteosarcoma: 11 patients, 7♂, 4♀; age range: 4-16; = 10; OS = 64%, EFS = 55%; Primary site of disease: Femur (47%), Tibia (41%), Humerus (5.5%), Scapula (5.5%), Other (1%); Metastatic Rate = 27% (OS = 0%). Ewing’s sarcoma: 24 patients, 10♂, 14♀; age range: 1-16, = 12; OS = 71%, EFS = 58%; Primary site of disease: Pelvis (29%), Femur (22%), Paraspinal (16%), Chest Wall (10%), Tibia (10%), Other (13%); Metastatic Rate = 21% (OS = 40%; EFS = 40%); Alveolar rhabdomyosarcoma: 10 patients; OS= 80%, EFS = 60%; Metastatic Rate = 20% (OS = 100%; EFS = 100%). Embryonal rhabdomyosarcoma: 11 patients; OS = 73%, EFS = 73%; Metastatic Rate = 0%. Conclusions: Our results reflect access to an experienced and innovative paediatric sarcoma service with close links to a national Sarcoma MDT. The data falls in line with other studies in terms of age of onset, location of primary tumour, metastatic rate, site of metastases, and prognosis for all cancer types. Limb salvage surgery is greatly favoured over amputation for both osteosarcoma and Ewing’s sarcoma. Females have a more favourable prognosis in osteosarcoma and a slightly poorer prognosis in Ewing’s sarcoma. Yorkhill’s overall survival rates are currently better than the UK-wide statistic for three of the four tumours examined.</p

K→πK \to \pi matrix elements of the chromomagnetic operator on the lattice

We present the results of the first lattice QCD calculation of the $K \to \pi$ matrix elements of the chromomagnetic operator $O_{CM} = g\, \bar s\, \sigma_{\mu\nu} G_{\mu\nu} d$, which appears in the effective Hamiltonian describing $\Delta S = 1$ transitions in and beyond the Standard Model. Having dimension 5, the chromomagnetic operator is characterized by a rich pattern of mixing with operators of equal and lower dimensionality. The multiplicative renormalization factor as well as the mixing coefficients with the operators of equal dimension have been computed at one loop in perturbation theory. The power divergent coefficients controlling the mixing with operators of lower dimension have been determined non-perturbatively, by imposing suitable subtraction conditions. The numerical simulations have been carried out using the gauge field configurations produced by the European Twisted Mass Collaboration with $N_f = 2+1+1$ dynamical quarks at three values of the lattice spacing. Our result for the B-parameter of the chromomagnetic operator at the physical pion and kaon point is $B_{CMO}^{K \pi} = 0.273 ~ (70)$, while in the SU(3) chiral limit we obtain $B_{CMO} = 0.072 ~ (22)$. Our findings are significantly smaller than the model-dependent estimate $B_{CMO} \sim 1 - 4$, currently used in phenomenological analyses, and improve the uncertainty on this important phenomenological quantity.Comment: 20 pages, 4 figures, 2 table. Refined SU(3) ChPT analysis with no changes in the final result. Version to appear in PR

Pseudo-critical clusterization in nuclear multifragmentation

In this contribution we show that the biggest fragment charge distribution in central collisions of Xe+Sn leading to multifragmentation is an admixture of two asymptotic distributions observed for the lowest and highest bombarding energies. The evolution of the relative weights of the two components with bombarding energy is shown to be analogous to that observed as a function of time for the largest cluster produced in irreversible aggregation for a finite system. We infer that the size distribution of the largest fragment in nuclear multifragmentation is also characteristic of the time scale of the process, which is largely determined by the onset of radial expansion in this energy range.Comment: 4 pages, 3 figures, Contribution to conference proceedings of the 25th International Nuclear Physics Conference (INPC 2013

Demodulation of Spatial Carrier Images: Performance Analysis of Several Algorithms Using a Single Image

http://link.springer.com/article/10.1007%2Fs11340-013-9741-6#Optical full-field techniques have a great importance in modern experimental mechanics. Even if they are reasonably spread among the university laboratories, their diffusion in industrial companies remains very narrow for several reasons, especially a lack of metrological performance assessment. A full-field measurement can be characterized by its resolution, bias, measuring range, and by a specific quantity, the spatial resolution. The present paper proposes an original procedure to estimate in one single step the resolution, bias and spatial resolution for a given operator (decoding algorithms such as image correlation, low-pass filters, derivation tools ...). This procedure is based on the construction of a particular multi-frequential field, and a Bode diagram representation of the results. This analysis is applied to various phase demodulating algorithms suited to estimate in-plane displacements.GDR CNRS 2519 “Mesures de Champs et Identification en Mécanique des Solide

