Regional mission impossible?:The Twente Region and the University of Twente

A well-functioning regional innovation system involves a lot of communication and interaction among the actors. However, sometimes the communication and interaction create tensions impeding regional development. In order to explore the reasons behind this, this study looks at the relationships between key stakeholders in the Twente Region in the Netherlands. The region has an established reputation for innovation and entrepreneurship, a high inter-connectedness between the actors, and a strong knowledge infrastructure. The research focuses on the University of Twente as a key actor contributing to regional growth in close cooperation with various stakeholders. This is an introductory interview-based case study that identifies four areas of tension between the university and its regional stakeholders. Our inquiry sheds light on the misalignment of stakeholders’ interests and expectations that lessens the actors’ capacity for policy formulation and strategic agenda setting, as well as hinders its successful translation into action. Then, the absence of clear intermediaries significantly increases the perceived distance between the University of Twente and the Twente region and impedes the university’s collaboration with companies outside the science and business park. Next, the tension of discontinuity highlights the complexities of human resources and personalised networks – their diversity, multidimensionality, and overlaps make it harder to synchronise action and enhance reciprocal benefits. The knowledge asymmetry between the parties further complicates their communication and weakens commitment. In the end, the paper offers a few ideas for action for academic leaders and regional policymakers

Universities as strategic agents in regional path development? A European comparison

This paper contributes to the discussion on the role of universities in regional path development, emphasizing the different agency types adapted. Accordingly, literature on ‘new path development’ is combined with the three agency types of innovative entrepreneurship, institutional entrepreneurship and place-based leadership. This paper applies a long-term qualitative empirical approach with three case studies–Aalborg (Denmark), Kaiserslautern (Germany) and Twente (Netherlands). Results reveal that different types of agency are closely interwoven and complement each other in their effects on regional (industrial) path development. Additionally, the agency types are strongly influenced by (a) highly motivated individuals/frontrunners, (b) support and openness from the university leadership and (c) regional structures that facilitate university-region collaboration and joint governance.</p

Universities and place leadership : a question of agency and alignment

There is increasing interest in the question of how different stakeholders develop, implement and lead regional upgrading processes with the concept of place leadership emerging as one response to this. Simultaneously, universities face growing expectations that they will contribute to regional development processes - often through their collaborative relationships with other regional stakeholders. But universities are complex in terms of their internal and institutional structures, which undermines their capacities to enact coherent place leadership roles. We seek to understand how strategic leadership in universities can contribute to innovation and regional development in the context of the fundamental institutional complexity of universities. We address this through a qualitative, explorative case study comparing six European regions where universities have sincerely attempted to deliver place leadership roles. We identify that the elements of agency and alignment are vital in that: firstly, university leadership has to align with regional coalitions on the one hand and internal structures on the other hand, and secondly, this leadership must give give individuals agency in their regional engagement activities

Embedding entrepreneurial regional innovation ecosystems: reflecting on the role of effectual entrepreneurial discovery processes

The encouragement of collaboration between regional stakeholders is increasingly emphasised in innovation policy as a way to activate the inherent agency in a regional innovation system. Partnerships of diverse stakeholders have been identified as critical, being able to envisage and implement future pathways that in turn bring change to a region. Thus, knowledge concerning the regional assets and possible future pathways is supposed to be discovered through cooperation between diverse stakeholders. Nevertheless, it has been recognised that these agency activation approaches often fail to deliver consequential transformations, agreed by partners in terms of a long-term vision. Sotarauta argues that partners may find themselves falling into a ‘black hole’ when subsequent policy cycles repeat earlier successes rather than consolidating those successes into more systemic change. Accordingly, understanding the conditions under which regional stakeholders can, through a process of constructive dialogue, build realistic and adaptable strategies that can shift regional development trajectories still remains a substantial challenge in innovative regional development theories. In this paper, we argue there is an issue arising from the way these agency activation strategies are supposed to develop long-term plans, as partners’ mind-sets may be too causal and lack the flexibility to reorient strategies in their implementation phases. Focusing specifically on one of these agency activation approaches, namely smart specialisation, we reflect on whether there are also the possibilities for more effectual (opportunistic/flexible) approaches to entrepreneurial discovery. We use a qualitative case study approach comparing entrepreneurial discovery processes in three less successful regions, namely Twente (Netherlands), Aveiro (Portugal), and Lincolnshire (UK), drawing on interviews with key stakeholders as well as analysis of process reports and policy documents

Reconnecting the University to the Region of Twente : Findings from the RUNIN-Design Lab Think Tank

The RUNIN project's Design Lab Think Tank took place on 28th June 2018. Its aim was to discuss the topic of universities' engagement with society, specifically in their region. It used a world café format that brought together regional stakeholders to discuss how the University of Twente (UT) can incorporate societal questions in its core activities and, through this, create regional benefits. This report provides a description of the event, a summation of the initiatives proposed and an analysis of the discussion that was prompted by the sub-questions around the subject of universities' societal engagement

Formulation, stabilisation and encapsulation of bacteriophage for phage therapy

Against a backdrop of global antibiotic resistance and increasing awareness of the importance of the human microbiota, there has been resurgent interest in the potential use of bacteriophages for therapeutic purposes, known as phage therapy. A number of phage therapy phase I and II clinical trials have concluded, and shown phages don’t present significant adverse safety concerns. These clinical trials used simple phage suspensions without any formulation and phage stability was of secondary concern. Phages have a limited stability in solution, and undergo a significant drop in phage titre during processing and storage which is unacceptable if phages are to become regulated pharmaceuticals, where stable dosage and well defined pharmacokinetics and pharmacodynamics are de rigueur. Animal studies have shown that the efficacy of phage therapy outcomes depend on the phage concentration (i.e. the dose) delivered at the site of infection, and their ability to target and kill bacteria, arresting bacterial growth and clearing the infection. In addition, in vitro and animal studies have shown the importance of using phage cocktails rather than single phage preparations to achieve better therapy outcomes. The in vivo reduction of phage concentration due to interactions with host antibodies or other clearance mechanisms may necessitate repeated dosing of phages, or sustained release approaches. Modelling of phage-bacterium population dynamics reinforces these points. Surprisingly little attention has been devoted to the effect of formulation on phage therapy outcomes, given the need for phage cocktails, where each phage within a cocktail may require significantly different formulation to retain a high enough infective dose. This review firstly looks at the clinical needs and challenges (informed through a review of key animal studies evaluating phage therapy) associated with treatment of acute and chronic infections and the drivers for phage encapsulation. An important driver for formulation and encapsulation is shelf life and storage of phage to ensure reproducible dosages. Other drivers include formulation of phage for encapsulation in micro- and nanoparticles for effective delivery, encapsulation in stimuli responsive systems for triggered controlled or sustained release at the targeted site of infection. Encapsulation of phage (e.g. in liposomes) may also be used to increase the circulation time of phage for treating systemic infections, for prophylactic treatment or to treat intracellular infections. We then proceed to document approaches used in the published literature on the formulation and stabilisation of phage for storage and encapsulation of bacteriophage in micro- and nanostructured materials using freeze drying (lyophilization), spray drying, in emulsions e.g. ointments, polymeric microparticles, nanoparticles and liposomes. As phage therapy moves forward towards Phase III clinical trials, the review concludes by looking at promising new approaches for micro- and nanoencapsulation of phages and how these may address gaps in the field