An Epidemiological Study of Psychological Disorders in Chaharmohal & Bakhtiari Province, 2001

زمینه و هدف: برنامه‏ریزی برای ارایه خدمات اساسی بهداشت روان به افراد جامعه، نیازمند آگاهی از وضعیت موجود بیماری روانی در جامعه است. این مطالعه با هدف بررسی همه‏گیری‏شناسی اختلالات روانی در افراد 18 سال به بالاتر مناطق شهری و روستایی استان چهارمحال و بختیاری انجام گرفت. روش مطالعه: نمونه های مورد مطالعه با روش نمونه‏گیری تصادفی خوشه‏ای و سیستماتیک از بین خانوارهای موجود استان چهارمحال و بختیاری انتخاب گردیدند و از طریق تکمیل پرسشنامه اختلالات عاطفی و اسکیزوفرنیا (SADS=Schedale Affective Disorders Schizophrenia) توسط کارشناسان روانشناسی در استان، جمعاً 305 نفر مورد مطالعه قرار گرفتند. تشخیص‏گذاری اختلالات بر اساس معیارهای طبقه‏بندی DSM-IV است. نتایج: نتایج این بررسی نشان داد شیوع انواع اختلالات روانی در استان 42/16 می‏باشد که این شیوع در زنان 20 و در مردان 14/13 است. اختلالات اضطرابی و عصبی‌ شناختی به ترتیب با 52/9 و 28/3، شایع‏ترین اختلالات روانی در استان بودند. شیوع اختلالات پسیکوتیک در این مطالعه 33/0، اختلالات خلقی 63/2 و اختلالات تجزیه‏ای 66/0 بود. در گروه اختلالات خلقی، افسردگی اساسی با 30/2 و در گروه اختلالات اضطرابی، اختلال فوبی با 62/2 شیوع بیشتری داشتند. شیوع اختلالات روانی در استان در افراد گروه سنی 65-56 سال با 30، افراد همسر فوت شده با 25، افراد ساکن در مناطق شهری با 53/15، افراد بی‏سواد با 66/12 و افراد بیکار با 74/21 بیش از گروه‌های دیگر بود. نتیجه‌گیری: در این مطالعه 49/10 افراد مورد مطالعه دچار حداقل یک اختلال روانی بودند. لذا نتایج این تحقیق مسئولیت سیاستگذاران و برنامه‌ریزان بهداشتی استان چهارمحال و بختیاری و کشور در رابطه با تدوین برنامه‌های عملی و اجرایی بهداشت روان را بیش از پیش روشن می‌سازد

Investigation of wedge water-entry under symmetric impact loads by experimental tests

One of the main challenges for engineers in designing high-speed crafts is the evaluation of hydrodynamic loads during the impact of hull to wave’s surface. This paper presents an experimental investigation on the pressure distribution on three wedge-sections with 15°, 20° and 30° deadrise during water-entry. Assessment of pressure distribution on the effects of parameters such as drop heights, deadrise angles and the weights of the models had done. Time histories of impact pressure were recorded. It was showed that, the maximum pressure for 20° wedge had increased 2.4 times in comparison with 30° wedge while this number is 1.23 time for the 15° wedge. But the effects of weight and drop height were not as much as deadrise angle. The results give an appropriate approximation of the maximum pressures by the model resembling high-speed craft’s hull sections, which can be used to estimate impact loads in different operational condition. The condition of water level during the impact process has also been observed in each test. The nature of impact test with non-constant speed can clarify the real behavior of falling objects, which can be assumed as the significance of current study

Natural language analysis of online health forums

Despite advances in concept extraction from free text, finding meaningful health related information from online patient forums still poses a significant challenge. Here we demonstrate how structured information can be extracted from posts found in such online health related forums by forming relationships between a drug/treatment and a symptom or side effect, including the polarity/sentiment of the patient. In particular, a rule-based natural language processing (NLP) system is deployed, where information in sentences is linked together though anaphora resolution. Our NLP relationship extraction system provides a strong baseline, achieving an F1 score of over 80% in discovering the said relationships that are present in the posts we analysed

Web動画マイニングのための時空間特徴抽出手法の提案

電気通信大学200

Is the Clinical Risk Score for Patients with Colorectal Liver Metastases Still Useable in the Era of Effective Neoadjuvant Chemotherapy?

Background: Several clinical risk scores (CRSs) for the outcome of patients with colorectal liver metastases have been validated, but not in patients undergoing neoadjuvant chemotherapy. Therefore, this study evaluates the predictive value of these CRSs in this specific group. Methods: Between January 2000 and December 2008, all patients undergoing a metastasectomy were analyzed and divided into two groups: 193 patients did not receive neoadjuvant chemotherapy (group A), and 159 patients received neoadjuvant chemotherapy (group B). In group B, the CRSs were calculated before and after administration of neoadjuvant chemotherapy. Results were evaluated by using the CRSs proposed by Nordlinger et al., Fong et al., Nagashima et al., and Konopke et al. Results: In groups A and B, the overall median survival was 43 and 47 months, respectively (P = 0.648). In group A, all CRSs used were of statistically significant predictive value. Before administration of neoadjuvant chemotherapy, only the Nordlinger score was of predictive value. After administration of neoadjuvant chemotherapy, all CRSs were of predictive value again, except for the Konopke score. Conclusions: Traditional CRSs are not a reliable prognostic tool when used in patients before treatment with neoadjuvant chemotherapy. However, CRSs assessed after the administration of neoadjuvant chemotherapy are useful to predict prognosis

