The End Of Nucleosynthesis: Production Of Lead And Thorium In The Early Galaxy

We examine the Pb and Th abundances in 27 metal-poor stars (-3.1 56) enrichment was produced only by the rapid (r-) nucleosynthesis process. New abundances are derived from Hubble Space Telescope/Space Telescope Imaging Spectrograph, Keck/High Resolution Echelle Spectrograph, and Very Large Telescope/UV-Visual Echelle Spectrograph spectra and combined with other measurements from the literature to form a more complete picture of nucleosynthesis of the heaviest elements produced in the r-process. In all cases, the abundance ratios among the rare earth elements and the third r-process peak elements considered (La, Eu, Er, Hf, and Ir) are constant and equivalent to the scaled solar system r-process abundance distribution. We compare the stellar observations with r-process calculations within the classical "waiting-point" approximation. In these computations a superposition of 15 weighted neutron-density components in the range 23 <= log n(n) <= 30 is fit to the r-process abundance peaks to successfully reproduce both the stable solar system isotopic distribution and the stable heavy element abundance pattern between Ba and U in low-metallicity stars. Under these astrophysical conditions, which are typical of the "main" r-process, we find very good agreement between the stellar Pb r-process abundances and those predicted by our model. For stars with anomalously high Th/Eu ratios (the so-called actinide boost), our observations demonstrate that any nucleosynthetic deviations from the main r-process affect-at most-only the elements beyond the third r-process peak, namely Pb, Th, and U. Our theoretical calculations also indicate that possible r-process abundance "losses" by nuclear fission are negligible for isotopes along the r-process path between Pb and the long-lived radioactive isotopes of Th and U.Deutsche Forschungsgemeinschaft KR 806/13-1Helmholtz Gemeinschaft VH-VI-061U S National Science Foundation AST 07-07447, AST 06-07708Astronom

Modules for the education of civil engineers and the management of expert knowledge

In the focus of the Bologna-contract of the European secretaries of education the universities are invited to aim a unification and comparability of certificates and to offer compatible and cooperative models of education. Among existing lectures in the Internet there will arise a new competition between the universities in netbased teaching and learning environments. For the use of distributed sources of information and for the possibility to generate free configurable sequences of education modules you need management systems which are able to handle different formats of documents and to assemble it to consistent and valid lessons. Beside elementar viewing-functions, fusion of information also administrative tasks are needed, e.g. automated efficiency controls, adaptive learning surroundings. This paper attends to three aspects: - netbased teaching and learning in the area of the instruction of civil engineers - netbased information assembling and fusion of knowledge bases to higher level documents - netbased learning with international coordinated project

Biogas Production From a Mixture of Cow Manure with Chicken Manure

Biogas technology with zero waste concept is expected to be the alternative energy and to reduce environmental problems. The purpose of this study is to know the biogas yield per kilogram of each chicken and cow manure comparison. The study was conducted in six treatments with the addition of chicken manure of 0, 100, 300, 500, 700 and 1000 grams. The fermentation process is done using a batch system and biogas measurement was taken daily. The parameters to be observed were organic matter, the degree of acidity (pH), temperature, volume of biogas, biogas productivity, and C / N ratio of each treatment. The results showed that the overall pH at the beginning and end of the study tend to be close to neutral. The highest biogas yield was resulted from a mixture of chicken manure and cow manure at the composition of 1:1 or 50%:50% with biogas total amount of 35.690 ml and biogas productivity of 0,33 liters/g (volatile solid)

24-h Efficacy of Glaucoma Treatment Options

Current management of glaucoma entails the medical, laser, or surgical reduction of intraocular pressure (IOP) to a predetermined level of target IOP, which is commensurate with either stability or delayed progression of visual loss. In the published literature, the hypothesis is often made that IOP control implies a single IOP measurement over time. Although the follow-up of glaucoma patients with single IOP measurements is quick and convenient, such measurements often do not adequately reflect the untreated IOP characteristics, or indeed the quality of treated IOP control during the 24-h cycle. Since glaucoma is a 24-h disease and the damaging effect of elevated IOP is continuous, it is logical that we should aim to understand the efficacy of all treatment options throughout the 24-h period. This article first reviews the concept and value of diurnal and 24-h IOP monitoring. It then critically evaluates selected available evidence on the 24-h efficacy of medical, laser and surgical therapy options. During the past decade several controlled trials have significantly enhanced our understanding on the 24-h efficacy of all glaucoma therapy options. Nevertheless, more long-term evidence is needed to better evaluate the 24-h efficacy of glaucoma therapy and the precise impact of IOP characteristics on glaucomatous progression and visual prognosis

Correction:Prevalence and Cardiovascular Associations of Diabetic Retinopathy and Maculopathy: Results from the Gutenberg Health Study

