Applications of Artificial Intelligence Techniques in Optimizing Drilling

Artificial intelligence has transformed the industrial operations. One of the important applications of artificial intelligence is reducing the computational costs of optimization. Various algorithms based on their assumptions to solve problems have been presented and investigated, each of which having assumptions to solve the problems. In this chapter, firstly, the concept of optimization is fully explained. Then, an artificial bee colony (ABC) algorithm is used on a case study in the drilling industry. This algorithm optimizes the problem of study in combination with ANN modeling. At the end, various models are fully developed and discussed. The results of the algorithm show that by better understanding the drilling data, the conditions can be improved

Longitudinal Molecular Trajectories of Diffuse Glioma in Adults

The evolutionary processes that drive universal therapeutic resistance in adult patients with diffuse glioma remain unclear ¹² . Here we analysed temporally separated DNA-sequencing data and matched clinical annotation from 222 adult patients with glioma. By analysing mutations and copy numbers across the three major subtypes of difuse glioma, we found that driver genes detected at the initial stage of disease were retained at recurrence, whereas there was little evidence of recurrence-specifc gene alterations. Treatment with alkylating agents resulted in a hypermutator phenotype at diferent rates across the glioma subtypes, and hypermutation was not associated with diferences in overall survival. Acquired aneuploidy was frequently detected in recurrent gliomas and was characterized by IDH mutation but without co-deletion of chromosome arms 1p/19q, and further converged with acquired alterations in the cell cycle and poor outcomes. The clonal architecture of each tumour remained similar over time, but the presence of subclonal selection was associated with decreased survival. Finally, there were no differences in the levels of immunoediting between initial and recurrent gliomas. Collectively, our results suggest that the strongest selective pressures occur during early glioma development and that current therapies shape this evolution in a largely stochastic manner

A new methodology for optimization and prediction of rate of penetration during drilling operations

Predictive models have been widely used in different engineering fields, as well as in petroleum engineering. Due to the development of high-performance computer systems, the accuracy and complexity of predictive models have been increased significantly. One of the common methods for prediction is artificial neural network (ANN). ANN models in combination with optimization algorithms provide a powerful and fast tool for the prediction and optimization of processes which take a large amount of time if they are simulated using common simulation technics. In the present paper, to predict penetration rate during drilling process, several ANN models were developed based on the data obtained from drilling of a gas well located in south of Iran. Regarding the R2 and RMSE values of the developed models, the best model was selected for prediction of penetration rate. In the next step, artificial bee colony algorithm was used for optimization of the parameters which are effective on rate of penetration (ROP). Results showed that the model is accurate enough for being used in the prediction and optimization of ROP in drilling operations

Anesthesia and analgesia for common research models of adult mice

Abstract Anesthesia and analgesia are major components of many interventional studies on laboratory animals. However, various studies have shown improper reporting or use of anesthetics/analgesics in research proposals and published articles. In many cases, it seems “anesthesia” and “analgesia” are used interchangeably, while they are referring to two different concepts. Not only this is an unethical practice, but also it may be one of the reasons for the proven suboptimal quality of many animal researches. This is a widespread problem among investigations on various species of animals. However, it could be imagined that it may be more prevalent for the most common species of laboratory animals, such as the laboratory mice. In this review, proper anesthetic/analgesic methods for routine procedures on laboratory mice are discussed. We considered the available literature and critically reviewed their anesthetic/analgesic methods. Detailed dosing and pharmacological information for the relevant drugs are provided and some of the drugs’ side effects are discussed. This paper provides the necessary data for an informed choice of anesthetic/analgesic methods in some routine procedures on laboratory mice