Research areas and trends in family-centered care in the 21st century: a bibliometric review

IntroductionFamily-centered care (FCC) is a model of care provision that sees a patient’s loved ones as essential partners to the health care team and positively influences the psychological safety of patients and loved ones.ObjectivesThis review aims to present an overview of impactful publications, authors, institutions, journals, countries, fields of application and trends of FCC in the 21st century as well as suggestions on further research.MethodsThe Web of Science Database was searched for publications on FCC between January 2000 and Dezember 2023. After screening for duplicates, VOS Viewer and CiteSpace were used to analyze and visualize the data.ResultsScientific interest in FCC has grown and resulted in the scientific output of 4,836 publications originating from 103 different countries. Based on the frequent author keywords, FCC was of greatest interest in neonatology and pediatrics, nursing, critical and intensive care, end-of-life and palliative care, and patient-related outcomes. The recent research hotspots are “patient engagement,” “qualitative study,” and “health literacy.”ConclusionFCC has gained recognition and spread from the pediatric to the adult palliative, intensive, end-of-life and geriatric care settings. This is a very reassuring development since adults, especially when older, want and need the assistance of their social support systems. Recent research directions include the involvement of patients in the development of FCC strategies, health literacy interventions and the uptake of telemedicine solutions

Compulsive internet use in adolescents with ASD

Autismus Spektrum Störungen (ASD) sind hauptsächlich durch zwei Symptomgruppen gekennzeichnet: eingeschränkte Interessen und wiederholende Verhaltensmuster (RIRB) und soziale Symptome wie Defizite in sozialen Interaktionen oder Schwierigkeiten bei der Interpretation non-verbaler Kommunikation. Aktuelle Forschung zeigt einen Zusammenhang zwischen ASD und zwanghaftem Internetgebrauch (CIU). Dies liefert Hinweise darauf, dass das Internet Personen mit ASD eine Möglichkeit bietet, die der Störung assoziierten Defizite zu kompensieren. Die aktuelle Studie untersuchte 15 Jugendliche mit ASD und deren Eltern sowie 24 Kontrollfamilien anhand von Fragebögen hinsichtlich CIU, RIRB und sozialen Symptomen. Jugendliche mit ASD schrieben sich selbst nicht mehr CIU zu, als Jugendliche in der Kontrollgruppe, jedoch war ein Trend für höheres CIU in der ASD Gruppe erkennbar. Auch Eltern von Jugendlichen mit ASD schrieben ihren Kindern nicht mehr CIU zu, verglichen mit Eltern der Kontrollgruppe. Es war kein eindeutiger Zusammenhang zwischen CIU und RIRB bzw. sozialen Symptomen erkennbar. Diese Ergebnisse lassen nicht darauf schließen, dass Jugendliche mit ASD das Internet benutzen, um Defizite im sozialen oder nicht-sozialen Bereich zu kompensieren. Zukünftige Forschung sollte eine größere Stichprobengröße zum Ziel haben und konkrete Gründe für Internetgebrauch bei Jugendlichen mit ASD untersuchen, da es plausibel scheint, dass ASD Jugendliche zu CIU prädisponiert. Dies könnte dabei helfen, Strategien zu identifizieren, das Internet als Coping-Instrument im Rahmen von ASD zu benutzen.Autism spectrum disorders (ASD) are characterized by two major symptom groups: restricted interests and repetitive behaviors (RIRB) and social symptoms such as deficits in social interaction and difficulty interpreting non-verbal communication. Research has shown a link between ASD and compulsive Internet use (CIU), suggesting that the Internet provides compensation for the deficits associated with ASD. In this study, 15 adolescents with ASD and their parents as well as 24 control families filled out questionnaires measuring CIU, social symptoms of ASD and RIRB. Adolescents with ASD did not report higher CIU when compared to the control group, although there was a slight trend for higher CIU in the ASD group. Parents in the ASD group did not report higher CIU for their child as well. The current study found no clear link between either RIRB or social symptoms and CIU. These results do not support the suggestion that individuals with ASD use the Internet to compensate for either social deficits or non-social personality traits. Future research should aim for a larger sample size and examine specific reasons for Internet use in individuals with ASD, as it seems likely that ASD predisposes individuals to show CIU. This could aid the identification of online coping strategies for dealing with ASD

Biomarkers for Anti-Angiogenic Therapy in Cancer

Angiogenesis, the development of new vessels from existing vasculature, plays a central role in tumor growth, survival, and progression. On the molecular level it is controlled by a number of pro- and anti-angiogenic cytokines, among which the vascular endothelial growth factors (VEGFs), together with their related VEGF-receptors, have an exceptional position. Therefore, the blockade of VEGF signaling in order to inhibit angiogenesis was deemed an attractive approach for cancer therapy and drugs interfering with the VEGF-ligands, the VEGF receptors, and the intracellular VEGF-mediated signal transduction were developed. Although promising in pre-clinical trials, VEGF-inhibition proved to be problematic in the clinical context. One major drawback was the generally high variability in patient response to anti-angiogenic drugs and the rapid development of therapy resistance, so that, in total, only moderate effects on progression-free and overall survival were observed. Biomarkers predicting the response to VEGF-inhibition might attenuate this problem and help to further individualize drug and dosage determination. Although up to now no definitive biomarker has been identified for this purpose, several candidates are currently under investigation. This review aims to give an overview of the recent developments in this field, focusing on the most prevalent tumor species

Proceedings Of The 23Rd Paediatric Rheumatology European Society Congress: Part Two

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