Influence of acute pancreatitis on the in vitro responsiveness of rat mesenteric and pulmonary arteries

<p>Abstract</p> <p>Background</p> <p>Acute pancreatitis is an inflammatory disease characterized by local tissue injury and systemic inflammatory response leading to massive nitric oxide (NO) production and haemodynamic disturbances. Therefore, the aim of this work was to evaluate the vascular reactivity of pulmonary and mesenteric artery rings from rats submitted to experimental pancreatitis.</p> <p>Male Wistar rats were divided into three groups: saline (SAL); tauracholate (TAU) and phospholipase A₂(PLA₂). Pancreatitis was induced by administration of TAU or PLA₂from <it>Naja mocambique mocambique </it>into the common bile duct of rats, and after 4 h of duct injection the animals were sacrificed. Concentration-response curves to acetylcholine (ACh), sodium nitroprusside (SNP) and phenylephrine (PHE) in isolated mesenteric and pulmonary arteries were obtained. Potency (pEC₅₀) and maximal responses (E_MAX) were determined. Blood samples were collected for biochemical analysis.</p> <p>Results</p> <p>In mesenteric rings, the potency for ACh was significantly decreased from animals treated with TAU (about 4.2-fold) or PLA₂(about 6.9-fold) compared to saline group without changes in the maximal responses. Neither pEC₅₀nor E_MAXvalues for Ach were altered in pulmonary rings in any group. Similarly, the pEC₅₀and the E_MAXvalues for SNP were not changed in both preparations in any group. The potency for PHE was significantly decreased in rat mesenteric and pulmonary rings from TAU group compared to SAL group (about 2.2- and 2.69-fold, for mesenteric and pulmonary rings, respectively). No changes were seen in the E_MAXfor PHE. The nitrite/nitrate (NO_x^-) levels were markedly increased in animals submitted to acute pancreatitis as compared to SAL group, approximately 76 and 68% in TAU and PLA₂protocol, respectively.</p> <p>Conclusion</p> <p>Acute pancreatitis provoked deleterious effects in endothelium-dependent relaxing response for ACh in mesenteric rings that were strongly associated with high plasma NO_x^-levels as consequence of intense inflammatory responses. Furthermore, the subsensitivity of contractile response to PHE in both mesenteric and pulmonary rings might be due to the complications of this pathological condition in the early stage of pancreatitis.</p

Lichen planus and Hepatitis C: a case-control study

BACKGROUND: The association of lichen planus with hepatitis C (HCV) has been widely reported in the literature. However, there are wide geographical variations in the reported prevalence of HCV infection in patients with lichen planus. This study was conducted to determine the frequency of hepatitis C in Iranian patients with lichen planus at Razi hospital, Tehran. METHODS: During the years 1997 and 1998, 146 cases of lichen planus, 78 (53.1%) women and 69 (46.9%) men were diagnosed. They were diagnosed on the basis of the usual clinical features and, if necessary, typical histological findings. The patients were screened for the presence of anti-HCV antibodies by third generation ELISA and liver function tests. We used the results from screening of blood donors for anti HCV (carried out by Iranian Blood Transfusion Organization) for comparison as the control group. RESULTS: Anti-HCV antibodies were detected in seven cases (4.8%). This was significantly higher than that of the blood donors' antibodies (p < 0.001). The odds ratio was 50.37(21.45–112.24). A statistically significant association was demonstrated between erosive lichen planus and HCV infection. Liver function tests were not significantly different between HCV infected and non-infected patients. CONCLUSION: HCV apears to have an etiologic role for lichen planus in Iranian patients. On the other hand, liver function tests are not good screening means for HCV infection

An enhanced gas ionization sensor from Y-doped vertically aligned conductive ZnO nanorods

A stable and highly sensitive gas ionization sensor (GIS) constructed from vertically aligned, conductive yttrium–doped ZnO nanorod (YZO NR) arrays is demonstrated. The conductive YZO NRs are synthesized using a facile one-pot hydrothermal method. At higher Y/Zn molar ratio, the aspect ratio of the YZO NRs is increased from 11 to 25. Doping with yttrium atoms decreases the electrical resistivity of ZnO NRs more than 100 fold. GIS measurements reveal a 6-fold enhancement in the sensitivity accompanied with a significant reduction in breakdown voltage from the highly conductive YZO NRs. Direct correlations between the resistivity of the NRs and GIS characteristics are established

Outcome of Microscopic Incomplete Resection (R1) of Colorectal Liver Metastases in the Era of Neoadjuvant Chemotherapy

Background: Data from patients with colorectal liver metastases (CRLM) who received neoadjuvant chemotherapy before resection were reviewed and evaluated to see whether neoadjuvant chemotherapy influences the predictive outcome of R1 resections (margin is 0 mm) in patients with CRLM. Methods: Between January 2000 and December 2008, all consecutive patients undergoing liver resection for CRLM were analyzed. Patients were divided into those who did and did not receive neoadjuvant chemotherapy. The outcome after R0 (tumor-free margin >0 mm) and R1 (tumor-free margin 0 mm) resection was compared. Results: A total of 264 were eligible for analysis. Median follow-up was 34 months. Patients without chemotherapy showed a significant difference in median disease-free survival (DFS) after R0 or R1 resection: 17 [95% confidence interval (CI) 10-24] months versus 8 (95% CI 4-12) months (P < 0.001), whereas in