Diabetic retinopathy (DR) is the leading cause of blindness in people of working age. The purpose of this paper is to report the prevalence and cardiovascular associations of diabetic retinopathy and maculopathy (DMac) in Germany.The Gutenberg Health Study (GHS) is a population-based study with 15,010 participants aged between 35 at 74 years from the city of Mainz and the district of Mainz-Bingen. We determined the weighted prevalence of DR and DMac by assessing fundus photographs of persons with diabetes from the GHS data base. Diabetes was defined as HbA1c ≥ 6.5%, known diagnosis diabetes mellitus or known diabetes medication. Furthermore, we analysed the association between DR and cardiovascular risk factors and diseases.Overall, 7.5% (1,124/15,010) of the GHS cohort had diabetes. Of these, 27.7% were unaware of their disease and thus were newly diagnosed by their participation in the GHS. The prevalence of DR and DMac was 21.7% and 2.3%, respectively among patients with diabetes. Vision-threatening disease was present in 5% of the diabetic cohort. In the multivariable analysis DR (all types) was associated with age (Odds Ratio [95% confidence interval]: 0.97 [0.955-0.992]; p = 0.006) arterial hypertension (1.90 [1.190-3.044]; p = 0.0072) and vision-threatening DR with obesity (3.29 [1.504-7.206]; p = 0.0029). DR (all stages) and vision-threatening DR were associated with duration of diabetes (1.09 [1.068-1.114]; p<0.0001 and 1.18 [1.137-1.222]; p<0.0001, respectively).Our calculations suggest that approximately 142 000 persons aged between 35 and 74 years have vision threatening diabetic retinal disease in Germany [corrected].Prevalence of DR was lower in the GHS compared to East-Asian studies. Associations were found with age, arterial hypertension, obesity, and duration of diabetes mellitus

The ophthalmic branch of the Gutenberg Health Study: study design, cohort profile and self-reported diseases

This paper describes the study design, methodology, cohort profile and self-reported diseases in the ophthalmological branch of the Gutenberg Health Study (GHS).The GHS is an ongoing, prospective, interdisciplinary, single-center, population-based cohort study in Germany. The main goals of the ophthalmological section are to assess the prevalence and incidence of ocular diseases and to explore risk factors, genetic determinants and associations with systemic diseases and conditions. The eye examination at baseline included a medical history, self-reported eye diseases, visual acuity, refractive errors, intraocular pressure, visual field, pachymetry, keratometry, fundus photography and tear sampling. The 5-year follow-up visit additionally encompassed optical coherence tomography, anterior segment imaging and optical biometry. The general examination included anthropometry; blood pressure measurement; carotid artery ultrasound; electrocardiogram; echocardiography; spirometry; cognitive tests; questionnaires; assessment of mental conditions; and DNA, RNA, blood and urine sampling.Of 15,010 participants (aged 35-74 years at the time of inclusion), ocular data are available for 14,700 subjects (97.9%). The mean visual acuity (standard deviation), mean spherical equivalent, median decimal visual acuity, and mean intraocular pressure were 0.08 (0.17) logMar, -0.42 (2.43) diopters, 0.9 and 14.24 (2.79) mm Hg, respectively. The frequencies of self-reported strabismus, glaucoma, surgery for retinal detachment and retinal vascular occlusions were 2.7%, 2.3%, 0.2% and 0.4%, respectively.The GHS is the most extensive dataset of ophthalmic diseases and conditions and their risk factors in Germany and one of the largest cohorts worldwide. This dataset will provide new insight in the epidemiology of ophthalmic diseases and related medical specialties

Modules for the education of civil engineers and the management of expert knowledge

In the focus of the Bologna-contract of the European secretaries of education the universities are invited to aim a unification and comparability of certificates and to offer compatible and cooperative models of education. Among existing lectures in the Internet there will arise a new competition between the universities in netbased teaching and learning environments. For the use of distributed sources of information and for the possibility to generate free configurable sequences of education modules you need management systems which are able to handle different formats of documents and to assemble it to consistent and valid lessons. Beside elementar viewing-functions, fusion of information also administrative tasks are needed, e.g. automated efficiency controls, adaptive learning surroundings. This paper attends to three aspects: - netbased teaching and learning in the area of the instruction of civil engineers - netbased information assembling and fusion of knowledge bases to higher level documents - netbased learning with international coordinated project

Muscarinic acetylcholine receptors in the retina: therapeutic implications

Muscarinic acetylcholine receptors (mAChRs) belong to the superfamily of G-protein-coupled receptors (GPCRs). The family of mAChRs is composed of five subtypes, M1, M2, M3, M4 and M5, which have distinct expression patterns and functions. In the eye and its adnexa, mAChRs are widely expressed and exert multiple functions, such as modulation of tear secretion, regulation of pupil size, modulation of intraocular pressure, participation in cell-to-cell signaling and modula-tion of vascular diameter in the retina. Due to this variety of functions, it is reasonable to assume that abnormalities in mAChR signaling may contribute to the development of various ocular diseases. On the other hand, mAChRs may offer an attractive therapeutic target to treat ocular diseases. Thus far, non-subtype-selective mAChR ligands have been used in ophthalmology to treat dry eye disease, myopia and glaucoma. However, these drugs were shown to cause various side-effects. Thus, the use of subtype-selective ligands would be useful to circumvent this problem. In this review, we give an overview on the localization and on the functional role of mAChR subtypes in the eye and its adnexa with a special focus on the retina. Moreover, we describe the pathophysiological role of mAChRs in retinal diseases and discuss potential therapeutic approaches

Author Correction: Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases.

Emmanuelle Souzeau, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this Article. This has now been corrected in both the PDF and HTML versions of the Article