Pedestal and Er profile evolution during an edge localized mode cycle at ASDEX Upgrade

The upgrade of the edge charge exchange recombination spectroscopy diagnostic at ASDEX Upgrade has enabled highly spatially resolved me asurements of the impurity ion dynamics during an edge-localized mode cycle ( ELM ) with unprecedented temp oral resolution, i.e. 65 μ s. The increase of transport during an ELM induces a relaxation of the ion, electron edge gradients in impurity density and fl ows. Detailed characterization of the recovery of the edge temperature gradients reveals a difference in the ion and electron channe l: the maximum ion temperature gradient T i is re-established on similar timescales as n e , which is faster than the recovery of T e .Afterthe clamping of the maximum gradient, T i and T e at the pedestal top continue to rise up to the next ELM while n e stays constant which means that the temperatur e pedestal and the resu lting pedestal pressure widen until the next ELM. The edge radial electric fi eld E r at the ELM crash is found to reduce to typical L-mode values and its ma ximum recovers to its pre-ELM conditions on a similar time scale as for n e and T i . Within the uncertainties, the measurements of E r align with their neoclassical predictions E r,neo for most of the ELM cycle, thus indicating that E r is dominated by collisional processes. However, between 2 and 4 ms af ter the ELM crash, other contributions to E B ́ fl ow, e.g. zonal fl ows or ion orbit effects, could not be excluded within the uncertainties.European Commission (EUROfusion 633053

ESC core curriculum for the general cardiologist (2013)

[No abstract available

Discovery of very high energy gamma-rays from the flat spectrum radio quasar 3C 279 with the MAGIC telescope

3C 279 is one of the best studied flat spectrum radio quasars located at a comparatively large redshift of z = 0.536. Observations in the very high energy band of such distant sources were impossible until recently due to the expected steep energy spectrum and the strong gamma-ray attenuation by the extragalactic background light photon field, which conspire to make the source visible only with a low energy threshold. Here the detection of a significant gamma-ray signal from 3C 279 at very high energies (E > 75 GeV) during a flare in early 2006 is reported. Implications of its energy spectrum on the current understanding of the extragalactic background light and very high energy gamma-ray emission mechanism models are discussed.Comment: 4 pages, 6 figures, submitted to proceedings of "4th Heidelberg International Symposium on High Energy Gamma-Ray Astronomy 2008

The asteroseismic ground-based observational counterpart of CoRoT

We present different aspects of the ground-based observational counterpart of the CoRoT satellite mission. We give an overview of the selected asteroseismic targets, the numerous instruments and observatories involved, and the first scientific results.Comment: 3 pages, 2 tables, 1 figure, to be published in the conference proceedings 'Stellar Pulsation: Challenges for Theory and Observation' (31 May - 5 June, Santa Fe, New Mexico, US), publishers: American Institute of Physic

Hysterectomy, endometrial destruction, and levonorgestrel releasing intrauterine system (Mirena) for heavy menstrual bleeding : systematic review and meta-analysis of data from individual patients

Peer reviewedPublisher PD

A Widespread, Clumpy Starburst in the Isolated Ongoing Dwarf Galaxy Merger dm1647+21

Interactions between pairs of isolated dwarf galaxies provide a critical window into low-mass hierarchical, gas-dominated galaxy assembly and the buildup of stellar mass in low-metallicity systems. We present the first VLT/MUSE optical IFU observations of the interacting dwarf pair dm1647+21, selected from the TiNy Titans survey. The H$\alpha$ emission is widespread and corresponds to a total unobscured star formation rate (SFR) of 0.44 M$_{\odot}$ yr$^{-1}$, 2.7 times higher than the SFR inferred from SDSS data. The implied specific SFR (sSFR) for the system is elevated by more than an order of magnitude above non-interacting dwarfs in the same mass range. This increase is dominated by the lower-mass galaxy, which has a sSFR enhancement of $>$ 50. Examining the spatially-resolved maps of classic optical line diagnostics, we find the ISM excitation can be fully explained by star formation. The velocity field of the ionized gas is not consistent with simple rotation. Dynamical simulations indicate that the irregular velocity field and the stellar structure is consistent with the identification of this system as an ongoing interaction between two dwarf galaxies. The widespread, clumpy enhancements in star formation in this system point to important differences in the effect of mergers on dwarf galaxies, compared to massive galaxies: rather than the funneling of gas to the nucleus and giving rise to a nuclear starburst, starbursts in low-mass galaxy mergers may be triggered by large-scale ISM compression, and thus be more distributed.Comment: Accepted for publication in ApJ. 11 pages, 5 figures, 1 table. Figures slightly degraded to meet arXiv size restrictions. For more information about TiNy Titans see https://lavinia.as.arizona.edu/~tinytitans