Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

РАБОЧАЯ ТЕТРАДЬ КАК ВАЖНОЕ ДИДАКТИЧЕСКОЕ СРЕДСТВО СОВРЕМЕННОГО ОБУЧЕНИЯ ИНОСТРАННЫХ СТУДЕНТОВ

The paper focuses on the issues of didactic support of the modern way of teaching the subject "Social Studies" to foreign students. The workbook is considered to be a promising learning tool as well as a means of self-study management of the students. The paper describes the main didactic and educational opportunities of the usage of the workbook in the learning process of the foreign students. The methodologically necessary kinds of tasks are also described in the paper. The essential didactic and methodological requirements to the workbook structure in the teaching of the subject to foreign students are defined.Данная статья посвящена вопросу дидактического обеспечения современного обучения иностранных студентов по «Обществознанию». В качестве перспективного средства обучения и организации самостоятельной работы студентов рассматривается рабочая тетрадь. Выявлены преимущественные дидактические и воспитательные возможности применения рабочей тетради в учебном процессе иностранных студентов. Дана характеристика оптимальной и методически необходимой системы задач. Выявлены основные методические и дидактические требования к структуре рабочей тетради. Определяется особая необходимость и важность использования рабочей тетради в процессе обучения иностранных по курсу «Обществознание

Особенности среднего и высшего образования стран Северной Африки

The article is devoted to the problem of secondary and higher education in North Africa. The main characteristics of the structure of secondary and higher education in North Africa are described. The directions of higher education reform in the countries of North Africa at the present stage are revealed. The problems of higher and secondary education in the region are revealed.Статья посвящена проблеме среднего и высшего образования в странах Северной Африки. Описаны основные характеристики структуры среднего и высшего образования в странах Северной Африки. Раскрыты направления реформирования высшего образования в странах Северной Африки на современном этапе. Выявлены проблемы высшего и среднего образования в регионе

Migration processes in the Trans-Dniester region of the republic of Moldova and their impact on the socio-economic situation

The purpose of the study is revealing the content and causes of migration processes in Trans-Dniester Region and their impact on the socio-economic situation in the region. From this perspective the main objectives of the study consisted in disclosing the reasons of con-siderable population outflow over the past two decades, the study of the peculiarities of different forms of migration in Trans-Dniester Region, identifying trends in migration of population, regulation of the migration mechanism at the present stage, the assessment of the current system of migration flows accounting in Trans-Dniester Region and the definition of its optimization directions. Particular atten-tion is paid to the consideration of the migration scale and the main areas of emigration. The loss of immigration attractiveness of the region and outflow of highly qualified young and active population from Trans-Dniester Region causes a steady reduction in the popula-tion, creates a significant imbalance in the demographic structure of the population (in terms of age and profession). Besides, the Trans-Dniester Region turned out to be actively involved in migration processes due to its relative geographical proximity to both Russia and the EU countries. Currently, the predominant role is played by labor migration. © 2018 Authors

Estudio de la etiología, patogenia y diagnóstico de las dermatomicosis del cuero cabelludo, uñas, pies, manos, piel lisa y dermatofitosis inguinal

Introduction: The increased incidence and preponderance of dermatomycosis cause the issue of determining antimycotic agents of systemic and external action to be particularly pertinent, considering the etiology, clinical form, and majority of mycoses, the sensitivity of pathogens to them, and the existence of concurrent conditions. The study aims to analyze the etiology, pathogenesis, and diagnosis of dermatomycosis of the scalp, nails, feet, hands, smooth skin, and inguinal dermatophytosis. Patients and methods: To meet the aim of the study, it is attempted to generate an algorithm for pharmaceutical counseling of patients suffering from various types of dermatomycosis. Over the span of five months, a survey was carried out of 25 visitors to the pharmacy with a diagnosis of dermatomycosis. Results: Based on the results, it was revealed that most of the visitors suffer from dermatomycosis of the feet - 10 people (40%), the second in terms of incidence is onychomycosis - 5 people (19%), the third in terms of incidence is dermatomycosis of the groin area - 4 people (15%), the fourth in the incidence is dermatomycosis of the scalp - 4 people (14%). Conclusion: To treat different types of dermatomycosis, various antifungal drugs in different dosage forms can be used. For each type of disease, a specific course of treatment is selected. The duration of the course of treatment depends on the skin lesion area, the duration of the disease, and the presence of complications.Introducción: El aumento de la incidencia y preponderancia de las dermatomicosis hace que el tema de la determinación de agentes antimicóticos de acción sistémica y externa sea particularmente pertinente, considerando la etiología, forma clínica y mayoría de las micosis, la sensibilidad de los patógenos a las mismas y la existencia de condiciones. El estudio tiene como objetivo analizar la etiología, patogenia y diagnóstico de las dermatomicosis del cuero cabelludo, uñas, pies, manos, piel lisa y dermatofitosis inguinal. Pacientes y métodos: Para cumplir con el objetivo del estudio, se intenta generar un algoritmo para el asesoramiento farmacéutico de pacientes que padecen diversos tipos de dermatomicosis. Durante cinco meses se realizó una encuesta a 25 visitantes de la farmacia con diagnóstico de dermatomicosis. Resultados: Con base en los resultados, se reveló que la mayoría de los visitantes padecen dermatomicosis de los pies - 10 personas (40%), el segundo en cuanto a incidencia es la onicomicosis - 5 personas (19%), el tercero en cuanto a la incidencia es dermatomicosis del área de la ingle - 4 personas (15%), el cuarto en la incidencia es dermatomicosis del cuero cabelludo - 4 personas (14%). Conclusión: Para tratar diferentes tipos de dermatomicosis, se pueden utilizar diversos fármacos antifúngicos en diferentes formas de dosificación. Para cada tipo de enfermedad, se selecciona un curso de tratamiento específico. La duración del curso del tratamiento depende del área de la lesión cutánea, la duración de la enfermedad y la presencia de complicaciones

Bactericidal effect of lysozyme

Isolation of lysozyme from hemolymph of Alveonasus lahorensis (Acari: Parasitiformes, Argasidae) and Hyalomma marginatum (Acari: Parasitiformes, Ixodidae) with using ultrasound is described. It was shown that the bactericidal effect of the ultrasoundextracted lysozyme against Staphylococcus aureus and Micrococcus luteus significantly exceeded that of the chicken egg lysozyme and lysozyme from ticks without ultrasound exposure. Disintegration of the hemolymph cells increased lysozyme production

Bactericidal effect of lysozyme

Isolation of lysozyme from hemolymph of Alveonasus lahorensis (Acari: Parasitiformes, Argasidae) and Hyalomma marginatum (Acari: Parasitiformes, Ixodidae) with using ultrasound is described. It was shown that the bactericidal effect of the ultrasoundextracted lysozyme against Staphylococcus aureus and Micrococcus luteus significantly exceeded that of the chicken egg lysozyme and lysozyme from ticks without ultrasound exposure. Disintegration of the hemolymph cells increased lysozyme production